Editor's Choice
ACP Guideline | Nonpharmacologic and pharmacologic treatments of adults in the acute phase of major depressive disorder
24 Jan, 2023 | 14:41h | UTCSee also:
RCT | Outcomes not different with early restrictive vs. liberal fluid management in sepsis-induced hypotension
24 Jan, 2023 | 14:38h | UTCEarly Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: Study comparing early interventions for sepsis shows patients have identical outcomes – Vanderbilt University Medical Center
Commentary on Twitter
This trial comparing treatment strategies that emphasized the use of vasopressors or intravenous fluids for early treatment of sepsis-induced hypotension showed no difference in 90-day mortality before discharge home. #SCCM2023 https://t.co/aIymxmBENE pic.twitter.com/18lFQLMBfA
— NEJM (@NEJM) January 22, 2023
SR | Medication review in hospitalized patients to reduce morbidity and mortality
24 Jan, 2023 | 14:37h | UTCMedication review in hospitalised patients to reduce morbidity and mortality – Cochrane Library
Summary: What are the benefits and risks of medication reviews for hospitalized adults? – Cochrane Library
Commentary on Twitter (thread – click for more)
https://twitter.com/tlassers/status/1617499045005758467
ChatGPT listed as author on research papers: many scientists disapprove
24 Jan, 2023 | 14:36h | UTCChatGPT listed as author on research papers: many scientists disapprove – Nature
Related: Abstracts written by ChatGPT fool scientists
RCT | 2 days of postoperative antibiotics is noninferior to 5 days in patients with complex appendicitis
24 Jan, 2023 | 14:33h | UTC2 days versus 5 days of postoperative antibiotics for complex appendicitis: a pragmatic, open-label, multicentre, non-inferiority randomised trial – The Lancet (link to abstract – $ for full-text)
Commentary: Trial supports shorter postoperative antibiotics for complex appendicitis – CIDRAP
Commentary on Twitter
https://twitter.com/TheLancet/status/1615998251945050112
Perspective | The case of statins, diabetes, and bias in observational studies
24 Jan, 2023 | 14:35h | UTCThe Case of Statins, Diabetes, and Bias in Observational Studies – Sensible Medicine
FDA no longer needs to require animal tests before human drug trials
24 Jan, 2023 | 14:32h | UTCFDA no longer needs to require animal tests before human drug trials – Science
See also: The FDA no longer requires all drugs to be tested on animals before human trials – NPR
Cohort Study | The temporal relationship between severe mental illness diagnosis and chronic physical comorbidity
24 Jan, 2023 | 14:31h | UTCCommentary: Severe mental illness and comorbid chronic physical illness: the clock’s ticking – The Mental Elf
Commentary on Twitter
https://twitter.com/TheLancetPsych/status/1551563396625170434
AHA Statement | Cancer therapy-related hypertension
23 Jan, 2023 | 13:46h | UTCTop Things to Know: Cancer Therapy-Related HTN – American Heart Association
Executive Summary | Guidelines for the diagnosis and management of pediatric acute respiratory distress syndrome
23 Jan, 2023 | 13:45h | UTC
M-A | Mean arterial pressure targets and patient-important outcomes in critically ill adults
23 Jan, 2023 | 13:41h | UTCMean Arterial Pressure Targets and Patient-Important Outcomes in Critically Ill Adults: A Systematic Review and Meta-Analysis of Randomized Trials – Critical Care Medicine (free for a limited period)
RCT | Effects of a web-guided system for self-treatment of recurrent benign paroxysmal positional vertigo
23 Jan, 2023 | 13:43h | UTCEffect of Self-treatment of Recurrent Benign Paroxysmal Positional Vertigo: A Randomized Clinical Trial – JAMA Neurology (free for a limited period)
Related Video: Web-Guided Canalith Reposition Maneuver – JAMA
Commentary: Web-Based System Works Well for Diagnosis, Treatment of Recurrent Vertigo – HealthDay
Commentary on Twitter
Patients may benefit from treating benign paroxysmal positional vertigo themselves using a web-guided system. https://t.co/9Hjwb0XGnl
— JAMA Neurology (@JAMANeuro) January 20, 2023
RCT | Intranasal mometasone furoate and saline are similarly effective for sleep-disordered breathing in children
23 Jan, 2023 | 13:39h | UTCEffectiveness of Intranasal Mometasone Furoate vs Saline for Sleep-Disordered Breathing in Children: A Randomized Clinical Trial – JAMA Pediatrics (free for a limited period)
News Release: Simple nasal spray significantly reduces snoring and breathing difficulties in children – Murdoch Childrens Research Institute
Commentary: Pediatric Sleep-Disordered Breathing Managed in Primary Care with Corticosteroid or Saline – HCP Live
Commentary on Twitter
Study suggests that in primary care, first-line treatment of sleep-disordered breathing in children could include 6 weeks of intranasal saline, or corticosteroid, which may resolve symptoms in almost one-half of children. https://t.co/oWrwcjgkPS @kirstenperrett
— JAMA Pediatrics (@JAMAPediatrics) January 17, 2023
Prescribing cascades: how to detect them, prevent them, and use them appropriately
23 Jan, 2023 | 13:41h | UTCRelated:
Evidence of a gabapentinoid and diuretic prescribing cascade among older adults with lower back pain – Journal of the American Geriatrics Society (link to abstract – $ for full-text)
Are you the victim of a prescribing cascade?
