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Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems

5 Apr, 2023 | 13:36h | UTC

Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems – Nature Reviews Drug Discovery

Commentary: Take Your Meds – Science

Commentary on Twitter

Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems https://t.co/WSyYu24Iw1 – a new review discussing how delivery systems can mitigate impediments to adherence such as frequent dosing, adverse effects and a delayed onset of action pic.twitter.com/xoSJYFo0Qs

— Nature Reviews Drug Discovery (@NatRevDrugDisc) March 28, 2023

Review | Computed tomographic angiography in coronary artery disease

5 Apr, 2023 | 13:33h | UTC

Computed tomographic angiography in coronary artery disease – EuroIntervention

RCT | Enzalutamide versus standard antiandrogen therapy in hormone-sensitive prostate cancer with metastasis

5 Apr, 2023 | 13:30h | UTC

Testosterone suppression plus enzalutamide versus testosterone suppression plus standard antiandrogen therapy for metastatic hormone-sensitive prostate cancer (ENZAMET): an international, open-label, randomised, phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)

News Release: ENZAMET shows promise as prostate cancer treatment – University of Adelaide

Review | Comprehensive care of women with genetic predisposition to breast and ovarian cancer

5 Apr, 2023 | 13:32h | UTC

Comprehensive Care of Women With Genetic Predisposition to Breast and Ovarian Cancer – Mayo Clinic Proceedings

Review | Why is intradialytic hypotension the commonest complication of outpatient dialysis treatments?

5 Apr, 2023 | 13:28h | UTC

Why is Intradialytic Hypotension the Commonest Complication of Outpatient Dialysis Treatments? – Kidney International Reports

Global, regional and national burden of inflammatory bowel disease in 204 countries and territories from 1990 to 2019

5 Apr, 2023 | 13:27h | UTC

Global, regional and national burden of inflammatory bowel disease in 204 countries and territories from 1990 to 2019: a systematic analysis based on the Global Burden of Disease Study 2019 – BMJ Open

Adolescent sudden cardiac death: the role of underlying conditions and physical activity

5 Apr, 2023 | 13:26h | UTC

Sudden Cardiac Death Among Adolescents in the United Kingdom – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentary on Twitter

Among the causes of SCD in adolescents, arrhythmogenic #cardiomyopathy, coronary artery anomalies & commotio cordis are more common in young athletes who die suddenly than in similarly aged sedentary individuals.

Read more on this https://t.co/VHRIiNz1hE… pic.twitter.com/N3bev3Nv8i

— JACC Journals (@JACCJournals) March 14, 2023

Updated ADAURA trial results | Adjuvant Osimertinib improves disease-free survival in resected EGFR-mutated NSCLC

5 Apr, 2023 | 13:21h | UTC

Adjuvant Osimertinib for Resected EGFR-Mutated Stage IB-IIIA Non–Small-Cell Lung Cancer: Updated Results From the Phase III Randomized ADAURA Trial – Journal of Clinical Oncology

News Release: Trial Shows Significant Disease-free Survival for Patients Diagnosed With Non-small Cell Lung Cancer – Yale School of Medicine

M-A | Vaginal swab outperforms urine for detection of Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis

5 Apr, 2023 | 13:23h | UTC

Vaginal Swab vs Urine for Detection of Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis: A Meta-Analysis – Annals of Family Medicine

M-A | The efficacy of topical prostaglandin analogs for hair loss

5 Apr, 2023 | 13:20h | UTC

The efficacy of topical prostaglandin analogs for hair loss: A systematic review and meta-analysis – Frontiers in Medicine

SR | The effectiveness of the interventions to reduce sound levels in the ICU

5 Apr, 2023 | 13:19h | UTC

The Effectiveness of the Interventions to Reduce Sound Levels in the ICU: A Systematic Review – Critical Care Explorations

Hydroxyurea use in youths with sickle cell anemia: underused despite updated 2014 guidelines

5 Apr, 2023 | 13:16h | UTC

Changes in Hydroxyurea Use Among Youths Enrolled in Medicaid With Sickle Cell Anemia After 2014 Revision of Clinical Guidelines – JAMA Network Open

Original Guideline: National Heart, Lung, and Blood Institute. Evidence-based management of sickle cell disease: expert panel report, 2014

Commentary on Twitter

Hydroxyurea prescribing in youths with sickle cell anemia insured by Medicaid modestly after the @nih_nhlbi guidelines recommended hydroxurea in 2014. Increasing hydroxyurea use may require a multifaceted approach. https://t.co/tkY0HiMvkv

— JAMA Network Open (@JAMANetworkOpen) March 24, 2023

Review | Use of cardio-pulmonary ultrasound in the neonatal intensive care unit

5 Apr, 2023 | 12:58h | UTC

Use of Cardio-Pulmonary Ultrasound in the Neonatal Intensive Care Unit – Children

Review | Evaluation of the hypotensive preterm infant: evidence-based practice at the bedside?

