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Allergy & Immunology

Consensus on the diagnosis and treatment of cow’s milk protein allergy.

2 Jun, 2022 | 10:56h | UTC

Consensus on the diagnosis and treatment of cow’s milk protein allergy of the Latin American Society for Pediatric Gastroenterology, Hepatology and Nutrition – Revista de Gastroenterología de México (English Edition)

 

Cohort Study: Risk of hematologic cancer in patients with undifferentiated pruritus.

30 May, 2022 | 10:35h | UTC

Risk of Hematologic Cancer in Patients With Undifferentiated Pruritus – JAMA Dermatology (link to abstract – $ for full-text)

Commentary: Undifferentiated Pruritus Associated with Increased Risk of Hematologic Cancer – HCP Live

 

Cohort Study: Most egg allergy and nearly one-third of peanut allergy resolves naturally by age 6 years.

27 May, 2022 | 11:46h | UTC

The natural history of peanut and egg allergy in children up to age 6 years in the HealthNuts population-based longitudinal study – The Journal of Allergy & Clinical Immunology (link to abstract – $ for full-text)

 

Joint consensus guidelines on the diagnosis and management of eosinophilic esophagitis in children and adults.

25 May, 2022 | 11:32h | UTC

British Society of Gastroenterology (BSG) and British Society of Paediatric Gastroenterology, Hepatology and Nutrition (BSPGHAN) joint consensus guidelines on the diagnosis and management of eosinophilic oesophagitis in children and adults – Gut

 

Cohort Study: Analysis of neuropsychiatric diagnoses after montelukast initiation.

25 May, 2022 | 11:05h | UTC

Analysis of Neuropsychiatric Diagnoses After Montelukast Initiation – JAMA Network Open

Related:

FDA requires Boxed Warning about serious mental health side effects for asthma and allergy drug montelukast (Singulair); advises restricting use for allergic rhinitis – U.S. Food & Drug Administration

Adverse drug reactions of montelukast in children and adults – Pharmacology Research & Perspectives

 

Commentary on Twitter

 

Review: Allergic asthma is a risk factor for human cardiovascular diseases.

23 May, 2022 | 00:48h | UTC

Allergic asthma is a risk factor for human cardiovascular diseases – Nature Cardiovascular Research

 

Commentary on Twitter

 

Review: Unexplained post-acute infection syndromes.

19 May, 2022 | 10:58h | UTC

Unexplained post-acute infection syndromes – Nature Medicine (if the link is paywalled, try this one)

 

Commentary on Twitter

 

Antibiotics given shortly before cesarean birth not linked to asthma and eczema in young children.

19 May, 2022 | 10:46h | UTC

News Release: Antibiotics given shortly before cesarean birth not linked to asthma and eczema in young children – University of Birmingham

Original Study: Long term impact of prophylactic antibiotic use before incision versus after cord clamping on children born by caesarean section: longitudinal study of UK electronic health records – The BMJ

 

Review | Disorders of ubiquitylation: unchained inflammation.

18 May, 2022 | 10:36h | UTC

Disorders of ubiquitylation: unchained inflammation – Nature Reviews Rheumatology (if the link is paywalled, try this one in PMC)

 

Commentary on Twitter

 

New versions of Omicron are masters of immune evasion.

13 May, 2022 | 11:37h | UTC

New versions of Omicron are masters of immune evasion – Science

 

Commentary on Twitter

 

Guideline: Contact dermatitis.

10 May, 2022 | 10:54h | UTC

German S1 guideline: Contact dermatitis – Journal of the German Society of Dermatology

 

Translating research into practice: What’s new in the 2021 EAACI food allergy prevention guidelines?

8 Apr, 2022 | 10:00h | UTC

Translating research into practice: What’s new in the 2021 EAACI food allergy prevention guidelines? – Clinical & Experimental Allergy

Original Guideline: EAACI guideline: Preventing the development of food allergy in infants and young children – Pediatric Allergy and Immunology

Related:

Practice Guideline: Prevention and management of allergic reactions to food in child care centers and schools

Study: Early Introduction of Allergenic Foods Can Prevent Food Allergies in High Risk Infants

AAP Updated Recommendations for Dietary Interventions to Prevent Atopic Disease

Timing of introduction of allergenic solids for infants at high risk – Canadian Paediatric Society (free)

Short Review: Food Allergy Prevention with Early Food Introduction

 

Review: Predicting the course of asthma from childhood until early adulthood.

1 Apr, 2022 | 08:32h | UTC

Predicting the course of asthma from childhood until early adulthood – Current Opinion in Allergy and Clinical Immunology

 

[Preprint] Retrospective cohort study: second booster vaccine and Covid-19 mortality in adults 60 to 100 years old.

30 Mar, 2022 | 10:44h | UTC

Second Booster Vaccine and Covid-19 Mortality in Adults 60 to 100 Years Old – Research Square

Commentaries:

Huge Study Finds Second COVID-19 Booster is ‘Life-saving’ for Over 60s – Health Policy Watch

Fourth COVID-19 vaccine dose substantially reduces mortality in the elderly – News Medical

 

U.S. approves second Covid-19 booster for people 50 and older and immunocompromised individuals.

