All Posts
Is there evidence of fabricated data in a Vitamin C trial published in CHEST?
28 Mar, 2022 | 09:58h | UTCEvidence of Fabricated Data in a Vitamin C trial by Paul E Marik et al in CHEST – This Scattrd Corn
Commentary on Twitter (thread – click for more)
Remember that Vitamin C cures sepsis paper that could never be replicated in 9 RCTs?
Turns out there is a good reason why: it’s very likely fraudulent.
More brilliant statistical sleuthing by @K_Sheldrick.https://t.co/eCayYZyeGo
1/— Nick Mark MD (@nickmmark) March 22, 2022
Cohort Study: SARS-CoV-2 co-infection with influenza viruses, respiratory syncytial virus, or adenoviruses is associated with increased mortality.
28 Mar, 2022 | 10:03h | UTCCommentary: Patients with Covid and flu double the risk of dying, say scientists – The Guardian
Commentary from the author on Twitter (thread – click for more)
https://twitter.com/kennethbaillie/status/1507501279181955076
Opinion: How we got herd immunity wrong.
28 Mar, 2022 | 09:50h | UTCHow we got herd immunity wrong – STAT
Canadian Tuberculosis Standards – 8th Edition.
28 Mar, 2022 | 09:46h | UTCChapter 1: Epidemiology of tuberculosis in Canada
Chapter 2: Transmission and pathogenesis of tuberculosis
Chapter 3: Diagnosis of tuberculosis disease and drug-resistant tuberculosis
Chapter 4: Diagnosis of tuberculosis infection
Chapter 5: Treatment of tuberculosis disease
Chapter 6: Tuberculosis preventive treatment in adults
Chapter 7: Extra-pulmonary tuberculosis
Chapter 8: Drug-resistant tuberculosis
Chapter 9: Pediatric tuberculosis
Chapter 10: Treatment of active tuberculosis in special populations
Chapter 11: Tuberculosis contact investigation and outbreak management
Chapter 13: Tuberculosis surveillance and tuberculosis infection testing and treatment in migrants
Chapter 14: Prevention and control of tuberculosis transmission in healthcare settings
Chapter 15: Monitoring tuberculosis program performance
The prevalence of penicillin allergy labeling ranged from 0.9% to 10.2% across practices in a large pediatric cohort, raising questions regarding the validity of those labels and the unnecessary use of second-line antibiotics that may follow.
28 Mar, 2022 | 09:48h | UTCM-A: Most patients with allergy to Penicillin can be given Cefazolin
Podcast: A Clinical Pharmacologist’s Perspective on Penicillin Allergy
Study: Development and Validation of a Penicillin Allergy Clinical Decision Rule
Consensus Recommendations: Management of a Surgical Patient with a Label of Penicillin Allergy
Practical Guide for Pharmacists to Successfully Implement Penicillin Allergy Skin Testing
NICE: Double Check Patients with ‘Penicillin Allergy’ to Avoid Increased MRSA Risk
Commentary on Twitter
In this cohort study of more than 330,000 children, less than 5% were labeled with penicillin allergy with wide variation across practices, with 8% of those labeled despite not receiving any penicillin prescription. https://t.co/kvXcm1RKRd
— JAMA Network Open (@JAMANetworkOpen) March 15, 2022
International consensus meeting on venous thromboembolism in orthopedic surgery.
28 Mar, 2022 | 09:45h | UTCHomepage: International Consensus Meeting on Venous Thromboembolism (free articles for a limited period)
Recommendations from the ICM-VTE: General
Recommendations from the ICM-VTE:: Foot & Ankle
Recommendations from the ICM-VTE: Hand & Wrist
Recommendations from the ICM-VTE: Hip & Knee
Recommendations from the ICM-VTE: Oncology
Recommendations from the ICM-VTE: Pediatric
Recommendations from the ICM-VTE: Shoulder & Elbow
Recommendations from the ICM-VTE: Sports
Recommendations from the ICM-VTE: Trauma
Recommendations from the ICM-VTE: Spine
Retrospective Cohort: A population-based study in Sweden and Norway did not find an increased risk of pregnancy complications after COVID-19 vaccination.
28 Mar, 2022 | 09:51h | UTCAssociation of SARS-CoV-2 Vaccination During Pregnancy With Pregnancy Outcomes – JAMA
See also: Association of COVID-19 Vaccination in Pregnancy With Adverse Peripartum Outcomes – JAMA
Editorial: COVID-19 mRNA Vaccines During Pregnancy: New Evidence to Help Address Vaccine Hesitancy – JAMA
News Release: No increase in pregnancy complications after COVID-19 vaccination – Karolinska Institutet
Systematic Review: Symptom‐ and chest‐radiography screening for active pulmonary tuberculosis in HIV‐negative adults and adults with unknown HIV status.
