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Bystander Efforts and 1-Year Outcomes in Out-of-Hospital Cardiac Arrest

4 May, 2017 | 20:17h | UTC

Bystander Efforts and 1-Year Outcomes in Out-of-Hospital Cardiac Arrest – New England Journal of Medicine (Link to abstract – $ for full-text)

Quick Take Video Summary: Bystander Efforts in Out-of-Hospital Cardiac Arrest (free)

Commentary: Bystander CPR and Defibrillation Are Associated with Better Long-Term Outcomes – Journal Watch (free)

In patients who have initially survived after out-of-hospital cardiac arrest, those who were submitted to bystander CPR and defibrillation had lower risk of brain damage, nursing home admission and death after one year when compared to patients who survived but were not submitted to bystander CPR.

 


Selection of patients for intra-arterial treatment for acute ischaemic stroke

4 May, 2017 | 20:18h | UTC

Selection of patients for intra-arterial treatment for acute ischaemic stroke: development and validation of a clinical decision tool in two randomised trials – The BMJ (free)

New decision tool: MR CLEAN-R Registry (free)

This new clinical decision tool will improve the selection of patients with acute ischemic stroke who will benefit the most from intra-arterial treatment.

 


World Asthma Day (May 2, 2017)

3 May, 2017 | 17:33h | UTC

World Asthma Day (May 2, 2017): Asthma Updated Fact Sheet – World Health Organization (free)

Related:  Cochrane Evidence resources related to World Asthma Day (free summaries)

 


Alternate-day fasting does not seem to lead to greater weight loss

3 May, 2017 | 17:26h | UTC

Effect of Alternate-Day Fasting on Weight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults: A Randomized Clinical Trial – JAMA Internal Medicine (free)

Commentaries: Fasting Studies Clash With Our Desire To Eat What We Want, When We Want It – NPR Health News (free) AND Fasting Every Other Day Does Not Lead to Greater Weight Loss – Physician’s First Watch (free) AND Same Weight Loss With Alternate-Day Fasting vs Cutting Calories – Medscape (free registration required) AND Alternate-Day Fasting Doesn’t Lead to Speedier Weight Loss – MedPage Today (free registration required)

Randomized trial with 100 patients showed no difference in weight loss between alternate-day fasting versus calorie restriction.

 


Urinary catheter care: what does the evidence say?

4 May, 2017 | 20:12h | UTC

Urinary catheter care: what does the evidence say? – Cochrane Library (free)

“How frequently should indwelling urinary catheters be changed? Are catheter washouts effective? Which type of catheter reduces rates of urinary tract infection?”. This post look at the evidence regarding urinary catheter care.

 


Thu, May 4 – 10 Medical Stories of The Day!

4 May, 2017 | 00:29h | UTC

 

1 – Selection of patients for intra-arterial treatment for acute ischaemic stroke: development and validation of a clinical decision tool in two randomised trials – The BMJ (free)

New decision tool: MR CLEAN-R Registry (free)

This new clinical decision tool will improve the selection of patients with acute ischemic stroke who will benefit the most from intra-arterial treatment.

 

2 – Bystander Efforts and 1-Year Outcomes in Out-of-Hospital Cardiac Arrest – New England Journal of Medicine (Link to abstract – $ for full-text)

Quick Take Video Summary: Bystander Efforts in Out-of-Hospital Cardiac Arrest (free)

Commentary: Bystander CPR and Defibrillation Are Associated with Better Long-Term Outcomes – Journal Watch (free)

In patients who have initially survived after out-of-hospital cardiac arrest, those who were submitted to bystander CPR and defibrillation had lower risk of brain damage, nursing home admission and death after one year when compared to patients who survived but were not submitted to bystander CPR.

