TOP 10 Medical News Stories
Fri April 26 – 10 Stories of The Day!
26 Apr, 2019 | 02:22h | UTC
1 – World Immunization Week, 24 – 30 April 2019 – World Health Organization (free resources)
See also: #vaccineswork (free text and infographics)
Related: NICE Guideline – Renal and Ureteric Stones: Assessment and Management (free guidelines)
3 – β blockers to prevent decompensation of cirrhosis in patients with clinically significant portal hypertension (PREDESCI): a randomised, double-blind, placebo-controlled, multicentre trial – The Lancet (link to abstract – $ for full-text)
Commentary: Beta-blockers linked to better outcomes in some patients with cirrhosis – ACP Gastroenterology (free)
See also: Long-Term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention: A Systematic Review – Agency for Healthcare Research and Quality (free) AND Full Report (free PDF) AND Evidence Summary (free PDF)
5 – Telehealth for Acute and Chronic Care Consultations – Agency for Healthcare Research and Quality (free)
See also: Full Report (free PDF) AND Evidence Summary (free PDF)
6 – Association of Duration and Type of Surgical Prophylaxis With Antimicrobial-Associated Adverse Events – JAMA Surgery (free for a limited period)
Commentaries: Balancing the Risks and Benefits of Surgical Prophylaxis: Timing and Duration Do Matter – JAMA Surgery (free for a limited period) AND Longer Antibiotic Rx After Surgery Tied to Increasing Harms, Limited Benefits – NEJM Journal Watch (free)
7 – Using behavioural economics to improve healthcare and prevent doctor burnout – The BMJ Opinion (free)
8 – A Good Life And A Good Death: What Is Palliative Care? – NPR (free)
9 – Colorectal Cancer Screening – JAMA (free for a limited period)
Related: Colorectal Cancer Screening for Average‐risk Adults (guidelines from other organizations)
Commentaries: How much do sedentary people really need to move? It’s less than you think – The Conversation (free) AND Physical Activity May Offset Mortality Risk Caused by Too Much Sitting – American College of Cardiology (free) AND Sitting Kills, in a Dose-Response Fashion, but Regular Physical Activity Attenuates Risks – TCTMD (free) AND Computers, not TV, are to blame for increase in US sitting time, study says – CNN (free)
Thu April 25 – 10 Stories of The Day!
25 Apr, 2019 | 07:15h | UTC
News Release: To grow up healthy, children need to sit less and play more (free)
Commentaries: WHO recommends one-hour maximum screen time per day for under-5s – Reuters (free) AND Expert reaction to guidance on physical activity, sedentary behaviour and sleep for children under 5 years of age – Science Media Centre (free) AND No sedentary screen time for babies, WHO says – BBC (free)
Related Cochrane Review: Posture and fluids for preventing post‐dural puncture headache (free) AND Summary: Body position and intake of fluids for preventing headache after a lumbar puncture (free)
After a lumbar puncture in children, a shorter time (30 min) of fasting and lying supine without a pillow is not associated with a higher risk of post-lumbar puncture headache or lower back pain.
Related: AAP/AHA Policy Statement: Public Policies to Reduce Sugary Drink Consumption in Children and Adolescents (free)
Related: Guidelines on the investigation and management of antiphospholipid syndrome – British Journal of Haematology (free)
6 – Malaria vaccine pilot launched in Malawi – World Health Organization (free)
Commentaries: World’s first malaria vaccine to go to 360,000 African children – CNN (free) AND Widespread Testing Begins on Malaria Vaccine That Is Only Partly Effective – The New York Times (10 articles per month are free)
Original Research: Oral versus Intravenous Antibiotics for Bone and Joint Infection (link to abstract and commentaries)
8 – The association between vegetation size and surgical treatment on 6-month mortality in left-sided infective endocarditis – European Heart Journal (link to abstract – $ for full-text)
Commentary: Early Surgery and Mortality Among Patients with IE and Large Vegetation – American College of Cardiology (free)
Wed April 24 – 10 Stories of The Day!
24 Apr, 2019 | 10:22h | UTC
1 – Draft Recommendation Statement: Asymptomatic Bacteriuria in Adults: Screening – U.S. Preventive Services Task Force (free)
Commentary: USPSTF Eases Recommendation for Asymptomatic Bacteriuria Screening in Pregnant Women – NEJM Journal Watch (free)
This review summarizes the latest exercise prescription treatments for 26 different diseases.
