Archives
Using resources wisely in the COVID-19 pandemic: an international list of Choosing Wisely recommendations.
24 May, 2021 | 08:36h | UTC
Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection.
24 May, 2021 | 08:38h | UTCCommentary: Scientists find new way of predicting COVID-19 vaccine efficacy – University of New South Wales
Commentary on Twitter (thread – click for more)
Just published @NatureMedicine: For 7 vaccines, the neutralizing antibody levels are highly predictive of the magnitude of clinical efficacy, support long term protection vs severe illness, and preserved efficacy vs variantshttps://t.co/ZQIrTQErMm pic.twitter.com/rUl9TMbVrC
— Eric Topol (@EricTopol) May 17, 2021
Risk factors for illness severity among pregnant women with confirmed SARS-CoV-2 infection – moderate-to-severe COVID-19 was associated with age 25 years and older, healthcare occupation, pre-pregnancy obesity, chronic lung disease, chronic hypertension, and pregestational diabetes mellitus.
24 May, 2021 | 08:34h | UTC
Indirect Protection by Reducing Transmission: Ending the Pandemic with SARS-CoV-2 Vaccination – “Tell the hesitant: the vaccines protect both you and protect others — a lot!”
24 May, 2021 | 08:31h | UTC
Commentary on Twitter
*Strongly* recommend this comprehensive review of just how much COVID19 vaccines reduce the risk of transmitting the virus to others. Tell the hesitant: the vaccines protect both you and protect others — a lot! @mugecevik @AaronRichterman @EricMeyerowitz https://t.co/Cv3t3zNMRL pic.twitter.com/sOLAKKIJnQ
— Paul Sax (@PaulSaxMD) May 21, 2021
#ACC21 – RCT: Among patients with resistant hypertension, ultrasound renal denervation resulted in a modest improvement in systolic BP (–4.5 mm Hg) vs. sham procedure.
24 May, 2021 | 08:28h | UTCUltrasound renal denervation for hypertension resistant to a triple medication pill (RADIANCE-HTN TRIO): a randomised, multicentre, single-blind, sham-controlled trial – The Lancet (link to abstract – $ for full-text)
Commentary: Renal Denervation for Resistant Hypertension Is Not Back on Track – “A systolic blood pressure (SBP) reduction of 4.5 mm Hg is not good enough—for an invasive procedure”. – Medscape (free registration required)
#ACC21 – Lessons from the ACC 2021 Meeting.
24 May, 2021 | 08:29h | UTCLessons from the ACC 2021 Meeting – by John Mandrola, MD
RCT: Among patients with pemphigus vulgaris, rituximab was superior to mycophenolate mofetil in producing sustained complete remission at 52 weeks (40% vs 10%) but was associated with increased risk of serious adverse events (22% vs. 15%).
24 May, 2021 | 08:24h | UTC
RCT: Endovascular therapy for stroke due to basilar-artery occlusion – “endovascular therapy and medical therapy did not differ significantly with respect to a favorable functional outcome”.
24 May, 2021 | 08:27h | UTCEndovascular Therapy for Stroke Due to Basilar-Artery Occlusion – New England Journal of Medicine (link to abstract – $ for full-text)
A deep learning algorithm can estimate malignancy risk of pulmonary nodules detected at low-dose screening CT.
24 May, 2021 | 08:21h | UTCCommentaries: AI predicts lung cancer risk – Radiological Society of North America AND AI Takes LDCT Further for Lung Cancer Prediction – Diagnostic Imaging
Commentary on Twitter
A deep learning algorithm can have a discriminative performance comparable to that of clinical experts on low-dose screening chest CTs. https://t.co/60U518u6eA pic.twitter.com/phZPFDpUpx
— Radiology (@radiology_rsna) May 20, 2021
New Google AI tool can help patients identify common skin conditions.
24 May, 2021 | 08:23h | UTCUsing AI to help find answers to common skin conditions – Google
Commentary: Google AI tool can help patients identify skin conditions – BBC
The state of diabetes treatment coverage in 55 low-income and middle-income countries – fewer than one in ten people with diabetes in LMICs receive comprehensive care such as low-cost medicines to reduce blood sugar, blood pressure and cholesterol levels, in addition to counseling on diet, exercise and weight.
24 May, 2021 | 08:18h | UTCCommentary: Vast under-treatment of diabetes seen in global study – Michigan Medicine
[Preprint] No safe level of alcohol consumption for brain health: observational cohort study of 25,378 UK Biobank participants.