 

3 – As scientists take to Twitter, study shows power of ‘visual abstract’ graphics – Scienmag (free) (RT @jdimick1 @UM_IHPI)

Have a look: Example of visual abstract and its benefits for engagement (Tweet)

Original article ($ for full-text): Visual Abstracts to Disseminate Research on Social Media: A Prospective, Case-control Crossover Study – Annals of Surgery

See also: an open-source primer on visual abstracts (free)

This new tendency might increase engagement with medical research.

 

4 – Cardiology groups issue guidance on heart failure – ACP Hospitalist

Key points from the recently published AHA Heart Failure Guideline (free)

See also our coverage on the new guidelines on our May 1st issue, see #2.

 

5 – Association Between Academic Medical Center Pharmaceutical Detailing Policies and Physician Prescribing – JAMA (link to abstract – $ for full-text)

Commentaries: Doctors Prescribe More Generics When Drug Reps Are Kept At Bay – NPR (free) AND Limiting Interactions with Pharma Reps Cuts Brand Name Drug Prescriptions – Physician’s First Watch (free)

See more about conflicts of interest in medicine in our yesterday’s issue, see #10.

 

6 – Long term gluten consumption in adults without celiac disease and risk of coronary heart disease: prospective cohort study – The BMJ (free)

Commentary: Gluten-Restricted Diets Seem Not to Lower Coronary Risk – Physician’s First Watch (free)

 

7 – Viewpoint: Breaking the Rules for Better Care – JAMA (free) (RT @gmacscotlan)

“Administrative burdens and complexity are alleged to be among the most costly forms of waste in US health care”. This comentary addresses the problem and provide a few suggestions for better care.

See more about the burden of administrative tasks in healthcare in our April 21st issue, see #5, and about physician’s burnout and clerical work in our April 24th issue, see #9.

 

8 – Interesting read: The Death of Expertise – The Federalist (free) (RT @wellcometrust and @MaryDixonWoods see Tweet)

This interesting commentary may as well be applied to the changing relationships between patients and doctors.

 

9 – Statins, Like All Medicines, Are Neither Good Nor Bad – By John Mandrola, MD (free)

I am sick of the “bad” drug frame. My latest fast-writing: Statins, Like All Medicines, Are Neither Good Nor Bad” (RT @drjohnm see Tweet)

 

10 – Urinary catheter care: what does the evidence say? – Cochrane Library (free)

How frequently should indwelling urinary catheters be changed? Are catheter washouts effective? Which type of catheter reduces rates of urinary tract infection?”. This post look at the evidence regarding urinary catheter care.

 


What is public health? Some reflections for teaching

3 May, 2017 | 17:29h | UTC

What is public health? Some reflections for teaching – Dr Graham Mackenzie, Consultant in Public Health (free)

 


Preventing drowning: an implementation guide – World Health Organization

3 May, 2017 | 17:32h | UTC

Report: Preventing drowning: an implementation guide – World Health Organization (free) (See @WHO Tweet 1 and Tweet 2)

Related publication: Global report on drowning: preventing a leading killer – World Health Organization (free)

 


PCSK9 inhibitors for prevention of cardiovascular disease – Cochrane Library

3 May, 2017 | 17:28h | UTC

Systematic review: PCSK9 inhibitors for prevention of cardiovascular disease – Cochrane Library (free summary – $ for full-text))

The evidence so far suggests that PCSK9 inhibitor use probably leads to little or no difference in mortality and leads to a modest absolute risk reduction (often less than 1%) in cardiovascular events in high-risk patients.

