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Cohort Study: Association of Social Contact with Dementia and Cognition

18 Aug, 2019 | 21:57h | UTC

Association of social contact with dementia and cognition: 28-year follow-up of the Whitehall II cohort study – PLOS Medicine (free)

Commentaries: Socially active 60-year-olds face lower dementia risk – University College London (free) AND Social Contact Associated With Lower Dementia Risk – MD Magazine (free)

Randomized Trial: Bismuth Subsalicylate Reduces Antibiotic Use Among Adult Outpatients With Diarrhea

18 Aug, 2019 | 21:59h | UTC

Effect of Bismuth Subsalicylate vs Placebo on Use of Antibiotics Among Adult Outpatients With Diarrhea in Pakistan: A Randomized Clinical Trial – JAMA Network Open (free)

[Abstract Only] Cohort Study: Surgery Does Not Improve Survival in Patients with Isolated Severe Tricuspid Regurgitation

18 Aug, 2019 | 21:51h | UTC

Surgery Does Not Improve Survival in Patients With Isolated Severe Tricuspid Regurgitation – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentary: Surgery for Severe Tricuspid Regurgitation – American College of Cardiology (free)

Related Commentary on Twitter

In patients with isolated severe tricuspid regurgitation, surgery is not associated with improved survival compared with medical therapy alone. https://t.co/mfEzSMfHzh #JACC pic.twitter.com/10xwdCKaqt

— JACC Journals (@JACCJournals) August 12, 2019

Management of Refractory Lupus Nephritis: Challenges and Solutions

18 Aug, 2019 | 21:53h | UTC

Management of refractory lupus nephritis: challenges and solutions – Open Access Rheumatology (free)

Precision Medicine in Breast Cancer: Scientists Have used Artificial Intelligence to Identified Gene Sequences and Molecular Data Patterns that May Predict Response to Different Treatments

18 Aug, 2019 | 21:39h | UTC

Heterocellular gene signatures reveal luminal-A breast cancer heterogeneity and differential therapeutic responses – npj Breast Cancer (free)

Commentary: AI reveals new breast cancer types that respond differently to treatment – Institute of Cancer Research (free)

Consensus: Oligometastatic Prostate Cancer

18 Aug, 2019 | 21:42h | UTC

Oligometastatic Prostate Cancer: Results of a Dutch Multidisciplinary Consensus Meeting – European Urology Oncology (free)

Related Guideline: NICE Guideline: Diagnosis and Management of Prostate Cancer (free)

Guideline: Management of Chronic Urticaria in Children

18 Aug, 2019 | 21:34h | UTC

Management of chronic urticaria in children: a clinical guideline – Italian Journal of Pediatrics (free)

Editorial: Focus on Blood Pressure Targets and Vasopressors in Critically Ill Patients

18 Aug, 2019 | 21:37h | UTC

Focus on blood pressure targets and vasopressors in critically ill patients – Intensive Care Medicine (free)

Alveolar Recruitment in ARDS: Should we Open the Lung (No Matter What) or May Accept (Part of) the Lung Closed?

18 Aug, 2019 | 21:36h | UTC

Alveolar recruitment in acute respiratory distress syndrome: should we open the lung (no matter what) or may accept (part of) the lung closed? – Intensive Care Medicine (free)

Prevention and Treatment of Pregnancy-Associated Venous Thromboembolism: Critical Appraisal of International Guidelines

18 Aug, 2019 | 21:35h | UTC

Critical appraisal of international guidelines for the prevention and treatment of pregnancy-associated venous thromboembolism: a systematic review – BMC Cardiovascular Disorders (free)

ASCO Guideline Update: Use of Biomarkers to Guide Decisions on Adjuvant Systemic Therapy for Women with Early-Stage Invasive Breast Cancer

18 Aug, 2019 | 21:32h | UTC

Use of Biomarkers to Guide Decisions on Adjuvant Systemic Therapy for Women With Early-Stage Invasive Breast Cancer: ASCO Clinical Practice Guideline Update—Integration of Results From TAILORx – Journal of Clinical Oncology (free)

NCCN Guidelines Insights: Ovarian Cancer

18 Aug, 2019 | 21:30h | UTC

NCCN Guidelines Insights: Ovarian Cancer, Version 1.2019 – Journal of the National Comprehensive Cancer Network (free)

Editorial: Ebola Could Be Eradicated — But Only if the World Works Together

18 Aug, 2019 | 21:25h | UTC

Ebola Could Be Eradicated — But Only if the World Works Together – The New York Times (10 articles per month are free)

“New treatments for Ebola and drug-resistant tuberculosis offer hope, but they won’t be successful on their own.”

