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RCT | Blood donor’s sex does not impact transfusion recipients’ survival

19 Apr, 2023 | 13:20h | UTC

Effect of Donor Sex on Recipient Mortality in Transfusion – New England Journal of Medicine (link to abstract – $ for full-text)

News release: Sex of blood donor has no effect on recipient survival – Ottawa Hospital

 

Commentary on Twitter

 

Perspective | Here’s a new data point for cancer patients to consider: ‘time toxicity’

19 Apr, 2023 | 13:18h | UTC

Here’s a new data point for cancer patients to consider: ‘time toxicity’ – STAT

 

Ischemia with nonobstructive coronary artery disease: concept, assessment, and management

19 Apr, 2023 | 13:17h | UTC

Ischemia With Nonobstructive Coronary Artery Disease: Concept, Assessment, and Management – JACC: Asia

Related:

Review: Myocardial infarction with non-obstructive coronary artery disease.

MINOCA from A to Z – American College of Cardiology

Guidelines for the Management of Myocardial Infarction/injury with Non-obstructive Coronary Arteries (MINOCA)

Prognosis and Predictors of Mortality in Patients Suffering Myocardial Infarction With Non‐Obstructive Coronary Arteries

Contemporary Diagnosis and Management of Patients With Myocardial Infarction in the Absence of Obstructive Coronary Artery Disease: A Scientific Statement From the American Heart Association

The What, When, Who, Why, How and Where of Myocardial Infarction With Non-Obstructive Coronary Arteries (MINOCA) – Circulation Journal

Systematic Review of Patients Presenting With Suspected Myocardial Infarction and Nonobstructive Coronary Arteries – Circulation

Nonobstructive Versus Obstructive Coronary Artery Disease in Acute Coronary Syndrome: A Meta‐Analysis – Journal of the American Heart Association

 

Opinion | Universal masking in health care settings: a pandemic strategy whose time has come and gone, for now

18 Apr, 2023 | 13:37h | UTC

Universal Masking in Health Care Settings: A Pandemic Strategy Whose Time Has Come and Gone, For Now – Annals of Internal Medicine

News Release: Healthcare epidemiologists and infectious diseases experts review changing context for masking in healthcare settings – Mass General Brigham

 

Opinion | In-person schooling is essential even during periods of high transmission of COVID-19

18 Apr, 2023 | 13:36h | UTC

In-person schooling is essential even during periods of high transmission of COVID-19 – BMJ Evidence-Based Medicine

 

Comprehensive clinical practice guidelines for the management of psychiatric emergencies

18 Apr, 2023 | 13:34h | UTC

Homepage: Clinical Practice Guidelines for Psychiatric Emergencies and Brain Stimulation Techniques – Indian Journal of Psychiatry

Editorial

Clinical Practice Guidelines for Management of Suicidal Behaviour

Clinical Practice Guidelines for Assessment and Management of Aggressive and Assaultive Behaviour

Clinical Practice Guidelines for the Assessment and Management of Elderly Presenting with Psychiatric Emergencies

Clinical Practice Guidelines for Assessment and Management of Children and Adolescents Presenting with Psychiatric Emergencies

Clinical Practice Guidelines for Assessment and Management of Psychiatric Emergencies in Victims of Sexual Violence

Clinical Practice Guidelines for Assessment and Management of Anxiety and Panic Disorders in Emergency Setting

Clinical Practice Guidelines for Assessment and Management of Dissociative Disorders Presenting as Psychiatric Emergencies

Clinical Practice Guidelines for Assessment and Management of Patients with Substance Intoxication Presenting to the Emergency Department

Clinical Practice Guidelines for Assessment and Management of Patients Presenting with Psychosocial Crisis

Clinical Practice Guidelines for Assessment and Management of Patients with Borderline Personality Disorder

Clinical Practice Guidelines on Breaking Bad News

Clinical Practice Guidelines for Assessment and Management of Psychiatric Morbidity in Medical Professionals

