All Posts | Links Medicus - Free Medical News & Perspective

Opinion | Should disease-free survival be used as a regulatory or clinical end point for adjuvant therapy of cancer?

3 Nov, 2022 | 13:37h | UTC

You’re Cured Till You’re Not: Should Disease-Free Survival Be Used as a Regulatory or Clinical End Point for Adjuvant Therapy of Cancer? – Journal of Clinical Oncology

Narrative review of machine learning in rheumatic and musculoskeletal diseases: biases, goals, and future directions.

3 Nov, 2022 | 13:34h | UTC

Narrative Review of Machine Learning in Rheumatic and Musculoskeletal Diseases for Clinicians and Researchers: Biases, Goals, and Future Directions – The Journal of Rheumatology

Observational study suggests Apixaban for AF is associated with a lower risk of GI bleeding vs. other DOACs.

3 Nov, 2022 | 13:32h | UTC

Comparative Effectiveness and Safety Between Apixaban, Dabigatran, Edoxaban, and Rivaroxaban Among Patients With Atrial Fibrillation: A Multinational Population-Based Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

News Release: Best blood thinner for minimizing bleeding risk identified – University College London

Commentary: GI Bleeding Lower With Apixaban Versus Other DOACs in A-Fib – HealthDay

Phase 2 RCT | A single injection of a monoclonal antibody was 88% effective for malaria prevention over 6 months.

2 Nov, 2022 | 14:30h | UTC

Safety and Efficacy of a Monoclonal Antibody against Malaria in Mali – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Monoclonal antibody prevents malaria infection in African adults – National Institutes of Health

Commentary: Monoclonal antibody infusion 88% effective against malaria – CIDRAP

Commentary on Twitter

In this phase 2 trial in Mali, an antimalarial monoclonal antibody (CIS43LS) at the higher dose (40 mg per kilogram) was approximately 88% effective at preventing P. falciparum infection as compared with placebo. #TropMed22 https://t.co/UGeBHOPhKY pic.twitter.com/uFX7w3qV0G

— NEJM (@NEJM) November 1, 2022

NICE Guideline | Osteoarthritis in over 16s: diagnosis and management.

2 Nov, 2022 | 14:29h | UTC

Osteoarthritis in over 16s: diagnosis and management – National Institute for Health and Care Excellence

NICE Guideline Update | Lung cancer: diagnosis and management.

2 Nov, 2022 | 14:28h | UTC

Lung cancer: diagnosis and management – National Institute for Health and Care Excellence

RCT | Povidone-iodine and chlorhexidine gluconate are similarly effective for preventing SSI in open fractures.

2 Nov, 2022 | 14:27h | UTC

Aqueous skin antisepsis before surgical fixation of open fractures (Aqueous-PREP): a multiple-period, cluster-randomised, crossover trial – The Lancet (link to abstract – $ for full-text)

News Release: Study finds antisepsis agents interchangeable in reducing infection risk in open fracture surgeries – Louisiana State University

Efficacy of different preoperative skin antiseptics on the incidence of surgical site infections: a systematic review, GRADE assessment, and network meta-analysis – The Lancet Microbe

Antiseptic Skin Agents to Prevent Surgical Site Infection After Incisional Surgery: A Randomized, Three-armed Combined Non-inferiority and Superiority Clinical Trial (NEWSkin Prep Study) – Annals of Surgery (link to abstract – $ for full-text)

Alcoholic chlorhexidine skin preparation or triclosan-coated sutures to reduce surgical site infection: a systematic review and meta-analysis of high-quality randomised controlled trials – The Lancet Infectious Diseases

Pragmatic randomized trial found similar rates of surgical site infectious with 2% alcoholic chlorhexidine skin preparation compared with povidone–iodine, or with triclosan-coated sutures compared with non-coated sutures.

Single-arm P2 study | Eliminating breast surgery for invasive breast cancer in exceptional responders to neoadjuvant systemic therapy.

2 Nov, 2022 | 14:23h | UTC

Eliminating breast surgery for invasive breast cancer in exceptional responders to neoadjuvant systemic therapy: a multicentre, single-arm, phase 2 trial – The Lancet Oncology (link to abstract – $ for full-text)

News Release: Some breast cancer patients with high responses to chemotherapy may not need surgery: Biopsy protocol identifies patients at low risk of recurrence – University of Texas M. D. Anderson Cancer Center

Commentary: Elimination of Surgery Explored for Selected Breast Cancer Patients – HealthDay

Commentary on Twitter

Online first: #Eliminating breast #surgery for invasive #breastcancer in exceptional #responders to #neoadjuvant systemic #therapy: a multicentre, single-arm, phase 2 trial https://t.co/lxZa62zFZT pic.twitter.com/TS1dKqFhF1

— The Lancet Oncology (@TheLancetOncol) October 26, 2022

RCT | Intensive BP control after thrombectomy for ischemic stroke is associated with increased risk of poor functional outcomes.

2 Nov, 2022 | 14:26h | UTC

Intensive blood pressure control after endovascular thrombectomy for acute ischaemic stroke (ENCHANTED2/MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial – The Lancet (link to abstract – $ for full-text)

News Release: Large stroke trial finds intensive blood pressure lowering after clot removal worsens recovery – George Institute for Global Health

Commentary on Twitter (thread – click for more)

1/ A #MorningPaper from @TheLancet on #Stroke. This large study randomised 821 patients into aggressive BP management (sBP <120mmHg) vs 140-180mmHg. Trial stopped early due to safety concerns. @neuro_at_ic @e1v1m1 @SomaBanerjee73 @StrokeImperial https://t.co/vnvnnI1KLq

— Kevin Tsang (@drtintin99) October 29, 2022

Post-trial follow-up | Endarterectomy vs. stenting vs. best medical treatment for asymptomatic carotid artery stenosis.