Position Statement: Hormonal Management of Adult Transgender and Gender Diverse Individuals

18 Aug, 2019 | 21:28h | UTC

Position statement on the hormonal management of adult transgender and gender diverse individuals – The Medical Journal of Australia (free)

U.S. Cancer Statistics for Adults Aged 85 Years and Older

18 Aug, 2019 | 21:26h | UTC

Cancer statistics for adults aged 85 years and older, 2019 – CA: A Cancer Journal for Clinicians (free)

Commentary: Cancer in Adults Aged 85 and Older: Rates, Screening, and Survival – The ASCO Post (free)

Related Commentary on Twitter

New @AmericanCancer report reveals unexpectedly high cancer screening rates among adults aged 85 years and older: https://t.co/Rhd1gLE0h1 pic.twitter.com/SW4h6SkfXr

— CA: A Cancer Journal for Clinicians (@CACancerJournal) August 8, 2019

Opinion: Unethical Work Must be Filtered Out or Flagged

18 Aug, 2019 | 21:22h | UTC

Unethical work must be filtered out or flagged – Nature (free)

[Abstract Only] Randomized Trial: Resection of Cavity Shave Margins in Stage 0–III Breast Cancer Patients Undergoing Breast Conserving Surgery

18 Aug, 2019 | 21:21h | UTC

Resection of Cavity Shave Margins in Stage 0–III Breast Cancer Patients Undergoing Breast Conserving Surgery: A Prospective Multicenter Randomized Controlled Trial – Annals of Surgery (link to abstract – $ for full-text)

Source: EvidenceAlerts

Related Commentary on Twitter

In this multicenter randomized trial, resecting cavity shave margins after lumpectomy reduced positive margin rates from 36% to 9% and re-excision/mastectomy rates from 23.5% to 8.7%: https://t.co/GZmrvMBaHd

from @WatsonClinic @JEFFsurgery @wakeforestmed @YaleSurgery et al pic.twitter.com/Mu2CDHOwze

— Annals of Surgery (@AnnalsofSurgery) August 9, 2019

Brazilian Consensus on Non-cystic Fibrosis Bronchiectasis

18 Aug, 2019 | 21:20h | UTC

Brazilian consensus on non-cystic fibrosis bronchiectasis – Jornal Brasileiro de Pneumologia (free PDF)

[Abstract Only] Randomized Trial: Intraperitoneal Cefepime Monotherapy Noninferior to Cefazolin Plus Ceftazidime for Empirical Treatment of Peritoneal Dialysis-associated Peritonitis

18 Aug, 2019 | 21:16h | UTC

Intraperitoneal Cefepime Monotherapy Versus Combination Therapy of Cefazolin Plus Ceftazidime for Empirical Treatment of CAPD-Associated Peritonitis: A Multicenter, Open-Label, Noninferiority, Randomized, Controlled Trial – American Journal of Kidney Diseases (link to abstract – $ for full-text)

Related Commentary on Twitter

Intraperitoneal Cefepime Monotherapy Versus Combination Therapy of Cefazolin Plus Ceftazidime for Empirical Treatment of CAPD-Associated Peritonitis: A Multicenter, Open-Label, Noninferiority, Randomized, Controlled Trial https://t.co/SNa7EvOqjR

@pongpratpk @TNephro pic.twitter.com/AnakbnmEFo

— AJKD (@AJKDonline) July 23, 2019

[Abstract Only] Meta-analysis: Long-term Macrolide Treatment Reduces the Frequency of Exacerbations in Patients with Bronchiectasis

