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Review: Diagnosis and management of acute appendicitis in adults.

15 Dec, 2021 | 08:28h | UTC

Diagnosis and Management of Acute Appendicitis in Adults: A Review – JAMA (free for a limited period)

Author Interview: Current Management of Acute Appendicitis: Antibiotics or Surgical Intervention

Commentary: Antibiotics can be first-line therapy for uncomplicated appendicitis cases – Duke University Medical Center

 


M-A: Pharmacotherapy for adults with overweight and obesity – “phentermine–topiramate and GLP-1 receptor agonists proved the best drugs in reducing weight”.

15 Dec, 2021 | 08:30h | UTC

Pharmacotherapy for adults with overweight and obesity: a systematic review and network meta-analysis of randomised controlled trials – The Lancet (link to abstract – $ for full-text)

 

Commentary on Twitter

 


RCT: In preterm infants with respiratory distress syndrome, surfactant administration via a thin catheter did not improve outcomes.

15 Dec, 2021 | 08:26h | UTC

Effect of Minimally Invasive Surfactant Therapy vs Sham Treatment on Death or Bronchopulmonary Dysplasia in Preterm Infants With Respiratory Distress Syndrome: The OPTIMIST-A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Minimally Invasive Surfactant Therapy to Prevent Bronchopulmonary Dysplasia in Extremely Preterm Infants – JAMA (free for a limited period)

Video: Demonstration of the Hobart Method of Minimally Invasive Surfactant Therapy in a Resuscitation Manikin Equivalent to a 27-Week Gestation 1-kg Preterm Infant – JAMA

 


Randomized crossover trial of metoprolol in patients with obstructive hypertrophic cardiomyopathy.

15 Dec, 2021 | 08:23h | UTC

Randomized Trial of Metoprolol in Patients With Obstructive Hypertrophic Cardiomyopathy – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentary: The Effect of Metoprolol in Patients With Hypertrophic Obstructive Cardiomyopathy – TEMPO – American College of Cardiology

 


Early hospital discharge feasible following PCI for patients with STEMI.

15 Dec, 2021 | 08:24h | UTC

Early Hospital Discharge Following PCI for Patients With STEMI – Journal of the American College of Cardiology (link to abstract – $ for full-text)

 


Proposed subtypes of long-Covid and their respective potential therapies.

14 Dec, 2021 | 09:49h | UTC

Proposed subtypes of post-COVID-19 syndrome (or long-COVID) and their respective potential therapies – Reviews in Medical Virology

Related:

EuGMS Guidance: Management of post-acute COVID-19 patients in geriatric rehabilitation.

Addressing Post-COVID Symptoms: A Guide for Primary Care Physicians.

Global surveillance, research, and collaboration needed to improve understanding and management of long COVID.

Provocative study suggests that persistent physical symptoms after COVID-19 infection may be associated more with the belief in having been infected with SARS-CoV-2 than with having laboratory-confirmed COVID-19 infection.

Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the ‘long-haulers’.

Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.

WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).

Characterizing long COVID: a living systematic review.

Long Covid – The illness narratives.

New guidelines to help doctors manage long COVID patients published.

M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)

 


Omicron: WHO updated technical brief and priority actions.

14 Dec, 2021 | 09:50h | UTC

Enhancing Readiness for Omicron (B.1.1.529): Technical Brief and Priority Actions for Member States – World Health Organization

 

Commentary on Twitter (thread – click for more)

 


Infectious diseases learning pearls from inpatient ID consults.

15 Dec, 2021 | 08:22h | UTC

ID Learning Units from Inpatient ID Consults – HIV and ID Observations

 


[Preprint] SARS-CoV-2 variant Omicron evades neutralization by sera from vaccinated and convalescent individuals.

14 Dec, 2021 | 09:46h | UTC

[Preprint] SARS-CoV-2 B.1.1.529 variant (Omicron) evades neutralization by sera from vaccinated and convalescent individuals – medRxiv

Commentary: SARS-CoV-2 omicron variant may evade host immune responses – News Medical

 

Commentary on Twitter (thread – click for more)

 


Recommendations for equitable COVID-19 pandemic recovery in Canada.

14 Dec, 2021 | 09:47h | UTC

Recommendations for equitable COVID-19 pandemic recovery in Canada – Canadian Medical Association Journal

News Release: Equitable COVID-19 pandemic recovery in Canada: New guideline – Canadian Medical Association Journal

Editorial: Build back more equitably

 


Lab study shows significant immune escape of pseudotyped SARS-CoV-2 variant Omicron.

14 Dec, 2021 | 09:43h | UTC

The significant immune escape of pseudotyped SARS-CoV-2 Variant Omicron – Emerging Microbes & Infections

News release: Vaccines and previous infection could offer some ‘stronger than basic’ protection to Omicron, early study suggests – Taylor & Francis Group

 


[Preprint] Reduced neutralization of SARS-COV-2 variant Omicron by post-immunization serum.

14 Dec, 2021 | 09:45h | UTC

[Preprint] Reduced neutralisation of SARS-COV-2 Omicron-B.1.1.529 variant by post-immunisation serum – medRxiv

News release: Vaccines shown to induce lower levels of neutralising antibodies against Omicron coronavirus variant – University of Oxford

 


WHO Reports | More than half a billion people pushed or pushed further into extreme poverty due to health care costs.

