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Daily Archives: March 28, 2022

Review Series: Selected articles from the Annual Update in Intensive Care and Emergency Medicine 2022.

28 Mar, 2022 | 10:06h | UTC

Homepage: Selected articles from the Annual Update in Intensive Care and Emergency Medicine 2022 – Critical Care

Vasopressor choice and timing in vasodilatory shock

Advanced life support update

Brain injury biomarkers for predicting outcome after cardiac arrest

The importance of neuromonitoring in non-brain injured patients

Artificial intelligence in critical care medicine

Artificial intelligence in infection management in the ICU

Sepsis performance improvement programs: from evidence towards clinical implementation

How to prolong filter life during continuous renal replacement therapy? 

Immunomodulation by tetracyclines in the critically ill: an emerging treatment option?

The role of mitochondria in the immune response in critical illness

 

AGA clinical practice update on the role of diet in irritable bowel syndrome.

28 Mar, 2022 | 10:04h | UTC

AGA Clinical Practice Update on the Role of Diet in Irritable Bowel Syndrome: Expert Review – Gastroenterology

Related:

RCT: Efficacy and acceptability of dietary therapies in non-constipated irritable bowel syndrome: a randomized trial of traditional dietary advice, the low FODMAP diet and the gluten-free diet.

10 mistakes in dietary management of irritable bowel syndrome and how to avoid them.

Supplement: Irritable bowel syndrome and related conditions.

RCT: FODMAPs, but not gluten, elicit modest symptoms of irritable bowel syndrome.

RCT: Among patients with diarrhea-predominant irritable bowel syndrome, a low FODMAP diet achieved earlier symptomatic improvements in stool frequency and excessive wind.

British Society of Gastroenterology guidelines on the management of irritable bowel syndrome

Guidelines for the treatment of irritable bowel syndrome

ACG Clinical Guideline: Management of irritable bowel syndrome

M-A: Efficacy of a low-FODMAP diet in adult irritable bowel syndrome

 

Study challenges the theory that light alcohol consumption benefits heart health.

28 Mar, 2022 | 10:09h | UTC

News Release: Large study challenges the theory that light alcohol consumption benefits heart health – Massachusetts General Hospital

Original Study: Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease – JAMA Network Open

Related: No amount of alcohol is good for the heart, says World Heart Federation.

 

Commentary on Twitter

 

Moderna to ask FDA to authorize Covid-19 vaccine in children 6 months to 6 years.

28 Mar, 2022 | 10:01h | UTC

Moderna to ask FDA to authorize Covid-19 vaccine in children 6 months to 6 years – STAT

 

Riding the Twitter wave: Enthusiasm for the social media platform changed science communication during the pandemic—but will it last?

28 Mar, 2022 | 09:56h | UTC

Riding the Twitter wave: Enthusiasm for the social media platform changed science communication during the pandemic—but will it last? – Science

Related:

Optimizing the use of Twitter for research dissemination: The “Three Facts and a Story” randomized-controlled trial.

Perspective: How Twitter is Changing Medical Research

Keeping Up With Cardiology: Old-School Learning Versus the Twittersphere – TCTMD

Scientists on Twitter: Preaching to the choir or singing from the rooftops? – Facets

Rise of the Tweetorial – Precious Bodily Fluids

Social Medicine: Twitter in Healthcare – Journal of Clinical Medicine

University of Twitter? Scientists give impromptu lecture critiquing nutrition research – CBC

Twitter-Based Medicine: How Social Media is Changing the Public’s View of Medicine – The Health Care Blog

What’s your doctor reading? How social media is disrupting medical education – National Post

 

Commentary on Twitter

 

Is there evidence of fabricated data in a Vitamin C trial published in CHEST?

28 Mar, 2022 | 09:58h | UTC

Evidence of Fabricated Data in a Vitamin C trial by Paul E Marik et al in CHEST – This Scattrd Corn

Commentary: Infamous Vitamin C Study May Rely on Fraudulent Data— Statistician alleges data in study led by Paul Marik, MD, were fabricated – MedPage Today

 

Commentary on Twitter (thread – click for more)

 

Cohort Study: SARS-CoV-2 co-infection with influenza viruses, respiratory syncytial virus, or adenoviruses is associated with increased mortality.

28 Mar, 2022 | 10:03h | UTC

SARS-CoV-2 co-infection with influenza viruses, respiratory syncytial virus, or adenoviruses – The Lancet

Commentary: Patients with Covid and flu double the risk of dying, say scientists – The Guardian

 

Commentary from the author on Twitter (thread – click for more)

 

Opinion: How we got herd immunity wrong.

28 Mar, 2022 | 09:50h | UTC

How we got herd immunity wrong – STAT

 

Canadian Tuberculosis Standards – 8th Edition.