Clinical Practice Guidelines for the Use of Electroconvulsive Therapy

Clinical Practice Guidelines for the Therapeutic Use of Repetitive Transcranial Magnetic Stimulation in Neuropsychiatric Disorders

Clinical Practice Guidelines for the Use of Transcranial Direct Current Stimulation in Psychiatry

 

Cluster RCT | Salt substitute outperforms salt restriction in lowering blood pressure in older patients

18 Apr, 2023 | 13:30h | UTC

Salt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial – Nature Medicine (if the link is paywalled, try this one)

Commentary: Exploring effectiveness of salt substitutes in elderly care facilities – Medical Xpress

Related:

Salt substitutes vs. regular salt: a quick look.

Effects of salt substitutes on clinical outcomes: a systematic review and meta-analysis – Heart (link to abstract – $ for full-text)

Cluster RCT: A household salt substitution intervention is a cost-effective intervention for preventing stroke and improving quality of life.

#ESCCongress – Cluster RCT: Among patients at increased risk for stroke, salt substitution (75% sodium chloride and 25% potassium chloride by mass) reduced the rates of stroke, major cardiovascular events, and death from any cause.

RCT: Reduced-sodium added-potassium salt substitute reduces blood pressure in hypertensive patients

Potassium Enriched Salt Substitution Could Prevent a Large Number of Cardiovascular Deaths

Cluster Randomized Trial: Effect of Salt Substitution on Community-wide Blood Pressure and Hypertension Incidence

 

Commentary on Twitter

 

Study shows approximately half of infectious diseases guideline authors have conflicts of interest with pharmaceutical companies

18 Apr, 2023 | 13:28h | UTC

Conflicts of Interest Among Infectious Diseases Clinical Practice Guideline Authors and the Pharmaceutical Industry – JAMA Network Open

 

Review | Management of cardiogenic shock after acute coronary syndromes

18 Apr, 2023 | 13:27h | UTC

Management of cardiogenic shock after acute coronary syndromes – BJA Education

 

Large-scale study finds genetic causes for 41% of rare pediatric diseases

18 Apr, 2023 | 13:25h | UTC

Genomic Diagnosis of Rare Pediatric Disease in the United Kingdom and Ireland – New England Journal of Medicine (free for a limited period)

News Release: 5,500 people diagnosed with rare genetic diseases in major research study – University of Exeter

Commentary: Study endeavors to strengthen genomic diagnosis of rare pediatric diseases in the United Kingdom and Ireland – News Medical

 

Commentary on Twitter

 

Guidelines for the management of adult acute and acute-on-chronic liver failure in the ICU

17 Apr, 2023 | 13:19h | UTC

Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Neurology, Peri-Transplant Medicine, Infectious Disease, and Gastroenterology Considerations – Critical Care Medicine (free for a limited period)

Executive Summary: Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU: Neurology, Peri-Transplant Medicine, Infectious Disease, and Gastroenterology Considerations – Critical Care Medicine (free for a limited period)

 

Consensus Paper | Strategies to prevent Clostridioides difficile infections in acute-care hospitals

17 Apr, 2023 | 13:17h | UTC

Strategies to prevent Clostridioides difficile infections in acute-care hospitals: 2022 Update – Infection Control & Hospital Epidemiology

News Release: Updated guidance: Antimicrobial stewardship programs essential for preventing C. difficile in hospitals – Society for Healthcare Epidemiology of America

Commentary: New guidance deems antibiotic stewardship essential for preventing C diff infections – CIDRAP

 

National clinical guideline for stroke for the UK and Ireland

17 Apr, 2023 | 13:15h | UTC

National clinical guideline for stroke for the UK and Ireland – Stroke Working Party (Full PDF here)

 

RCT | Heterogeneity in blood pressure response to 4 antihypertensive drugs

17 Apr, 2023 | 13:14h | UTC

Heterogeneity in Blood Pressure Response to 4 Antihypertensive Drugs: A Randomized Clinical Trial – JAMA (free for a limited period)

News Release: Personalized blood pressure treatment more effective – Uppsala University

