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Global Burden, Risk Factors, and Interventions for Diarrhea Among Children Younger than 5 Years

1 Nov, 2019 | 08:09h | UTC

Quantifying risks and interventions that have affected the burden of diarrhoea among children younger than 5 years: an analysis of the Global Burden of Disease Study 2017 – The Lancet Infectious Diseases (free)

Invited Commentary: Early childhood diarrhoea: from data to interventions (free)

Related Global Burden of Disease Report: Global Burden of Diarrhea (free)

Related Commentary on Twitter

Our study, "Quantifying risks and interventions that have affected the burden of diarrhoea among children younger than 5 years: an analysis of the Global Burden of Disease Study 2017" was published in @TheLancetInfDis. Read the open access study online: https://t.co/evz4CWyowu pic.twitter.com/9SSxebzPYm

— Institute for Health Metrics and Evaluation (IHME) (@IHME_UW) October 31, 2019

Meta-Analysis: Calcium Supplementation May Increase the Risk of Myocardial Infarction

1 Nov, 2019 | 07:42h | UTC

The Evidence and Controversy Between Dietary Calcium Intake and Calcium Supplementation and the Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis of Cohort Studies and Randomized Controlled Trials – Journal of the American College of Nutrition (free)

Related Meta-Analysis with Conflicting Results: Calcium Intake and Cardiovascular Disease Risk: An Updated Systematic Review and Meta-analysis – Annals of Internal Medicine (free)

Systematic Review: Early Enteral Nutrition vs. Delayed Enteral Nutrition, With or Without Supplemental Parenteral Nutrition in Critically Ill Adults

1 Nov, 2019 | 07:45h | UTC

Early enteral nutrition (within 48 hours) versus delayed enteral nutrition (after 48 hours) with or without supplemental parenteral nutrition in critically ill adults – Cochrane Library (free)

Summary: Early versus delayed feeding through a tube for critically ill adults in intensive care, with or without extra nutrition into a vein – Cochrane Library (free)

Systematic Review: Antiplatelet Agents for Preventing Pre‐eclampsia and its Complications

1 Nov, 2019 | 07:54h | UTC

Antiplatelet agents for preventing pre‐eclampsia and its complications – Cochrane Library (free)

Summary: Antiplatelet agents for preventing pre-eclampsia and its complications – Cochrane Library (free)

Related Randomized Trial: Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia – New England Journal of Medicine (free study and commentaries)

AHA/ASA Guideline Update: Early Management of Acute Ischemic Stroke

31 Oct, 2019 | 08:49h | UTC

Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association – Stroke (free PDF)

Top Things to Know: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke (free)

Thu October 31 – 10 Stories of The Day!

31 Oct, 2019 | 10:45h | UTC

1 – Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association – Stroke (free PDF)

Top Things to Know: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke (free)

2 – A management algorithm for patients with intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC) – Intensive Care Medicine (free)

3 – WHO guidelines for the use of thermal ablation for cervical pre-cancer lesions – World Health Organization (free PDF)

4 – Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism – JAMA (free for a limited period)

Editorial: The Thyrotropin Reference Range Should Be Changed in Older Patients (free for a limited period)

Related Review: Subclinical Hypothyroidism – JAMA (free for a limited period)

5 – Massachusetts General Hospital oversaw trial that led to the first death from a fecal transplant, a new paper shows – STAT (free)

Original Article: Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant – New England Journal of Medicine ($)

Related FDA Safety Alert: Fecal Transplant May Have Caused a Patient’s Death Due to Transmission of a Multi-Drug Resistant Organism (free)

6 – Long-term survival and cause-specific mortality of patients newly diagnosed with tuberculosis in São Paulo state, Brazil, 2010–15: a population-based, longitudinal study – The Lancet Infectious Diseases (free) (via @otavio_ranzani see Tweet)

Invited Commentary: Tuberculosis: an instrument of early mortality in life course (free)

7 – Intra‐pleural fibrinolytic therapy versus placebo, or a different fibrinolytic agent, in the treatment of adult parapneumonic effusions and empyema – Cochrane Library (free)

Summary: Clot-busting drugs for infections of the lining of the lung – Cochrane Library (free)

8 – Risk of Mortality Following Catheter Ablation of Atrial Fibrillation – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentary: Mortality Risk After Catheter Ablation of Atrial Fibrillation – American College of Cardiology (free) AND Early mortality ‘a very real complication’ after catheter ablation of AFib – Cardiovascular Business (free) AND Afib Ablation Deaths Do Happen – MedPage Today (free registration required)

