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UN Global Road Safety Week, 8-14 May 2017

9 May, 2017 | 18:20h | UTC

UN Global Road Safety Week, 8-14 May 2017 – World Health Organization

Press release 1: Fourth UN Global Road Safety Week 2017, 8-14 May 2017 (free)

Press release 2: Speed management key to saving lives, making cities more livable (free)

New WHO Report: Save LIVES: a road safety technical package (free)

WHO campaign: “Road Safety: Around 1.25 million people die every year on the world’s roads. Save lives, Slow Down!” (see Tweet) AND “Global Road Safety week: Excessive or inappropriate speed contributes to 1 in 3 road traffic fatalities, Slow Down!” (see Tweet).

Fever of unknown origin (FUO) revised

9 May, 2017 | 20:42h | UTC

Review: Fever of unknown origin (FUO) revised – Wiener klinische Wochenschrift (free) (RT @HMVJC)

The Paternal Epigenome Makes Its Mark

6 May, 2017 | 20:38h | UTC

Medical News & Perspectives: The Paternal Epigenome Makes Its Mark – JAMA (free)

“Epigenetic changes may be the underlying mechanism by which paternal factors such as age, diet, weight, stress, and alcohol consumption contribute to a range of health outcomes in offspring including birth defects, behavioral problems, developmental disorders, obesity, diabetes, cardiovascular disease, and cancer”.

New Osteoporosis Guidelines from ACP

9 May, 2017 | 18:19h | UTC

Treatment of Low Bone Density or Osteoporosis to Prevent Fractures in Men and Women: A Clinical Practice Guideline Update from the American College of Physicians – Annals of Internal Medicine (free)

Commentaries: ACP Updates Guidelines on Treating Low Bone Density, Osteoporosis – Physician’s First Watch (free) AND New ACP Guidelines on the Treatment of Osteoporosis – Medscape (free registration required)

Reducing inappropriate prescribing easier said than done

6 May, 2017 | 20:37h | UTC

Reducing inappropriate prescribing easier said than done – CMAJ News (free)

Related: Canadian Deprescribing Network (CaDeN) (free)

AND CaDeN Deprescribing Guidelines and Algorithms (free) AND Deprescribing guidelines for the elderly – Ontario Pharmacy Evidence Network(free)

Series: Acute Kidney Injury in the Intensive Care Unit

6 May, 2017 | 20:32h | UTC

Series: Acute Kidney Injury in the Intensive Care Unit

Fluid management in acute kidney injury – Intensive Care Medicine (free PDF)

Renal recovery after acute kidney injury – Intensive Care Medicine (free)

Diagnostic work-up and specific causes of acute kidney injury – Intensive Care Medicine (free PDF)

Acute kidney injury in the ICU: from injury to recovery: reports from the 5th Paris International Conference – Annals of Intensive Care (free)

Source: Critical Care Reviews Newsletter

Mon, May 8 – 10 Medical Stories of The Day!

8 May, 2017 | 00:01h | UTC

1 – Conflict of Interest Theme Issue – JAMA

Theme Issue – Homepage (free)

Highlights (free)

Editorial: The Complex and Multifaceted Aspects of Conflicts of Interest (free)

Editorial: Conflict of Interest and Medical Journals (free)

Conflict of Interest: Why Does It Matter? (free)

Payments to Physicians: Does the Amount of Money Make a Difference? (free)

Why There Are No “Potential” Conflicts of Interest (free)

Addressing Bias and Conflict of Interest Among Biomedical Researchers (free)

Conflict of Interest and the Integrity of the Medical Profession (free)

Strategies for Addressing a Broader Definition of Conflicts of Interest (free)

Role of Leaders in Fostering Meaningful Collaborations Between Academic Medical Centers and Industry While Also Managing Individual and Institutional Conflicts of Interest (free)

Conflict of Interest Among Medical School Faculty: Achieving a Coherent and Objective Approach (free)

Teaching Medical Students About Conflicts of Interest (free)

Funding, Institutional Conflicts of Interest, and Schools of Public Health: Realities and Solutions (free)

Conflicts of Interest and Professional Medical Associations: Progress and Remaining Challenges (free)

Conflict of Interest in Practice Guidelines Panels (free)

Financial Conflicts of Interest in Continuing Medical Education: Implications and Accountability (free)

Challenges and Opportunities in Disclosing Financial Interests to Patients (free)

Business Model–Related Conflict of Interests in Medicine: Problems and Potential Solutions (free)

What Do Patients Think About Physicians’ Conflicts of Interest? Watching Transparency Evolve (free)

Public Disclosure of Payments to Physicians From Industry (free)

