Archives
Management of patients after coronary artery bypass grafting surgery: a guide for primary care practitioners.
28 May, 2021 | 08:12h | UTC
Count the cost of disability caused by COVID-19 – “Focusing only on cases and deaths hides the pandemic’s lasting health burden on people, societies and economies”.
27 May, 2021 | 08:35h | UTCCount the cost of disability caused by COVID-19 – Nature
RCT: 2 inactivated SARS-CoV-2 vaccines show efficacy of 72.8% and 78.1% on symptomatic COVID-19 infection in adults.
27 May, 2021 | 08:38h | UTCCommentary: China’s Sinopharm Publishes Awaited Covid Vaccine Study Details – Bloomberg
Commentary on Twitter (thread – click for more)
https://twitter.com/hildabast/status/1397678056270012419
Systematic review of 45 studies including 9751 participants, most of which were hospitalized, found 73% had at least 1 persistent symptom for weeks after Covid-19.
27 May, 2021 | 08:37h | UTCCommentary: Seven out of ten hospitalized COVID-19 patients will have long-haul symptoms – MedicalXpress
Can people vaccinated against COVID-19 still spread the coronavirus? – “Preliminary evidence seems to suggest the COVID-19 vaccines make it less likely someone who’s vaccinated will transmit the coronavirus”.
27 May, 2021 | 08:27h | UTCCan people vaccinated against COVID-19 still spread the coronavirus? – The Conversation
Related: Indirect Protection by Reducing Transmission: Ending the Pandemic with SARS-CoV-2 Vaccination – “Tell the hesitant: the vaccines protect both you and protect others — a lot!”
[Preprint] More data showing a single-dose SARS-CoV-2 mRNA vaccine may be enough in individuals with previous COVID-19.
27 May, 2021 | 08:31h | UTCSingle-dose SARS-CoV-2 vaccine in a prospective cohort of COVID-19 patients – medRxiv
See also: SARS-CoV-2 vaccines for all but a single dose for COVID-19 survivors – EClinicalMedicine
Related: Another study shows a single dose of mRNA vaccine may be enough for patients with previous Covid-19
Commentaries on Twitter
If you had prior covid and you're wondering about getting vaccinated, here's a new prospective study showing single dose -> marked neutralizing antibody protection to the major variants AND again more than without prior covid and 2 mRNA doses https://t.co/k9v5gEDn2M pic.twitter.com/Z8nT3pL04v
— Eric Topol (@EricTopol) May 26, 2021
One dose of vaccine for prior covid.
Change the policy. Avoid unnecessary side effects and instead of wasting vaccine doses get them to the people around the world in needhttps://t.co/ODhx5kgAnq @EBioMedicine @MattFrieman @VivianaSimonLab @florian_krammer pic.twitter.com/oAeju9AASm— Eric Topol (@EricTopol) May 26, 2021
COVID Morbidity – The emerging burden of long COVID is significant, and needs to be considered when evaluating the risk vs. benefit of pandemic measures.
27 May, 2021 | 08:34h | UTCCOVID Morbidity – Science-Based Medicine
Opinion | Rich countries cornered COVID-19 vaccine doses. Four strategies to right a ‘scandalous inequity’.
27 May, 2021 | 08:29h | UTCRich countries cornered COVID-19 vaccine doses. Four strategies to right a ‘scandalous inequity’ – Science (a few articles per month are free)
Commentary on Twitter
Tedros @WHO calls it a "scandalous inequity" that COVID-19 vaccine doses largely have gone to wealthy countries. @kakape and I took a close look at four strategies to improve access and equity–and the likely timelines.
https://t.co/10Os0yCnFE pic.twitter.com/RMeL6t8aCV— Jon Cohen (@sciencecohen) May 26, 2021
Moderna says its Covid vaccine is 100% effective in teens, plans to seek FDA OK in early June.