9 – Schizophrenia—An Overview – JAMA Psychiatry (free for a limited period)

10 – Association of Cord Plasma Biomarkers of In Utero Acetaminophen Exposure With Risk of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in Childhood – JAMA Psychiatry (free for a limited period)

Commentaries: NIH-funded study suggests acetaminophen exposure in pregnancy linked to higher risk of ADHD, autism – NIH News Releases (free) AND Babies at higher risk for ADHD, autism if pregnant moms took acetaminophen – Reuters (free) AND Expert reaction to study looking at paracetamol in pregnancy and autism, ADHD and other developmental disabilities in children – Science Media Centre (free)

WHO Guidelines for the Use of Thermal Ablation for Cervical Pre-cancer Lesions

31 Oct, 2019 | 08:43h | UTC

WHO guidelines for the use of thermal ablation for cervical pre-cancer lesions – World Health Organization (free PDF)

Study: Treatment of Subclinical Hypothyroidism Not Beneficial for Elderly Patients

31 Oct, 2019 | 08:42h | UTC

Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism – JAMA (free for a limited period)

Editorial: The Thyrotropin Reference Range Should Be Changed in Older Patients (free for a limited period)

Related Review: Subclinical Hypothyroidism – JAMA (free for a limited period)

Related Commentary on Twitter

Important RCT data demonstrating that routine treatment with levothyroxine for subclinical hypothyroidism in adults aged 80 years and older was not associated with improved patient-reported quality of life outcome scores for hypothyroid symptoms https://t.co/KboKmMFcxm

— Joseph Ross (@jsross119) October 30, 2019

Consensus Statement: A Management Algorithm for Patients with Intracranial Pressure Monitoring

31 Oct, 2019 | 08:48h | UTC

A management algorithm for patients with intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC) – Intensive Care Medicine (free)

Related Commentary on Twitter

A management algorithm for patients with intracranial pressure monitoring.
A useful resource for everyone interested in traumatic brain injury worldwide…free access at https://t.co/PHjX73Rto9
A "must read" pic.twitter.com/vMoq1ZZgaO

— Intensive Care Medicine (@yourICM) October 29, 2019

[Abstract Only] New Details Emerge in Case of First Death from Fecal Transplant

31 Oct, 2019 | 08:30h | UTC

Massachusetts General Hospital oversaw trial that led to the first death from a fecal transplant, a new paper shows – STAT (free)

Original Article: Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant – New England Journal of Medicine ($)

Study: Long-term Survival and Cause-specific Mortality of Patients Newly Diagnosed with Tuberculosis

31 Oct, 2019 | 08:27h | UTC

Long-term survival and cause-specific mortality of patients newly diagnosed with tuberculosis in São Paulo state, Brazil, 2010–15: a population-based, longitudinal study – The Lancet Infectious Diseases (free) (via @otavio_ranzani see Tweet)

Invited Commentary: Tuberculosis: an instrument of early mortality in life course (free)

Related Commentary on Twitter

Important study from Brazil! Post-tuberculosis sequelae and vulnerability are associated with excess mortality and must be addressed to mitigate the tuberculosis burden worldwide. Via ⁦@TheLancetInfDis⁩ ⁦@otavio_ranzani⁩ https://t.co/xHtEmBc4Sr

— Madhu Pai, MD, PhD (@paimadhu) October 31, 2019

Update on Oral Appliance Therapy

23 Oct, 2019 | 07:21h | UTC

Update on oral appliance therapy – European Respiratory Review (free)

Schizophrenia—An Overview

31 Oct, 2019 | 08:14h | UTC

Schizophrenia—An Overview – JAMA Psychiatry (free for a limited period)

[Abstract Only] Randomized Trial: Experimental Vaccine Partially Effective at Preventing Latent Tuberculosis from Turning into Active Disease

30 Oct, 2019 | 08:20h | UTC

Final Analysis of a Trial of M72/AS01_E Vaccine to Prevent Tuberculosis – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Vaccine shows promise for preventing active TB disease – Associated Press (free) AND Researchers move closer to new vaccine for killer TB – MedicalXpress (free)

[Abstract Only] Risk of Mortality Following Catheter Ablation of Atrial Fibrillation