 


ASCO Guideline on Castrate-Resistant Prostate Cancer

3 May, 2017 | 17:23h | UTC

Second-Line Hormonal Therapy for Men With Chemotherapy-Naïve, Castration-Resistant Prostate Cancer: American Society of Clinical Oncology Provisional Clinical Opinion (free)

Source: ASCO Issues Guideline on Castrate-Resistant Prostate Cancer – Medscape (free registration required)

 


Updated Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection

3 May, 2017 | 17:25h | UTC

Updated Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection – AIDSInfo (free)

 


Effect of Using the HEART Score in Patients With Chest Pain in the Emergency Department

2 May, 2017 | 17:20h | UTC

Effect of Using the HEART Score in Patients With Chest Pain in the Emergency Department: A Stepped-Wedge, Cluster Randomized Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

See also: HEART Score for Major Cardiac Events – MdCalc (free)

Commentaries: HEART Score for Chest Pain in ED Found to Be Safe, Cost-Effective – Physician’s First Watch (free) AND HEART Score Safely Informs Chest Pain Decisions in ED – Medscape (free registration required) AND HEART score to risk stratify patients with chest pain is safe but underutilized in the ED – ScienceDaily (free)

 


Wed, May 3 – 10 Medical Stories of The Day!

3 May, 2017 | 00:02h | UTC

 

1 – World Asthma Day (May 2, 2017): Asthma Updated Fact Sheet – World Health Organization (free)

Related:  Cochrane Evidence resources related to World Asthma Day (free summaries)

 

2 – Report: Preventing drowning: an implementation guide – World Health Organization (free) (See @WHO Tweet 1 and Tweet 2)

Related publication: Global report on drowning: preventing a leading killer – World Health Organization (free)

 

3 – Embrace the facts about vaccines, not the myths – World Health Organization (free) (RT @gmacscotland see Tweet)

Related: The amazing power of vaccines, explained in 6 seconds – World Economic Forum (free) AND World Immunisation Week: The Rise of Anti-Vaccine Movement and What it Means for Public Health – Independent (free) (RT @LSHTMpress see Tweet)

See also our coverage on World Immunization Week in our April 25 issue, see #1.

 

4 – What is public health? Some reflections for teaching – Dr Graham Mackenzie, Consultant in Public Health (free)

 

5 – Systematic review: PCSK9 inhibitors for prevention of cardiovascular disease – Cochrane Library (free summary – $ for full-text))

The evidence so far suggests that PCSK9 inhibitor use probably leads to little or no difference in mortality and leads to a modest absolute risk reduction (often less than 1%) in cardiovascular events in high-risk patients.

 

6 – Effect of Alternate-Day Fasting on Weight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults: A Randomized Clinical Trial – JAMA Internal Medicine (free)

Commentaries: Fasting Studies Clash With Our Desire To Eat What We Want, When We Want It – NPR Health News (free) AND Fasting Every Other Day Does Not Lead to Greater Weight Loss – Physician’s First Watch (free) AND Same Weight Loss With Alternate-Day Fasting vs Cutting Calories – Medscape (free registration required) AND Alternate-Day Fasting Doesn’t Lead to Speedier Weight Loss – MedPage Today (free registration required)

Randomized trial with 100 patients showed no difference in weight loss between alternate-day fasting versus calorie restriction.

 

7 – Updated Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection – AIDSInfo (free)

 

8 – Second-Line Hormonal Therapy for Men With Chemotherapy-Naïve, Castration-Resistant Prostate Cancer: American Society of Clinical Oncology Provisional Clinical Opinion (free)

Source: ASCO Issues Guideline on Castrate-Resistant Prostate Cancer – Medscape (free registration required)

 

9 – Interesting read: Here’s What Your Future Doctor Visits Could Look Like – Fortune (free) (RT @EricTopol see Tweet)

According to this point of view “tomorrow’s office visit will increasingly take place everywhere but the office”, with a sharp increase in virtual visits and home visits, with doctors coming to patients.