14 Dec, 2021 | 08:55h | UTC

News release: More than half a billion people pushed or pushed further into extreme poverty due to health care costs – World Health Organization

Report 1: Tracking Universal Health Coverage: 2021 Global monitoring report – World Health Organization

Report 2: Global monitoring report on financial protection in health 2021 – World Health Organization

 


Consensus Recommendations: Non-invasive imaging in coronary syndromes.

14 Dec, 2021 | 08:51h | UTC

Non-invasive imaging in coronary syndromes: recommendations of the European Association of Cardiovascular Imaging and the American Society of Echocardiography, in collaboration with the American Society of Nuclear Cardiology, Society of Cardiovascular Computed Tomography, and Society for Cardiovascular Magnetic Resonance – European Heart Journal – Cardiovascular Imaging

 


WHO Report | Saving lives, spending less: the case for investing in noncommunicable diseases.

14 Dec, 2021 | 08:53h | UTC

Report: Saving lives, spending less: the case for investing in noncommunicable diseases – World Health Organization

News Release: Investing 1 dollar per person per year could save 7 million lives in low and lower-middle income countries – World Health Organization

 

Commentary on Twitter

 


[Preprint] COVID vaccines cut the risk of transmitting Delta — but not for long

14 Dec, 2021 | 09:42h | UTC

COVID vaccines cut the risk of transmitting Delta — but not for long – Nature

Original Study [preprint]: The impact of SARS-CoV-2 vaccination on Alpha & Delta variant transmission – medRxiv

 


Review: Immunotherapies for hepatocellular carcinoma.

14 Dec, 2021 | 08:47h | UTC

Immunotherapies for hepatocellular carcinoma – Nature Reviews Clinical Oncology (free for a limited period – if the link is paywalled, try this one)

 


Review | Anti-obesity drug discovery: advances and challenges.

14 Dec, 2021 | 08:49h | UTC

Anti-obesity drug discovery: advances and challenges – Nature Reviews Drug Discovery (free for a limited period – if the link is paywalled, try this one)

 


Cannabinoid metabolites as inhibitors of major hepatic CYP450 enzymes, with implications for cannabis-drug interactions.

14 Dec, 2021 | 08:44h | UTC

News release: Cannabis use could cause harmful drug interactions – Washington State University

Original Study: Cannabinoid Metabolites as Inhibitors of Major Hepatic CYP450 Enzymes, with Implications for Cannabis-Drug Interactions – Drug Metabolism and Disposition

 


Retrospective study: antimicrobial susceptibility profiles among neonatal early-onset sepsis (EOS) pathogens – “The vast majority of contemporary EOS pathogens are susceptible to the combination of ampicillin and gentamicin”.

14 Dec, 2021 | 08:46h | UTC

Antimicrobial Susceptibility Profiles Among Neonatal Early-onset Sepsis Pathogens – The Pediatric Infectious Disease Journal

 

Commentary on Twitter

 


Short Review: Lymphogranuloma venereum.

14 Dec, 2021 | 08:42h | UTC

Lymphogranuloma venereum – Canadian Medical Association Journal

 


Podcast: No tension about inpatient hypertension.

14 Dec, 2021 | 08:39h | UTC

#310 No Tension About Inpatient Hypertension with Dr. Noble Maleque – The Curbsiders

 


An observational study showed Moderna is associated with increased effectiveness vs. Pfizer vaccine against symptomatic SARS-CoV-2 infection.

13 Dec, 2021 | 09:52h | UTC

Comparative effectiveness of mRNA-1273 and BNT162b2 against symptomatic SARS-CoV-2 infection – Med

Related:

Opinion | Is Moderna really better than Pfizer—or is it just a higher dose?

CDC Report: Moderna’s vaccine associated with greater effectiveness (93%) against Covid-19 hospitalization compared to Pfizer (88%) and J&J (71%) vaccines.

 

Commentary on Twitter

 


Perspective: Alcohol-related harm is a public health issue, not a lifestyle choice.

14 Dec, 2021 | 08:41h | UTC

Alcohol-related harm is a public health issue, not a lifestyle choice – Health Policy Watch

Related:

COVID-19 pandemic and alcohol consumption: Impacts and interconnections – Toxicology Reports

National, Regional, and Global Burdens of Disease Attributable to Alcohol Use

Study: Alcohol Use and Burden for 195 Countries and Territories

Study: The Global Burden of Disease Attributable to Alcohol and Drug Use

Study: Global Alcohol Exposure Between 1990 and 2017 and Forecasts Until 2030

Analysis: Prioritizing Action on Alcohol for Health and Development

5000 alcohol-related cancer deaths could be prevented every year by doubling alcohol taxes in the European Region, says WHO/Europe.

Global burden of cancer attributable to alcohol consumption – “Globally, an estimated 741.300, or 4·1% of all new cases of cancer in 2020 were attributable to alcohol consumption”.

Research: Contribution of alcohol use disorders to the burden of dementia

 


UK Report on SARS-CoV-2 variants of concern finds significantly lower vaccine effectiveness (VE) against Omicron infection, but a moderate to high VE of 70 to 75% is seen after a third (booster) dose.

13 Dec, 2021 | 09:53h | UTC

Report: SARS-CoV-2 variants of concern and variants under investigation in England – UK Health Security Agency

Commentaries:

Omicron: Three vaccine doses key for protection against variant – BBC

Two jabs offer little protection against Omicron infection, UK data shows – The Guardian

UK Says Omicron to Become Its Dominant Variant Within Days – Associated Press

 


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