Commentary: Getting hospital patients up and moving shortens stay and improves fitness – NIHR Signal (free)
Related: Randomized Trial: Effect of Exercise Intervention on Functional Decline in Very Elderly Patients During Acute Hospitalization (link to abstract and commentaries)
Related: Things We Do For No Reason: Neutropenic Diet – Journal of Hospital Medicine (free)
7 – Long-Term Weight Loss with Metformin or Lifestyle Intervention in the Diabetes Prevention Program Outcomes Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Metformin may help patients maintain weight loss long-term – American College of Physicians (free) AND Metformin may help people at high diabetes risk to maintain weight loss – Medicine Matters (free) AND Metformin may help patients maintain long-term weight loss – 2 Minute Medicine (free)
8 – Association of Caloric Intake From Sugar-Sweetened Beverages With Water Intake Among US Children and Young Adults in the 2011-2016 National Health and Nutrition Examination Survey – JAMA Pediatrics (free for a limited period)
Commentaries: Kids Who Don’t Drink Water, More Likely To Drink Sugar-Sweetened Beverages – MedicalResearch.com (free) AND Not drinking water may boost kids’ consumption of sugary beverages – Penn State (free) AND Drinking water linked to fewer sugary drinks — and calories — in kids – CNN (free) AND Drinking water might help kids limit soda – Reuters (free)
9 – Hepatorenal Syndrome – Clinical Journal of American Society of Nephrology (free for a limited period)
Related: Epidemiology, Pathophysiology, and Management of Hepatorenal Syndrome (free guidelines and reviews)
Tue April 23 – 10 Stories of The Day!
23 Apr, 2019 | 01:58h | UTC
3 – Metformin in 2019 – JAMA (free for a limited period)
4 – High-Fiber Diet Might Protect Against Range of Conditions – JAMA (free for a limited period)
5 – Why most diagnostic procedures aren’t beneficial – PulmCrit (free)
“when strict evidence-based medicine is applied to procedures, they are often less impressive”.
6 – Sleep-Related Infant Suffocation Deaths Attributable to Soft Bedding, Overlay, and Wedging – Pediatrics (link to abstract – $ for full-text)
News Release: Study: Soft bedding top cause of infant suffocation during sleep – AAP News (free)
Commentaries: Soft bedding poses grave danger to sleeping babies, study shows – University of Virginia Health System (free) AND Soft bedding top cause of suffocation death for sleeping babies in U.S. – Reuters (free) AND Soft Bedding a Leading Cause of Infant Suffocation – U.S. News (free)
7 – Foreign-Body Ingestions of Young Children Treated in US Emergency Departments: 1995–2015 – Pediatrics (link to abstract – $ for full-text)
Commentaries: Increase in foreign body ingestions among young children – Nationwide Children’s Hospital (free) AND US sees sharp rise in number of kids swallowing small objects – Nature News (free) AND Children Are Swallowing Foreign Objects More Frequently, Study Finds – The New York Times (10 articles per month are free)
Commentary: Study finds that quitting smoking during pregnancy lowers risk of preterm births – The Geisel School of Medicine at Dartmouth (free)
Mon April 22 – 10 Stories of The Day!
22 Apr, 2019 | 02:27h | UTC
1 – Nutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus Report – Diabetes Care (free PDF)
2 – Chronic cough and gastroesophageal reflux in children – CHEST Guideline and Expert Panel Report (free PDF)
Related: Clinical Practice Guidelines for Diagnosis and Management of Cough (free guidelines)
News Release: New safety and health issues emerge as work changes (free)
Commentary: Stress, overtime, disease, contribute to 2.8 million workers’ deaths per year, reports UN labour agency – United Nations (free)
4 – Shared Decision Making and the Importance of Time – JAMA (free for a limited period)
5 – How long do vaccines last? The surprising answers may help protect people longer – Science (free)
6 – Perspective: Why Do Doctors Overtreat? For Many, It’s What They’re Trained to Do – NPR (free)
Commentary: Paracetamol for dengue fever: no benefit and potential harm? – The Lancet Global Health (free)
9 – Measles in 2019 — Going Backward – New England Journal of Medicine (free)
Related: Measles Cases are up Nearly 300% From Last Year. This is a Global Crisis (free commentary and WHO Statement)
10 – Effectiveness and Acceptability of Cognitive Behavior Therapy Delivery Formats in Adults With Depression: A Network Meta-analysis – JAMA Psychiatry (free for a limited period)
Editorial: Can Network Meta-analysis Substitute for Direct Comparisons in Psychotherapy Trials? (free for a limited period)
Commentaries: Certain Variations of CBT Found as Effective as Individual CBT – Psychiatric News Alert (free) AND Group, telephone, guided CBT treatment effective for depression – MedicalXpress (free)
Fri April 19 – 10 Stories of The Day!