28 Mar, 2022 | 09:46h | UTC

Homepage: Canadian Tuberculosis Standards – 8th Edition – Canadian Journal of Respiratory, Critical Care, and Sleep Medicine

Preface

Chapter 1: Epidemiology of tuberculosis in Canada
Chapter 2: Transmission and pathogenesis of tuberculosis

Chapter 3: Diagnosis of tuberculosis disease and drug-resistant tuberculosis

Chapter 4: Diagnosis of tuberculosis infection

Chapter 5: Treatment of tuberculosis disease

Chapter 6: Tuberculosis preventive treatment in adults
Chapter 7: Extra-pulmonary tuberculosis

Chapter 8: Drug-resistant tuberculosis

Chapter 9: Pediatric tuberculosis

Chapter 10: Treatment of active tuberculosis in special populations

Chapter 11: Tuberculosis contact investigation and outbreak management

Chapter 12: An introductory guide to tuberculosis care to improve cultural competence for health care workers and public health professionals serving Indigenous Peoples of Canada

Chapter 13: Tuberculosis surveillance and tuberculosis infection testing and treatment in migrants

Chapter 14: Prevention and control of tuberculosis transmission in healthcare settings

Chapter 15: Monitoring tuberculosis program performance

 

The prevalence of penicillin allergy labeling ranged from 0.9% to 10.2% across practices in a large pediatric cohort, raising questions regarding the validity of those labels and the unnecessary use of second-line antibiotics that may follow.

28 Mar, 2022 | 09:48h | UTC

Factors Associated With Penicillin Allergy Labels in Electronic Health Records of Children in 2 Large US Pediatric Primary Care Networks – JAMA Network Open

Related: A pharmacist-led penicillin allergy assessment program can delabel many “penicillin allergic” patients through allergy histories and penicillin skin testing. The program was associated with reduced use of high Clostridioides difficile infection–risk antibiotics.

M-A: Most patients with allergy to Penicillin can be given Cefazolin

Systematic review: Safety and efficacy of de-labelling penicillin allergy in adults using direct oral challenge

Penicillin allergy labels increase second-line broad-spectrum antibiotic prescribing for pediatric respiratory tract infections

Podcast: A Clinical Pharmacologist’s Perspective on Penicillin Allergy

Study: Development and Validation of a Penicillin Allergy Clinical Decision Rule

Consensus Recommendations: Management of a Surgical Patient with a Label of Penicillin Allergy

Practical Guide for Pharmacists to Successfully Implement Penicillin Allergy Skin Testing

NICE: Double Check Patients with ‘Penicillin Allergy’ to Avoid Increased MRSA Risk

Cohort Study: Risk of Meticillin Resistant Staphylococcus Aureus and Clostridium Difficile in Patients with a Documented Penicillin Allergy

 

Commentary on Twitter

 

International consensus meeting on venous thromboembolism in orthopedic surgery.

28 Mar, 2022 | 09:45h | UTC

Homepage: International Consensus Meeting on Venous Thromboembolism (free articles for a limited period)

Editorial

Recommendations from the ICM-VTE: General

Recommendations from the ICM-VTE:: Foot & Ankle

Recommendations from the ICM-VTE: Hand & Wrist

Recommendations from the ICM-VTE: Hip & Knee

Recommendations from the ICM-VTE: Oncology

Recommendations from the ICM-VTE: Pediatric

Recommendations from the ICM-VTE: Shoulder & Elbow

Recommendations from the ICM-VTE: Sports

Recommendations from the ICM-VTE: Trauma

Recommendations from the ICM-VTE: Spine

 

Retrospective Cohort: A population-based study in Sweden and Norway did not find an increased risk of pregnancy complications after COVID-19 vaccination.

28 Mar, 2022 | 09:51h | UTC

Association of SARS-CoV-2 Vaccination During Pregnancy With Pregnancy Outcomes – JAMA

See also: Association of COVID-19 Vaccination in Pregnancy With Adverse Peripartum Outcomes – JAMA

Editorial: COVID-19 mRNA Vaccines During Pregnancy: New Evidence to Help Address Vaccine Hesitancy – JAMA

News Release: No increase in pregnancy complications after COVID-19 vaccination – Karolinska Institutet

 

Systematic Review: Symptom‐ and chest‐radiography screening for active pulmonary tuberculosis in HIV‐negative adults and adults with unknown HIV status.

28 Mar, 2022 | 08:54h | UTC

Symptom‐ and chest‐radiography screening for active pulmonary tuberculosis in HIV‐negative adults and adults with unknown HIV status – Cochrane Library

Summary: How accurate are asking about symptoms and doing a chest X-ray to screen for tuberculosis of the lungs among adults who are HIV-negative or with unknown HIV status? – Cochrane Library

 

Guidelines for Parkinson’s disease treatment.

28 Mar, 2022 | 09:43h | UTC

Guidelines for Parkinson’s disease treatment: consensus from the Movement Disorders Scientific Department of the Brazilian Academy of Neurology – Arquivos de Neuro-Psiquiatria

 

RCT: Two phase 3 trials of Baricitinib for Alopecia Areata.