Managing Conflicts of Interest in Industry-Sponsored Clinical Research: More Physician Engagement Is Required (free)

Physicians, Industry Payments for Food and Beverages, and Drug Prescribing (free)

Conflict of Interest and the Role of the Food Industry in Nutrition Research (free)

How Should Journals Handle the Conflict of Interest of Their Editors? Who Watches the “Watchers”? (free)

Medical Journals, Publishers, and Conflict of Interest (free)

Conflict of Interest and Legal Issues for Investigators and Authors (free)

Is There a Conflict of Interest? (free)

2 – Research letter: Applicability of the IMPROVE-IT Trial to Current Patients With Acute Coronary Syndrome – JAMA Internal Medicine (link to abstract – $ for full text)

Source: Cardiac Patients in Trials Don’t Reflect Real-World Populations – MedPage Today (free registration required)

Patients in clinical trials are often younger, healthier (with less comorbidities), better plugged in to the health care system, better educated and wealthier, indicating that the external validity or generalizability of much of the current evidence to real-world settings may be relatively weak.

3 – Medical News & Perspectives: The Paternal Epigenome Makes Its Mark – JAMA (free)

“Epigenetic changes may be the underlying mechanism by which paternal factors such as age, diet, weight, stress, and alcohol consumption contribute to a range of health outcomes in offspring including birth defects, behavioral problems, developmental disorders, obesity, diabetes, cardiovascular disease, and cancer”.

4 – Reducing inappropriate prescribing easier said than done – CMAJ News (free)

Related: Canadian Deprescribing Network (CaDeN) (free)

AND CaDeN Deprescribing Guidelines and Algorithms (free) AND Deprescribing guidelines for the elderly – Ontario Pharmacy Evidence Network (free)

5 – USPSTF recommendations: A 2017 roundup – Journal of Family Practice

6 – Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up – Annals of Oncology (free)

7 – Guidelines for Management of Incidental Pulmonary Nodules Detected on CT Images: From the Fleischner Society 2017 – Radiology (free)

Source: Management of Pulmonary Nodules Found Incidentally on Computed Tomography Scans – Journal Watch (free)

Incidental pulmonary nodules discovered outside the context of screening or cancer follow-up are increasingly common in clinical practice. The purpose of these updated recommendations is to reduce the number of unnecessary follow-up examinations while providing practical guidance on follow-up intervals for selected larger nodules.

8 – CDC updates Zika test guidance for pregnant women – CIDRAP (free)

Centers for Disease Control and Prevention (CDC) related resources: CDC Zika Interim Response Plan (free) (RT @greg_folkers) AND CDC updates guidance on interpretation of Zika testing results for pregnant women AND Outcomes of Pregnancies with Laboratory Evidence of Possible Zika Virus Infection in the United States AND Prolonged IgM Antibody Response in People Infected with Zika Virus: Implications for Interpreting Serologic Testing Results for Pregnant Women (free)

9 – Series: Acute Kidney Injury in the Intensive Care Unit

Fluid management in acute kidney injury – Intensive Care Medicine (free PDF)

Renal recovery after acute kidney injury – Intensive Care Medicine (free)

Diagnostic work-up and specific causes of acute kidney injury – Intensive Care Medicine (free PDF)

Acute kidney injury in the ICU: from injury to recovery: reports from the 5th Paris International Conference – Annals of Intensive Care (free)

Source: Critical Care Reviews Newsletter

10 – Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology (free)

Source: Critical Care Reviews Newsletter

Tue, May 9 – 10 Medical Stories of The Day!

9 May, 2017 | 00:01h | UTC

1 – Noncommunicable diseases: the slow-motion disaster – World Health Organization (free)

Source: Noncommunicable Diseases: A Global ‘Slow-Motion Disaster’ – Medscape (free registration required)

2 – UN Global Road Safety Week, 8-14 May 2017 – World Health Organization

Press release 1: Fourth UN Global Road Safety Week 2017, 8-14 May 2017 (free)

Press release 2: Speed management key to saving lives, making cities more livable (free)

New WHO Report: Save LIVES: a road safety technical package (free)

WHO campaign: “Road Safety: Around 1.25 million people die every year on the world’s roads. Save lives, Slow Down!” (see Tweet) AND “Global Road Safety week: Excessive or inappropriate speed contributes to 1 in 3 road traffic fatalities, Slow Down!” (see Tweet).

