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New CDC Guidance shortens isolation and quarantine period for Covid-19; patients that tested positive should isolate for 5 days and, if asymptomatic after this period, can leave isolation if they can continue to mask for 5 days to minimize the risk of infecting others.

9 Jan, 2022 | 01:13h | UTC

CDC Updates and Shortens Recommended Isolation and Quarantine Period for General Population – Centers for Disease Control and Prevention

See also: Quarantine and Isolation – Centers for Disease Control and Prevention

Commentaries:

Facing criticism, CDC updates Covid-19 isolation recommendations with guidance on testing – CNN

CDC posts rationale for shorter isolation, quarantine – Associated Press

Covid-19: CDC shortens isolation period as US cases hit record high – The BMJ

Shortened CDC COVID isolation guide draws sharply mixed reviews – CIDRAP

New CDC isolation guidelines raise concerns among health experts – NPR

CDC Reduces Recommended Isolation Time for People With COVID-19 – HealthDay

COVID isolation and quarantine period for general population shortened by CDC – News Medical

CDC shortens recommended Covid-19 isolation and quarantine time – CNN

CDC cuts the recommended isolation and quarantine periods for coronavirus infections – NPR

US officials recommend shorter COVID isolation, quarantine – Associated Press

See new recommendations from other countries:

France cuts isolation times and plans crackdown on unvaccinated amid record surge in Covid cases – CNN

Covid: Self-isolation cut from 10 days to seven with negative tests – BBC

 

Omicron’s feeble attack on the lungs could make it less dangerous.

11 Jan, 2022 | 01:23h | UTC

Omicron’s feeble attack on the lungs could make it less dangerous – Nature

 

CDC Study: A test to stay strategy (allowing close contacts with masked COVID-19 exposures to remain in school) was very efficacious in preventing further school spread and allowed children to stay in the classroom as an alternative to home quarantine.

9 Jan, 2022 | 01:07h | UTC

Evaluation of Test to Stay Strategy on Secondary and Tertiary Transmission of SARS-CoV-2 in K–12 Schools — Lake County, Illinois, August 9–October 29, 2021 – CDC Morbidity and Mortality Weekly Report

Related CDC Study: Evaluation of a Test to Stay Strategy in Transitional Kindergarten Through Grade 12 Schools — Los Angeles County, California, August 16–October 31, 2021 – CDC Morbidity and Mortality Weekly Report

Related CDC Guidance:

What You Should Know About COVID-19 Testing in Schools – Centers for Disease Control and Prevention

Science Brief: Transmission of SARS-CoV-2 in K-12 Schools and Early Care and Education Programs – Updated – Centers for Disease Control and Prevention

Commentary: ‘Test-to-stay’ works to keep students in school safely, CDC director says – CNN

Related:

Instead of quarantine for Covid-exposed students, some schools are trying test-to-stay.

Cluster RCT: Daily contact testing of school-based contacts was non-inferior to self-isolation for control of COVID-19 transmission.

Kids are losing school days to quarantines. Here’s a way to keep them in classrooms – “Test-to-stay could dramatically reduce close contact quarantines”.

Opinion | Data from routine Covid testing can help schools stay open this year.

 

Commentary on Twitter

 

Diagnostics for COVID-19: moving from pandemic response to control.

8 Jan, 2022 | 23:33h | UTC

Diagnostics for COVID-19: moving from pandemic response to control – The Lancet

 

Commentary on Twitter

 

[Preprint] Among individuals with prior SARS-CoV-2 infection in Brazil, vaccine effectiveness against hospitalization or death after vaccine series completion was 81.3% for CoronaVac, 89.9% for AstraZeneca, 57.7% for J&J, and 89.7% for Pfizer.

8 Jan, 2022 | 23:26h | UTC

Effectiveness of CoronaVac, ChAdOx1, BNT162b2 and Ad26.COV2.S among – medRxiv

 

[In Portuguese] Commentary from one of the authors on Twitter (thread – click for more)

 

[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.

9 Jan, 2022 | 01:05h | UTC

Risk of myocarditis following sequential COVID-19 vaccinations by age and sex – medRxiv

Commentary: An evaluation of the association between COVID vaccination and myocarditis in 42 million people aged 13 or older – News Medical

Note: this study is an updated analysis of a recent study published in Nature Medicine; see below:

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

 

Compared with previous waves, the Omicron wave in South Africa was associated with fewer hospitalizations and decreased severity and mortality.

8 Jan, 2022 | 23:23h | UTC

Characteristics and Outcomes of Hospitalized Patients in South Africa During the COVID-19 Omicron Wave Compared With Previous Waves – JAMA

 

[Preprint] RCT: In symptomatic adults above 18 years positive for SARS-CoV-2, early outpatient treatment with high-titer convalescent plasma significantly reduced hospitalizations.

