Archives
State-of-the-Art Review: Clinical approach to cardiovascular toxicity of oral antineoplastic agents
26 May, 2021 | 08:20h | UTCSummary: Cardiovascular Toxicity of Oral Antineoplastic Agents – American College of Cardiology
M-A: Prokinetics may improve tolerance to gastric feeding to some extent in critically ill adults.
26 May, 2021 | 08:16h | UTC
Admission respiratory status predicts mortality in COVID-19 – hypoxemic patients (oxygen saturation less than 92%) had a 1.8- to 4.0-fold increased mortality risk; those with respiratory rates over 22 breaths per minute were at 1.9- to 3.2-fold elevated mortality risk.
25 May, 2021 | 08:56h | UTCAdmission respiratory status predicts mortality in COVID-19 – Influenza and Other Respiratory Virus
Commentaries: COVID-19 mortality associated with 2 signs easily measured at home – University of Washington School of Medicine AND Low oxygen levels, shallow breathing tied to COVID death – CIDRAP
2 signs easily measured at home can indicate increased Covid mortality risk—respiration rate & blood-oxygen saturation. Both are distinctly predictive of higher mortality. Anyone receiving a positive Covid test can easily monitor for these signs at home https://t.co/8n7oc0d4E4 pic.twitter.com/02ysVaElsL
— delthia ricks 🔬 (@DelthiaRicks) May 24, 2021
RCT: Manual rotation of occiput posterior fetal positions at the start of the second stage of labor does not increase the rate of vaginal delivery without instrumental assistance.
26 May, 2021 | 08:17h | UTC
M-A: A biofeedback‐guided program or pelvic floor muscle electric stimulation can improve early recovery of urinary continence after radical prostatectomy.
26 May, 2021 | 08:13h | UTC
The IMF says ending the COVID-19 pandemic is possible by vaccinating at least 40% of the population in all countries by the end of 2021, and at least 60% by the first half of 2022 at the cost of $50 billion.
25 May, 2021 | 08:58h | UTCA Proposal to End the COVID-19 Pandemic – IMFBlog
Commentary: IMF says ending COVID-19 pandemic possible at cost of some $50 billion – Reuters
Living systematic review: The evidence is insufficient to determine the benefits and harms of vitamin D supplementation as a treatment of COVID‐19.
25 May, 2021 | 08:55h | UTCSummary: Is vitamin D an effective and safe treatment for COVID-19? – Cochrane Library
Perspective | Coronavirus: so many variants, but vaccines are still effective.
25 May, 2021 | 08:46h | UTCCoronavirus: so many variants, but vaccines are still effective – The Conversation
Secondary analysis of RCT finds Tocilizumab was beneficial to patients hospitalized with Covid-19 if CRP levels were greater than 15.0 mg/dL, but not if CRP levels were 15.0 mg/dL or less.
25 May, 2021 | 08:52h | UTC
Mild COVID-19 induces lasting antibody protection, study finds.
25 May, 2021 | 08:51h | UTCOriginal study: SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans – Nature
Commentary on Twitter (thread – click for more)
Just published @nature
After even mild covid infections there are, in addition to memory B cells, bone marrow plasma cells are induced to provide long-term protection > 1 yrhttps://t.co/zVfUFvciVk
@TheBcellArtist @WUSTLmed
(NB vaccination still provides further protection) pic.twitter.com/rUd8pMAP1T— Eric Topol (@EricTopol) May 24, 2021
WHO: At least 115,000 health workers have died from COVID
25 May, 2021 | 08:49h | UTCAt least 115,000 health workers have died from COVID: WHO – MedicalXpress
AHA/ASA Guideline: Prevention of stroke in patients with previous stroke and transient ischemic attack – prevention efforts should be based on the cause of the first ischemic event.
25 May, 2021 | 08:43h | UTCNews Release: Risk of second stroke can be reduced with prevention efforts based on cause of first stroke – American Heart Association
Meta-analysis: New generation antidepressants for depression in children and adolescents – “most newer antidepressants may reduce depression symptoms in a small and unimportant way compared with placebo”.
25 May, 2021 | 08:40h | UTC
AAP Clinical Report: Collaborative care in the identification and management of psychosis in adolescents and young adults.
25 May, 2021 | 08:41h | UTC
Systematic Review: Oral dextrose gel reduces the risk of neonatal hypoglycemia in at‐risk infants and probably reduces the risk of major neurological disability at two years.
