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“maternal influenza vaccination is not associated with harmful effects on birth outcomes. The beneficial effects reported from previous studies on preterm birth, low birth weight, and fetal death could not be confirmed.”

8 – Global Incidence of Frailty and Prefrailty Among Community-Dwelling Older Adults: A Systematic Review and Meta-analysis – JAMA Network Open (free)

Commentaries: The Dynamics of Frailty Among Older Adults – JAMA Network Open (free) AND Frailty is a medical condition, not an inevitable result of aging – Monash University (free)

Related: Best practice guidelines for the management of frailty: a British Geriatrics Society, Age UK and Royal College of General Practitioners report – Age and Ageing (free) AND A Review of Frailty Syndrome and Its Physical, Cognitive and Emotional Domains in the Elderly – Geriatrics (free) AND Frailty: Identifying elderly patients at high risk of poor outcomes – Canadian Family Physician (free)

9 – Early discharge hospital at home – NEJM Catalyst (free)

Related: Interventions to Promote Early Discharge and Avoid Inappropriate Hospital (Re)Admission: A Systematic Review – International Journal of Environmental Research and Public Health (free) AND Early discharge hospital at home – Cochrane Library (free) AND Early discharge ‘hospital-at-home’ gives similar outcomes to in-patient care – NIHR Signal (free)

10 – Difficult airway management algorithms: a directed review – Anaesthesia (free)

Related Guidelines: Difficult intubation and extubation in adult anaesthesia – Anaesthesia Critical Care & Pain Medicine (free) AND Difficult Airway Society 2015 guidelines for management of unanticipated difficult intubation in adults – British Journal of Anaesthesia (free) AND Practice Guidelines for Management of the Difficult Airway: An Updated Report by the American Society of Anesthesiologists Task Force on Management of the Difficult Airway – Anesthesiology (free) AND The difficult airway with recommendations for management – Part 1 – Difficult tracheal intubation encountered in an unconscious/induced patient – Canadian Journal of Anesthesia (free) AND The difficult airway with recommendations for management – Part 2 – The anticipated difficult airway – Canadian Journal of Anesthesia (free) AND Guidelines for the management of tracheal intubation in critically ill adults – British Journal of Anaesthesia (free) AND S1 guidelines on airway management – German Society of Anesthesiology and Intensive Care Medicine (free)

Study: Association Between Maternal Fluoride Exposure During Pregnancy and IQ Scores in Offspring

21 Aug, 2019 | 08:30h | UTC

Association Between Maternal Fluoride Exposure During Pregnancy and IQ Scores in Offspring in Canada – JAMA Pediatrics (free)

Editor’s Note: Decision to Publish Study on Maternal Fluoride Exposure During Pregnancy (free)

Editorial: Is Fluoride Potentially Neurotoxic? (free)

Audio Summary: Association Between Maternal Fluoride Exposure During Pregnancy and IQ Scores in Offspring in Canada (free)

Commentaries: No proof that a mother’s intake of fluoride in pregnancy affects their child’s IQ – NHS Choices (free) AND Fluoride And IQ? What Is The Link, What This Study Says – Forbes (free) AND Expert reaction to study looking at maternal exposure to fluoride and IQ in children – Science Media Centre (free)

New Guidelines on the Spinal Stabilization of Adult Trauma Patients

20 Aug, 2019 | 08:55h | UTC

New clinical guidelines on the spinal stabilisation of adult trauma patients – consensus and evidence based – Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine (free)

Related: The Norwegian guidelines for the prehospital management of adult trauma patients with potential spinal injury (free) AND Cervical spine collar clearance in the obtunded adult blunt trauma patient: A systematic review and practice management guideline from the Eastern Association for the Surgery of Trauma (free) AND Prehospital Cervical Spinal Immobilization After Trauma – Neurosurgery (free) AND Pre-Hospital Care Management of a Potential Spinal Cord Injured Patient: A Systematic Review of the Literature and Evidence-Based Guidelines – Journal of Neurotrauma (free) AND Wilderness Medical Society Practice Guidelines for Spine Immobilization in the Austere Environment (free)

