Mon, May 8 – 10 Medical Stories of The Day!

1 – Conflict of Interest Theme Issue – JAMA

Theme Issue – Homepage (free)

Highlights (free)

Editorial: The Complex and Multifaceted Aspects of Conflicts of Interest (free)

Editorial: Conflict of Interest and Medical Journals (free)

Conflict of Interest: Why Does It Matter? (free)

Payments to Physicians: Does the Amount of Money Make a Difference? (free)

Why There Are No “Potential” Conflicts of Interest (free)

Addressing Bias and Conflict of Interest Among Biomedical Researchers (free)

Conflict of Interest and the Integrity of the Medical Profession (free)

Strategies for Addressing a Broader Definition of Conflicts of Interest (free)

Role of Leaders in Fostering Meaningful Collaborations Between Academic Medical Centers and Industry While Also Managing Individual and Institutional Conflicts of Interest (free)

Conflict of Interest Among Medical School Faculty: Achieving a Coherent and Objective Approach (free)

Teaching Medical Students About Conflicts of Interest (free)

Funding, Institutional Conflicts of Interest, and Schools of Public Health: Realities and Solutions (free)

Conflicts of Interest and Professional Medical Associations: Progress and Remaining Challenges (free)

Conflict of Interest in Practice Guidelines Panels (free)

Financial Conflicts of Interest in Continuing Medical Education: Implications and Accountability (free)

Challenges and Opportunities in Disclosing Financial Interests to Patients (free)

Business Model–Related Conflict of Interests in Medicine: Problems and Potential Solutions (free)

What Do Patients Think About Physicians’ Conflicts of Interest? Watching Transparency Evolve (free)

Public Disclosure of Payments to Physicians From Industry (free)

Managing Conflicts of Interest in Industry-Sponsored Clinical Research: More Physician Engagement Is Required (free)

Physicians, Industry Payments for Food and Beverages, and Drug Prescribing (free)

Conflict of Interest and the Role of the Food Industry in Nutrition Research (free)

How Should Journals Handle the Conflict of Interest of Their Editors? Who Watches the “Watchers”? (free)

Medical Journals, Publishers, and Conflict of Interest (free)

Conflict of Interest and Legal Issues for Investigators and Authors (free)

Is There a Conflict of Interest? (free)

2 – Research letter: Applicability of the IMPROVE-IT Trial to Current Patients With Acute Coronary Syndrome – JAMA Internal Medicine (link to abstract – $ for full text)

Source: Cardiac Patients in Trials Don’t Reflect Real-World Populations – MedPage Today (free registration required)

Related: Exclusion of patients with concomitant chronic conditions in ongoing randomised controlled trials targeting 10 common chronic conditions and registered at ClinicalTrials.gov: a systematic review of registration details – BMJ Open (free) AND Do cancer clinical trials exaggerate the real-world benefits of drugs? – STAT News (free)

Patients in clinical trials are often younger, healthier (with less comorbidities), better plugged in to the health care system, better educated and wealthier, indicating that the external validity or generalizability of much of the current evidence to real-world settings may be relatively weak.

3 – Medical News & Perspectives: The Paternal Epigenome Makes Its Mark – JAMA (free)

Related: Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype – American Journal of Stem Cells (free)

“Epigenetic changes may be the underlying mechanism by which paternal factors such as age, diet, weight, stress, and alcohol consumption contribute to a range of health outcomes in offspring including birth defects, behavioral problems, developmental disorders, obesity, diabetes, cardiovascular disease, and cancer”.

4 – Reducing inappropriate prescribing easier said than done – CMAJ News (free)

Related: Canadian Deprescribing Network (CaDeN) (free)

AND CaDeN Deprescribing Guidelines and Algorithms (free) AND Deprescribing guidelines for the elderly – Ontario Pharmacy Evidence Network (free)

5 – USPSTF recommendations: A 2017 roundup – Journal of Family Practice

6 – Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up – Annals of Oncology (free)

7 – Guidelines for Management of Incidental Pulmonary Nodules Detected on CT Images: From the Fleischner Society 2017 – Radiology (free)

Source: Management of Pulmonary Nodules Found Incidentally on Computed Tomography Scans – Journal Watch (free)

Incidental pulmonary nodules discovered outside the context of screening or cancer follow-up are increasingly common in clinical practice. The purpose of these updated recommendations is to reduce the number of unnecessary follow-up examinations while providing practical guidance on follow-up intervals for selected larger nodules.

8 – CDC updates Zika test guidance for pregnant women – CIDRAP (free)

Centers for Disease Control and Prevention (CDC) related resources: CDC Zika Interim Response Plan (free) (RT @greg_folkers) AND CDC updates guidance on interpretation of Zika testing results for pregnant women AND Outcomes of Pregnancies with Laboratory Evidence of Possible Zika Virus Infection in the United States AND Prolonged IgM Antibody Response in People Infected with Zika Virus: Implications for Interpreting Serologic Testing Results for Pregnant Women (free)

9 – Series: Acute Kidney Injury in the Intensive Care Unit

Fluid management in acute kidney injury – Intensive Care Medicine (free PDF)

Renal recovery after acute kidney injury – Intensive Care Medicine (free)

Diagnostic work-up and specific causes of acute kidney injury – Intensive Care Medicine (free PDF)

Acute kidney injury in the ICU: from injury to recovery: reports from the 5th Paris International Conference – Annals of Intensive Care (free)

Source: Critical Care Reviews Newsletter

10 – Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology (free)

Source: Critical Care Reviews Newsletter