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CDC study showed a reduced risk of reinfection with SARS-CoV-2 after covid-19 vaccination.
9 Aug, 2021 | 00:03h | UTC
Commentaries on Twitter
This is non randomized. The two biases are:
1. Behavior among those who got vaccinated likely different than those who don't
2. Likely those who didn't tested more aggressively
I would not cite this as many are doinghttps://t.co/rSkBC37uq0
— Vinay Prasad MD MPH (@VPrasadMDMPH) August 7, 2021
Study shows that full #COVIDVaccination ⬇️ likelihood of being re-infected with #COVID19 compared to those who were previously had COVID but were not vaccinated (risk ⬆️ 2.3 fold)#GetVaccinated even if you have had COVID previouslyhttps://t.co/3dF3XPxwYp
@fascinatorfun pic.twitter.com/ip6zTvNN86
— Prof Kamlesh Khunti (@kamleshkhunti) August 7, 2021
M-A: SARS-CoV-2 Setting-specific transmission rates – “Households showed the highest transmission rates, with a pooled secondary attack rates of 21.1%”.
8 Aug, 2021 | 23:57h | UTC
Commentary on Twitter
SARS-CoV-2 setting-specific transmission rates: a systematic review and meta-analysis
Households highest transmission rates, pooled SAR~21.1%. Contacts at social events~5.9%. Workplaces~1.9%. Age gradient for transmission potential in h/hold context. https://t.co/m27kkDrTgy
— Andrew Lee is heading to @andrewleedr.bsky.social (@andrewleedr) March 10, 2021
COVID vaccine boosters: the most important questions.
8 Aug, 2021 | 23:52h | UTCCOVID vaccine boosters: the most important questions – Nature
Commentary on Twitter
I agree with @nataliexdean: “We just don’t have clear evidence of enough of a loss of efficacy to change our focus or distract from the main goal, which is trying to get as many people first doses” as possible." https://t.co/FEKB4vg0Dz
— Sanghyuk Shin (@sanghyuk_shin) August 6, 2021
Tokyo feared Games would spread COVID; numbers suggest that didn’t happen.
8 Aug, 2021 | 23:56h | UTCTokyo feared Games would spread COVID; numbers suggest that didn’t happen – Reuters
Commentary on Twitter
Before the #Olympics began, Japan feared that the Games might spread COVID-19, introduce new variants and overwhelm the medical system. The infection numbers from inside the Olympic 'bubble' tell a different story https://t.co/EsIxj3gsNx
— Reuters (@Reuters) August 7, 2021
More data showing one dose of Pfizer vaccine may be enough for individuals who’ve had COVID.
8 Aug, 2021 | 23:50h | UTCCommentary: One Dose of Pfizer Vaccine May Be Enough for Folks Who’ve Had COVID – HealthDay
Related:
Perspective | Is one vaccine dose enough if you’ve had COVID? What the science says.
Another study shows a single dose of mRNA vaccine may be enough for patients with previous Covid-19
Spain to give just one vaccine dose to under 55-year olds who had COVID-19
Perspective: Is one vaccine dose enough after COVID-19 infection?
France’s health authority recommends single vaccine shot for people who have had COVID-19
Covid-19: People who have had infection might only need one dose of mRNA vaccine
Commentary on Twitter
SARS-CoV-2 Antibody Responses After 1 and 2 Doses of the BNT162b2 Vaccine https://t.co/ARMdH8Yboo via @JAMANetworkOpen part of @JAMANetwork Small study but one that confirms the policy of many European countries in which one dose of vaccine is sufficient after having COVID.
— Carlos del Rio (@CarlosdelRio7) August 7, 2021
Adapting interventions to new contexts—the ADAPT guidance – “Use of interventions with a previous evidence base in new contexts might be more efficient than developing new interventions”.
8 Aug, 2021 | 23:46h | UTCAdapting interventions to new contexts—the ADAPT guidance – The BMJ
Commentary on Twitter
"Although some interventions transfer well, effectiveness and implementation often depend on the context."
This paper presents new evidence and consensus informed guidance for adapting and transferring interventions to new contextshttps://t.co/of1ojFR6VD
— The BMJ (@bmj_latest) August 8, 2021
AARC Guideline: Management of pediatric patients with oxygen in the acute care setting.
8 Aug, 2021 | 23:43h | UTC
Case report: Systemic capillary leak syndrome after ChAdOx1 nCOV-19 (Oxford–AstraZeneca) vaccination.