Cohort Study: Intensifying Antihypertensive Medication Regimens Among Older Adults at Hospital Discharge Linked to Worse Outcomes

20 Aug, 2019 | 08:35h | UTC

Clinical Outcomes After Intensifying Antihypertensive Medication Regimens Among Older Adults at Hospital Discharge – JAMA Internal Medicine (free for a limited period)

Commentary: Intensifying Antihypertensives at Discharge Tied to Adverse Events – NEJM Journal Watch (free)

Related Study: Overtreatment of Blood Pressure Common at Hospital Discharge (free)

Guideline: Diagnosis and Management of Sepsis‐induced Coagulopathy and Disseminated Intravascular Coagulation

20 Aug, 2019 | 08:53h | UTC

Diagnosis and management of sepsis‐induced coagulopathy and disseminated intravascular coagulation – Journal of Thrombosis and Haemostasis (free)

Related Reviews: Diagnosis of sepsis‐induced disseminated intravascular coagulation and coagulopathy – Acute Medicine & Surgery (free) AND Sepsis-associated disseminated intravascular coagulation and its differential diagnoses – Journal of Intensive Care (free) AND Advance in the Management of Sepsis-Induced Coagulopathy and Disseminated Intravascular Coagulation – Journal of Clinical Medicine (free)

Source: Critical Care Reviews Newsletter

CDC Investigating Severe Pulmonary Disease Cases Among People Who Use E-Cigarettes

20 Aug, 2019 | 08:27h | UTC

News Release: CDC, states investigating severe pulmonary disease among people who use e-cigarettes – Centers for Disease Control and Prevention (free)

Commentaries: More than 120 cases of lung disease in 15 states could be linked to vaping – CNN (free) AND CDC probes lung illnesses linked to e-cigarette use – Reuters (free) AND What’s Behind A Cluster Of Vaping-Related Hospitalizations? – NPR (free) AND CDC Investigating Cases of Severe Lung Disease Tied to Vaping – NEJM Journal Watch (free)

Study: Dual Antiplatelet Therapy Should be Used for 21 Days After Minor Ischemic Stroke or High-risk Transient Ischemic Attack

20 Aug, 2019 | 08:32h | UTC

Outcomes Associated With Clopidogrel-Aspirin Use in Minor Stroke or Transient Ischemic Attack: A Pooled Analysis of Clopidogrel in High-Risk Patients With Acute Non-Disabling Cerebrovascular Events (CHANCE) and Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trials – JAMA Neurology (free for a limited period)

Related Study: The Benefits of Clopidogrel-aspirin Combination after Minor Stroke/TIA occurs Predominantly Within the First 21 Days (free)

Related Guideline: Dual Antiplatelet Therapy for Acute High-Risk TIA and Minor Ischemic Stroke – The BMJ (free)

Meta-Analysis: Maternal Influenza Vaccination is Not Associated with Harmful Effects on Birth Outcomes

20 Aug, 2019 | 08:24h | UTC

Effects of maternal influenza vaccination on adverse birth outcomes: A systematic review and Bayesian meta-analysis – PLOS One (free)

Related Research: Cohort Study: Flu Vaccine in Pregnancy Safe for Children and Mothers (free)

Related ACOG Guideline: Influenza Vaccination During Pregnancy (free)

Meta-Analysis: Global Incidence of Frailty and Prefrailty Among Community-Dwelling Older Adults

20 Aug, 2019 | 08:20h | UTC

Global Incidence of Frailty and Prefrailty Among Community-Dwelling Older Adults: A Systematic Review and Meta-analysis – JAMA Network Open (free)

Commentaries: The Dynamics of Frailty Among Older Adults – JAMA Network Open (free) AND Frailty is a medical condition, not an inevitable result of aging – Monash University (free)