2 Nov, 2022 | 14:25h | UTC

Carotid endarterectomy or stenting or best medical treatment alone for moderate-to-severe asymptomatic carotid artery stenosis: 5-year results of a multicentre, randomised controlled trial – The Lancet Neurology (link to abstract – $ for full-text)

Original Study: Angioplasty in asymptomatic carotid artery stenosis vs. endarterectomy compared to best medical treatment: One-year interim results of SPACE-2 – International Journal of Stroke

Commentary on Twitter

5 year results of SPACE 2 in @TheLancetNeuro show low event rates in all groups. With best medical therapy only 3.1%, CEA+BMT 2.5%, CAS+BMT 4.4%. Study underpowered for firm conclusions. @CREST2_Study will have close to 2500 pts@ESOstroke @WorldStrokeOrg https://t.co/nUE0WxWidk

— Seemant Chaturvedi (@ChaturvediNeuro) September 17, 2022

Global epidemiology of systemic lupus erythematosus: a comprehensive systematic analysis and modelling study.

2 Nov, 2022 | 14:21h | UTC

Global epidemiology of systemic lupus erythematosus: a comprehensive systematic analysis and modelling study – Annals of the Rheumatic Diseases

Commentary: SLE Rates Vary Worldwide and Require Further Study, Study Emphasizes – AJMC

M-A | Perioperative interventions to reduce pancreatic fistula following pancreatoduodenectomy.

2 Nov, 2022 | 14:22h | UTC

Perioperative interventions to reduce pancreatic fistula following pancreatoduodenectomy: meta-analysis – British Journal of Surgery (link to abstract – $ for full-text)

Commentary on Twitter

https://twitter.com/Gio_Marchegiani/status/1542268331528445953

EULAR points to consider to support people with rheumatic and musculoskeletal diseases in work participation.

2 Nov, 2022 | 14:20h | UTC

2021 EULAR points to consider to support people with rheumatic and musculoskeletal diseases to participate in healthy and sustainable paid work – Annals of the Rheumatic Diseases

News Release: Supporting workers with rheumatic and musculoskeletal diseases – European Alliance of Associations for Rheumatology

ERAS Guidelines for perioperative care for liver surgery.

1 Nov, 2022 | 12:16h | UTC

Guidelines for Perioperative Care for Liver Surgery: Enhanced Recovery After Surgery (ERAS) Society Recommendations 2022 – World Journal of Surgery

Complete List of Enhanced Recovery After Surgery (ERAS) Society Guidelines

Top 100 Most-Cited Articles on Enhanced Recovery After Surgery: A Bibliometric Analysis and Visualized Study – Frontiers in Surgery

ACCP Guideline | Perioperative management of antithrombotic therapy.

1 Nov, 2022 | 12:18h | UTC

Perioperative Management of Antithrombotic Therapy: An American College of Chest Physicians Clinical Practice Guideline – CHEST

Executive Summary: Perioperative Management of Antithrombotic Therapy: An American College of Chest Physicians Clinical Practice Guideline – CHEST

Commentary on Twitter

2022 guideline for perioperative management of VKAs, heparin bridging, DOACs & antiplatelets
Pts requiring elective surgery, in general,🛑💊 before surgery
👉VKAs 3-5d
👉DOACS 1-2d
👉P2Y12 receptor inhibitors 3-7d✅drug specificshttps://t.co/RYNrEOovRe @SCCM_Surgery @SCCM_CPP

— Lauren R. Sorce, PhD, RN, CPNP-AC/PC, FAAN, FCCM (@SCCMPresident) August 26, 2022

M-A | Safety and efficacy of interrupting dual antiplatelet therapy one month following percutaneous coronary intervention.

1 Nov, 2022 | 12:14h | UTC

Safety and efficacy of interrupting dual antiplatelet therapy one month following percutaneous coronary intervention: a meta-analysis of randomized controlled trials – BMC Cardiovascular Disorders

Commentary on Twitter

Interrupting DAPT after 1 month post PCI:
Meta-analysis of 4 RCTs, >25000 pts
Events between 31days and 1yr:
Less bleeding (1.1 vs 1.5%) but no difference in death (1.3 vs 1.6%), MI (1.4 vs 1.2%), ST (0.3 vs 0.2%) or stroke (0.5 vs 0.6%) https://t.co/rdNgCg032B #cardiotwitter pic.twitter.com/yLWREcDzYe

— Heeraj Bulluck (@DrHBulluck) October 30, 2022

Under a http://creativecommons.org/licenses/by/4.0/ license

WHO Guidelines on mental health at work.

1 Nov, 2022 | 12:15h | UTC

Guidelines on mental health at work – World Health Organization

News Release: WHO and ILO call for new measures to tackle mental health issues at work – World Health Organization

Commentary on Twitter (thread – click for more)

Work affects #MentalHealth & well-being.

1 in 6 working-age adults are estimated to have a mental disorder.

Globally, 12 billion working days are lost every year on account of #depression and anxiety.

🆕 WHO recommended guidelines to protect #MentalHealthAtWork ⬇️

— World Health Organization (WHO) (@WHO) September 28, 2022