Commentary: Hypertension: Personalized Treatment May Reduce Need for Higher Doses and Multiple Medications – MedicalResearch.com

 

Phase 2 RCT | High-dose VE303 reduces recurrent Clostridioides difficile infection rates

17 Apr, 2023 | 13:12h | UTC

VE303, a Defined Bacterial Consortium, for Prevention of Recurrent Clostridioides difficile Infection: A Randomized Clinical Trial – JAMA (free for a limited period)

See also: Visual Abstract

 

Identifying perioperative anaphylaxis in Japan: epidemiology, allergens, and diagnostic tools

17 Apr, 2023 | 13:10h | UTC

The Japanese Epidemiologic Study for Perioperative Anaphylaxis, a prospective nationwide study: allergen exposure, epidemiology, and diagnosis of anaphylaxis during general anaesthesia – British Journal of Anaesthesia

 

Propofol and survival: an updated meta-analysis of randomized clinical trials

17 Apr, 2023 | 13:09h | UTC

Propofol and survival: an updated meta-analysis of randomized clinical trials – Critical Care

 

Commentary on Twitter (thread – click for more)

 

Review | Diagnosis and management of prediabetes

12 Apr, 2023 | 13:28h | UTC

Diagnosis and Management of Prediabetes: A Review – JAMA (free for a limited period)

Editorial: Prediabetes Diagnosis and Management – JAMA (free for a limited period)

Video: Screening for Prediabetes – JAMA

Audio Clinical Review: Diagnosis and Management of Patients With Prediabetes – JAMA

 

RCT | Doxycycline postexposure prophylaxis effective in preventing gonorrhea, chlamydia, and syphilis in MSM

12 Apr, 2023 | 13:30h | UTC

Summary: In this open-label, randomized study involving 501 men who have sex with men (MSM) and transgender women, researchers investigated the effectiveness of postexposure doxycycline in preventing bacterial sexually transmitted infections (STIs), specifically gonorrhea, chlamydia, and syphilis. Participants with a previous STI in the past year, either taking preexposure prophylaxis (PrEP) against HIV or living with HIV, were randomly assigned to receive 200 mg of doxycycline within 72 hours after condomless sex or standard care without doxycycline. STI testing was performed quarterly, with the primary end point being the incidence of at least one STI per follow-up quarter.

Results demonstrated a significant reduction in STI incidence in both the PrEP and persons living with HIV cohorts who received doxycycline.  Overall, the combined incidence of these three STIs was lower by two thirds with doxycycline postexposure prophylaxis compared to standard care. The study also reported five grade 3 adverse events but no serious adverse events attributed to doxycycline. This finding supports the use of doxycycline postexposure prophylaxis among MSM with recent bacterial STIs.

Article: Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Doxycycline after sex found to reduce STI incidence in gay men, transgender women – CIDRAP

 

Commentary on Twitter

 

RCT | Low-dose olanzapine enhances appetite & weight gain in chemotherapy patients

11 Apr, 2023 | 14:41h | UTC

Randomized Double-Blind Placebo-Controlled Study of Olanzapine for Chemotherapy-Related Anorexia in Patients With Locally Advanced or Metastatic Gastric, Hepatopancreaticobiliary, and Lung Cancer – Journal of Clinical Oncology (link to abstract – $ for full-text)

Commentaries:

Olanzapine to Prevent Chemotherapy-Related Anorexia in Newly Diagnosed Patients With Advanced Cancers – The ASCO Post

Low-dose olanzapine improves appetite in chemotherapy patients – MDedge

 

Commentary on Twitter

 

Pharmacological treatments for low back pain in adults: an overview of Cochrane Reviews

11 Apr, 2023 | 14:39h | UTC

Pharmacological treatments for low back pain in adults: an overview of Cochrane Reviews – Cochrane Database of Systematic Reviews

Summary: Pharmacological treatments for low back pain in adults: an overview of Cochrane Reviews – Cochrane Database of Systematic Reviews

Related:

SR | Nonopioid pharmacological management of acute low back pain

M-A | Limited evidence for analgesic effectiveness in acute low back pain treatment

Chronic Low Back Pain: A Narrative Review of Recent International Guidelines for Diagnosis and Conservative Treatment – Journal of Clinical Medicine

M-A: Effectiveness of treatments for acute and subacute mechanical non-specific low back pain

Guideline Interventions for the management of acute and chronic low back pain.

