Archives

Meta-analysis of randomized controlled trials comparing intraoperative red blood cell transfusion strategies.

14 Mar, 2022 | 01:47h | UTC

A Systematic Review and Meta-analysis of Randomized Controlled Trials Comparing Intraoperative Red Blood Cell Transfusion Strategies – Annals of Surgery

Related:

Systematic Review: Restrictive transfusion thresholds can safely decrease transfusions by 41% across a broad range of clinical contexts.

RCT: Among patients with acute MI and anemia, a restrictive transfusion strategy resulted in a noninferior rate of major cardiovascular events compared to a liberal transfusion strategy

Randomized trial: Liberal vs. restrictive transfusion thresholds in extremely low-birth-weight infants

Meta-Analysis: Effects of Restrictive vs. Liberal Transfusion Strategies on Longer-term Outcomes After Cardiac Surgery

Randomized Trial: In Patients Undergoing Cardiac Surgery, A Restrictive Transfusion Approach Does Not Increase the Risk of Acute Kidney Injury

Effects of restrictive red blood cell transfusion on the prognoses of adult patients undergoing cardiac surgery: a meta-analysis of randomized controlled trials – Critical Care

Research: Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery

Transfusion Requirements After Cardiac Surgery: The TRACS Randomized Controlled Trial – JAMA

 

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The changing epidemiology of SARS-CoV-2.

14 Mar, 2022 | 01:37h | UTC

The changing epidemiology of SARS-CoV-2 – Science

 

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Duration of effectiveness of vaccines against SARS-CoV-2 infection and COVID-19 disease: results of a systematic review and meta-regression.

14 Mar, 2022 | 01:44h | UTC

Duration of effectiveness of vaccines against SARS-CoV-2 infection and COVID-19 disease: results of a systematic review and meta-regression – The Lancet

Commentaries:

Review of pre-Omicron data finds COVID-19 vaccine protection from severe disease remains strong at six months – Johns Hopkins University Bloomberg School of Public Health

Waning of COVID-19 vaccine effectiveness: individual and public health risk – The Lancet

Related: [Preprint] Systematic Review: Duration of Effectiveness of Vaccines Against SARS-CoV-2 Infection and COVID-19 Disease – “effectiveness against COVID-19 severe disease remained high (>70%) in most studies in the six months after full vaccination, although it did decrease some (on average, 8-10 percentage points) between one and six months after full vaccination”.

 

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Stopping pandemics before they start: Lessons learned from SARS-CoV-2.

14 Mar, 2022 | 01:38h | UTC

Stopping pandemics before they start: Lessons learned from SARS-CoV-2 – Science

 

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Writing up your clinical trial report for a scientific journal: the REPORT trial guide for effective and transparent research reporting without spin.

14 Mar, 2022 | 01:32h | UTC

Writing up your clinical trial report for a scientific journal: the REPORT trial guide for effective and transparent research reporting without spin – British Journal of Sports Medicine

 

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Review: Post-acute COVID-19 syndrome.

14 Mar, 2022 | 01:34h | UTC

Post-acute COVID-19 syndrome – European Respiratory Journal

Related:

ESCMID rapid guidelines for assessment and management of long COVID.

ERS statement on Long COVID-19 follow-up.

Proposed subtypes of long-Covid and their respective potential therapies.

EuGMS Guidance: Management of post-acute COVID-19 patients in geriatric rehabilitation.

Addressing Post-COVID Symptoms: A Guide for Primary Care Physicians.

Global surveillance, research, and collaboration needed to improve understanding and management of long COVID.

Provocative study suggests that persistent physical symptoms after COVID-19 infection may be associated more with the belief in having been infected with SARS-CoV-2 than with having laboratory-confirmed COVID-19 infection.

Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the ‘long-haulers’.

Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.

WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).

Characterizing long COVID: a living systematic review.

Long Covid – The illness narratives.

New guidelines to help doctors manage long COVID patients published.

M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)

 

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Comprehensive quality of life outcomes with invasive vs. conservative management of chronic coronary disease in the ISCHEMIA trial.

14 Mar, 2022 | 01:27h | UTC

Comprehensive Quality of Life Outcomes with Invasive versus Conservative Management of Chronic Coronary Disease in ISCHEMIA – Circulation (link to abstract – $ for full-text)

Original Articles:

ISCHEMIA Trial: Health-Status Outcomes with Initial Invasive vs. Conservative Care in Stable Coronary Disease

ISCHEMIA Trial: Initial Invasive vs. Conservative Strategy for Stable Coronary Disease

ISCHEMIA Trial: Health Status after Invasive or Conservative Care in Coronary and Advanced Kidney Disease

ISCHEMIA Trial: Management of Coronary Disease in Patients with Advanced Kidney Disease

 

Commentary on Twitter

https://twitter.com/CircAHA/status/1502052947869503497

 

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Practical, evidence-based approaches to nutritional modifications to reduce atherosclerotic cardiovascular disease.

