Critical Care & Emergencies (all articles) | Page 51 of 187 | Links Medicus Content Curation & Alerts in Medicine

HOT OFF THE PRESS:POISE-3 Tranexamic Acid
Incidence of composite bleeding outcome significantly lower with tranexamic acid vs placebo; between-group difference in composite CV outcome was small, but noninferiority of tranexamic acid was not established.https://t.co/FyuBliD0Mr

— Steven Cohn, MD (@preopconsult) April 2, 2022

Among patients undergoing noncardiac surgery, the incidence of the composite bleeding outcome was significantly lower with tranexamic acid than with placebo. #ACC22 https://t.co/cYIQhE7YCD pic.twitter.com/l0QKgpEqnG

— NEJM (@NEJM) April 2, 2022

POISE-3 trial results showed a single dose of tranexamic acid before & after surgery significantly ⬇️ severe bleeding risk in pts undergoing noncardiac surgery compared w/ placebo. Findings could have global 🌏 impact, researchers said. https://t.co/LratgyadtE #ACC22 #cvSurg pic.twitter.com/HXlcp6bb0M

— American College of Cardiology (@ACCinTouch) April 2, 2022

Systematic review: there is insufficient evidence that therapeutic drug monitoring improves outcomes during treatment with penicillins.

4 Apr, 2022 | 00:47h | UTC

A systematic review of the effect of therapeutic drug monitoring on patient health outcomes during treatment with penicillins – Journal of Antimicrobial Chemotherapy

State of the Art Review: The heart brain team and patient-centered management of ischemic stroke.

1 Apr, 2022 | 09:53h | UTC

The Heart Brain Team and Patient-Centered Management of Ischemic Stroke – JACC: Advances

Development of a consensus-based definition of Focused Assessment with Sonography for Trauma (FAST) in children.

1 Apr, 2022 | 08:35h | UTC

Development of a Consensus-Based Definition of Focused Assessment With Sonography for Trauma in Children – JAMA Network Open

Commentaries:

New FAST Definitions May Improve Trauma Assessment of Children – Medscape (free registration required)

Ultrasonographic views, landmarks, and patient-specific factors to consider in a consensus-based definition of the Focused Assessment With Sonography for Trauma in children with abdominal injury – Physician’s Weekly

Commentary on Twitter

Qualitative study describes the development of an expert definition for high-quality & accurate pediatric Focused Assessment with Sonography for Trauma (FAST), including recommended views, landmarks & imaging quality. @aaronkornblith @nkpluso @pocusnetwork https://t.co/4CTvGp2Rqs

— JAMA Network Open (@JAMANetworkOpen) March 18, 2022

RCT: Early treatment with ivermectin does not improve outcomes in patients with Covid-19.

31 Mar, 2022 | 08:41h | UTC

Effect of Early Treatment with Ivermectin among Patients with Covid-19- New England Journal of Medicine

Commentary: Ivermectin does not prevent COVID-19 hospitalization, a new study says – NPR

Commentary on Twitter

Ivermectin: the largest randomized, double-blind trial yet conducted, with early treatment, indicates there is no difference compared with placebo. It doesn't work. Period. https://t.co/wiFygjRgkk
just published @NEJM pic.twitter.com/uZ0mMZnO0E

— Eric Topol (@EricTopol) March 30, 2022

RCT: Early outpatient treatment with convalescent plasma reduces the risk of hospitalization in patients with Covid-19.

31 Mar, 2022 | 08:39h | UTC

Early Outpatient Treatment for Covid-19 with Convalescent Plasma – New England Journal of Medicine

Commentaries:

Study finds convalescent plasma can be effective early COVID-19 therapy – Johns Hopkins University School of Medicine

Early Use of High-Titer Plasma Reduced COVID Hospitalizations— Randomized trial that influenced indication shows benefits in a mostly unvaccinated population – MedPage Today (free registration required)

Commentary on Twitter

https://twitter.com/NEJM/status/1509278140433981444

A Narrative Review on the approach to antimicrobial use in ventilated patients with multidrug resistant organisms in respiratory samples—to treat or not to treat?

31 Mar, 2022 | 08:27h | UTC

A Narrative Review on the Approach to Antimicrobial Use in Ventilated Patients with Multidrug Resistant Organisms in Respiratory Samples—To Treat or Not to Treat? That Is the Question – Antibiotics

Commentary on Twitter

https://twitter.com/ABsteward/status/1508917245740818438

Review | Advanced heart failure: guideline-directed medical therapy, diuretics, inotropes, and palliative care.

31 Mar, 2022 | 08:09h | UTC

Advanced heart failure: guideline-directed medical therapy, diuretics, inotropes, and palliative care – ESC Heart Failure

Complicated and uncomplicated S. aureus bacteremia: an international Delphi survey among infectious diseases experts on definitions and treatment.

30 Mar, 2022 | 10:34h | UTC

Complicated and uncomplicated S. aureus bacteremia: an international Delphi survey among infectious diseases experts on definitions and treatment – Clinical Microbiology and Infection

The RECOVERY Trial – two years on.