8 Jan, 2022 | 23:28h | UTC

Randomized Controlled Trial of Early Outpatient COVID-19 Treatment with High-Titer Convalescent Plasma – medRxiv

News release: Early Use of Convalescent Plasma May Help Outpatients with COVID-19 Avoid Hospitalization – Johns Hopkins Medicine

Commentary: Convalescent plasma shows renewed promise for COVID-19 in outpatient trial – Science

 

Guideline: ADA 2022 Standards of Medical Care in Diabetes.

24 Dec, 2021 | 13:38h | UTC

Guideline Homepage: ADA 2022 Standards of Medical Care in Diabetes – American Diabetes Association

Introduction: Standards of Medical Care in Diabetes—2022

Summary of Revisions: Standards of Medical Care in Diabetes—2022

Standards of Medical Care in Diabetes—2022 Guideline Abridged for Primary Care Providers

Video Summary: Standards of Care in Diabetes – 2022

  1. Improving Care and Promoting Health in Populations
  2. Classification and Diagnosis of Diabetes 
  3. Prevention or Delay of Type 2 Diabetes and Associated Comorbidities
  4. Comprehensive Medical Evaluation and Assessment of Comorbidities
  5. Facilitating Behavior Change and Well-being to Improve Health Outcomes
  6. Glycemic Targets
  7. Diabetes Technology
  8. Obesity and Weight Management for the Prevention and Treatment of Type 2 Diabetes
  9. Pharmacologic Approaches to Glycemic Treatment
  10. Cardiovascular Disease and Risk Management
  11. Chronic Kidney Disease and Risk Management
  12. Retinopathy, Neuropathy, and Foot Care
  13. Older Adults
  14. Children and Adolescents
  15. Management of Diabetes in Pregnancy
  16. Diabetes Care in the Hospital
  17. Diabetes Advocacy

 

Commentaries on Twitter

 

[Preprint] Study showed reduced clinical severity of Covid-19 patients admitted to hospitals in Gauteng, South Africa, during the Omicron-dominant fourth wave – “any combination of a less-virulent virus, comorbidities, high immunity from prior infection(s) or vaccination may be important contributors to this clinical presentation”.

8 Jan, 2022 | 23:24h | UTC

Clinical Severity of COVID-19 Patients Admitted to Hospitals in Gauteng, South Africa During the Omicron-Dominant Fourth Wave – SSRN/Preprints with The Lancet

Commentary: SARS-CoV-2 omicron variant may be less severe than the delta variant – News Medical

 

WHO: 10 key global health moments from 2021.

8 Jan, 2022 | 23:20h | UTC

10 key global health moments from 2021 – World Health Organization

 

Commentary on Twitter (thread – click for more)

 

AHA Scientific Statement | Hypertension in pregnancy: diagnosis, blood pressure goals, and pharmacotherapy.

8 Jan, 2022 | 23:16h | UTC

Hypertension in Pregnancy: Diagnosis, Blood Pressure Goals, and Pharmacotherapy: A Scientific Statement From the American Heart Association – Hypertension

News Release: High blood pressure treatment in pregnancy is safe, prevents maternal heart risks – American Heart Association

 

Commentary on Twitter

 

AAN Guideline: Oral and topical treatment of painful diabetic polyneuropathy.

8 Jan, 2022 | 23:18h | UTC

Oral and Topical Treatment of Painful Diabetic Polyneuropathy: Practice Guideline Update Summary: Report of the AAN Guideline Subcommittee – Neurology

News Release: AAN Issues Guideline for Treatment of Painful Diabetic Neuropathy – American Academy of Neurology

 

AHA names top heart disease and stroke research advances of 2021.

8 Jan, 2022 | 23:14h | UTC

AHA names top heart disease and stroke research advances of 2021 – American Heart Association

 

New AAP Guidance recommends routine HIV screening to all youth 15 years or older.

8 Jan, 2022 | 23:13h | UTC

Adolescents and Young Adults: The Pediatrician’s Role in HIV Testing and Pre- and Postexposure HIV Prophylaxis – Pediatrics

Commentary: Pediatricians Can Play Key Role in HIV Testing, Prophylaxis – HealthDay

 

RCT: In older patients undergoing hip fracture surgery, regional anesthesia did not reduce the incidence of postoperative delirium compared to general anesthesia.

8 Jan, 2022 | 23:09h | UTC

Effect of Regional vs General Anesthesia on Incidence of Postoperative Delirium in Older Patients Undergoing Hip Fracture Surgery: The RAGA Randomized Trial – JAMA (link to abstract – $ for full-text)

Commentary: China-wide study will boost understanding of fatal surgical complication – University of Birmingham

Related:

RCT: Spinal Anesthesia not Superior to General Anesthesia for Hip Surgery in Older Adults.