14 Mar, 2022 | 01:25h | UTC

Practical, Evidence-Based Approaches to Nutritional Modifications to Reduce Atherosclerotic Cardiovascular Disease: An American Society For Preventive Cardiology Clinical Practice Statement – American Journal of Preventive Cardiology

 

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Cohort Study: Long-term cannabis use is associated with cognitive deficits and smaller hippocampal volume in midlife.

14 Mar, 2022 | 01:31h | UTC

Long-Term Cannabis Use and Cognitive Reserves and Hippocampal Volume in Midlife – The American Journal of Psychiatry (link to abstract – $ for full-text)

Commentary: Long-Term Cannabis Use Associated With Cognitive Deficits in Midlife – Psychiatric News Alert

 

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Choosing Wisely Canada: Canadian fertility and andrology society’s list of top items physicians and patients should question in fertility medicine.

14 Mar, 2022 | 01:23h | UTC

Choosing Wisely Canada: Canadian fertility and andrology society’s list of top items physicians and patients should question in fertility medicine – Archives of Gynecology and Obstetrics (if the link is paywalled, try this one)

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada

 

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Systematic Review: Systemic interventions for treatment of Stevens‐Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome.

14 Mar, 2022 | 01:20h | UTC

Systemic interventions for treatment of Stevens‐Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and SJS/TEN overlap syndrome – Cochrane Library

Summary: Which treatments that affect the whole body work best to treat severe skin reactions (Stevens-Johnson syndrome and toxic epidermal necrolysis)? – Cochrane Library

 

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Systematic Review: Point‐of‐care viral load tests to detect high HIV viral load in people living with HIV/AIDS attending health facilities.

14 Mar, 2022 | 01:19h | UTC

Point‐of‐care viral load tests to detect high HIV viral load in people living with HIV/AIDS attending health facilities – Cochrane Library

Summary: Point-of-care tests for detecting high viral load in people living with HIV attending healthcare facilities – Cochrane Library

 

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Systematic Review: Binocular versus standard occlusion or blurring treatment for unilateral amblyopia in children aged three to eight years.

14 Mar, 2022 | 01:16h | UTC

Binocular versus standard occlusion or blurring treatment for unilateral amblyopia in children aged three to eight years – Cochrane Library

Related: Binocular treatment for amblyopia: A meta-analysis of randomized clinical trials – PLOS One

 

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Systematic Review: Poly(ADP‐ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer.

14 Mar, 2022 | 01:17h | UTC

Poly(ADP‐ribose) polymerase (PARP) inhibitors for the treatment of ovarian cancer – Cochrane Library

 

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Healthcare-associated infections in adult intensive care unit patients: Changes in epidemiology, diagnosis, prevention and contributions of new technologies.

14 Mar, 2022 | 01:04h | UTC

Healthcare-associated infections in adult intensive care unit patients: Changes in epidemiology, diagnosis, prevention and contributions of new technologies – Intensive and Critical Care Nursing

 

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RCT: Vortioxetine 5, 10, and 20 mg significantly reduces the risk of relapse compared with placebo in patients with remitted major depressive disorder.

14 Mar, 2022 | 01:03h | UTC

Vortioxetine 5, 10, and 20 mg significantly reduces the risk of relapse compared with placebo in patients with remitted major depressive disorder: The RESET study – Journal of Affective Disorders

 

Commentary on Twitter

RCT: In patients with remitted MDD with 10 mg/day of vortioxetine, time to relapse was longer and cumulative relapse rates were lower for vortioxetine 5 mg (19.3%), 10 mg (17.9%), and 20 mg (17.4%) versus placebo (32.5%) over 28 weeks (p<0.05 for all) https://t.co/LzwFaxVt4d pic.twitter.com/Gq3lLTtVcS

— P𝘧OL (@psychopharmacol) March 11, 2022

 

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Target temperature management following cardiac arrest: a systematic review and Bayesian meta-analysis.

14 Mar, 2022 | 01:14h | UTC

Target temperature management following cardiac arrest: a systematic review and Bayesian meta-analysis – Critical Care

Related:

ERC-ESICM guidelines on temperature control after cardiac arrest in adults.