30 Mar, 2022 | 10:38h | UTC

The RECOVERY Trial – two years on – University of Oxford

How the UK found the first effective Covid-19 treatment — and saved a million lives (about the RECOVERY trial and the effects of Dexamethasone)

Covid: The London bus trip that saved maybe a million lives (about the creation of the RECOVERY Trial)

Low-cost dexamethasone reduces death by up to one third in hospitalised patients with severe respiratory complications of COVID-19 – Recovery Trial

[Preprint] RECOVERY trial shows Baricitinib reduces deaths in patients hospitalized with COVID-19.

RCT: CPAP improved outcomes in patients with acute hypoxemic respiratory failure due to COVID-19, but high-flow nasal oxygen was not better than conventional oxygen therapy.

RECOVERY Trial: In patients admitted to hospital with COVID-19, Colchicine did not reduce 28-day mortality, duration of hospital stay, or risk of progressing to invasive mechanical ventilation or death.

RECOVERY Trial: No benefit from convalescent plasma in patients admitted to hospital with COVID-19.

RECOVERY Trial: Aspirin as an add-on therapy did not reduce mortality in patients hospitalized with COVID-19.

RECOVERY trial: In hospitalized COVID-19 patients with hypoxia and systemic inflammation (C-reactive protein ≥75 mg/L), tocilizumab improved survival and other clinical outcomes

RECOVERY trial: Azithromycin not beneficial for patients admitted to hospital with COVID-19

[Preprint] RECOVERY trial finds Regeneron’s monoclonal antibody combination reduces deaths for hospitalized COVID-19 patients who have not mounted their own immune response.

RECOVERY trial: Effect of hydroxychloroquine in hospitalized patients with Covid-19

Randomized trial: Lopinavir–ritonavir not beneficial for patients admitted to hospital with COVID-19

Commentary on Twitter

https://twitter.com/MartinLandray/status/1508492188560371717

The harms of postoperative antibiotic prophylaxis: a teachable moment.

30 Mar, 2022 | 10:36h | UTC

The Harms of Postoperative Antibiotic Prophylaxis: A Teachable Moment – JAMA Internal Medicine (free for a limited period)

AHA/ASA Scientific Statement: Endovascular treatment and thrombolysis for acute ischemic stroke in patients with premorbid disability or dementia.

30 Mar, 2022 | 10:33h | UTC

Endovascular Treatment and Thrombolysis for Acute Ischemic Stroke in Patients With Premorbid Disability or Dementia: A Scientific Statement From the American Heart Association/American Stroke Association – Stroke

News Release: Stroke treatments safe and effective for people with existing disability or dementia – American Heart Association

Commentary on Twitter (thread – click for more)

1/ Endovascular Treatment and Thrombolysis for Acute Ischemic Stroke in Patients with Pre-morbid Disability or Dementia

Authors: @draravindganesh @pecouille @SMGreenbergNeur @Doctorjfred @mayank_G0 @NAsdaghi @GPerue

Published today in @StrokeAHA_ASA: https://t.co/9VdIvGDNoN pic.twitter.com/CgET4ygCHu

— AHA Science (@AHAScience) March 28, 2022

Extracorporeal life support organization guidelines for fluid overload, acute kidney injury, and electrolyte management.

30 Mar, 2022 | 10:20h | UTC

Extracorporeal Life Support Organization Guidelines for Fluid Overload, Acute Kidney Injury, and Electrolyte Management – ASAIO Journal

ELSO Guidelines for adult and pediatric extracorporeal membrane oxygenation circuits.

ELSO Guidelines for anticoagulation in adult and pediatric patients using extracorporeal membrane oxygenation (ECMO).

Guidelines for extracorporeal cardiopulmonary resuscitation in children and adults

Commentary on Twitter

https://twitter.com/ELSOOrg/status/1508860598406242306

End-of-life care in the cardiac intensive care unit: a contemporary view from the Critical Care Cardiology Trials Network (CCCTN) Registry.

30 Mar, 2022 | 10:08h | UTC

End-of-life care in the cardiac intensive care unit: a contemporary view from the Critical Care Cardiology Trials Network (CCCTN) Registry – European Heart Journal. Acute Cardiovascular Care

Commentary on Twitter

#EHJACVC Editors Choice:
End-of-life care in the cardiac intensive care unit: a contemporary view from the Critical Care Cardiology Trials Network (CCCTN) Registry

Big thank you to the @TIMIStudyGroup #CCCTN group for this important analysis! https://t.co/QJaPoTurLc pic.twitter.com/leOZRBNGTB

— EHJACVC Editor-in-Chief (@EHJACVCEiC) March 29, 2022

Cohort Study: Coronary artery and cardiac disease are common in patients with type 2 myocardial infarction.

29 Mar, 2022 | 10:14h | UTC

Coronary Artery and Cardiac Disease in Patients With Type 2 Myocardial Infarction: A Prospective Cohort Study – Circulation

Commentary: AHA News: Undiagnosed Heart Disease May Be Common in People With Heart Attacks Not Caused by Clots – HealthDay

Commentary on Twitter

#OriginalResearch: #DEMAND_MI 1st prospective study to undertake systematic cardiac imaging in patients with type 2 MI. Results show high prevalence of LV dysfunction & CAD @damini_dey @imagingmedsci @marcdweck @jdinaus @andabularga @RyanWereski @chapdoc1 https://t.co/dygODQ92vs pic.twitter.com/ny3Fsyx7wH

— Circulation (@CircAHA) March 28, 2022