25 May, 2021 | 08:38h | UTCOral dextrose gel to prevent hypoglycaemia in at‐risk neonates – Cochrane Library
Summary: Oral dextrose gel for prevention of low blood glucose levels in newborn babies – Cochrane Library
Science, Medicine, And The Anesthesiologist | June 2021: Key Papers from the Most Recent Literature Relevant to Anesthesiologists.
25 May, 2021 | 08:35h | UTCScience, Medicine, And The Anesthesiologist | June 2021 – Anesthesiology
Transfusion management of severe anemia in African children: a consensus algorithm.
25 May, 2021 | 08:32h | UTC
Podcast | Bariatric Surgery for the Internist – Patient selection, perioperative management, and post-operative care.
25 May, 2021 | 08:37h | UTC#275 Bariatric Surgery for the Internist with Dr. Vivian Sanchez – The Curbsiders
Consensus report: Postoperative acute kidney injury in adult non-cardiac surgery.
25 May, 2021 | 08:34h | UTC
CDC is investigating several reports that teenagers and young adults may have developed myocarditis after receiving mRNA vaccines. Most cases were mild, more often in males than females, more often following dose 2 than dose 1, and typically, within 4 days after vaccination.
24 May, 2021 | 08:41h | UTCCommentaries: C.D.C. Is Investigating a Heart Problem in a Few Young Vaccine Recipients – The New York Times AND U.S. CDC looking into heart inflammation in some young vaccine recipients – Reuters
Related: Israel said probing link between Pfizer shot and heart problem in men under 30 – The Times of Israel
[Preprint] RCT: Both REGEN-COV 2400mg and 1200mg antibody cocktails significantly reduced Covid-19-related hospitalization or all-cause death compared to placebo (71.3% reduction and 70.4% reduction, respectively).
24 May, 2021 | 08:46h | UTCREGEN-COV Antibody Cocktail Clinical Outcomes Study in Covid-19 Outpatients – medRxiv
Commentary on Twitter
REGEN-COV Antibody Cocktail(casirivimab with imdevimab) Clinical Outcomes Study in Covid-19 Outpatients: N:>4000 pts
Both 1200mg IV&2400mg REGEN-COV led to a ≥70% ⬇️ (vs placebo) in Covid-19 hospitalization or all-cause death over 28 days after treatmenthttps://t.co/NJxF4BjZRs pic.twitter.com/CFdvEEIWEL— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) May 21, 2021
[Preprint] Pfizer and AstraZeneca Vaccines effective against B.1.617.2 variant after 2 doses.
24 May, 2021 | 08:42h | UTCNews release: Vaccines highly effective against B.1.617.2 variant after 2 doses – Public Health England
Original study: Effectiveness of COVID-19 vaccines against the B.1.617.2 variant – Public Health England
Commentary: Covid: Pfizer and AstraZeneca jabs effective against Indian variant – study – BBC
[Preprint] Effectiveness of the CoronaVac vaccine in the elderly population during a P.1 variant-associated epidemic of COVID-19 in Brazil – “CoronaVac was 42% effective in the real-world setting of extensive P.1 transmission, but significant protection was not observed until completion of the two-dose regimen”.
24 May, 2021 | 08:43h | UTC
M-A: Tocilizumab in COVID-19 – “For hospitalized COVID-19 patients, there is some evidence that tocilizumab use may be associated with a short-term mortality benefit, but further high-quality data are required”.
24 May, 2021 | 08:39h | UTC
Commentary on Twitter
Tocilizumab as IL-6 antagonist in hospitalized #COVID19 pts, SR/MA/TSA:
➡️10 RCTs/6493 pts (52.2% ➡️ tocilizumab)
➡️some evidence suggests tocilizumab may be associated with short-term mortality benefit
➡️tocilizumab may prevent disease progression to MVhttps://t.co/sWR4Y351sl pic.twitter.com/JPD31Nb5rn— Intensive Care Medicine (@yourICM) May 22, 2021
WHO: The impact of COVID-19 on global health goals – COVID-19 responsible for at least 3 million excess deaths in 2020.
24 May, 2021 | 08:49h | UTCThe impact of COVID-19 on global health goals – World Health Organization
Related: Covid-19 pandemic: approximately one million excess deaths occurred in 2020 in 29 high income countries. AND Perspective | Tracking lives we’ve lost to COVID-19. AND COVID-19 has caused 6.9 million deaths globally, more than double what official reports show
Commentary on Twitter (thread – click for more)
🆕 The latest World Health Statistics report finds that #COVID19 is responsible for at least 3 million excess deaths in 2020 👉 https://t.co/yAXB5bzx1g#HealthData pic.twitter.com/DMd9fg69I2
— World Health Organization (WHO) (@WHO) May 21, 2021