M-A: In comatose survivors of cardiac arrest, targeted hypothermia is not associated with improved survival or better neurological outcomes vs. targeted normothermia.

RCT: In comatose survivors of out-of-hospital cardiac arrest, there was no difference in mortality and neurologic outcomes with mild (target temperature of 34 °C) vs. moderate therapeutic hypothermia (target temperature of 31 °C).

M-A: Targeted temperature management following out-of-hospital cardiac arrest – “Routine use of moderate or deep hypothermia in comatose survivors of OHCA may potentially be associated with more harm than benefit”.

RCT: In patients with coma after out-of-hospital cardiac arrest, targeted hypothermia did not improve outcomes.

 

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Review: Mycobacterial skin infection.

14 Mar, 2022 | 00:59h | UTC

Mycobacterial skin infection – Current Opinion in Infectious Diseases

 

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Diagnostic test interpretation: cardiopulmonary exercise testing.

14 Mar, 2022 | 01:01h | UTC

Cardiopulmonary Exercise Testing – JAMA (free for a limited period)

 

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Review: Electrical management of heart failure: from pathophysiology to treatment.

14 Mar, 2022 | 00:58h | UTC

Electrical management of heart failure: from pathophysiology to treatment – European Heart Journal

 

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Update on management of atrial fibrillation in heart failure: a focus on ablation.

14 Mar, 2022 | 00:57h | UTC

Update on management of atrial fibrillation in heart failure: a focus on ablation – Heart

 

Commentary on Twitter

https://t.co/M9tKQXJWwe Update on management of atrial fibrillation in heart failure: a focus on ablation pic.twitter.com/flPdBMcHwM

— Heart_BMJ (@Heart_BMJ) June 15, 2021

 

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Observational Study: Comparison of intracranial pressure measurements before and after hypertonic saline or mannitol treatment in children with severe traumatic brain injury.

14 Mar, 2022 | 00:51h | UTC

Comparison of Intracranial Pressure Measurements Before and After Hypertonic Saline or Mannitol Treatment in Children With Severe Traumatic Brain Injury – JAMA Network Open

Invited Commentary: ADAPTing to a New Era of Comparative Effectiveness Research in Traumatic Brain Injury—Generating Evidence From Observational Data – JAMA Network Open

 

Commentary on Twitter

For children with severe TBI, hypertonic saline is recommended in published guidelines. However, mannitol is in wide-spread clinical use. In this comparative effectiveness, hypertonic saline was associated with improved ICP compared to mannitol. https://t.co/7JW224Dbio

— JAMA Network Open (@JAMANetworkOpen) March 10, 2022

 

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RCT: Effectiveness of Fosfomycin for treating multidrug-resistant Escherichia coli bacteremic urinary tract infections.

14 Mar, 2022 | 00:53h | UTC

Effectiveness of Fosfomycin for the Treatment of Multidrug-Resistant Escherichia coli Bacteremic Urinary Tract Infections: A Randomized Clinical Trial – JAMA Network Open

Commentaries:

The Role of Intravenous Fosfomycin: Finding Our Way Out of Dante’s Forest Dark – JAMA Network Open

Fosfomycin Not Noninferior to Comparators for Bacteremic UTI – HealthDay

‘Forgotten’ antibiotic recovered for resistant bacterial infections – University of Seville

 

Commentary on Twitter

In this RCT, fosfomycin did not demonstrate noninferiority in MDR-E coli bacteremic UTI, mostly due to adverse event-related withdrawals in mITT, but showed efficacy in per protocol analysis. #FORESTtrial @jesusrbano https://t.co/oiPtiQo2XA pic.twitter.com/Q44QQb18cN

— JAMA Network Open (@JAMANetworkOpen) January 13, 2022

 

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Bioethics | The rupture of anonymity for sperm donors—a tangled web of conflicting rights.

14 Mar, 2022 | 00:49h | UTC

The rupture of anonymity for sperm donors—a tangled web of conflicting rights – The BMJ

 

Commentary on Twitter

Direct-to-consumer DNA testing has torn the veil separating social family and genetic heritage. This Opinion article examines how it has brought the rights of donor conceived people to information into conflict with donors’ right to privacyhttps://t.co/avX64dbnhb

— The BMJ (@bmj_latest) March 11, 2022

 

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Management of respiratory failure: ventilator management 101 and noninvasive ventilation.

14 Mar, 2022 | 00:45h | UTC

Management of Respiratory Failure: Ventilator Management 101 and Noninvasive Ventilation – Clinical Journal of the American Society of Nephrology

 

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