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Autoimmune encephalitis after SARS-CoV-2 infection: case frequency, findings, and outcomes.

16 Dec, 2021 | 09:47h | UTC

Autoimmune Encephalitis After SARS-CoV-2 Infection: Case Frequency, Findings, and Outcomes – Neurology

 

Commentary on Twitter

 

Merck’s COVID pill loses its luster: what that means for the pandemic – “Molnupiravir was initially heralded by public-health officials as a game-changer for COVID-19, but full clinical-trial data showed lower-than-expected efficacy”.

16 Dec, 2021 | 09:52h | UTC

Merck’s COVID pill loses its lustre: what that means for the pandemic – Nature

Related:

FDA panel narrowly recommends authorization of first antiviral pill to treat COVID.

[Press release – not published yet] Merck’s new Covid-19 pill Molnupiravir updated data shows reduced efficacy (30%) for preventing hospitalization and death compared to initial results (50%). Absolute risk reduction of hospitalization and death fell from 7% to 3%.

8 lingering questions about the new Covid pills from Merck and Pfizer.

COVID antiviral pills: what scientists still want to know – “Drugs like Molnupiravir and Paxlovid could change the course of the pandemic if clinical trial results hold up in the real world”.

[Press release – not published yet] RCT: Pfizer’s novel Covid-19 oral antiviral treatment candidate reduced risk of hospitalization or death by 89% in interim analysis of phase 2/3 EPIC-HR study.

A prominent virologist warns new COVID-19 pill could unleash dangerous mutants. Others see little cause for alarm.

The U.K. approves Merck’s COVID-19 antiviral pill, calling it a world first.

Merck to allow other nations to produce new COVID-19 antiviral.

Video: Merck’s Covid pill could transform treatment. Here’s how it works.

How antiviral pill Molnupiravir shot ahead in the COVID drug hunt.

What we know — and don’t know — about Merck’s new Covid-19 pill.

[Press release – not published yet] Merck announces oral antiviral Molnupiravir reduced the risk of hospitalization or death by approximately 50 Percent compared to placebo for patients with mild or moderate COVID-19.

Merck’s Covid-19 pill is great news but may not be a game-changer.

Video | A Pill For COVID? A Doctor Explains Molnupiravir.

 

Opinion: Unequal global vaccine coverage is at the heart of the current covid-19 crisis.

16 Dec, 2021 | 09:50h | UTC

Unequal global vaccine coverage is at the heart of the current covid-19 crisis – The BMJ

 

Management of Hip Fractures in Older Adults: Evidence-Based Clinical Practice Guideline.

16 Dec, 2021 | 09:42h | UTC

Management of Hip Fractures in Older Adults Evidence-Based Clinical Practice Guideline – American Academy of Orthopaedic Surgeons

Summary: Management of Hip Fractures in Older Adults – American Academy of Orthopaedic Surgeons

News Release: AAOS Updates Clinical Practice Guideline for Management of Hip Fractures in Older Adults

 

Recommendations for antibiotic selection for severe nosocomial infections.

16 Dec, 2021 | 09:40h | UTC

Recommendations for antibiotic selection for severe nosocomial infections – Revista Espanola de Quimioterapia

 

T Cells might be our bodies’ best shot against Omicron.

16 Dec, 2021 | 09:45h | UTC

T Cells Might Be Our Bodies’ Best Shot Against Omicron – The Atlantic

 

Sepsis in children: state-of-the-art treatment.

16 Dec, 2021 | 08:56h | UTC

Sepsis in children: state-of-the-art treatment – Therapeutic Advances in Infectious Disease

 

Abortion safety and use with normally prescribed Mifepristone in Canada.

16 Dec, 2021 | 08:51h | UTC

Abortion Safety and Use with Normally Prescribed Mifepristone in Canada – New England Journal of Medicine

News Release: Prescribing the abortion pill without restrictions is safe and effective, study finds – University of British Columbia

 

Antibiotics in critically ill children—a narrative review on different aspects of a rational approach.

16 Dec, 2021 | 08:53h | UTC

Antibiotics in critically ill children—a narrative review on different aspects of a rational approach – Pediatric Research

 

Phase 3 trials of Tapinarof cream for plaque psoriasis.

16 Dec, 2021 | 08:49h | UTC

Phase 3 Trials of Tapinarof Cream for Plaque Psoriasis – New England Journal of Medicine

Commentary: Topical tapinarof reduces severity of plaque psoriasis – HealthDay

 

Commentary on Twitter

 

Review: Impact of obesity in critical illness.

16 Dec, 2021 | 08:45h | UTC

Impact of Obesity in Critical Illness – CHEST

 

Opinion: Decision makers need constantly updated evidence synthesis.

16 Dec, 2021 | 08:39h | UTC

Decision makers need constantly updated evidence synthesis – Nature

 

A guide to enteral nutrition in intensive care units: 10 expert tips for the daily practice.