Related: Best practice guidelines for the management of frailty: a British Geriatrics Society, Age UK and Royal College of General Practitioners report – Age and Ageing (free) AND A Review of Frailty Syndrome and Its Physical, Cognitive and Emotional Domains in the Elderly – Geriatrics (free) AND Frailty: Identifying elderly patients at high risk of poor outcomes – Canadian Family Physician (free)

Consensus Recommendations: Pregnancy After Bariatric Surgery

18 Aug, 2019 | 22:08h | UTC

Pregnancy after bariatric surgery: Consensus recommendations for periconception, antenatal and postnatal care – Obesity Reviews (free)

Related: Pregnancy after bariatric surgery and adverse perinatal outcomes: A systematic review and meta-analysis – PLOS Medicine (free)

Perspective: Early Discharge Hospital at Home

20 Aug, 2019 | 08:14h | UTC

Early discharge hospital at home – NEJM Catalyst (free)

Related: Interventions to Promote Early Discharge and Avoid Inappropriate Hospital (Re)Admission: A Systematic Review – International Journal of Environmental Research and Public Health (free) AND Early discharge hospital at home – Cochrane Library (free) AND Early discharge ‘hospital-at-home’ gives similar outcomes to in-patient care – NIHR Signal (free)

Review: Difficult Airway Management Algorithms

20 Aug, 2019 | 08:10h | UTC

Difficult airway management algorithms: a directed review – Anaesthesia (free)

Related Guidelines: Difficult intubation and extubation in adult anaesthesia – Anaesthesia Critical Care & Pain Medicine (free) AND Difficult Airway Society 2015 guidelines for management of unanticipated difficult intubation in adults – British Journal of Anaesthesia (free) AND Practice Guidelines for Management of the Difficult Airway: An Updated Report by the American Society of Anesthesiologists Task Force on Management of the Difficult Airway – Anesthesiology (free) AND The difficult airway with recommendations for management – Part 1 – Difficult tracheal intubation encountered in an unconscious/induced patient – Canadian Journal of Anesthesia (free) AND The difficult airway with recommendations for management – Part 2 – The anticipated difficult airway – Canadian Journal of Anesthesia (free) AND Guidelines for the management of tracheal intubation in critically ill adults – British Journal of Anaesthesia (free) AND S1 guidelines on airway management – German Society of Anesthesiology and Intensive Care Medicine (free)

Mon August 19 – 10 Stories of The Day!

19 Aug, 2019 | 08:29h | UTC

1 -2019 update of EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases – Annals of Rheumatic Diseases (free)

2 – Pregnancy after bariatric surgery: Consensus recommendations for periconception, antenatal and postnatal care – Obesity Reviews (free)

Related: Pregnancy after bariatric surgery and adverse perinatal outcomes: A systematic review and meta-analysis – PLOS Medicine (free)

3 – Perioperative covert stroke in patients undergoing non-cardiac surgery (NeuroVISION): a prospective cohort study – The Lancet (link to abstract – $ for full-text)

Commentaries: ‘Silent’ strokes common after surgery, linked to cognitive decline – McMaster University (free) AND ‘Silent’ strokes after elective surgeries in older adults double their risk of later cognitive decline, study finds – The Globe and Mail (free)

4 – Lactate guided resuscitation—nothing is more dangerous than conscientious foolishness – Journal of Thoracic Disease (free PDF)

Related Opinion: The ten pitfalls of lactate clearance in sepsis – Intensive Care Medicine (free)

Related Randomized Trial: Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels in Patients with Septic Shock (free)

5 – The Global Prevalence of Anxiety Among Medical Students: A Meta-Analysis – International Journal of Environmental Research and Public Health (free)

Related: Medical student wellbeing – a consensus statement from Australia and New Zealand – BMC Medical Education (free) AND Prevalence of Depression, Depressive Symptoms, and Suicidal Ideation Among Medical Students: A Systematic Review and Meta-Analysis – JAMA (free)