27 May, 2021 | 08:25h | UTCModerna says its Covid vaccine is 100% effective in teens, plans to seek FDA OK in early June – CNBC
Commentary on Twitter
BREAKING: Moderna study of more than 3,700 12- to 17-year olds found 100% effficacy in those who received 2-dose #covid19 #vaccine, no significant safety problems. Will apply for FDA authorization.https://t.co/l0MHiLjCcA
— Leana Wen, M.D. (@DrLeanaWen) May 25, 2021
RCT: Among patients with prosthetic joint infection, antibiotic therapy for 6 weeks was NOT shown to be noninferior to antibiotic therapy for 12 weeks and resulted in a higher percentage of patients with unfavorable outcomes.
27 May, 2021 | 08:20h | UTCAntibiotic Therapy for 6 or 12 Weeks for Prosthetic Joint Infection – New England Journal of Medicine (link to abstract – $ for full-text)
Study suggests it is safe to discontinue antiseizure medication for most neonates with acute symptomatic seizures prior to discharge from the hospital.
27 May, 2021 | 08:14h | UTCSafety of Early Discontinuation of Antiseizure Medication After Acute Symptomatic Neonatal Seizures – JAMA Neurology (free for a limited period)
Editorial: Discontinuing Antiseizure Medication in Neonates With Acute Symptomatic Seizures—Primum non nocere – JAMA Neurology (free for a limited period)
Commentaries: Stopping Antiseizure Medication After Acute Symptomatic Neonatal Seizures Is Found to Be Safe – Neurology Today AND Babies with Seizures May Be Overmedicated – Michigan Medicine
Commentary on Twitter
New CER study on @JAMANeuro finds no difference in functional neurodevelopment or epilepsy at 24 mnths in children whose antiseizure meds was discont'd vs maintained at discharge after resolution of acute symptomatic neonatal seizures: https://t.co/yvKbrJuCvQ #ebneoalerts #neoEBM pic.twitter.com/810weSUSgb
— Evidence-Based Neo (@EBNEO) May 26, 2021
RCT: First-attempt intubation success is increased with the use an endotracheal tube + stylet vs. an endotracheal tube alone.
27 May, 2021 | 08:16h | UTC
Commentary on Twitter
Endotracheal tube + stylet vs tube alone, RCT
➡️999 critically ill adults
➡️significantly higher first-attempt intubation success 78.2% vs 71.5%
➡️related complications 38.7% vs 40.2%
➡️similar rate of serious adverse events (traumatic injuries) 4% vs 3.6%https://t.co/EQ6sqS75hN pic.twitter.com/zF9PguNCSK— Intensive Care Medicine (@yourICM) May 26, 2021
Global cardiovascular organizations release joint opinion on achieving the ‘tobacco endgame’.
27 May, 2021 | 08:22h | UTCNews release: Global cardiovascular organizations release joint opinion on achieving the ‘tobacco endgame’ – American College of Cardiology
Commentary: The Tobacco Endgame—Eradicating a Worsening Epidemic – American College of Cardiology
COVID-19 in Amazonas, Brazil, was driven by the persistence of endemic lineages and P.1 emergence – “viral load was tenfold higher in P.1 infections than in non-P.1”.
26 May, 2021 | 08:42h | UTC
What scientists know about new, fast-spreading coronavirus variants.
26 May, 2021 | 08:45h | UTCWhat scientists know about new, fast-spreading coronavirus variants – Nature
RCT: Immediate “kangaroo mother care” improves survival in infants with low birth weight compared to conventional care with “kangaroo mother care” initiated after stabilization.
27 May, 2021 | 08:18h | UTCCommentary: Immediate skin-to-skin contact after birth improves survival of pre-term babies – Karolisnka Institutet
Related: RCT: Community-initiated kangaroo mother care reduced the risk of moderate-to-severe maternal postpartum depressive symptoms among mothers of low-birth-weight infants in low-income areas in India AND WHO: New research highlights risks of separating newborns from mothers during COVID-19 pandemic AND Randomized Trial: Kangaroo Mother Care Improves Survival of Infants with Low Birthweight
[Preprint] Meta-analysis of RCT: Ivermectin for the treatment of COVID-19 – no effect on all-cause mortality, length of stay, or viral clearance
26 May, 2021 | 08:41h | UTC
Commentary on Twitter
🆕💥💥Preprint
Ivermectin for the treatment of #COVID19 : A systematic review & meta-analysis of RCTs
10 RCTs
1173 patients
8 RCTs➡️ Mild
1 RCT ➡️ Moderate
1 RCT➡️ Mild& mod
Ivermectin did not reduce all-cause mortality,length of stay or viral clearance https://t.co/QMx0wlfS8f pic.twitter.com/6yddqwqPF6— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) May 25, 2021
Study shows acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection.