19 Apr, 2019 | 08:45h | UTC
1 – Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation – Cochrane Library (free)
Commentaries: Nicotine replacement: when quitting cigarettes, consider using more nicotine, not less – The Conversation (free) AND Nicotine replacement therapy: new evidence on help to quit smoking – Evidently Cochrane (free) AND Nicotine replacement therapy more successful in combination form – Nuffield Department of Primary Care Health Sciences (free)
Related: Guideline: Indications for Thrombectomy in Acute Ischemic Stroke from Emergent Large Vessel Occlusion (free guidelines)
Commentaries: The accuracy of the Patient Health Questionnaire-9 for detecting major depression – The BMJ Opinion (free) AND Screening tools for depression offer value when combined with an informed shared decision process – The BMJ Opinion (free) AND Using the Patient Health Questionnaire-9 to Screen for Major Depression – NEJM Journal Watch (free)
Commentaries: Diabetes drug Metformin may fight heart disease, study says – UPI (free) AND Diabetic drug shown to reduce the risk of heart disease in non-diabetic patients – University of Dundee (free) AND Metformin reduces left ventricular mass in nondiabetic patients with CAD – Cardiovascular Business (free)
5 – Part-revived pig brains raise slew of ethical quandaries – Nature (free)
Original Study: Restoration of brain circulation and cellular functions hours post-mortem – Nature (free)
See also: Pig Experiment Raises Ethical Questions Around Brain Damage – Case Western Reserve University (free) AND Scientists: We kept pig brains alive 10 hours after death. Bioethicists: “Holy shit.” – Vox (free) AND The pigs were dead. But four hours later, scientists restored cellular functions in their brains – STAT (free) AND Scientists Partly Restore Activity in Dead-Pig Brains – The Atlantic (free)
6 – Hypertension in pregnancy: Pathophysiology and treatment – SAGE Open Medicine (free)
Related Guidelines: WHO recommendations: Drug treatment for severe hypertension in pregnancy – World Health Organization (free) AND Hypertension Canada’s 2018 Guidelines for the Management of Hypertension in Pregnancy (free)
Related Meta-Analysis: Drugs for Treating Severe Hypertension in Pregnancy (free study and commentary)
Related Review: State-of-the-Art Diagnosis and Treatment of Hypertension in Pregnancy – Mayo Clinic Proceedings (free)
8 – Management of Hypertension in Chronic Kidney Disease – Drugs (free)
Commentaries: Some patients with imminently fatal cancer still receive treatment – eCancer News (free) AND With Weeks to Live, Many Cancer Patients Try Useless Treatments – HealthDay (free)
Editorial: Perils of Observational Data Analyses (free)
Commentary: Statins for primary prevention: do benefits outweigh DM risk? – Univadis (free registration required)
Related: Cohort Study: Statin Use Associated with a 38% Higher Risk of Incident Type 2 Diabetes (free study and commentaries)
Thu April 18 – 10 Stories of The Day!