 

10 – Viewpoint: Conflict of Interest: Why Does It Matter? – JAMA (free)

Editorial 1: The Complex and Multifaceted Aspects of Conflicts of Interest (free)

Editorial 2: Conflict of Interest and Medical Journals (free)

Source: Bruno Besen, MD

 


Prevalence of multidrug-resistant gram-negative bacteria among nursing home residents

2 May, 2017 | 17:14h | UTC

Prevalence of multidrug-resistant gram-negative bacteria among nursing home residents: A systematic review and meta-analysis – American Journal of Infection Control (free)

Sources: Study: Resistant gram-negative bacteria common in nursing homes – CIDRAP (free) (RT @IDSAInfo see Tweet) AND A quarter of nursing home residents are colonized with drug-resistant bacteria – EurekAlert (free)

 


Embrace the facts about vaccines, not the myths – World Health Organization

3 May, 2017 | 17:30h | UTC

Embrace the facts about vaccines, not the myths – World Health Organization (free) (RT @gmacscotland see Tweet)

Related: The amazing power of vaccines, explained in 6 seconds – World Economic Forum (free) AND World Immunisation Week: The Rise of Anti-Vaccine Movement and What it Means for Public Health – Independent (free) (RT @LSHTMpress see Tweet)

See also our coverage on World Immunization Week in our April 25 issue, see #1.

 


CPAP Use in Obstructive Sleep Apnea: What a Cardiologist Needs to Know

2 May, 2017 | 17:17h | UTC

Review: CPAP Use in Obstructive Sleep Apnea: What a Cardiologist Needs to Know – American College of Cardiology, Latest in Cardiology(free)

 


Essentials of Global Health – Free Online Course

2 May, 2017 | 17:20h | UTC

Just started. Essentials of Global Health – Free Online Course from the Yale University and Coursera (RT @glassmanamanda)

 


Use of antibiotics during pregnancy and risk of spontaneous abortion

2 May, 2017 | 17:21h | UTC

Use of antibiotics during pregnancy and risk of spontaneous abortion – Canadian Medical Association Journal (free) (RT @CMAJ see Tweet)

Commentary: Use of Certain Antibiotics in Pregnancy Tied to Spontaneous Abortion – Physician’s First Watch (free)

In this nested case-control study, use of common antibiotics such as macrolides (excluding erythromycin), quinolones, tetracyclines, sulfonamides and metronidazole during early pregnancy was associated with an increased risk of spontaneous abortion.

 


Here’s What Your Future Doctor Visits Could Look Like

3 May, 2017 | 17:22h | UTC

Interesting read: Here’s What Your Future Doctor Visits Could Look Like – Fortune (free) (RT @EricTopol see Tweet)

According to this point of view “tomorrow’s office visit will increasingly take place everywhere but the office”, with a sharp increase in virtual visits and home visits, with doctors coming to patients.

 


Echocardiography and lung ultrasonography for the assessment and management of acute heart failure

2 May, 2017 | 17:18h | UTC

Expert consensus document: Echocardiography and lung ultrasonography for the assessment and management of acute heart failure – Nature Reviews Cardiology (free)

Source: Critical Care Reviews Newsletter

 


Women with symptoms of a urinary tract infection but a negative urine culture

2 May, 2017 | 17:15h | UTC

Women with symptoms of a urinary tract infection but a negative urine culture: PCR-based quantification of Escherichia coli suggests infection in most cases – Clinical Microbiology and Infection (link to abstract – Free and legal PDF here – via @unpaywall)

Sources: The most reliable test and predictive entity for uncomplicated UTI is the patient’s symptoms – Emergency Literature of Note Blog(free) AND Negative Urine Culture + Symptoms = UTI in Most Women – MedPage Today (free registration required)

This study suggests that women with symptoms of uncomplicated cystitis and a negative urinary culture should be treated nonetheless.

 


Tue, May 2 – 10 Medical Stories of The Day!

2 May, 2017 | 00:38h | UTC

 

1 – Use of antibiotics during pregnancy and risk of spontaneous abortion – Canadian Medical Association Journal (free) (RT @CMAJ see Tweet)

Commentary: Use of Certain Antibiotics in Pregnancy Tied to Spontaneous Abortion – Physician’s First Watch (free)

In this nested case-control study, use of common antibiotics such as macrolides (excluding erythromycin), quinolones, tetracyclines, sulfonamides and metronidazole during early pregnancy was associated with an increased risk of spontaneous abortion.