30 Mar, 2022 | 10:42h | UTC

U.S. approves second Covid-19 booster for people 50 and older – STAT

FDA OKs second COVID booster shot for older Americans – CIDRAP

See Guidance: Coronavirus (COVID-19) Update: FDA Authorizes Second Booster Dose of Two COVID-19 Vaccines for Older and Immunocompromised Individuals – U.S. Food & Drug Administration

 

Retrospective Cohort Study: Risks for anaphylaxis with intravenous iron formulations.

30 Mar, 2022 | 10:16h | UTC

Risks for Anaphylaxis With Intravenous Iron Formulations: A Retrospective Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

News Release: Risk of Severe Allergic Reaction Higher with Two Intravenous Iron-Boosting Products – Rutgers University

Commentary: Risks for Anaphylaxis Compared Among IV Iron Products – HealthDay

 

Cohort Study: Prenatal occupational disinfectant exposure linked to increased risk of childhood allergies.

30 Mar, 2022 | 08:48h | UTC

Prenatal occupational disinfectant exposure and childhood allergies: the Japan Environment and Children’s study – Occupational & Environmental Medicine

Commentary: Disinfectant use by pregnant women may increase risk for asthma and eczema in children – BMJ/News Medical

 

Commentary on Twitter

 

The prevalence of penicillin allergy labeling ranged from 0.9% to 10.2% across practices in a large pediatric cohort, raising questions regarding the validity of those labels and the unnecessary use of second-line antibiotics that may follow.

28 Mar, 2022 | 09:48h | UTC

Factors Associated With Penicillin Allergy Labels in Electronic Health Records of Children in 2 Large US Pediatric Primary Care Networks – JAMA Network Open

Related: A pharmacist-led penicillin allergy assessment program can delabel many “penicillin allergic” patients through allergy histories and penicillin skin testing. The program was associated with reduced use of high Clostridioides difficile infection–risk antibiotics.

M-A: Most patients with allergy to Penicillin can be given Cefazolin

Systematic review: Safety and efficacy of de-labelling penicillin allergy in adults using direct oral challenge

Penicillin allergy labels increase second-line broad-spectrum antibiotic prescribing for pediatric respiratory tract infections

Podcast: A Clinical Pharmacologist’s Perspective on Penicillin Allergy

Study: Development and Validation of a Penicillin Allergy Clinical Decision Rule

Consensus Recommendations: Management of a Surgical Patient with a Label of Penicillin Allergy

Practical Guide for Pharmacists to Successfully Implement Penicillin Allergy Skin Testing

NICE: Double Check Patients with ‘Penicillin Allergy’ to Avoid Increased MRSA Risk

Cohort Study: Risk of Meticillin Resistant Staphylococcus Aureus and Clostridium Difficile in Patients with a Documented Penicillin Allergy

 

Commentary on Twitter

 

A practical guide to implementing SMART in asthma management.

28 Mar, 2022 | 08:42h | UTC

A Practical Guide to Implementing SMART in Asthma Management – The Journal of Allergy and Clinical Immunology

 

Food protein-induced enterocolitis syndrome: A large French multicentric experience.

25 Mar, 2022 | 08:27h | UTC

Food protein-induced enterocolitis syndrome: A large French multicentric experience – Clinical and Translational Allergy

 

RCT: Inhibition of Prekallikrein for hereditary angioedema.

23 Mar, 2022 | 10:02h | UTC

Inhibition of Prekallikrein for Hereditary Angioedema – New England Journal of Medicine (link to abstract – $ for full-text)

Related:

Phase 2 RCT: Prophylactic use of garadacimab in patients with hereditary angioedema.

Evaluation and Management of Angioedema in the Emergency Department

 

Antigenic evolution will lead to new SARS-CoV-2 variants with unpredictable severity.

21 Mar, 2022 | 09:47h | UTC

Antigenic evolution will lead to new SARS-CoV-2 variants with unpredictable severity – Nature Reviews Microbiology

 

Commentary on Twitter

 

Systematic Review: Strategies for using topical corticosteroids in children and adults with eczema.

21 Mar, 2022 | 08:33h | UTC

Strategies for using topical corticosteroids in children and adults with eczema – Cochrane Library

Summary: What is the best way to use topical corticosteroids to treat people with eczema? – Cochrane Library

 

Commentary on Twitter

https://twitter.com/CochraneUK/status/1504548242738102273

 

Phase 2 RCT: Prophylactic use of garadacimab in patients with hereditary angioedema.

18 Mar, 2022 | 08:09h | UTC

Prophylactic use of an anti-activated factor XII monoclonal antibody, garadacimab, for patients with C1-esterase inhibitor-deficient hereditary angioedema: a randomised, double-blind, placebo-controlled, phase 2 trial – The Lancet (link to abstract – $ for full-text)

Commentary: Garadacimab significantly reduces frequency of hereditary angioedema exacerbations – Physician’s Weekly

 

Follow-up data from 2 randomized trials: efficacy and safety of Upadacitinib in patients with moderate to severe atopic dermatitis.

18 Mar, 2022 | 07:48h | UTC

Efficacy and Safety of Upadacitinib in Patients With Moderate to Severe Atopic Dermatitis: Analysis of Follow-up Data From the Measure Up 1 and Measure Up 2 Randomized Clinical Trials – JAMA Dermatology

 

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