18 Apr, 2019 | 08:05h | UTC
News Release: WHO releases first guideline on digital health interventions (free)
Related Guidelines: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free)
Related Reviews: New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free) AND Severe toxicity from checkpoint protein inhibitors: What intensive care physicians need to know? – Annals of Intensive Care (free) AND Checkpoint Inhibitors: The diagnosis and treatment of side effects – Deutsches Ärzteblatt international (free)
5 – Reducing surgical mortality in Scotland by use of the WHO Surgical Safety Checklist – BJS (free)
Commentaries: Hospital deaths after surgery fall after launch of surgical safety checklists in Scotland – Wiley (free) AND Surgical safety checklist linked to decline in hospital deaths – UPI (free)
See also: WHO Surgical Safety Checklist – World Health Organization (free resources)
Commentaries: Expert reaction to screen time and inattention in preschoolers – Science Media Centre (free) AND More Screen Time = More Behavioral Problems in Preschoolers – NEJM Journal Watch (free) AND Increased screen time in preschool is linked to inattention – PLOS (free)
Commentary: Physical Inactivity Not Tied to Dementia – NEJM Journal Watch (free)
Commentaries: Smoking cessation in people with serious mental illness – The Lancet Psychiatry (free) AND New intervention doubles quit rate among smokers with severe mental illness – University of York (free) AND Smoking cessation for people with severe mental illness? “Oh yes they can!” SCIMITAR+ – The Mental Elf (free)
9 – Intensive Care Utilization in Stable Patients With ST-Segment Elevation Myocardial Infarction Treated with Rapid Reperfusion – JACC: Cardiovascular Interventions (link to abstract – $ for full-text)’
Commentaries: Many heart attack patients may be needlessly treated in ICU, study suggests – American College of Cardiology (free) AND Reperfusion Timing May Predict Post-PCI ICU Complication Rate in Stable STEMI – Cardiology Advisor (free) AND Most STEMI Patients Head to ICU After PCI, but Not All Need to Go – TCTMD (free) AND ICUs overused for STEMI patients – Cardiovascular Business (free)
Commentaries: Even moderate red and processed meat eaters at risk of bowel cancer – Cancer Research UK (free) AND Expert reaction to red and processed meat consumption and risk of colorectal cancer – Science Media Centre (free)
Wed April 17 – 10 Stories of The Day!
17 Apr, 2019 | 06:40h | UTC
3 – NICE Guideline: Ectopic pregnancy and miscarriage: diagnosis and initial management – National Institute for Health and Care Excellence (free)
4 – Effect of a Workplace Wellness Program on Employee Health and Economic Outcomes: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Employer Wellness Programs—A Work in Progress (free)
Commentaries: Workplace wellness programs may help people change certain behaviors but do little to improve overall health or lower spending, study shows – Harvard Medical School (free) AND How Well Do Workplace Wellness Programs Work? – NPR (free) AND Harvard Study On Workplace Wellness: Behaviors Change But Health Does Not — So Far – CommonHealth (free) AND Employee Wellness Programs Yield Little Benefit, Study Shows – The New York Times (free)
Related: Workplace Wellness Programs Don’t Work Well. Why Some Studies Show Otherwise (free)
Commentary: Mid-life resting heart rate of 75 plus beats/minute linked to doubling in early death risk – BMJ (free)
Commentaries: A Modern Snapshot of the Daily Work of Medical Interns—The Burden of Indirect Patient Care – JAMA Internal Medicine (free) AND First-year doctors spend almost 90% of their time away from patients – University Of Pennsylvania School Of Medicine (free) AND First-year trainee doctors spend little time on patient care – Reuters (free) AND Medical Interns Spend 87 percent of Their Work Time Away From Patients – MedicalResearch.com (free)
Commentaries: Additional routine ultrasounds benefit mothers and babies, and could be cost saving, study finds – PLOS (free) AND Expert reaction to study on additional routine ultrasounds – Science Media Centre (free)
8 – Management of transient ischemic attack or nondisabling stroke related to extracranial internal carotid artery stenosis – Canadian Medical Association Journal (free for a limited period)
Commentaries: FDA: Companies Must Stop Selling Vaginal Meshes for Pelvic Organ Prolapse – NEJM Journal Watch (free) AND F.D.A. Halts U.S. Sales of Pelvic Mesh, Citing Safety Concerns for Women – The New York Times (10 articles per month are free) AND US halts sales of pelvic mesh tied to injuries in women – Associated Press (free)
Related: Mesh Implants for Women: Scandal or Standard of Care? – JAMA (free for a limited period)
Commentaries: Population versus individual protection by pneumococcal conjugate vaccination – The Lancet (free) AND PCV10 pneumococcal vaccine has big impact in Kenya, even among unvaccinated individuals – Johns Hopkins University Bloomberg School of Public Health (free)
Tue April 16 – 10 Stories of The Day!