 

2 – Effect of Using the HEART Score in Patients With Chest Pain in the Emergency Department: A Stepped-Wedge, Cluster Randomized Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

See also: HEART Score for Major Cardiac Events – MdCalc (free)

Commentaries: HEART Score for Chest Pain in ED Found to Be Safe, Cost-Effective – Physician’s First Watch (free) AND HEART Score Safely Informs Chest Pain Decisions in ED – Medscape (free registration required) AND HEART score to risk stratify patients with chest pain is safe but underutilized in the ED – ScienceDaily (free)

 

3 – Just started. Essentials of Global Health – Free Online Course from the Yale University and Coursera (RT @glassmanamanda)

 

4 – Expert consensus document: Echocardiography and lung ultrasonography for the assessment and management of acute heart failure – Nature Reviews Cardiology (free)

Source: Critical Care Reviews Newsletter

 

5 – Short review: CPAP Use in Obstructive Sleep Apnea: What a Cardiologist Needs to Know – American College of Cardiology, Latest in Cardiology (free)

 

6 – Review: Acute Respiratory Distress Syndrome – European Respiratory Review (free)

 

7 – Women with symptoms of a urinary tract infection but a negative urine culture: PCR-based quantification of Escherichia coli suggests infection in most cases – Clinical Microbiology and Infection (link to abstract – Free and legal PDF here – via @unpaywall)

Sources: The most reliable test and predictive entity for uncomplicated UTI is the patient’s symptoms – Emergency Literature of Note Blog (free) AND Negative Urine Culture + Symptoms = UTI in Most Women – MedPage Today (free registration required)

This study suggests that women with symptoms of uncomplicated cystitis and a negative urinary culture should be treated nonetheless.

 

8 – Prevalence of multidrug-resistant gram-negative bacteria among nursing home residents: A systematic review and meta-analysis – American Journal of Infection Control (free)

Sources: Study: Resistant gram-negative bacteria common in nursing homes – CIDRAP (free) (RT @IDSAInfo see Tweet) AND A quarter of nursing home residents are colonized with drug-resistant bacteria – EurekAlert (free)

 

9 – For Pregnant Women, Getting Serious About Whooping Cough – The New York Times (10 articles per month are free)

Related: Effectiveness of Vaccination During Pregnancy to Prevent Infant Pertussis – Pediatrics (free) AND Study: Pertussis shot in pregnant moms protects newborns – CIDRAP (free) AND Get the Whooping Cough Vaccine While You Are Pregnant – Centers for Disease Control and Prevention (CDC) (free)

 

10 – More Evidence that Excessive Blood Pressure Lowering Can Heighten Cardiovascular Risk – Journal Watch (free)

Original article abstract ($ for full-text): Achieved blood pressure and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials – The Lancet

See more about this article in our April 11 issue, see #8.

 


Guidelines for the Economic Evaluation of Health Technologies

1 May, 2017 | 16:47h | UTC

Guidelines for the Economic Evaluation of Health Technologies: Canada – 4th Edition – Canadian Agency for Drugs and Technologies in Health(free)

News release: Guidelines for the Economic Evaluation of Health Technologies (free)

Commentary: New guidelines for evaluating health tech: New guide for economic analysis of drugs and technology – CMAJ News (free)

Best practices guidelines for conducting economic evaluations of health care technologies, so that the information produced is standardized and of high quality and can effectively inform health care decision-making.

 


Review: Acute Respiratory Distress Syndrome

2 May, 2017 | 17:16h | UTC

Review: Acute Respiratory Distress Syndrome – European Respiratory Review (free)

 


Management of Inherited Bleeding Disorders in Pregnancy

1 May, 2017 | 16:47h | UTC

Management of Inherited Bleeding Disorders in Pregnancy: Green-top Guideline – Royal College of Obstetricians and Gynaecologists (free)

 


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