28 Mar, 2022 | 08:54h | UTC
Guidelines for Parkinson’s disease treatment.
28 Mar, 2022 | 09:43h | UTC
RCT: Two phase 3 trials of Baricitinib for Alopecia Areata.
28 Mar, 2022 | 08:49h | UTCTwo Phase 3 Trials of Baricitinib for Alopecia Areata – New England Journal of Medicine
Commentary on Twitter
Alopecia areata is a distressing disorder of hair loss that is mediated partly by cytokines dependent on Janus kinases. The JAK1 and JAK2 inhibitor baricitinib reduced the extent of hair loss in two randomized trials over a period of 36 weeks. #AAD2022 https://t.co/oKKzGF7Q5S pic.twitter.com/gsgWJ1asZN
— NEJM (@NEJM) March 26, 2022
RCT: In critically ill immunocompromised patients with acute respiratory failure, outcomes were similar with the use of high-flow nasal oxygen alone vs. alternating with non-invasive ventilation.
28 Mar, 2022 | 08:51h | UTCHigh-flow nasal oxygen alone or alternating with non-invasive ventilation in critically ill immunocompromised patients with acute respiratory failure: a randomised controlled trial – The Lancet Respiratory Medicine (free registration required)
Commentary on Twitter
https://twitter.com/LancetRespirMed/status/1506175093474414592
Half of all women experience false positive mammograms after 10 years of annual screening.
28 Mar, 2022 | 08:53h | UTC
Commentary on Twitter
Comparative effectiveness study finds biennial screening interval, older age, and non-dense breasts were associated with larger reductions in false-positive results than screening with tomosynthesis vs digital mammography. @BCSC_research @dmiglio https://t.co/16CMFH5bcI
— JAMA Network Open (@JAMANetworkOpen) March 25, 2022
Review | Preparing for CAR T cell therapy: patient selection, bridging therapies and lymphodepletion.
28 Mar, 2022 | 08:47h | UTCPreparing for CAR T cell therapy: patient selection, bridging therapies and lymphodepletion – Nature Reviews Clinical Oncology (if the link is paywalled, try this one)
Commentary on Twitter
In a new Review now online, @abouelem and co-authors discuss the preparation and management of patients with cancer before #CARTcells, an area in which evidence on optimal conditions needs to grow https://t.co/Sb6rgcOTTJ pic.twitter.com/wjRrPDpoT7
— NatureRevClinOncol (@NatRevClinOncol) March 23, 2022
RCT: Trastuzumab Deruxtecan vs. Trastuzumab Emtansine for breast cancer.
28 Mar, 2022 | 08:48h | UTCTrastuzumab Deruxtecan versus Trastuzumab Emtansine for Breast Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Trastuzumab Deruxtecan Ups PFS in HER2+ Metastatic Breast Cancer – HealthDay
Commentary on Twitter
In patients with metastatic HER2+ breast cancer that progressed after primary therapy, treatment with trastuzumab deruxtecan resulted in a higher response rate and longer progression-free survival than trastuzumab emtansine. https://t.co/R5suUeMLgE pic.twitter.com/yMiGrJw71U
— NEJM (@NEJM) March 24, 2022
Cohort study: Long-term treatment with clozapine is associated with increased risk of hematological malignancies.
28 Mar, 2022 | 08:43h | UTCLong-term treatment with clozapine and other antipsychotic drugs and the risk of haematological malignancies in people with schizophrenia: a nationwide case-control and cohort study in Finland – The Lancet Psychiatry (link to abstract – $ for full-text)
Commentary on Twitter
Clozapine associated with an increased risk of haematological malignancies with a dose-response effect.
More deaths than from agranulocytosis, but absolute risk small compared to overall mortality benefit with clozapine.https://t.co/BK3P7GgPiv
@TheLancetPsych— Jonathan Rogers (@drjprogers) March 24, 2022
First case of HIV cure in a woman after stem cell transplantation reported at CROI-2022.
28 Mar, 2022 | 08:46h | UTC
Study Commentary: Symptoms can appear up to 10 years before a Parkinson’s disease diagnosis in a primary care setting.