16 Apr, 2019 | 02:56h | UTC
1 – Measles cases are up nearly 300% from last year. This is a global crisis – CNN (free)
WHO Statement: New measles surveillance data for 2019 – World Health Organization (free)
By Henrietta H Fore (executive director of UNICEF) and Tedros Adhanom Ghebreyesus (director general of the World Health Organization).
2 – Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy – New England Journal of Medicine (free for a limited period)
Commentary: Canagliflozin may offer renal protection in people with type 2 diabetes and CKD – Medicine Matters (free)
“among 1000 patients treated for 2.5 years, 21.2 individuals would need to be treated to prevent the composite primary outcome.” (from Medicine Matters)
Commentaries: Statins safe for rheumatoid arthritis patients – University of Dundee (free) AND Statins safe for preventing cardiovascular events in rheumatoid arthritis patients, study suggests – Wiley (free)
Commentaries: FDA added sugar label could be a cost-effective way to improve health, generate savings – Tufts University (free) AND New Added Sugar Labeling Could Cut CVD, Spur $31 Billion in Healthcare Savings – TCTMD (free) AND Study: Sugar-added labels could prevent 600,000 diabetes cases – UPI (free) AND New ‘added sugars’ labeling could save money and improve health – Reuters (free)
5 – Alex Nowbar’s research reviews, 15 April 2019 – The BMJ Opinion (free)
6 – Prevalence and Nondisclosure of Complementary and Alternative Medicine Use in Patients With Cancer and Cancer Survivors in the United States – JAMA Oncology (free for a limited period)
Commentary: One-third of cancer patients use complementary and alternative medicine – UT Southwestern Medical Center (free) AND How Many Cancer Patients Use Complementary or Alternative Medicine Treatments? – MedicalResearch.com (free) AND Many cancer patients take alternative meds but don’t tell doctors – UPI (free)
Related: Use of Alternative Medicine for Cancer and Its Impact on Survival (free study and commentaries)
7 – Natural History of Spontaneous Coronary Artery Dissection With Spontaneous Angiographic Healing – JACC: Cardiovascular Interventions (link to abstract – $ for full-text)
Commentaries: Majority of SCAD Lesions Heal With Conservative Treatment – TCTMD (free) AND Spontaneous Angiographic Healing With SCAD – American College of Cardiology (free) AND SCAD: Spontaneous Healing Common With Conservative Treatment – Medscape (free registration required)
9 – Acute Renal Failure of Nosocomial Origin – Deutsches Ärzteblatt international (free)
Commentary: Maternal gestational diabetes linked to diabetes in children – CMAJ (free)
Mon, April 15 – 10 Stories of The Day!
15 Apr, 2019 | 01:07h | UTC
1 – EASL Clinical Practice Guidelines: Drug-induced liver injury – Journal of Hepatology (free)
Related Review: Drug-induced liver injury: recent advances in diagnosis and risk assessment – Gut (free)
4 – Top studies relevant to primary care from 2018 – Canadian Family Physician (free)
5 – Postoperative Mobilization After Superior Rotator Cuff Repair: Sling Versus No Sling: A Randomized Prospective Study – The Journal of Bone & Joint Surgery (link to abstract – $ for full-text)
Commentaries: No Sling After Rotator Cuff Repair: Balancing Short-Term Benefit with Long-Term Health of Shoulder – The Journal of Bone & Joint Surgery (free) AND To Sling or Not to Sling? Study Finds Better Outcomes with Early Motion after Rotator Cuff Surgery – Wolters Kluwer (free)
6 – Pruritus and Patient Reported Outcomes in Non-Dialysis CKD – Clinical Journal of the American Society of Nephrology (free for a limited period)
Commentaries: Itchy Skin Affects the Health and Quality of Life of Many Patients with Kidney Disease – American Society of Nephrology (ASN) (free) AND Pruritus Common, Bothersome in Non-Dialysis CKD – Renal & Urology News (free)
7 – Ultrasound-guided vascular access in critical illness – Intensive Care Medicine (free PDF)
Related: Guidelines for Colonic Diverticular Bleeding and Colonic Diverticulitis (free guidelines on the subject)
Original Report: Statement on the meeting of the International Health Regulations (2005) Emergency Committee for Ebola virus disease in the Democratic Republic of the Congo on 12th April 2019 – World Health Organization (free)
See also: WHO stops short of declaring Ebola crisis a global health emergency – STAT (free) AND The WHO just decided the latest Ebola outbreak is not a global emergency – Vox (free)
Fri, April 12 – 10 Stories of The Day!