16 Dec, 2021 | 08:47h | UTC

A guide to enteral nutrition in intensive care units: 10 expert tips for the daily practice – Critical Care

 

Perspective: Doctors are trained to be kind and empathetic – but a ‘hidden curriculum’ makes them forget on the job.

16 Dec, 2021 | 08:41h | UTC

Doctors are trained to be kind and empathetic – but a ‘hidden curriculum’ makes them forget on the job – The Conversation

 

Management of patellar tendinopathy: a systematic review and network meta-analysis of randomized studies.

16 Dec, 2021 | 08:35h | UTC

Management of patellar tendinopathy: a systematic review and network meta-analysis of randomised studies – BMJ Open Sport & Exercise Medicine

 

Perspective: Introducing nephrocardiology.

16 Dec, 2021 | 08:31h | UTC

Introducing Nephrocardiology – Clinical Journal of the American Society of Nephrology

 

M-A: Global percentage of asymptomatic SARS-CoV-2 infections around 40%.

15 Dec, 2021 | 08:47h | UTC

Global Percentage of Asymptomatic SARS-CoV-2 Infections Among the Tested Population and Individuals With Confirmed COVID-19 Diagnosis: A Systematic Review and Meta-analysis – JAMA Network Open

Commentary: ~40 Percent With Confirmed COVID-19 Are Asymptomatic – HealthDay

 

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

15 Dec, 2021 | 08:43h | UTC

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination or SARS-CoV-2 infection – Nature Medicine

News release: COVID-19 infection, more likely than vaccines, to cause rare cardiovascular complications – University of Oxford

 

Commentaries on Twitter

 

[Press release – not published yet] Pfizer’s Covid pill remains 89% effective for reducing the risk of hospitalization or death in final analysis.

15 Dec, 2021 | 08:46h | UTC

News release: Pfizer announces additional phase 2/3 study results confirming robust efficacy of novel Covid-19 oral antiviral treatment candidate in reducing risk of hospitalization or death

Commentaries:

Pfizer’s Covid pill remains 89% effective in final analysis, company says – STAT

Pfizer confirms COVID pill’s results, potency versus omicron – Associated Press

Related:

8 lingering questions about the new Covid pills from Merck and Pfizer.

COVID antiviral pills: what scientists still want to know – “Drugs like Molnupiravir and Paxlovid could change the course of the pandemic if clinical trial results hold up in the real world”.

[Press release – not published yet] RCT: Pfizer’s novel Covid-19 oral antiviral treatment candidate reduced risk of hospitalization or death by 89% in interim analysis of phase 2/3 EPIC-HR study.

 

Commentary on Twitter (thread – click for more)

 

Rapidly spreading Omicron is now in 77 countries and WHO warns against assuming its effects are mild.

15 Dec, 2021 | 08:39h | UTC

Rapidly Spreading Omicron is Now in 77 Countries and WHO Warns Against Assuming its Effects are Mild – Health Policy Watch

 

Study suggests COVID-19 certificates may boost vaccine uptake in countries with below average coverage.

15 Dec, 2021 | 08:41h | UTC

News Release: COVID-19 certificates may boost vaccine uptake in countries with below average coverage – University of Oxford

Original Study: The effect of mandatory COVID-19 certificates on vaccine uptake: synthetic-control modelling of six countries – The Lancet Public Health

 

Commentary on Twitter

https://twitter.com/ruettenauer/status/1470675353937063937

 

COVID-19 in 2022: controlling the pandemic is within our grasp.

15 Dec, 2021 | 08:36h | UTC

COVID-19 in 2022: controlling the pandemic is within our grasp – Nature Medicine

 

Commentaries on Twitter

 

Expert consensus and practical guidance: A global perspective on improving patient care in uncomplicated urinary tract infection.

15 Dec, 2021 | 08:33h | UTC

A global perspective on improving patient care in uncomplicated urinary tract infection: Expert consensus and practical guidance – Journal of Global Antimicrobial Resistance

 

[Not published yet] Initial data from South Africa showed vaccine protection vs. Omicron infection may drop to 30% but does cut severe disease.

15 Dec, 2021 | 08:38h | UTC

Vaccine protection vs. omicron infection may drop to 30% but does cut severe disease – NPR

See also: South Africa Omicron study finds drop in vaccine protection, fewer hospitalized – CIDRAP

 

Position Paper: Diagnosis, management, and prevention of button battery ingestion in childhood.

15 Dec, 2021 | 08:32h | UTC

Diagnosis, Management, and Prevention of Button Battery Ingestion in Childhood: A European Society for Paediatric Gastroenterology Hepatology and Nutrition Position Paper – Journal of Pediatric Gastroenterology and Nutrition

Visual summary: Diagnosis, Management, and Prevention of Button Battery Ingestion in Childhood

 

Commentary on Twitter (thread – click for more)

 

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