RCT | Outcomes not different with early restrictive vs. liberal fluid management in sepsis-induced hypotension

Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Study comparing early interventions for sepsis shows patients have identical outcomes – Vanderbilt University Medical Center

Commentary on Twitter

This trial comparing treatment strategies that emphasized the use of vasopressors or intravenous fluids for early treatment of sepsis-induced hypotension showed no difference in 90-day mortality before discharge home. #SCCM2023 https://t.co/aIymxmBENE pic.twitter.com/18lFQLMBfA

— NEJM (@NEJM) January 22, 2023