5 Apr, 2023 | 12:55h | UTC

Evaluation of the Hypotensive Preterm Infant: Evidence-Based Practice at the Bedside? – Children

Review | Respiratory management of the preterm infant: supporting evidence-based practice at the bedside

5 Apr, 2023 | 12:53h | UTC

Respiratory Management of the Preterm Infant: Supporting Evidence-Based Practice at the Bedside – Children

Consensus Paper | Definition and criteria for diagnosing cesarean scar disorder

5 Apr, 2023 | 12:51h | UTC

Definition and Criteria for Diagnosing Cesarean Scar Disorder – JAMA Network Open

Pharmacotherapy of obesity: an update on the available medications and drugs under investigation

5 Apr, 2023 | 12:50h | UTC

Pharmacotherapy of obesity: an update on the available medications and drugs under investigation – eClinicalMedicine

SR | Efficacy and tolerance of second-generation antipsychotics in anorexia nervosa

5 Apr, 2023 | 12:48h | UTC

Efficacy and tolerance of second-generation antipsychotics in anorexia nervosa: A systematic scoping review – PLOS One

M-A | Efficacy of flash glucose monitoring in type 1 and type 2 diabetes

5 Apr, 2023 | 12:46h | UTC

Efficacy of Flash Glucose Monitoring in Type 1 and Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomised Controlled Trials – Frontiers in Clinical Diabetes and Healthcare

Analysis | Global coverage and design of sugar-sweetened beverage taxes

5 Apr, 2023 | 12:43h | UTC

Global Coverage and Design of Sugar-Sweetened Beverage Taxes – JAMA Network Open

WHO manual on sugar-sweetened beverage taxation policies to promote healthy diets.

M-A: Outcomes following taxation of sugar-sweetened beverages.

Public Policies to Reduce Sugary Drink Consumption in Children and Adolescents – Pediatrics

Cutting back on sugar-sweetened beverages: What works? – Cochrane Library

Association of a Beverage Tax on Sugar-Sweetened and Artificially Sweetened Beverages With Changes in Beverage Prices and Sales at Chain Retailers in a Large Urban Setting – JAMA

Association between tax on sugar sweetened beverages and soft drink consumption in adults in Mexico: open cohort longitudinal analysis of Health Workers Cohort Study – The BMJ

Potential impact on prevalence of obesity in the UK of a 20% price increase in high sugar snacks: modelling study – The BMJ

Changes in food purchases after the Chilean policies on food labelling, marketing, and sales in schools: a before and after study – The Lancet Planetary Health

Association of a Sweetened Beverage Tax With Soda Consumption in High School Students – JAMA Pediatrics

Sugar-sweetened beverage taxes: Lessons to date and the future of taxation – PLOS Medicine

Banning the promotion of soft drinks could be more effective than a sugar tax – The Conversation

Sugar tax: why health experts want it but politicians and industry are resisting – The Guardian

Commentary on Twitter

With 105 national SSB taxes in effect covering 51% of the world’s population, SSB taxes are no longer a novel policy tool. https://t.co/P0TvIdB4D3

— JAMA Network Open (@JAMANetworkOpen) March 29, 2023

M-A | Efficacy of atropine for myopia control in children

5 Apr, 2023 | 12:45h | UTC

Efficacy of atropine for myopia control in children: A meta-analysis of randomized controlled trials – Journal of Family Medicine and Primary Care

RCT | Effect of low-concentration atropine eyedrops vs. placebo on myopia incidence in children

Crossover RCT | Spectacle lenses with highly aspherical lenslets for slowing myopia.

RCT | Effect of text messaging parents of school-aged children on outdoor time to control myopia.

RCT | Myopia control effect of repeated low-level red-light therapy in children.

RCT: Spectacle lenses with aspherical lenslets for myopia control vs. single-vision spectacle lenses.

Randomized trial: Effect of High add power, medium add power, or single-vision contact lenses on myopia progression in children

RCT | Mindfulness therapy proves more effective and affordable than cognitive behavioral therapy for depression

4 Apr, 2023 | 14:04h | UTC

Summary: The LIGHTMind Randomized Clinical Trial studied 410 adults with mild to moderate depression, comparing the clinical effectiveness and cost-effectiveness of practitioner-supported mindfulness-based cognitive therapy self-help (MBCT-SH) to practitioner-supported cognitive behavioral therapy self-help (CBT-SH). The trial provided participants with either an MBCT-SH or CBT-SH workbook and six support sessions with a trained practitioner. Depressive symptom severity was measured using the Patient Health Questionnaire (PHQ-9) score at 16 weeks after randomization.

Results showed that MBCT-SH led to significantly greater reductions in depressive symptoms and was more cost-effective than CBT-SH. The between-group difference was 1.5 PHQ-9 points, and MBCT-SH cost health services £526 ($631) less per participant over a 42-week follow-up period. A substantial portion of this cost difference was due to additional face-to-face individual psychological therapy accessed by CBT-SH participants outside of the study intervention.

The trial concluded that offering practitioner-supported MBCT-SH for mild to moderate depression could improve outcomes and save money compared to CBT-SH. To translate these findings into practice, proper training and supervision for practitioners delivering MBCT-SH are necessary. Future research should focus on corroborating and extending these findings, exploring factors contributing to MBCT-SH’s relative effectiveness, and examining potential barriers and facilitators for successful implementation in routine clinical practice.

Article: Clinical Effectiveness and Cost-Effectiveness of Supported Mindfulness-Based Cognitive Therapy Self-help Compared With Supported Cognitive Behavioral Therapy Self-help for Adults Experiencing Depression: The Low-Intensity Guided Help Through Mindfulness (LIGHTMind) Randomized Clinical Trial – JAMA Psychiatry

Commentary:

Mindfulness better than CBT for treating depression, study finds – The Guardian

Practitioner-Supported Mindfulness-Based Cognitive Therapy Aids Depression – HealthDay

Commentary on Twitter

Practitioner-supported mindfulness-based cognitive therapy self-help for mild-moderate depression is clinically- and cost-effective compared to currently recommended practitioner-support CBT self-help. https://t.co/H23AfwiO7X pic.twitter.com/xTHzYG4oqg

— JAMA Psychiatry (@JAMAPsych) March 22, 2023