28 Mar, 2022 | 08:37h | UTCOriginal Study: Assessment of Risk Factors and Early Presentations of Parkinson Disease in Primary Care in a Diverse UK Population – JAMA Neurology (link to abstract – $ for full-text)
Cohort Study: Association of lower extremity lymphedema with physical functioning and activities of daily living among older survivors of colorectal, endometrial, and ovarian cancer.
28 Mar, 2022 | 08:39h | UTCCommentaries:
Lower-Extremity Lymphedema Common in Older, Female Cancer Survivors – HealthDay
Commentary on Twitter
Cohort study found nearly 1/3 of older female survivors of #ColorectalCancer, #EndometrialCancer, or #OvarianCancer have lower-extremity lymphedema (LEL), which is associated with worse physical function and needing assistance with ADLs. https://t.co/806Tt88TuV
— JAMA Network Open (@JAMANetworkOpen) March 9, 2022
RCT: Effect of induction chemotherapy with Paclitaxel, Cisplatin, and Capecitabine vs. Cisplatin and Fluorouracil on failure-free survival for patients with stage IVA to IVB Nasopharyngeal Carcinoma.
28 Mar, 2022 | 08:36h | UTCEffect of Induction Chemotherapy With Paclitaxel, Cisplatin, and Capecitabine vs Cisplatin and Fluorouracil on Failure-Free Survival for Patients With Stage IVA to IVB Nasopharyngeal Carcinoma: A Multicenter Phase 3 Randomized Clinical Trial – JAMA Oncology (link to abstract – $ for full-text)
Commentary: Triplet Induction Regimen Bests Doublet for Nasopharyngeal Carcinoma — Three drugs reduced risk of disease failure, but longer follow-up needed to assess OS – MedPage Today (free registration required)
Commentary on Twitter
Phase 3 randomized trial of paitents with stage IVA to IVB nasopharyngeal carcinoma shows that induction chemotherapy w 2 cycles of paclitaxel/cisplatin/capecitabine improved failure-free survival vs. cisplatin/5-FU before concurrent chemoradiation. https://t.co/YYEvFsTxgd pic.twitter.com/7qbSXLWCE1
— JAMA Oncology (@JAMAOnc) March 24, 2022
RCT: Hydrosurgical vs. conventional debridement of burns.
28 Mar, 2022 | 08:34h | UTC
Commentary on Twitter
In the April issue of BJS: Hydrosurgical and conventional debridement of burns: randomized clinical trial https://t.co/XoN6w3xkRU @AmyLightnerMD @bplwijn @des_winter @ksoreide @MalinASund @evanscolorectal @nfmkok @robhinchliffe1 @young_bjs pic.twitter.com/YSkczkqnTU
— BJS (@BJSurgery) March 25, 2022
Systematic Review: Management of cervical spondylotic radiculopathy.
28 Mar, 2022 | 08:30h | UTCManagement of Cervical Spondylotic Radiculopathy: A Systematic review – Global Spine Journal
A practical guide to implementing SMART in asthma management.
28 Mar, 2022 | 08:42h | UTC
Targeted systemic therapies for psoriatic arthritis: a systematic review and comparative synthesis of short-term articular, dermatological, enthesitis and dactylitis outcomes.
28 Mar, 2022 | 08:28h | UTC
M-A: Comparative effectiveness of statins on non-HDL cholesterol in people with diabetes and at risk of cardiovascular disease.
25 Mar, 2022 | 10:01h | UTCNews Release: Best statins for reducing cardiovascular risk in people with diabetes found – University of Manchester
Commentary on Twitter
This network meta-analysis indicated that rosuvastatin, at moderate and high intensity doses, and simvastatin and atorvastatin, at high intensity doses, were most effective at moderately reducing levels of non-HDL-C in patients with diabeteshttps://t.co/NwUf4sX5KA
— The BMJ (@bmj_latest) March 24, 2022
Review: How to improve compliance to hypertension treatment.
28 Mar, 2022 | 08:31h | UTCHow to improve compliance to hypertension treatment – European Society of Cardiology
Commentary on Twitter
#NonAdherence is a major factor for suboptimal #BP control. A one-size-fits-all approach is not ideal. A personalised approach is needed to address it. @spoorthy_burli in #CVPracticeJournal https://t.co/mm1Tjd8fPT@HeartOTXHeartMD @iamritu @AnastasiaSMihai @KreutzReinhold pic.twitter.com/Gdd693gfmU
— European Society of Cardiology Journals (@ESC_Journals) March 25, 2022