18 Aug, 2019 | 21:19h | UTC

Long-term macrolide antibiotics for the treatment of bronchiectasis in adults: an individual participant data meta-analysis – The Lancet Respiratory Medicine (link to abstract – $ for full-text)

Related Commentary on Twitter

A NEW 🔥 systematic review and individual patient data meta-analysis :long-term macrolide treatment significantly reduces the frequency of exacerbations in patients with bronchiectasis, with similar benefits observed in all subgroups based on patient characteristics. #IDTwitter https://t.co/pey2x23BRf

— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) August 10, 2019

[Abstract Only] Meta-analysis: Inhaled Antibiotics Provide Limited Benefit for the Treatment of Bronchiectasis in Adults

18 Aug, 2019 | 21:18h | UTC

The efficacy and safety of inhaled antibiotics for the treatment of bronchiectasis in adults: a systematic review and meta-analysis – The Lancet Respiratory Medicine (link to abstract – $ for full-text)

Related Commentary on Twitter

The efficacy and safety of inhaled antibiotics for the treatment of bronchiectasis. New data from an analysis of nearly 2600 patients finds only limited benefits associated with inhaled antibiotic use across 16 trials. https://t.co/q4ixUb5Q7p @EMBARCnetwork @EuroRespSoc @lunguk

— EMBARC (@EMBARCnetwork) August 9, 2019

Fri August 16 – 10 Stories of The Day!

16 Aug, 2019 | 08:23h | UTC

1 – Diagnosis and management of metabolic acidosis: guidelines from a French expert panel – Annals of Intensive Care (free)

2 – Interdisciplinary consensus on indications for transfemoral transcatheter aortic valve implantation (TF-TAVI) – Clinical Research in Cardiology (free)

3 – How doctors in senior leadership roles establish and maintain a positive patient-centred culture – General Medical Council (free PDF)

Summary: How doctors in senior leadership roles establish and maintain a positive patient-centred culture (free)

Commentary: Do You Work in a ‘Diva Subculture’? – Medscape (free registration required)

4 – Two weeks versus four weeks of antibiotic therapy after surgical drainage for native joint bacterial arthritis: a prospective, randomised, non-inferiority trial – Annals of Rheumatic Diseases (free)

Commentary: Optimal Duration of Antibiotic Use in Septic Arthritis – NEJM Journal Watch (free for a limited period)

5 – Communication Strategies for Sharing Prognostic Information With Patients: Beyond Survival Statistics – JAMA (free for a limited period)

See also: Author Interview (free audio)

6 – Resident Physicians are at Increased Risk for Dangerous Driving after Extended-duration Work Shifts: A Systematic Review – Cureus (free)

Source: Hospital Medicine Virtual Journal Club

7 – Association between vitamin D supplementation and mortality: systematic review and meta-analysis – The BMJ (free)

Related: Meta-Analysis: Vitamin D Not Effective for Cardiovascular Disease Prevention (link to abstract and commentary) AND NICE Guideline: Vitamin D Supplementation (free)

Vitamin D supplementation was not associated with all-cause mortality, cardiovascular mortality, or non-cancer, non-cardiovascular mortality. However, Vitamin D supplementation statistically significantly reduced the risk of cancer death by 16%.

8 – Essential tremor: diagnosis and management – The BMJ (free for a limited period)

9 – Human Papillomavirus Vaccination for Adults: Updated Recommendations of the Advisory Committee on Immunization Practices – Centers for Disease Control and Prevention (free)

Commentaries: CDC Recommends HPV Catch-Up Vaccine in Those 26 and Younger – NEJM Journal Watch (free) AND Confused About Who Should Get the HPV Vaccine, and When? The CDC Has New Recommendations – Time (free)

10 – Severe Hypoglycemia Attributable to Intensive Glucose-Lowering Therapy Among US Adults With Diabetes – Mayo Clinic Proceedings (link to abstract – $ for full-text)

Commentary: Too Much of a Good Thing Can Be Dangerous, Finds Researchers Investigating Hypoglycemia – Mayo Clinic (free)