Archives
Meta-analysis (mostly of observational studies): In patients undergoing pancreaticoduodenectomy, routine nasogastric decompression is associated with increased rates of delayed gastric emptying, major complications, and longer length of stay compared to no routine nasogastric decompression.
8 Jan, 2022 | 22:44h | UTCRelated Study: Nasogastric Decompression vs No Decompression After Pancreaticoduodenectomy: The Randomized Clinical IPOD Trial – JAMA Surgery
Commentary on Twitter
Nasogastric decompression after pancreaticoduodenectomy 🐘 what is your practice?!
👎 Routine NG tube associated with ⬆️ rates of DGE, major complications and longer length of stay
✅ @ErasSociety policies should be standard
New meta analys on @BjsOpen https://t.co/OStyWOfrPV pic.twitter.com/tuwjPYFWia
— Giovanni Marchegiani (@Gio_Marchegiani) January 3, 2022
In a large retrospective cohort study of patients with atrial fibrillation 65 years or older, treatment with rivaroxaban compared with apixaban was associated with increased risk of major ischemic or hemorrhagic events.
8 Jan, 2022 | 22:37h | UTCCommentary: Apixaban Appears Safer, More Effective Than Rivaroxaban in Medicare Study – TCTMD
Related:
RCT: Postoperative radiotherapy (PORT) did not increase disease-free survival compared with no PORT in patients with completely resected non-small-cell lung cancer and proven mediastinal N2 involvement.
8 Jan, 2022 | 22:38h | UTCPostoperative radiotherapy versus no postoperative radiotherapy in patients with completely resected non-small-cell lung cancer and proven mediastinal N2 involvement (Lung ART): an open-label, randomised, phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)
Commentaries:
Post-Operative Radiotherapy Not Tied to Better Disease-Free Survival in NSCLC – MedPage Today (free registration required)
Happy Holidays! We will return with our activities on January 10, 2022. Any breakthrough articles during this break will be delivered at the beginning of the year.
20 Dec, 2021 | 10:28h | UTCAAP Interim guidance on supporting the emotional and behavioral health needs of children, adolescents, and families during the COVID-19 pandemic.
17 Dec, 2021 | 09:57h | UTCCommentary: AAP Issues Guidance for Children’s Emotional Needs During COVID-19 – HealthDay
Retrospective cohort study: In patients with venous thromboembolism (VTE), treatment with apixaban was associated with lower rates for recurrent VTE and bleeding compared to rivaroxaban.
8 Jan, 2022 | 22:36h | UTCCommentaries:
Apixaban shows superior effectiveness, safety compared to rivaroxaban – ACP Internist
Recurrent VTE and Bleeding With Apixaban vs. Rivaroxaban – American College of Cardiology
RCT: Among patients hospitalized with COVID-19 at increased risk for venous thromboembolism, post-discharge thromboprophylaxis with Rivaroxaban for 35 days may improve outcomes.
17 Dec, 2021 | 09:50h | UTCInvited commentary: Anticoagulation in COVID-19 – The Lancet
Commentary on Twitter
NEW: The role of extended thromboprophylaxis in patients hospitalised with COVID-19 at risk for thrombotic events after discharge – findings from MICHELLE trial https://t.co/OWcmjCLBTw pic.twitter.com/3Bl4lV16Va
— The Lancet (@TheLancet) December 16, 2021
RCT: Molnupiravir reduced the risk of hospitalization or death in at-risk (i.e., obesity, over 60 years, etc.) unvaccinated adults with Covid-19.
17 Dec, 2021 | 09:52h | UTCRelated: Merck’s COVID pill loses its lustre: what that means for the pandemic – Nature (several articles on the subject)
WHO issues interim recommendations for heterologous COVID-19 vaccine schedules.
17 Dec, 2021 | 10:01h | UTCInterim recommendations for heterologous COVID-19 vaccine schedules – World Health Organization
Commentary: Coronavirus: WHO gives the nod for mix-and-match vaccine schedules – South China Morning Post
Randomized trial with nearly 30.000 individuals showed Novavax vaccine was safe and had an overall efficacy of 90.4% against symptomatic infections.
17 Dec, 2021 | 09:54h | UTCCommentaries:
Novavax COVID vaccine shows 90.4% efficacy against infection – CIDRAP
Novavax COVID-19 vaccine found to be safe and effective – University of Maryland School of Medicine
Related: [Preprint] In RCT with 29,949 participants, the Novavax vaccine demonstrated high overall efficacy (>90%) for the prevention of Covid-19, and all moderate-to-severe cases occurred in placebo recipients. (several articles on the subject)
CDC advisors recommend mRNA COVID vaccines over J&J.