M-A: Little benefit from muscle relaxants for adults with non-specific low back pain.

 

RCT | Exploring the potential of peritumoral lidocaine infiltration to improve outcomes in early breast cancer

11 Apr, 2023 | 14:37h | UTC

Effect of Peritumoral Infiltration of Local Anesthetic Before Surgery on Survival in Early Breast Cancer – Journal of Clinical Oncology (link to abstract – $ for full-text)

Editorial: Peritumoral Lidocaine Injection: A Low-Cost, Easily Implemented Intervention to Improve Outcomes in Early-Stage Breast Cancer – Journal of Clinical Oncology

 

Blinded, randomized trial of sonographer versus AI cardiac function assessment

11 Apr, 2023 | 14:34h | UTC

Blinded, randomized trial of sonographer versus AI cardiac function assessment – Nature

News Release: Is artificial intelligence better at assessing heart health? – Cedars-Sinai Medical Center

 

ChatGPT et al? Not so fast, say journal editors

11 Apr, 2023 | 14:36h | UTC

ChatGPT et al? Not So Fast, Say Journal Editors – TCTMD

Related:

AI-Generated Medical Advice—GPT and Beyond – JAMA (free for a limited period)

Chat GPT will change Medicine – Vinay Prasad’s Observations and Thoughts

The use of ChatGPT and other large language models in surgical science – BJS Open

ChatGPT vs. NCI: analyzing the quality of cancer information on myths and misconceptions

ChatGPT has many uses. Experts explore what this means for healthcare and medical research – The Conversation

Artificial Intelligence in Medicine & ChatGPT: De-Tether the Physician – Journal of Medical Systems (if the link is paywalled, try this one)

Can artificial intelligence help for scientific writing? – Critical Care

Artificial intelligence in academic writing: a paradigm-shifting technological advance

Performance of ChatGPT on USMLE: potential for AI-assisted medical education using large language models

Perspective | ChatGPT-assisted diagnosis: is the future suddenly here?

Perspective | Generating scholarly content with ChatGPT: ethical challenges for medical publishing

ChatGPT: Will It Transform the World of Health Care? – UCSF Department of Medicine

ChatGPT and the future of medical writing (ChatGPT itself wrote this paper)

ChatGPT: five priorities for research – Nature

The path forward for ChatGPT in academia – Lumo’s Newsletter

Nonhuman “Authors” and Implications for the Integrity of Scientific Publication and Medical Knowledge – JAMA

ChatGPT is fun, but not an author – Science

Tools such as ChatGPT threaten transparent science; here are our ground rules for their use – Nature

ChatGPT listed as author on research papers: many scientists disapprove – Nature

Abstracts written by ChatGPT fool scientists

 

M-A | Timing of allergenic food introduction and risk of immunoglobulin E–mediated food allergy

11 Apr, 2023 | 14:32h | UTC

Timing of Allergenic Food Introduction and Risk of Immunoglobulin E–Mediated Food Allergy: A Systematic Review and Meta-analysis – JAMA Pediatrics

News Release: Earlier introduction of allergenic foods in children may prevent food allergies – Imperial College London

Commentary: Allergenic Food Introduction Led to Fewer Allergies, Higher Withdrawal Rate from Intervention – HCP Live

Related:

Study | Public health policies should recommend introducing peanut products to infants at 4-6 months of age to prevent peanut allergy

AAP Updated Recommendations for Dietary Interventions to Prevent Atopic Disease

Timing of introduction of allergenic solids for infants at high risk – Canadian Paediatric Society

 

Commentary on Twitter

 

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