8 Aug, 2021 | 23:49h | UTC
Pediatric asthma: The REGAP consensus.
8 Aug, 2021 | 23:45h | UTCPediatric asthma: The REGAP consensus – Anales de Pediatría
M-A: Effect of low glycemic index or load dietary patterns on glycemic control and cardiometabolic risk factors in diabetes.
8 Aug, 2021 | 23:42h | UTCCommentary: Low glycaemic diet shows meaningful improvements for people with diabetes – The British Medical Journal
Commentary on Twitter
New #BMJResearch finds that low glycaemic index/glycaemic load dietary patterns provide small important benefits for glycaemic control and other established cardiometabolic risk factors in adults with moderately controlled type 1 and type 2 diabeteshttps://t.co/EIMXUhICee
— The BMJ (@bmj_latest) August 7, 2021
ASCO Resource-Stratified Guideline: Assessment of adult women with ovarian masses and treatment of epithelial ovarian cancer.
8 Aug, 2021 | 23:38h | UTCCommentary: ASCO Publishes Resource-Stratified Guideline on Assessment and Treatment of Ovarian Cancer – The ASCO Post
Viewpoint: Cancer as a Global Health Priority.
8 Aug, 2021 | 23:37h | UTCCancer as a Global Health Priority – JAMA (free for a limited period)
M-A: Colchicine in patients with coronary artery disease – “colchicine reduces the risk of myocardial infarction and stroke, but has a higher rate of gastrointestinal upset with no influence on all‐cause mortality”.
8 Aug, 2021 | 23:40h | UTCRelated:
Review: Colchicine and the heart.
M-A: Colchicine administration for percutaneous coronary intervention
M-A: Efficacy and safety of low-dose colchicine in patients with coronary disease
Meta-analysis: Colchicine reduces new cardiovascular events in patients with coronary artery disease
Expert analysis: Efficacy and safety of colchicine in patients with chronic stable coronary disease
#ESCCongress – Randomized trial: Colchicine not beneficial for patients with acute coronary syndrome
Research: Colchicine Therapy and Plaque Stabilization in Patients With Acute Coronary Syndrome
Endometrial scratching: what’s the latest evidence? – “we are uncertain whether endometrial injury has an effect on the probability of getting pregnant and having a baby”.
8 Aug, 2021 | 23:33h | UTCEndometrial scratching: what’s the latest evidence? – Cochrane Library
Original Review: Endometrial injury for pregnancy following sexual intercourse or intrauterine insemination – Cochrane Library
Commentary on Twitter
Endometrial scratching is a procedure that is sometimes done with the aim of increasing the chance of pregnancy, but its use is debated. @SarahLensen of @CochraenCGF explains the latest Cochrane evidence in this new @CochraneUK blog: https://t.co/IFyYlXvS6v pic.twitter.com/PDEWRx4JPA
— Cochrane (@cochranecollab) August 6, 2021
RCT: Efficacy of concurrent chemoradiotherapy with S-1 vs. radiotherapy alone for older patients with esophageal cancer.
8 Aug, 2021 | 23:35h | UTCEfficacy of Concurrent Chemoradiotherapy With S-1 vs Radiotherapy Alone for Older Patients With Esophageal Cancer: A Multicenter Randomized Phase 3 Clinical Trial – JAMA Oncology (free for a limited period)
Editorial: Primary Chemoradiotherapy for Older Patients With Esophageal Cancer (free for a limited period)
Commentary: Concurrent CRT Effective for Esophageal Cancer in Older Patients — Overall survival at 2 years significantly better versus radiotherapy alone – MedPage Today (free registration required)
Commentary on Twitter
Randomized phase 3 trial of radiation with or w/o S-1 chemo in 298 older pts (median age 77) with esophageal cancer reveals concurrent chemoradiation led to significantly improved progression-free & overall survival https://t.co/wx5FG5VDUH #GICSM pic.twitter.com/SFddL53lCi
— JAMA Oncology (@JAMAOnc) August 6, 2021
Sudden Death in Adults: A practical flow chart for pathologist guidance.