28 Mar, 2022 | 08:49h | UTC

Two Phase 3 Trials of Baricitinib for Alopecia Areata – New England Journal of Medicine

 

Commentary on Twitter

 

RCT: In critically ill immunocompromised patients with acute respiratory failure, outcomes were similar with the use of high-flow nasal oxygen alone vs. alternating with non-invasive ventilation.

28 Mar, 2022 | 08:51h | UTC

High-flow nasal oxygen alone or alternating with non-invasive ventilation in critically ill immunocompromised patients with acute respiratory failure: a randomised controlled trial – The Lancet Respiratory Medicine (free registration required)

 

Commentary on Twitter

 

Half of all women experience false positive mammograms after 10 years of annual screening.

28 Mar, 2022 | 08:53h | UTC

News Release: Half of all women experience false positive mammograms after 10 years of annual screening – University of California – Davis Health

Original Study: Cumulative Probability of False-Positive Results After 10 Years of Screening With Digital Breast Tomosynthesis vs Digital Mammography – JAMA Network Open

 

Commentary on Twitter

 

Review | Preparing for CAR T cell therapy: patient selection, bridging therapies and lymphodepletion.

28 Mar, 2022 | 08:47h | UTC

Preparing for CAR T cell therapy: patient selection, bridging therapies and lymphodepletion – Nature Reviews Clinical Oncology (if the link is paywalled, try this one)

 

Commentary on Twitter

 

RCT: Trastuzumab Deruxtecan vs. Trastuzumab Emtansine for breast cancer.

28 Mar, 2022 | 08:48h | UTC

Trastuzumab Deruxtecan versus Trastuzumab Emtansine for Breast Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Trastuzumab Deruxtecan Ups PFS in HER2+ Metastatic Breast Cancer – HealthDay

 

Commentary on Twitter

 

Cohort study: Long-term treatment with clozapine is associated with increased risk of hematological malignancies.

28 Mar, 2022 | 08:43h | UTC

Long-term treatment with clozapine and other antipsychotic drugs and the risk of haematological malignancies in people with schizophrenia: a nationwide case-control and cohort study in Finland – The Lancet Psychiatry (link to abstract – $ for full-text)

 

Commentary on Twitter

 

First case of HIV cure in a woman after stem cell transplantation reported at CROI-2022.

28 Mar, 2022 | 08:46h | UTC

First case of HIV cure in a woman after stem cell transplantation reported at CROI-2022 – World Health Organization

 

Study Commentary: Symptoms can appear up to 10 years before a Parkinson’s disease diagnosis in a primary care setting.

28 Mar, 2022 | 08:37h | UTC

Symptoms Can Appear Up to 10 Years Before a Parkinson’s Disease Diagnosis in a Primary Care Setting – Neurology Today

Original Study: Assessment of Risk Factors and Early Presentations of Parkinson Disease in Primary Care in a Diverse UK Population – JAMA Neurology (link to abstract – $ for full-text)

 

Cohort Study: Association of lower extremity lymphedema with physical functioning and activities of daily living among older survivors of colorectal, endometrial, and ovarian cancer.

28 Mar, 2022 | 08:39h | UTC

Association of Lower Extremity Lymphedema With Physical Functioning and Activities of Daily Living Among Older Survivors of Colorectal, Endometrial, and Ovarian Cancer – JAMA Network Open

Commentaries:

Older female cancer survivors face challenges with physical activity due to chronic lower extremity lymphedema – News Medical

Lower-Extremity Lymphedema Common in Older, Female Cancer Survivors – HealthDay

 

Commentary on Twitter

 

RCT: Effect of induction chemotherapy with Paclitaxel, Cisplatin, and Capecitabine vs. Cisplatin and Fluorouracil on failure-free survival for patients with stage IVA to IVB Nasopharyngeal Carcinoma.

28 Mar, 2022 | 08:36h | UTC

Effect of Induction Chemotherapy With Paclitaxel, Cisplatin, and Capecitabine vs Cisplatin and Fluorouracil on Failure-Free Survival for Patients With Stage IVA to IVB Nasopharyngeal Carcinoma: A Multicenter Phase 3 Randomized Clinical Trial – JAMA Oncology (link to abstract – $ for full-text)

Commentary: Triplet Induction Regimen Bests Doublet for Nasopharyngeal Carcinoma — Three drugs reduced risk of disease failure, but longer follow-up needed to assess OS – MedPage Today (free registration required)

 

Commentary on Twitter

 

RCT: Hydrosurgical vs. conventional debridement of burns.

28 Mar, 2022 | 08:34h | UTC

Hydrosurgical and conventional debridement of burns: randomized clinical trial – British Journal of Surgery

 

Commentary on Twitter

 

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