3 – Treatment of Low Bone Density or Osteoporosis to Prevent Fractures in Men and Women: A Clinical Practice Guideline Update from the American College of Physicians – Annals of Internal Medicine (free)

Commentaries: ACP Updates Guidelines on Treating Low Bone Density, Osteoporosis – Physician’s First Watch (free) AND New ACP Guidelines on the Treatment of Osteoporosis – Medscape (free registration required)

4 – Review: Atrial Fibrillation: Epidemiology, Pathophysiology, and Clinical Outcomes – Circulation Research (free)

5 – Intravenous fluid therapy in adults in hospital – Updated National Institute for Health and Care Excellence (NICE – UK) Guideline (free)

6 – Type 2 diabetes in adults: management – Updated National Institute for Health and Care Excellence (NICE – UK) Guideline (free)

7 – Missed Opportunities for Deprescription: A Teachable Moment – JAMA Internal Medicine (free)

For more on ”Deprescribing” see our May 8^th issue, see #4

“Deprescription needs to be prescribed more” (RT @EricTopol see Tweet)

8 – Richard Lehman’s weekly review of medical journals – The BMJ Blogs (free)

9 – Review: Approach to the Patient with Hematochezia – Mayo Clinic Proceedings (free) (RT @HMVJC)

10 – Review: Fever of unknown origin (FUO) revised – Wiener klinische Wochenschrift (free) (RT @HMVJC)

CDC updates Zika test guidance for pregnant women

6 May, 2017 | 20:33h | UTC

CDC updates Zika test guidance for pregnant women – CIDRAP (free)

Centers for Disease Control and Prevention (CDC) related resources: CDC Zika Interim Response Plan (free) (RT @greg_folkers) AND CDC updates guidance on interpretation of Zika testing results for pregnant women AND Outcomes of Pregnancies with Laboratory Evidence of Possible Zika Virus Infection in the United States AND Prolonged IgM Antibody Response in People Infected with Zika Virus: Implications for Interpreting Serologic Testing Results for Pregnant Women (free)

Guidelines for Management of Incidental Pulmonary Nodules Detected on CT Images

6 May, 2017 | 20:34h | UTC

Guidelines for Management of Incidental Pulmonary Nodules Detected on CT Images: From the Fleischner Society 2017 – Radiology (free)

Source: Management of Pulmonary Nodules Found Incidentally on Computed Tomography Scans – Journal Watch (free)

Cardiac Patients in Trials Don’t Reflect Real-World Populations – MedPage Today

6 May, 2017 | 20:39h | UTC

Research letter: Applicability of the IMPROVE-IT Trial to Current Patients With Acute Coronary Syndrome – JAMA Internal Medicine (link to abstract – $ for full text)

Source: Cardiac Patients in Trials Don’t Reflect Real-World Populations – MedPage Today (free registration required)

Patients in clinical trials are often younger, healthier (with less comorbidities), better plugged in to the health care system, better educated and wealthier, indicating that the external validity or generalizability of much of the current evidence to real-world settings may be relatively weak.

USPSTF recommendations: A 2017 roundup

6 May, 2017 | 20:36h | UTC

USPSTF recommendations: A 2017 roundup – Journal of Family Practice

World Hand Hygiene Day (May 5th, 2017)

5 May, 2017 | 20:28h | UTC

World Hand Hygiene Day (May 5^th, 2017)

World Health Organization: SAVE LIVES: Clean Your Hands 5 May 2017 AND Campaign Resources

Centers for Disease Control and Prevention (CDC): Clean Hands Count Campaign (free) AND Hand Hygiene in Healthcare Settings (free)

Management of severe perioperative bleeding

6 May, 2017 | 20:31h | UTC

Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology (free)

Source: Critical Care Reviews Newsletter

Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017

5 May, 2017 | 20:29h | UTC

Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017 – JAMA Surgery (free) (RT @jankluytmans and @CIDRAP_ASP see Tweet)

Invited commentary: Surgical Site Infection Prevention – What We Know and What We Do Not Know – JAMA Surgery (free)

Commentary: ‘Long-Awaited’ CDC Guidelines on SSI Prevention Released – Medscape (free registration required)

Donor Age and Sex Do Not Affect of Patients Receiving Transfusions

5 May, 2017 | 20:21h | UTC

Association of Donor Age and Sex With Survival of Patients Receiving Transfusions – JAMA Internal Medicine (link to abstract – $ required for full-text)

Source: Blood Donor Age, Sex Do Not Affect Outcomes After All – Medscape (free registration required)

“After reviewing almost 1 million transfusions, the researchers concluded all donations are about the same” (RT @theheartorg see Tweet)

The World Is Not Ready for the Next Pandemic

5 May, 2017 | 20:23h | UTC

The World Is Not Ready for the Next Pandemic – TIME cover story (RT @HealthTalkUMN and @paimadhu see Tweet)

Multiple-micronutrient supplementation for women during pregnancy

5 May, 2017 | 20:26h | UTC

Multiple-micronutrient supplementation for women during pregnancy – Cochrane Library (free summary – $ for full-text)

See also a recent landmark study on the subject in our March 27^th issue, see #9.