RCT: Similar long-term survival after combined epidural–general anesthesia vs. general anesthesia alone.

Delirium in Older Patients after Combined Epidural–General Anesthesia or General Anesthesia for Major Surgery: A Randomized Trial – Anesthesiology

 

FDA approves first injectable treatment for HIV pre-exposure prevention.

8 Jan, 2022 | 23:04h | UTC

FDA Approves First Injectable Treatment for HIV Pre-Exposure Prevention – U.S. Food & Drug Administration

Commentaries:

NIH celebrates FDA approval of long-acting injectable drug for HIV prevention – NIH News Releases

A new injection to prevent HIV, rather than pills, is a game-changer, scientists say – NPR

Related:

CDC Guidance: Preexposure Prophylaxis for Prevention of HIV Acquisition Among Adolescents

Study Shows High Burden of STI Among Individuals Using Preexposure Prophylaxis for the Prevention of HIV Infection

USPSTF Statement: Preexposure Prophylaxis for the Prevention of HIV Infection

British Guidelines on the Use of HIV Pre–exposure Prophylaxis (PrEP) (several guidelines on the subject)

New Protocol for HIV Prevention Drug Reduces The Number Of Pills Required

 

RCT: Long-term supplementation with marine Omega-3 fatty acids does not reduce the risk of depressive symptoms.

8 Jan, 2022 | 23:10h | UTC

Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression or Clinically Relevant Depressive Symptoms and on Change in Mood Scores: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentary: Clinical trial reveals that omega-3 fish oil supplements do not help prevent depression – Massachusetts General Hospital

 

RCT: Low-cost, easy to take antiretroviral treatment based on Dolutegravir as first- or second-Line therapy found to be non-inferior to standard care for treating HIV-1 infection in children.

8 Jan, 2022 | 23:07h | UTC

Dolutegravir as First- or Second-Line Treatment for HIV-1 Infection in Children – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Easy-to-take medicine better at suppressing HIV in children – University College London

 

Commentaries on Twitter

 

Janus kinase-targeting therapies in rheumatology: a mechanisms-based approach.

8 Jan, 2022 | 22:45h | UTC

Janus kinase-targeting therapies in rheumatology: a mechanisms-based approach – Nature Reviews Rheumatology (if the link is paywalled, try this one)

 

RCT: Vitamin D supplementation does not improve outcomes in people with early psychosis.

8 Jan, 2022 | 22:52h | UTC

Effect of Vitamin D Supplementation on Outcomes in People With Early Psychosis: The DFEND Randomized Clinical Trial – JAMA Network Open

 

5 things we learned about journal peer review in 2021.

8 Jan, 2022 | 22:51h | UTC

5 Things We Learned About Journal Peer Review in 2021 – Absolutely Maybe Blog, by Hilda Bastian

Related:

A billion-dollar donation: estimating the cost of researchers’ time spent on peer review.

M-A: Effects of experimental interventions to improve the peer‐review process – “Modifications of the traditional peer‐review process at reviewer‐level are associated with improved quality, at the price of longer duration.”

The $450 question: Should journals pay peer reviewers?

Opinion: Peer reviewers—time for mass rebellion?

5 things we learned about peer review in 2020

Editorial: Evaluation and Peer Review During a Pandemic

 

Review: Large-vessel vasculitis.

8 Jan, 2022 | 22:50h | UTC

Large-vessel vasculitis – Nature Reviews Disease Primers (if the link is paywalled, try this one)

Infographic: Large-vessel vasculitis (if the link is paywalled, try this one)

 

M-A of two randomized trials: Among men with high-risk non-metastatic prostate cancer, adding abiraterone and prednisolone to standard androgen-deprivation therapy was associated with improved 6-year metastasis-free survival (82% vs. 69% in the control group).

8 Jan, 2022 | 22:42h | UTC

Abiraterone acetate and prednisolone with or without enzalutamide for high-risk non-metastatic prostate cancer: a meta-analysis of primary results from two randomised controlled phase 3 trials of the STAMPEDE platform protocol – The Lancet (link to abstract – $ for full-text)

Related Audio: Key messages of the recent report from the STAMPEDE trial platform

 

Systematic Review: Active surveillance for clinically localized prostate cancer to develop recommendations regarding inclusion of intermediate-risk disease, biopsy characteristics at inclusion and monitoring, and surveillance repeat biopsy strategy.

8 Jan, 2022 | 22:41h | UTC

Systematic Review of Active Surveillance for Clinically Localised Prostate Cancer to Develop Recommendations Regarding Inclusion of Intermediate-risk Disease, Biopsy Characteristics at Inclusion and Monitoring, and Surveillance Repeat Biopsy Strategy – European Urology

 

Commentary on Twitter

 

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