31 Oct, 2019 | 08:16h | UTC

Risk of Mortality Following Catheter Ablation of Atrial Fibrillation – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentary: Mortality Risk After Catheter Ablation of Atrial Fibrillation – American College of Cardiology (free) AND Early mortality ‘a very real complication’ after catheter ablation of AFib – Cardiovascular Business (free) AND Afib Ablation Deaths Do Happen – MedPage Today (free registration required)

Related Commentary on Twitter

New #JACC study finds early mortality following #AFib ablation occurs in 1/200 patients, with most deaths occurring during 30-day readmission. https://t.co/kwl1yRFza4 pic.twitter.com/Kh9utLctd0

— JACC Journals (@JACCJournals) October 29, 2019

Study: In Utero Acetaminophen Exposure Linked to Increased Risk of ADHD and Autism Spectrum Disorder in Childhood

31 Oct, 2019 | 08:12h | UTC

Association of Cord Plasma Biomarkers of In Utero Acetaminophen Exposure With Risk of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in Childhood – JAMA Psychiatry (free for a limited period)

Commentaries: NIH-funded study suggests acetaminophen exposure in pregnancy linked to higher risk of ADHD, autism – NIH News Releases (free) AND Babies at higher risk for ADHD, autism if pregnant moms took acetaminophen – Reuters (free) AND Expert reaction to study looking at paracetamol in pregnancy and autism, ADHD and other developmental disabilities in children – Science Media Centre (free)

Wed October 30 – 10 Stories of The Day!

30 Oct, 2019 | 10:26h | UTC

1 – Final Analysis of a Trial of M72/AS01_E Vaccine to Prevent Tuberculosis – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Vaccine shows promise for preventing active TB disease – Associated Press (free) AND Researchers move closer to new vaccine for killer TB – MedicalXpress (free)

2 – Efficacy and safety of anti-inflammatory agents for the treatment of major depressive disorder: a systematic review and meta-analysis of randomised controlled trials – Journal of Neurology, Neurosurgery & Psychiatry (free)

Commentaries: Expert reaction to systematic review and meta-analysis of RCTs on anti-inflammatory drugs for depression – Science Media Centre (free) AND Anti-inflammatories can curb major depressive symptoms – OnMedica (free) AND Anti-inflammatory agents can effectively and safely curb major depressive symptoms, study suggests – BMJ (free)

3 – Levofloxacin prophylaxis in patients with newly diagnosed myeloma (TEAMM): a multicentre, double-blind, placebo-controlled, randomised, phase 3 trial – The Lancet Oncology (free)

Commentaries: Reducing infection-related morbidity and mortality in patients with myeloma – The Lancet Oncology (free) AND Abx Prophylaxis Cuts Early Death in Newly Diagnosed Myeloma – MedPage Today (free)

4 – Randomized Trial of Lenalidomide Versus Observation in Smoldering Multiple Myeloma – Journal of Clinical Oncology (free)

Commentary: Lenalidomide may delay onset of myeloma-related bone, organ damage – Mayo Clinic (free)

5 – Meta-analysis comparing double versus Triple Anti-thrombotic Therapy in Patients with Atrial Fibrillation and Coronary Artery Disease – The American Journal of Cardiology (link to abstract – $ for full-text)

Commentary: Meta-analysis: Dual therapy yields less bleeding than triple therapy in AF, CAD – Healio (free registration required)

Related Randomized Trial: Dual Antithrombotic Therapy after PCI in Atrial Fibrillation (free study and commentaries)

6 – It’s time to talk about physician burnout and moral injury – The Lancet Psychiatry (free)

7 – The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 – The Lancet Gastroenterology & Hepatology (free)

Invited Commentary: Global burden of inflammatory bowel disease (free)

8 – The global, regional, and national burden of pancreatic cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 – The Lancet Gastroenterology & Hepatology (free)

Invited Commentary: Pancreatic cancer: a growing burden (free)

9 – The global, regional, and national burden of stomach cancer in 195 countries, 1990–2017: a systematic analysis for the Global Burden of Disease study 2017 – The Lancet Gastroenterology & Hepatology (free)

Invited Commentary: 27 years of stomach cancer: painting a global picture (free)

10 – The global, regional, and national burden of colorectal cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 – The Lancet Gastroenterology & Hepatology (free)

Invited Commentary: The global challenge of colorectal cancer (free)

Meta-Analysis: Medications with Anti-inflammatory Properties Show Promising Effects in the Treatment of Depression