Prescribing Cascade in a Cardiology Practice
Perspective | The next generation of evidence-based medicine
23 Jan, 2023 | 13:37h | UTCThe next generation of evidence-based medicine – Nature Medicine
Commentary: What does the future of clinical trials and evidence-based medicine look like? – News Medical
Commentary on Twitter
Technological advances are transforming evidence generation in medicine. For these advances to impact public health, the clinical trial landscape must evolve and adapt to keep pace, a Perspective in @NatureMedicine argues. https://t.co/5qwE1de26c pic.twitter.com/6RkJSmXXaC
— Nature Portfolio (@NaturePortfolio) January 21, 2023
Cohort Study | Prevalence of colorectal neoplasia 10 or more years after a negative screening colonoscopy in 120 000 repeated screening colonoscopies
23 Jan, 2023 | 13:36h | UTCCommentaries:
Prevalence of Colorectal Cancers Low 10 Years Following Negative Screening Test – HCP Live
Risk for Advanced Neoplasm Low 10+ Years After Negative Colonoscopy – HealthDay
Commentary on Twitter
Large registry-based study finds strong potential for risk-adapted #colorectalcancer screening, suggests extension of screening endoscopy intervals beyond 10 years may be warranted particularly in asymptomatic female and younger participants. https://t.co/fChg6DRyPw @DKFZ
— JAMA Internal Medicine (@JAMAInternalMed) January 17, 2023
Brief review and algorithm | Management of latent tuberculosis infection
23 Jan, 2023 | 13:35h | UTCManagement of Latent Tuberculosis Infection – JAMA (free for a limited period)
An updated “norepinephrine equivalent” score in intensive care as a marker of shock severity
23 Jan, 2023 | 13:34h | UTC
AHA Scientific Statement | Diagnosis, workup, risk reduction of transient ischemic attack in the ED setting
20 Jan, 2023 | 14:56h | UTCNews Release: Stroke symptoms, even if they disappear within an hour, need emergency assessment – American Heart Association
Guideline | Diagnosis and treatment of pleural effusion
20 Jan, 2023 | 14:55h | UTCRelated:
Update on Management of Pleural Disease – Current Pulmonology Reports
Pleural Effusion in Adults—Etiology, Diagnosis, and Treatment – Deutsches Ärzteblatt international
Evaluation of the patient with pleural effusion – Canadian Medical Association Journal
State-of-the-art: Radiological investigation of pleural disease – Respiratory Medicine
Cohort Study | Increased coffee consumption linked to increased CVD risk in patients with severe hypertension
20 Jan, 2023 | 14:53h | UTCCommentaries:
Hypertension and Heavy Coffee Consumption a Bad Combo, Study Finds – TCTMD
Guidelines | Enhanced recovery after surgery recommendations for renal transplantation
20 Jan, 2023 | 14:51h | UTCRelated:
Complete List of Enhanced Recovery After Surgery (ERAS) Society Guidelines
Commentary on Twitter
Free to access in January's BJS: Enhanced recovery after surgery recommendations for renal transplantation: guidelines https://t.co/VkTRQmDWRS @bplwijn @des_winter @ksoreide @MalinASund @evanscolorectal @nfmkok @paulo_sutt @robhinchliffe1 @young_bjs pic.twitter.com/7JQYrlZJnO
— BJS (@BJSurgery) December 30, 2022
Key elements of enhanced recovery after total joint arthroplasty: a reanalysis of the ERAS guidelines
20 Jan, 2023 | 14:49h | UTCRelated:
Enhanced recovery pathways in orthopedic surgery – Journal of Anaesthesiology Clinical Pharmacology
Recommendations for the diagnosis and management of COVID-19 associated bacterial and fungal infections
20 Jan, 2023 | 14:48h | UTC
RCT | Oral ibuprofen and oral ketorolac are similarly effective for children with acute traumatic pain
20 Jan, 2023 | 14:47h | UTC