24 May, 2021 | 08:20h | UTCCommentaries: Drinking any amount of alcohol causes damage to the brain, study finds – CNN AND Expert reaction to a preprint looking at alcohol consumption and brain health – Science Media Centre AND Any amount of alcohol consumption harmful to the brain, finds study – The Guardian
Covid-19 pandemic: approximately one million excess deaths occurred in 2020 in 29 high income countries.
21 May, 2021 | 08:52h | UTCEditorial: Measuring the impact of covid-19
Commentary: Nearly 1 million excess deaths in 29 nations during pandemic – CIDRAP
Related: COVID-19 has caused 6.9 million deaths globally, more than double what official reports show
Pessaries for pelvic organ prolapse – looking at the Cochrane evidence.
24 May, 2021 | 08:17h | UTCPessaries for pelvic organ prolapse – looking at the Cochrane evidence – Evidently Cochrane
Original Review: Pessaries (mechanical devices) for managing pelvic organ prolapse in women – Cochrane Library
Nonreplicable publications are cited more than replicable ones
24 May, 2021 | 08:15h | UTCNonreplicable publications are cited more than replicable ones – Science Advances
Commentary on Twitter
Not only does misinformation flow at considerably higher velocity across the Internet than truth, but science publications without replication are cited much more than those which are replicated
New @ScienceAdvances https://t.co/aNSKyv1alq @UriGneezy @m_serra_garcia pic.twitter.com/eWWc0NZwgi— Eric Topol (@EricTopol) May 21, 2021
Perspective | Tracking lives we’ve lost to COVID-19.
21 May, 2021 | 08:51h | UTCTracking Lives We’ve Lost to COVID-19 – Think Global Health
Related: COVID-19 has caused 6.9 million deaths globally, more than double what official reports show
How the Covid pandemic ends: Scientists look to the past to see the future.
21 May, 2021 | 08:46h | UTCHow the Covid pandemic ends: Scientists look to the past to see the future – STAT
Commentary on Twitter
https://twitter.com/HelenBranswell/status/1395007060002152450
Observational study finds a single dose of either Pfizer-BioNTech and Oxford-AstraZeneca vaccines in older adults is about 80% effective at preventing admission to hospital with covid-19.
21 May, 2021 | 08:54h | UTCEditorial: Effectiveness of England’s initial vaccine roll out – The BMJ
M-A: Prevalence and outcomes of co-infection and superinfection with SARS-CoV-2 and other pathogens – The pooled prevalence of co-infection at the time of a SARS-CoV-2 diagnosis was 19%, and that of superinfection was 24%.
21 May, 2021 | 08:48h | UTC
Report: Face masks effectively limit the probability of SARS-CoV-2 transmission.
21 May, 2021 | 08:49h | UTCFace masks effectively limit the probability of SARS-CoV-2 transmission – Science
Perspective | Contact Tracing for Covid-19 — A Digital Inoculation against Future Pandemics.
21 May, 2021 | 08:45h | UTC
RCT: In Africa, children hospitalized with severe pneumonia with oxygen saturations between 80 and 91% who did not receive oxygen had comparable mortality to children who received oxygen.
21 May, 2021 | 08:30h | UTC
Commentary on Twitter
COAST RCT O2 in African children >28 days w severe pneumonia, less is more!
SO2 80-91%? no O2 ➡️48h mortality comparable to low-flow O2/HFNC. O2-sparing strategies potentially offer cost-effective approaches to reduce requirements in low resource settings. https://t.co/8JHit94WQY pic.twitter.com/EEIybSOlmy— Intensive Care Medicine (@yourICM) May 6, 2021
Clinical review: Treatment of opioid use disorder in primary care.
21 May, 2021 | 08:31h | UTCTreatment of opioid use disorder in primary care – The BMJ (free for a limited period)
New WHO report highlights global progress on reducing HIV, viral hepatitis and sexually transmitted infections and signals need for renewed efforts to reach 2030 targets.
21 May, 2021 | 08:33h | UTCOriginal report: Global progress report on HIV, viral hepatitis and sexually transmitted infections, 2021 – World Health Organization
Commentary on Twitter (thread – click for more)
Every year HIV, viral hepatitis, and sexually transmitted infections account for 2.3M deaths, and 1.2M cancers
🆕WHO report highlights achievements, gaps, and actions towards eliminating these diseases as public health threats by 2030 👉https://t.co/8kcVqZe0Yj pic.twitter.com/U07hKRumVt
— World Health Organization (WHO) (@WHO) May 20, 2021
M-A: Comparison of treatments for cocaine use disorder among adults – Only contingency management programs were significantly associated with an increased likelihood of reductions in cocaine use among adults.
21 May, 2021 | 08:28h | UTC