6 – Sick hospital workers often expose patients to contagious illness – Reuters (free)

Original Study: Which healthcare workers work with acute respiratory illness? Evidence from Canadian acute-care hospitals during 4 influenza seasons: 2010–2011 to 2013–2014 – Infection Control & Hospital Epidemiology (free)

Related: Working While Sick: A Systematic Review of Infectious Illness Presenteeism (free)

7 – Promising new tuberculosis drug pretomanid approved, but will it be affordable? – Médecins Sans Frontières (free)

Original News Release: FDA approves new drug for treatment-resistant forms of tuberculosis that affects the lungs – U.S. Food & Drug Administration (free)

See also: New Drug Could Be Game Changer For Drug-Resistant TB. But A Question Looms – NPR (free) AND Treatment for extreme drug-resistant tuberculosis wins US government approval – Nature (free) AND Scientists Discover New Cure for the Deadliest Strain of Tuberculosis – The New York Times (10 articles per month are free) AND U.S. FDA approves TB Alliance’s treatment for drug-resistant tuberculosis – Reuters (free)

8 – Effect of Bismuth Subsalicylate vs Placebo on Use of Antibiotics Among Adult Outpatients With Diarrhea in Pakistan: A Randomized Clinical Trial – JAMA Network Open (free)

9 – Association of social contact with dementia and cognition: 28-year follow-up of the Whitehall II cohort study – PLOS Medicine (free)

Commentaries: Socially active 60-year-olds face lower dementia risk – University College London (free) AND Social Contact Associated With Lower Dementia Risk – MD Magazine (free)

10 – Association Between Electronic Cigarette Use and Marijuana Use Among Adolescents and Young Adults: A Systematic Review and Meta-analysis – JAMA Pediatrics (abstract Only – $ for full-text)

Commentaries: Youth Who Use E-Cigarettes May Be More Likely to Use Marijuana, Study Finds – Psychiatric News Alert (free) AND Teens who vape three times more likely to use marijuana – UPI (free) AND Vaping linked to marijuana use in young people, research says – CNN (free)

EULAR Recommendations for Vaccination in Adult Patients with Autoimmune Inflammatory Rheumatic Diseases

18 Aug, 2019 | 22:09h | UTC

2019 update of EULAR recommendations for vaccination in adult patients with autoimmune inflammatory rheumatic diseases – Annals of Rheumatic Diseases (free)

Related Commentary on Twitter

Update of the @eular_org #recommendations for #vaccination in adult patients with #autoimmune #inflammatory #rheumatic diseases just published. See the overarching priniciples at first glance attached!
FULTTEXT: https://t.co/BxNO6JfOws pic.twitter.com/m3yowT4zVm

— Annals of the Rheumatic Diseases (@eular_ARD) August 16, 2019

[Abstract Only] Cohort Study: ‘Silent’ Strokes Common After Non-cardiac Surgery, Linked to Cognitive Decline

18 Aug, 2019 | 22:07h | UTC

Perioperative covert stroke in patients undergoing non-cardiac surgery (NeuroVISION): a prospective cohort study – The Lancet (link to abstract – $ for full-text)

Commentaries: ‘Silent’ strokes common after surgery, linked to cognitive decline – McMaster University (free) AND ‘Silent’ strokes after elective surgeries in older adults double their risk of later cognitive decline, study finds – The Globe and Mail (free)

Related Commentary on Twitter

NEW: Perioperative covert stroke is associated with increased risk of cognitive decline 1 year after non-cardiac surgery & occurred in 1 in 14 patients aged ≥65 years undergoing non-cardiac surgery: findings from NeuroVISION, a prospective cohort study https://t.co/jWXkl6GllU pic.twitter.com/w3mDziUPSR

— The Lancet (@TheLancet) August 16, 2019