Source: EvidenceAlerts

The findings of this systematic review support the effect of Multiple-micronutrient supplements with iron and folic acid in improving some birth outcomes.

8 things that excellent hospital doctors do

5 May, 2017 | 20:27h | UTC

First opinion: 8 things that excellent hospital doctors do – STAT News (free)

Fri, May 5 – 10 Medical Stories of The Day!

5 May, 2017 | 00:12h | UTC

1 – Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017 – JAMA Surgery (free) (RT @jankluytmans and @CIDRAP_ASP see Tweet)

Invited commentary: Surgical Site Infection Prevention – What We Know and What We Do Not Know – JAMA Surgery (free)

Commentary: ‘Long-Awaited’ CDC Guidelines on SSI Prevention Released – Medscape (free registration required)

2 – World Hand Hygiene Day (May 5^th, 2017)

World Health Organization: SAVE LIVES: Clean Your Hands 5 May 2017 AND Campaign Resources

Centers for Disease Control and Prevention (CDC): Clean Hands Count Campaign (free) AND Hand Hygiene in Healthcare Settings (free)

3 – First opinion: 8 things that excellent hospital doctors do – STAT News (free)

4 – Multiple-micronutrient supplementation for women during pregnancy – Cochrane Library (free summary – $ for full-text)

See also a recent landmark study on the subject in our March 27^th issue, see #9.

Source: EvidenceAlerts

The findings of this systematic review support the effect of Multiple-micronutrient supplements with iron and folic acid in improving some birth outcomes.

5 – The World Is Not Ready for the Next Pandemic – TIME cover story (RT @HealthTalkUMN and @paimadhu see Tweet)

6 – Handheld screen time linked with speech delays in young children – ScienceDaily (free)

Commentary on text and video: Letting a baby play on an iPad might lead to speech delays, study says – CNN (free)

“New research being presented at the 2017 Pediatric Academic Societies Meeting suggests the more time children under 2 years old spend playing with smartphones, tablets and other handheld screens, the more likely they are to begin talking later” (from ScienceDaily).

7 – Randomized controlled trial: Extended and standard duration weight-loss programme referrals for adults in primary care (WRAP): a randomised controlled trial – The Lancet (free)

Invited commentary: Weight management programmes of extended duration – The Lancet (free)

Commentary: Give overweight patients a year of weight-loss classes, say researchers – The Guardian (free)

In this trial with 1,267 overweight or obese participants an extended weight loss program (1 year) was more effective for weight loss and seems cost-effective in the longer term.

8 – Association of Donor Age and Sex With Survival of Patients Receiving Transfusions – JAMA Internal Medicine (link to abstract – $ required for full-text)

Source: Blood Donor Age, Sex Do Not Affect Outcomes After All – Medscape (free registration required)

“After reviewing almost 1 million transfusions, the researchers concluded all donations are about the same” (RT @theheartorg see Tweet)

9 – Editor’s Choice: Give patients access to their medical records – The BMJ, by Fiona Godlee, editor in chief (free)

Patients are being empowered in decisions regarding their health care, and this is probably a tendency for the future.

10 – Correspondence: Trial of Transplantation of HCV-Infected Kidneys into Uninfected Recipients – The New England Journal of Medicine (free)

Transplantation of HCV-infected-kidneys into uninfected recipients seems feasible in this era of direct-acting antiviral agents, maybe shortening waiting times for those willing to take the risk.

Weight management programmes of extended duration

5 May, 2017 | 20:22h | UTC

Randomized controlled trial: Extended and standard duration weight-loss programme referrals for adults in primary care (WRAP): a randomised controlled trial – The Lancet (free)

Invited commentary: Weight management programmes of extended duration – The Lancet (free)

Commentary: Give overweight patients a year of weight-loss classes, say researchers – The Guardian (free)

In this trial with 1,267 overweight or obese participants an extended weight loss program (1 year) was more effective for weight loss and seems cost-effective in the longer term.

Trial of Transplantation of HCV-Infected Kidneys into Uninfected Recipients

5 May, 2017 | 20:19h | UTC

Correspondence: Trial of Transplantation of HCV-Infected Kidneys into Uninfected Recipients – The New England Journal of Medicine (free)

Transplantation of HCV-infected-kidneys into uninfected recipients seems feasible in this era of direct-acting antiviral agents, maybe shortening waiting times for those willing to take the risk.