17 Dec, 2021 | 09:46h | UTCCDC advisors recommend mRNA COVID vaccines over J&J – CIDRAP
Covid-19: Runny nose, headache, and fatigue are commonest symptoms of Omicron, early data show.
17 Dec, 2021 | 09:48h | UTCSee also: Omicron and cold-like symptoms rapidly taking over in London – ZOE COVID Study
Commentary on Twitter
The UK government has been urged to update its list of symptoms for covid-19, after early data showed cold-like symptoms of a runny nose, headache, fatigue, sneezing, and sore throat were the most commonly reported by people with the new omicron variant https://t.co/n6OJYIDTgf
— The BMJ (@bmj_latest) December 16, 2021
Breakthrough infections generate ‘super immunity’ to COVID-19, study suggests.
17 Dec, 2021 | 09:47h | UTCNews Release: Breakthrough infections generate ‘super immunity’ to COVID-19, study suggests – Oregon Health & Science University
Original Study: Antibody Response and Variant Cross-Neutralization After SARS-CoV-2 Breakthrough Infection – JAMA
NICE Guideline | Acute heart failure: diagnosis and management.
17 Dec, 2021 | 08:48h | UTCAcute heart failure: diagnosis and management – National Institute for Health and Care Excellence
Opinion: COVID-19 vaccine strategies must focus on severe disease and global equity.
17 Dec, 2021 | 09:45h | UTCCOVID-19 vaccine strategies must focus on severe disease and global equity – The Lancet
How COVID vaccines shaped 2021 in eight powerful charts.
17 Dec, 2021 | 09:44h | UTCHow COVID vaccines shaped 2021 in eight powerful charts – Nature
Consensus Statement: Treatment of combined injuries to the anterior cruciate ligament and the medial collateral ligament complex.
17 Dec, 2021 | 08:38h | UTC
NICE Guideline | Type 2 diabetes in adults: management.
17 Dec, 2021 | 08:45h | UTCType 2 diabetes in adults: management – National Institute for Health and Care Excellence
Related: Guideline: ADA 2021 Standards of Medical Care in Diabetes
Guideline: Prevention, diagnosis, and management of post-surgical mediastinitis in adults.
17 Dec, 2021 | 08:41h | UTC
NICE Guideline | Fever in under 5s: assessment and initial management.
17 Dec, 2021 | 08:44h | UTCRelated: AAP Guideline: Evaluation and management of well-appearing febrile infants 8 to 60 days old.
Prevention of Chemotherapy-induced nausea and vomiting in the older patient: optimizing outcomes.
17 Dec, 2021 | 08:32h | UTCPrevention of Chemotherapy-Induced Nausea and Vomiting in the Older Patient: Optimizing Outcomes – Drugs & Aging (if the link is paywalled, try this one)
M-A: Adjuvant chemotherapy for muscle-invasive bladder cancer.
17 Dec, 2021 | 08:28h | UTC
Commentary on Twitter
Adjuvant Chemotherapy for MIBC: A Systematic Review and Meta-analysis of Individual Participant Data from Randomised Controlled Trialshttps://t.co/EZzsMirWAz
"Cisplatin-based adjuvant chemotherapy is a valid option for improving outcomes for muscle-invasive bladder cancer" pic.twitter.com/dIB1aqqNHn
— European Urology (@EUplatinum) November 26, 2021
Review uncovers weak COVID clinical practice guidelines.
16 Dec, 2021 | 10:31h | UTCReview uncovers weak COVID clinical practice guidelines – CIDRAP
Commentary on Twitter
This systematic review found that few clinical practice guidelines for pharmacologic treatment of hospitalized patients with #COVID19 met the National Academy of Medicine standards for trustworthy guidelines. https://t.co/nOCDp4pJWx
— JAMA Network Open (@JAMANetworkOpen) December 10, 2021
Year In Review: Top Non-COVID Infectious Diseases Articles Of 2021.
17 Dec, 2021 | 08:36h | UTCYear In Review: Top Non-COVID Infectious Diseases Articles Of 2021 – IDStewardship
Commentary on Twitter
🔥🔥NEW 🔥🔥
My new post a great collaboration w the amazing @IDstewardship
Year In Review: Top✨ Non-COVID Infectious Diseases Articles Of 2021
18 high quality 🆔 RCTs
6 RCTs @NEJM#Shorterisbetter #IDTwitter #MedEd #TwitteRx #ASPchat #SoMeDocs
Others🤔https://t.co/wJtdjYJ0Gf pic.twitter.com/ugILKX5RQO— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) December 17, 2021
Modeling COVID-19 mortality across 44 Countries: Face covering may reduce deaths.
16 Dec, 2021 | 10:33h | UTCCommentary: Mask laws could prevent unnecessary COVID-19 deaths, study shows – News Medical