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Daily Archives: January 30, 2022

Position Paper: Preventing heart failure.

30 Jan, 2022 | 14:53h | UTC

Preventing heart failure: a position paper of the Heart Failure Association in collaboration with the European Association of Preventive Cardiology

 

Studies show parental vaccination provided indirect protection of children from SARS-CoV-2 infection during the Delta wave.

30 Jan, 2022 | 14:52h | UTC

Indirect protection of children from SARS-CoV-2 infection through parental vaccination – Science

See also: Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel – Science

Commentary: COVID vaccine markedly cuts household transmission, studies show – CIDRAP

 

Commentary on Twitter

 

A nationwide cohort study in Denmark showed Long Covid in children is rare and mainly of short duration.

30 Jan, 2022 | 14:40h | UTC

Long COVID symptoms and duration in SARS-CoV-2 positive children — a nationwide cohort study – European Journal of Pediatrics

Related:

Editorial | Long covid in children and adolescents – “Risk appears low, but many questions remain”.

M-A: Persistent symptoms following SARS-CoV-2 infection among children and young people – “Higher study quality was associated with lower prevalence of all symptoms, except loss of smell and cognitive symptoms”.

Review: Long COVID symptoms in children rarely persist beyond three months.

Cohort study: long term follow-up showed most patients with post–COVID-19 Multisystem Inflammatory Syndrome in Children had good outcomes with no significant medium- or long-term sequelae.

Do kids get long COVID? And how often? A pediatrician looks at the data – Children also get Long Covid, but much less often than adults.

Illness duration and symptom profile in symptomatic school-aged children tested for SARS-CoV-2 – “Only 25 (1.8%) of 1379 children experienced symptoms for at least 56 days.”

Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents – “This study found a low prevalence of symptoms compatible with long COVID in a randomly selected cohort of children assessed 6 months after serologic testing”.

Study shows low incidence of post-acute COVID-19 symptoms (“Long Covid”) in children after mild disease

 

Commentary on Twitter

 

Observational analysis in Lombardy, Italy, showed a gradual decrease in protection against SARS-CoV-2 clinical outcomes after the second dose of vaccine.

30 Jan, 2022 | 14:51h | UTC

Persistence of protection against SARS-CoV-2 clinical outcomes up to 9 months since vaccine completion: a retrospective observational analysis in Lombardy, Italy – The Lancet Infectious Diseases

Commentary: COVID-19 vaccine: what are we doing and what should we do? – The Lancet Infectious Diseases

 

FDA halts use of antibody drugs that don’t work vs. Omicron.

30 Jan, 2022 | 14:35h | UTC

FDA halts use of antibody drugs that don’t work vs. omicron – Associated Press

Related: Lab study shows new antiviral pills maintain efficacy against Omicron, but antibody drugs are substantially less effective.

 

RCT: Vitamin D supplementation for older adults (mean age 67 years) for 5 years reduced the risk of autoimmune diseases by 22%. Absolute risk in the treatment group was 0.95% vs. 1.19% in the placebo group.

30 Jan, 2022 | 14:30h | UTC

Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial – The BMJ

Commentary: Vitamin D and fish oil supplements may help prevent autoimmune disease, study says – CNN

Related:

RCT: Oral Vitamin D supplementation (60.000 IU per month) did not reduce mortality in patients 60 years or older (unscreened individuals in Australia, many without insufficiency, average 30ng/mL). Exploratory analyses pointed towards an increased risk of death from cancer.

RCT: Vitamin D supplementation is not beneficial for the prevention of cardiovascular disease and cancer.

USPSTF Draft Statement: Insufficient evidence to recommend multivitamin supplements for the prevention of CVD or cancer. The statement also recommends against the use of beta-carotene (increases risk of CVD mortality and lung cancer) or vitamin E (clear evidence of no benefit)

USPSTF Statement: Insufficient evidence to recommend Vitamin D deficiency screening

Vitamin D, calcium, other vitamins, and supplements do not prevent cardiovascular diseases

 

Despite the ongoing spread of Omicron, some European countries have decided to lift Covid-19 restrictions.

