Cohort study: Long-term treatment with clozapine is associated with increased risk of hematological malignancies.

Long-term treatment with clozapine and other antipsychotic drugs and the risk of haematological malignancies in people with schizophrenia: a nationwide case-control and cohort study in Finland – The Lancet Psychiatry (link to abstract – $ for full-text)

Commentary on Twitter

Clozapine associated with an increased risk of haematological malignancies with a dose-response effect.

More deaths than from agranulocytosis, but absolute risk small compared to overall mortality benefit with clozapine.https://t.co/BK3P7GgPiv@TheLancetPsych

— Jonathan Rogers (@drjprogers) March 24, 2022