12 Apr, 2019 | 01:55h | UTC
1 – Compendium on the Pathophysiology and Treatment of Hypertension – Circulation Research (free articles)
– Homepage
– Editorial: Introduction to a Compendium on the Pathophysiology and Treatment of Hypertension
– Adherence in Hypertension: A Review of Prevalence, Risk Factors, Impact, and Management
– Two-Drug Combinations as First-Step Antihypertensive Treatment
– Preeclampsia: Pathophysiology, Challenges, and Perspectives
– Treatment of Resistant and Refractory Hypertension
– Hypertension Management in Older and Frail Older Patients
– Neurovascular and Cognitive Dysfunction in Hypertension: Epidemiology, Pathobiology, and Treatment
– Metabolic Surgery for Hypertension in Patients With Obesity
– Blood Pressure Measurement and Treatment Decisions: Masked and White-Coat Hypertension
2 – NICE Guideline: Surgical site infections: prevention and treatment – National Institute for Health and Care Excellence (free)
Related Guidelines: Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017 – JAMA Surgery (free) AND Global guidelines on the prevention of surgical site infection – World Health Organization (free) AND Infection prevention in the operating room anesthesia work area – Infection Control & Hospital Epidemiology (free)
3 – NICE Guideline: Caesarean section – National Institute for Health and Care Excellence (free)
Editorial: Stress, psychiatric disorders, and cardiovascular disease (free)
Commentaries: Stress-related disorders linked to heightened risk of cardiovascular disease – The BMJ (free) AND Stress from Traumatic Events Linked to Increased Risk of Heart Disease – MedicalResearch.com (free) AND Expert reaction to study looking at stress related disorders and risk of cardiovascular disease – Science Media Centre (free)
Commentary: 1 in 8 MSM Tested Positive for STIs in Throat, Rectum – NEJM Journal Watch (free)
6 – Association of Positive Airway Pressure Prescription With Mortality in Patients With Obesity and Severe Obstructive Sleep Apnea: The Sleep Heart Health Study – JAMA Otolaryngology Head Neck Surgery (free for a limited period)
Commentaries: Positive Airway Pressure and Survival in Patients With Obstructive Sleep Apnea – JAMA Otolaryngology Head Neck Surgery (free) AND Positive Airway Pressure Might Reduce Mortality in Sleep Apnea – NEJM Journal Watch (free)
Related: Pro/Con Debate: Should Asymptomatic Patients with Moderate-to-severe OSA be Treated? (free)
Long term randomized trials are required to better address this issue.
Commentaries: NO2 increases the risk for childhood asthma: a global concern – The Lancet Planetary Health (free) AND Traffic-related air pollution associated with 4 million new cases of childhood asthma every year – The Lancet (free) AND Millions of children worldwide develop asthma annually due to traffic-related pollution – George Washington University (free) AND Expert reaction to air pollution and childhood asthma – Science Media Centre (free)
Related: Hypothyroidism in the Elderly: Who Should Be Treated and How? (free) AND Meta-Analysis: Treating Subclinical Hypothyroidism is Not Associated with Quality of Life and Thyroid-Related Symptoms (free) AND Review: Pitfalls on the Replacement Therapy for Hypothyroidism (free) AND Subclinical Hypothyroidism: When to Treat (free) AND Randomized Trial: Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism (free study and commentary)
Thu, April 11 – 10 Stories of The Day!
11 Apr, 2019 | 00:52h | UTC
Commentaries: Stillbirth threefold increase when sleeping on back in pregnancy – University of Huddersfield (free) AND Mega study confirms pregnant women can reduce risk of stillbirth by sleeping on their side – The Conversation (free)
5 – Proposal: Reforming disease definitions: a new primary care led, people-centred approach – BMJ Evidence Based Medicine (free)
Commentary: We need new rules for defining who is sick. Step 1: remove vested interests – The Conversation (free)
6 – Annals Graphic Medicine – Patient-Informed Consent – Annals of Internal Medicine (free)
Original Article: Medical Graphic Narratives to Improve Patient Comprehension and Periprocedural Anxiety Before Coronary Angiography and Percutaneous Coronary Intervention: A Randomized Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary: Comic illustrations enhance informed consent before coronary angiography – Cardiovascular Business (free)
7 – Effect of an Incentive Spirometer Patient Reminder After Coronary Artery Bypass Grafting: A Randomized Clinical Trial – JAMA Surgery (free for a limited period)
Invited Commentary: Benefits of Incentive Spirometry: Still More Work to Do – JAMA Surgery (free)
Simple intervention leading to improved outcomes, but confirmatory studies are required (see invited commentary).