30 Jan, 2022 | 14:37h | UTC

England lifts COVID restrictions as omicron threat recedes – Associated Press

Denmark confirms plan to lift Covid-19 restrictions on February 1st – The Local dk

Netherlands lifts toughest Covid curbs with Denmark and France set to follow – The Guardian

Denmark will lift nearly ALL Covid restrictions within days and return to ‘life as we knew it before corona’ after vaccine programme proved a ‘super-weapon’ – despite soaring cases – Daily Mail

 

Commentary on Twitter

 

Robot performs first laparoscopic surgery in a pig without human help.

30 Jan, 2022 | 14:31h | UTC

Autonomous robotic laparoscopic surgery for intestinal anastomosis – Science Robotics

Commentaries:

Robot performs first laparoscopic surgery without human help – Johns Hopkins University

In a First, a Robot Performs Laparoscopic Surgery on Pig Without Human Help – HealthDay

 

Myocarditis after BNT162b2 vaccination in Israeli adolescents.

30 Jan, 2022 | 14:34h | UTC

Myocarditis after BNT162b2 Vaccination in Israeli Adolescents – New England Journal of Medicine

Related:

Myocarditis cases reported after mRNA-Based COVID-19 vaccination in the US from December 2020 to August 2021.

A case-control study showed an increased risk of myocarditis after COVID-19 vaccination with a messenger RNA vaccine compared to an inactivated virus vaccine.

[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

Case series with 139 adolescents and young adults with suspected myocarditis following mRNA vaccination showed most cases had a mild clinical course and rapid resolution of symptoms.

Heart-inflammation risk from Pfizer COVID vaccine is very low.

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

Large Observational study shows Pfizer Covid vaccine is mostly safe but is associated with increased risk of myocarditis, adenopathy, appendicitis, and herpes zoster.

 

Commentary on Twitter

 

ELSO Guidelines for adult and pediatric extracorporeal membrane oxygenation circuits.

30 Jan, 2022 | 14:25h | UTC

ELSO Guidelines for Adult and Pediatric Extracorporeal Membrane Oxygenation Circuits – ASAIO Journal

Related: ELSO Guidelines for anticoagulation in adult and pediatric patients using extracorporeal membrane oxygenation (ECMO).

 

Commentary on Twitter

 

Systematic Review: Low‐carbohydrate vs. balanced‐carbohydrate diets for reducing weight and cardiovascular risk.

30 Jan, 2022 | 14:28h | UTC

Low‐carbohydrate versus balanced‐carbohydrate diets for reducing weight and cardiovascular risk – Cochrane Library

Summary: Low-carbohydrate diets or balanced-carbohydrate diets: which works better for weight loss and heart disease risks? – Cochrane Library

Commentary: Featured review: Low-carbohydrate versus balanced-carbohydrate diets for reducing weight and cardiovascular risk – Cochrane Library

 

Commentary on Twitter

 

The 2021 EULAR and ACR points to consider for diagnosis and management of autoinflammatory type I interferonopathies: CANDLE/PRAAS, SAVI and AGS.

30 Jan, 2022 | 14:19h | UTC

The 2021 EULAR and ACR points to consider for diagnosis and management of autoinflammatory type I interferonopathies: CANDLE/PRAAS, SAVI and AGS – Annals of Rheumatic Diseases

 

ESPEN practical guideline: Home enteral nutrition.

30 Jan, 2022 | 14:21h | UTC

ESPEN practical guideline: Home enteral nutrition – Clinical Nutrition

 

RCT: Olanzapine may improve the control of vomiting in the delayed phase in children receiving highly emetogenic chemotherapy.

30 Jan, 2022 | 14:13h | UTC

Efficacy and Safety of Olanzapine in Children Receiving Highly Emetogenic Chemotherapy: A Randomized, Double-blind Placebo-controlled Phase 3 Trial – Journal of Pediatric Hematology/Oncology (link to abstract – $ for full-text)

 

European Consensus: Prevention of periprosthetic joint infection in total hip and knee replacement.

30 Jan, 2022 | 14:17h | UTC

Prevention of Periprosthetic Joint Infection in Total Hip and Knee Replacement: One European Consensus – Journal of Clinical Medicine

 

Guideline Summary: Management of the top 10 most common immune-related adverse events in patients treated with immune checkpoint inhibitor therapy.

30 Jan, 2022 | 14:11h | UTC

Management of the Top 10 Most Common Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy – JCO Oncology Practice

Original Article: ASCO Guideline Update: Management of immune-related adverse events in patients treated with immune checkpoint inhibitor therapy.