8 Aug, 2021 | 23:27h | UTCSudden Death in Adults: A Practical Flow Chart for Pathologist Guidance – Healthcare
Perspective: Does Treating Sleep Apnea With CPAP Improve Cardiovascular Outcomes or Lower Risk of Atrial Fibrillation? – “Despite numerous flawed observational studies suggesting an association between sleep apnea and cardiovascular outcomes including atrial fibrillation the gold standard, high-quality RCT data do not clearly show that treatment of sleep apnea with CPAP improves cardiovascular outcomes”.
8 Aug, 2021 | 23:31h | UTCRelated:
AHA Scientific Statement: Obstructive Sleep Apnea and Cardiovascular Disease.
Non-sleepy Obstructive Sleep Apnea: To Treat or Not to Treat?
Pro/Con Debate: Should Asymptomatic Patients with Moderate-to-severe OSA be Treated?
Positive airway pressure doesn’t reduce cardiovascular events and death in adults with sleep apnea
[Preprint] RCT: non-invasive respiratory strategies in acute respiratory failure in patients with COVID-19 – CPAP reduced the composite outcome of intubation or death within 30 days; high-flow nasal oxygenation was not associated with better outcomes.
6 Aug, 2021 | 10:18h | UTCCommentary: Covid: Pressured oxygen reduces ventilator need – BBC
Commentary on Twitter (thread – click for more)
RECOVERY-RS results out, and confirm what most of us have been doing:
CPAP reduces intubation/mortality by 28% compared with no CPAP/HFNO (composite outcome, mostly intubation)
Nasal high flow not so successful1/https://t.co/bcB2sTdAsu pic.twitter.com/fvT8IbyxUr
— 𝚃𝚘𝚖 𝙻𝚊𝚠𝚝𝚘𝚗 💙 (@LawtonTri) August 5, 2021
Antibody-mediated autoimmune encephalitis: A practical approach.
8 Aug, 2021 | 23:29h | UTC
Review: Transmission of infections during cardiopulmonary resuscitation.
8 Aug, 2021 | 23:16h | UTCTransmission of Infections during Cardiopulmonary Resuscitation – Clinical Microbiology Reviews
Perspective | Expertise from outside the Academy: tapering off antidepressants.
8 Aug, 2021 | 23:27h | UTCExpertise from outside the Academy: tapering off antidepressants – The Mental Elf
Related:
A method for tapering antipsychotic treatment that may minimize the risk of relapse
Systematic Review: Managing Antidepressant Discontinuation
Randomized controlled trial: preventive cognitive therapy for prevention of depressive recurrence
Systematic Review: “Remdesivir probably has little or no effect on all‐cause mortality at up to 28 days in hospitalized adults with SARS‐CoV‐2 infection. We are uncertain about the effects of remdesivir on clinical improvement and worsening”.
6 Aug, 2021 | 10:15h | UTCRemdesivir for the treatment of COVID‐19 – Cochrane Library
Summary: Remdesivir for the treatment of COVID-19 – Cochrane Library
Commentary on Twitter (thread – click for more)
JUST PUBLISHED – Is #remdesivir an effective treatment for #COVID19? https://t.co/ntgfDQjMqs This @CochraneHaem systematic review looked at this antiviral medicine to see if it's an effective treatment for people in hospital w #COVID & if it causes unwanted effects. 1/5 pic.twitter.com/UtIW83uTtn
— The Cochrane Library (@CochraneLibrary) August 5, 2021
Flawed ivermectin preprint highlights challenges of COVID drug studies.
6 Aug, 2021 | 10:07h | UTCFlawed ivermectin preprint highlights challenges of COVID drug studies – Nature
Related:
Systematic review: no evidence to support the use of Ivermectin for treating or preventing COVID-19.
Why was a major study on ivermectin for covid-19 just retracted?
Dexamethasone and tocilizumab treatment considerably reduces the value of C-reactive protein and procalcitonin to detect secondary bacterial infections in COVID-19 patients.
6 Aug, 2021 | 10:13h | UTC
Clinical Picture: Mucormycosis after COVID-19 in a patient with diabetes.
6 Aug, 2021 | 10:09h | UTCMucormycosis after COVID-19 in a patient with diabetes – The Lancet
Related:
COVID-19 and mucormycosis superinfection: the perfect storm.
What is mucormycosis, the fungal infection affecting COVID patients in India?
[Preprint] The Emergence of COVID-19 Associated Mucormycosis: Analysis of Cases From 18 Countries.
Mucormycosis: The ‘black fungus’ maiming Covid patients in India
Global Guideline for the Diagnosis and Management of Mucormycosis