Commentary: Reducing the risk of type 2 diabetes in men with benign prostatic hyperplasia—old steroids, new tricks – The BMJ Opinion (free)
9 – Guideline Synopsis: 2018 American Heart Association / American College of Cardiology Multisociety Guideline on the Management of Blood Cholesterol: Primary Prevention – JAMA Cardiology (free for a limited period)
10 – Four Cases of Cholesterol Management Informed by the 2018 American Heart Association / American College of Cardiology Multisociety Guideline on the Management of Blood Cholesterol – JAMA Cardiology (free for a limited period)
Wed, April 10 – 10 Stories of The Day!
10 Apr, 2019 | 06:25h | UTC
News Release: How can therapy for heart attack patients help cancer survivors? (free)
Top Things to Know: Cardio-Oncology Rehabilitation to Manage Cardiovascular Outcomes in Cancer Patients and Survivors (free)
Commentaries: Exercise-focused Rehabilitation for Cancer Survivors: Creating a CORE Component of Oncology Care – American Heart Association (free) AND Cardio-oncology rehab programs proposed for CVD risk reduction – Cardiovascular Business (free)
Related: AHA Scientific Statement on Cardio-Oncology: Vascular and Metabolic Perspectives (several guidelines on the subject)
2 – Association of HIV Preexposure Prophylaxis With Incidence of Sexually Transmitted Infections Among Individuals at High Risk of HIV Infection – JAMA (free for a limited period)
Editorial: Addressing the Sexually Transmitted Infection and HIV Syndemic (free)
Commentary: Dramatic Rise in STIs With PrEP Among Gay, Bisexual Men – MedPage Today (free registration required)
Related Study: Incidence of sexually transmitted infections before and after preexposure prophylaxis for HIV (free)
3 – Non‐invasive positive pressure ventilation (CPAP or bilevel NPPV) for cardiogenic pulmonary oedema – Cochrane Library (free)
Summary: A breathing intervention for shortness of breath due to heart failure – Cochrane Library (free)
Related Guidelines: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free)
Related Reviews: New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free) AND Severe toxicity from checkpoint protein inhibitors: What intensive care physicians need to know? – Annals of Intensive Care (free)
Related: Optimal Perioperative Management of the Geriatric Patient: A Best Practices Guideline from the American College of Surgeons NSQIP and the American Geriatrics Society (free) AND Peri‐operative optimisation of elderly and frail patients: a narrative review – Anaesthesia (free) AND Surgical Guidelines for Perioperative Management of Older Adults: What Geriatricians Need to Know – Journal of The American Geriatrics Society (free) AND Peri-operative care of the elderly 2014: Association of Anaesthetists of Great Britain and Ireland (free)
6 – Ann Robinson’s research reviews, 9 April 2019 – The BMJ Opinion (free)
Ann Robinson reviews the latest research from the top medical journals.
7 – What Are Polygenic Scores and Why Are They Important? – JAMA (free for a limited period)
Related: How Scientists are Learning to Predict Your Future with Your Genes (free)
“Before polygenic scores can be translated into clinical practice they will need to be extensively validated in clinical and population-based cohorts for their ability to predict meaningful outcomes that can be modified with intervention.”
8 – France Is First to Ban Breast Implants Linked to Rare Cancer – The New York Times (10 articles per month are free)
Related: FDA Report: 660 Cases of Breast Implant-Associated Anaplastic Large Cell Lymphoma (report and commentaries on the subject)
9 – Unusual Effects of Common Antibiotics – Cleveland Clinic Journal of Medicine (free)
10 – Association Among Dietary Supplement Use, Nutrient Intake, and Mortality Among U.S. Adults: A Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Nutrients from food, not supplements, linked to lower risks of death, cancer – Tufts University (free) AND Taking Vitamins Doesn’t Seem to Lower Mortality Risk – NEJM Journal Watch (free) AND Elevated cancer risk linked to excessive calcium intake, study says – UPI (free) AND Expert reaction to nutrient intake, dietary supplement use and mortality in the US – Science Media Centre (free)
Related: The Multivitamin Industry Rakes in Billions of Dollars. But Science Says We’re Not Getting Healthier (free commentary)
Tue, April 9 – 10 Stories of The Day!