Related:

Clinical practice guideline on immune checkpoint inhibitor-related adverse events.

NCCN Guidelines Insights: Management of Immunotherapy-Related Toxicities (several resources on the subject)

 

Systematic Review: Combined intermittent pneumatic leg compression and pharmacological prophylaxis for prevention of venous thromboembolism.

30 Jan, 2022 | 14:04h | UTC

Combined intermittent pneumatic leg compression and pharmacological prophylaxis for prevention of venous thromboembolism – Cochrane Library

 

Review: Essential tremor.

30 Jan, 2022 | 14:08h | UTC

Essential tremor – Nature Reviews Disease Primers (if the link is paywalled, try this one)

Infographic: Essential tremor (if the link is paywalled, try this one)

 

Commentary on Twitter

 

M-A: Helicobacter pylori eradication may result in modest improvement in functional dyspepsia.

30 Jan, 2022 | 14:01h | UTC

Efficacy of Helicobacter pylori eradication therapy for functional dyspepsia: updated systematic review and meta-analysis – Gut (link to abstract – $ for full-text)

Commentary: H. pylori eradication therapy may lead to better outcomes for functional dyspepsia – ACP Gastroenterology

 

Cohort study: Functional ophthalmic factors associated with extreme prematurity in young adults.

30 Jan, 2022 | 14:03h | UTC

Functional Ophthalmic Factors Associated With Extreme Prematurity in Young Adults – JAMA Network Open

Commentary: Extremely Preterm Babies Have Higher Risk of Eye Problems as Adults – MedPage Today (free registration required)

 

Commentary on Twitter

 

M-A: SGLT-2 inhibitors and cardiovascular outcomes in patients with and without a history of heart failure.

30 Jan, 2022 | 13:56h | UTC

SGLT-2 inhibitors and cardiovascular outcomes in patients with and without a history of heart failure: a systematic review and meta-analysis – European Heart Journal – Cardiovascular Pharmacotherapy

 

Commentary on Twitter

 

Risk of obstetric anal sphincter injury among women who birth vaginally after a prior cesarean section: A state-wide cohort study.

30 Jan, 2022 | 13:48h | UTC

Risk of obstetric anal sphincter injury among women who birth vaginally after a prior caesarean section: A state-wide cohort study – BJOG (link to abstract – $ for full-text)

Commentary: Vaginal birth after caesarean increases the risk of serious perineal tear by 20%, our large-scale review shows – The Conversation

 

Differential levels of plasma biomarkers of neurodegeneration in Lewy body dementia, Alzheimer’s disease, frontotemporal dementia and progressive supranuclear palsy.

30 Jan, 2022 | 13:53h | UTC

Differential levels of plasma biomarkers of neurodegeneration in Lewy body dementia, Alzheimer’s disease, frontotemporal dementia and progressive supranuclear palsy – Journal of Neurology, Neurosurgery, and Psychiatry

Commentary: Blood Biomarkers May Distinguish Dementia Disorders – MedPage Today (free registration required)

 

10 mistakes in dietary management of irritable bowel syndrome and how to avoid them.

30 Jan, 2022 | 13:59h | UTC

Mistakes in dietary management of IBS and how to avoid them – United European Gastroenterology

Related:

Supplement: Irritable bowel syndrome and related conditions.

RCT: FODMAPs, but not gluten, elicit modest symptoms of irritable bowel syndrome.

RCT: Among patients with diarrhea-predominant irritable bowel syndrome, a low FODMAP diet achieved earlier symptomatic improvements in stool frequency and excessive wind.

British Society of Gastroenterology guidelines on the management of irritable bowel syndrome

Guidelines for the treatment of irritable bowel syndrome

ACG Clinical Guideline: Management of irritable bowel syndrome

M-A: Efficacy of a low-FODMAP diet in adult irritable bowel syndrome

 

Commentary on Twitter (thread – click for more)

 

Registry study in South Korea showed delayed hospitalization for Non–ST-Segment Elevation Myocardial Infarction is associated with increased risk of 3-year all-cause mortality.

30 Jan, 2022 | 13:45h | UTC

Clinical Outcomes in Patients With Delayed Hospitalization for Non–ST-Segment Elevation Myocardial Infarction – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentary: Delays in NSTEMI hospitalization linked to lower survival – MDedge Cardiology

 

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