RCT: In Africa, children hospitalized with severe pneumonia with oxygen saturations between 80 and 91% who did not receive oxygen had comparable mortality to children who received oxygen.

Randomised controlled trial of oxygen therapy and high-flow nasal therapy in African children with pneumonia – Intensive Care Medicine

Commentary on Twitter

COAST RCT O2 in African children >28 days w severe pneumonia, less is more!
SO2 80-91%? no O2 ➡️48h mortality comparable to low-flow O2/HFNC. O2-sparing strategies potentially offer cost-effective approaches to reduce requirements in low resource settings. https://t.co/8JHit94WQY pic.twitter.com/EEIybSOlmy

— Intensive Care Medicine (@yourICM) May 6, 2021