26 May, 2021 | 08:37h | UTCRelated: Distinguishing the real from the hyperglycaemia: does COVID-19 induce diabetes? – The Lancet Diabetes & Endocrinology AND SARS-CoV-2 infects human pancreatic β-cells and elicits β-cell impairment – Cell Metabolism
Commentary on Twitter
For at least 2 months after COVID-19 in people without #diabetes, glucose regulation can be abnormal, along with insulin resistance and abnormal cytokineshttps://t.co/P1xa0lx2c4 @NatMetabolism @PAOLOFIORINA @FiorinaLab pic.twitter.com/Lu7GDMjzdy
— Eric Topol (@EricTopol) May 25, 2021
Estimating infectiousness throughout SARS-CoV-2 infection course – 8% of subjects had very high viral loads, one-third of whom had little to no symptoms; in individuals infected with the B.1.1.7 variant, average viral loads were 10 times higher.
26 May, 2021 | 08:43h | UTCEstimating infectiousness throughout SARS-CoV-2 infection course – Science
Commentary: Estimating infectiousness of SARS-CoV-2: New study on viral load – Universitätsmedizin Berlin
Commentary on Twitter
Of 25,000+ people who tested positive for #COVID19 in Germany, 8% had very high viral loads; about a third of these had little to no symptoms. The results suggest asymptomatic people can be expected to be as infectious as hospitalized patients @c_drosten https://t.co/mRkzJrwFwU pic.twitter.com/vsrameCAWk
— Science Magazine (@ScienceMagazine) May 25, 2021
Methotrexate reduces immune response to mRNA COVID-19 vaccine in patients with immune-mediated inflammatory disease.
26 May, 2021 | 08:38h | UTCCommentary: Methotrexate users have a reduced immune response to mRNA COVID-19 vaccine – BMJ
Editorial | A patent waiver on COVID vaccines is right and fair.
26 May, 2021 | 08:35h | UTCA patent waiver on COVID vaccines is right and fair – Nature
Related: Analysis: Covid-19: How will a waiver on vaccine patents affect global supply?
RCT: Continuous infusion of 20% hypertonic saline does not improve neurological outcomes in patients with traumatic brain injury
26 May, 2021 | 08:22h | UTCEffect of Continuous Infusion of Hypertonic Saline vs Standard Care on 6-Month Neurological Outcomes in Patients With Traumatic Brain Injury: The COBI Randomized Clinical Trial – JAMA (free for a limited period)
Commentary on Twitter
Among patients with moderate to severe traumatic brain injury, treatment with continuous infusion of 20% hypertonic saline compared with standard care did not result in a significantly better neurological status at 6 months https://t.co/zyPhO0Y2Yy
— JAMA (@JAMA_current) May 25, 2021
Addressing distress management challenges: Recommendations from the consensus panel of the American Psychosocial Oncology Society and the Association of Oncology Social Work.
26 May, 2021 | 08:18h | UTC
Opinion | Protecting Olympic Participants from Covid-19 — The Urgent Need for a Risk-Management Approach.
26 May, 2021 | 08:33h | UTC
Short review: Diagnosis and management of acute respiratory distress syndrome
26 May, 2021 | 08:19h | UTC
Commentary on Twitter
#ARDS is an important priority in our ICUs at the moment. Our @CMAJ review looks at diagnosis, and provides a guideline-based approach to management, along with a discussion on #COVID19 ARDS.
A great primer for those new to ARDS!
OPEN ACCESS Link: https://t.co/saVdFT6Wyn pic.twitter.com/HbhoYbeG3u
— Shannon Fernando (@shanfernands) May 25, 2021