30 Oct, 2019 | 08:18h | UTC

Efficacy and safety of anti-inflammatory agents for the treatment of major depressive disorder: a systematic review and meta-analysis of randomised controlled trials – Journal of Neurology, Neurosurgery & Psychiatry (free)

Commentaries: Expert reaction to systematic review and meta-analysis of RCTs on anti-inflammatory drugs for depression – Science Media Centre (free) AND Anti-inflammatories can curb major depressive symptoms – OnMedica (free) AND Anti-inflammatory agents can effectively and safely curb major depressive symptoms, study suggests – BMJ (free)

Randomized Trial: Levofloxacin Prophylaxis Reduces Early Deaths in Patients with Newly Diagnosed Myeloma

30 Oct, 2019 | 08:17h | UTC

Levofloxacin prophylaxis in patients with newly diagnosed myeloma (TEAMM): a multicentre, double-blind, placebo-controlled, randomised, phase 3 trial – The Lancet Oncology (free)

Commentaries: Reducing infection-related morbidity and mortality in patients with myeloma – The Lancet Oncology (free) AND Abx Prophylaxis Cuts Early Death in Newly Diagnosed Myeloma – MedPage Today (free)

Randomized Trial: Treatment vs. Observation in Smoldering Multiple Myeloma

30 Oct, 2019 | 08:15h | UTC

Randomized Trial of Lenalidomide Versus Observation in Smoldering Multiple Myeloma – Journal of Clinical Oncology (free)

Commentary: Lenalidomide may delay onset of myeloma-related bone, organ damage – Mayo Clinic (free)

[Abstract Only] Meta-analysis: Double Anti-thrombotic Therapy Safer than Triple Therapy in Patients with Atrial Fibrillation and Coronary Artery Disease

30 Oct, 2019 | 08:14h | UTC

Meta-analysis comparing double versus Triple Anti-thrombotic Therapy in Patients with Atrial Fibrillation and Coronary Artery Disease – The American Journal of Cardiology (link to abstract – $ for full-text)

Commentary: Meta-analysis: Dual therapy yields less bleeding than triple therapy in AF, CAD – Healio (free registration required)

Related Randomized Trial: Dual Antithrombotic Therapy after PCI in Atrial Fibrillation (free study and commentaries)

Opinion: It’s Time to Talk About Physician Burnout and Moral Injury

30 Oct, 2019 | 08:12h | UTC

It’s time to talk about physician burnout and moral injury – The Lancet Psychiatry (free)

The Global Burden of Pancreatic Cancer

30 Oct, 2019 | 07:59h | UTC

The global, regional, and national burden of pancreatic cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 – The Lancet Gastroenterology & Hepatology (free)

Invited Commentary: Pancreatic cancer: a growing burden (free)

Related Commentary on Twitter

New research: Globally, the number of deaths, incident cases, and DALYs caused by #pancreaticcancer has more than doubled from 1990 to 2017 – https://t.co/ErtopvrIP5 #UEGWeek #GBDStudy @IHME_UW #pancsm pic.twitter.com/8L7sdjAGtm

— The Lancet Gastroenterology & Hepatology (@LancetGastroHep) October 22, 2019

The Global Burden of Colorectal Cancer

30 Oct, 2019 | 07:55h | UTC

The global, regional, and national burden of colorectal cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 – The Lancet Gastroenterology & Hepatology (free)

Invited Commentary: The global challenge of colorectal cancer (free)

Related Commentary on Twitter

New research: In 2017, there were 1·8 million incident cases of #colorectalcancer worldwide; the age-standardised incidence rate showed an increase of 9·5% from 1990 to 2017 – https://t.co/lqAbA8nKJL #UEGWeek #GBDStudy @IHME_UW #crcsm pic.twitter.com/juXBZ6Xcgo

— The Lancet Gastroenterology & Hepatology (@LancetGastroHep) October 22, 2019

The Global Burden of Inflammatory Bowel Disease

30 Oct, 2019 | 08:01h | UTC

The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 – The Lancet Gastroenterology & Hepatology (free)

Invited Commentary: Global burden of inflammatory bowel disease (free)

Related Commentary on Twitter

New research: Global estimates suggest there were more than 6·8 million cases of #inflammatoryboweldisease in 2017; the highest age-standardised prevalence rates were in the #USA and the #UK – https://t.co/lLb6sXn4Jh #UEGWeek #GBDStudy @IHME_UW #IBD pic.twitter.com/k1txxA52VO

— The Lancet Gastroenterology & Hepatology (@LancetGastroHep) October 22, 2019

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