9 Apr, 2019 | 02:30h | UTC
Summary for Patients: Breast Cancer Screening in Average-Risk Women (free)
News Release: ACP issues guidance statement for breast cancer screening of average-risk women (free)
Commentaries: ACP Guideline Discourages Breast Cancer Screening for Average-Risk Women in Their 40s – NEJM Journal Watch (free) AND Most women need mammograms every other year starting at 50 – Reuters (free)
Related Guidelines: Breast Cancer: Screening – U.S.Preventive Services Task Force (free) AND New Canadian Recommendations on Screening for Breast Cancer (free) AND American Cancer Society Breast Cancer Screening Guideline (free) AND Breast Cancer Risk Assessment and Screening in Average-Risk Women – American College of Obstetricians and Gynecologists (free) AND Recommendations from European Breast Guidelines (free)
News Release: Experts issue new recommendations for the diagnosis & treatment of maternal sepsis – Society for Maternal-Fetal Medicine (free)
3 – Endoscopic management of common bile duct stones: European Society of Gastrointestinal Endoscopy (ESGE) guideline – Endoscopy (free for a limited period)
Commentary: New Guideline on Management of Common Bile Duct Stones – NEJM Journal Watch (free for a limited period)
4 – Antibiotic Prescribing During Pediatric Direct-to-Consumer Telemedicine Visits – Pediatrics (link to abstract – $ for full-text)
Commentaries: Study finds high rate of antibiotic prescribing in kids’ telemedicine visits – CIDRAP (free) AND Pediatric telemedicine visits may increase antibiotic overprescribing – University of Pittsburgh (free)
5 – Cost Avoidance Associated with Clinical Pharmacist Presence in a Medical Intensive Care Unit – Journal of the American College of Clinical Pharmacy (free PDF) (via @ABsteward)
6 – Podcast: #147 Rheumatoid Arthritis for the Internist – The Curbsiders Internal Medicine Podcast (free audio and summary)
7 – State of the Art Review: Depression in primary care: part 1—screening and diagnosis – The BMJ (free for a limited period)
Depression in primary care: part 2—management (free)
8 – Tailoring the Approach to Embolic Stroke of Undetermined Source: A Review – JAMA Neurology (free for a limited period)
“Vitamin D toxicity is rare, but clinicians must be aware of the risks of vitamin D use to limit complications related to hypercalcemia”.
10 – 10 Tips for Intensive Care Management of Transplanted Patients – Intensive Care Medicine (free articles)
– 10 tips for intensive care management of transplanted heart patients
– 10 tips for intensive care management of transplanted liver patients
– 10 tips for the intensive care management of transplanted lung patients
– 10 tips to manage renal transplant recipients
Mon, April 8 – 10 Stories of The Day!
8 Apr, 2019 | 01:24h | UTC
News Release: Uneven access to health services drives life expectancy gaps: WHO (free)
Editorial: The CHAT Trial:Time for a Heart to Heart Talk (free)
Very important negative study.
Commentaries: Control of scabies and secondary impetigo: optimising treatment effectiveness in endemic settings – The Lancet Infectious Diseases (free) AND Mass drug administration reduces scabies cases by 90% in Solomon Islands’ communities – London School of Hygiene & Tropical Medicine (free)
News Release: Real cost of heart attacks and strokes: double the direct medical expense – European Society of Cardiology (free)
7 – Cardiogenic Shock – Journal of the American Heart Association (free)
Related Guideline: AHA Guideline: Contemporary Management of Cardiogenic Shock (free)
Related Review: Reconsidering Vasopressors for Cardiogenic Shock: Everything should be made as simple as possible, but not simpler – Chest (free PDF)
Commentaries: Nonsmokers at Risk for COPD, Too – NEJM Journal Watch (free) AND CDC: Prevalence of COPD High Among Some Nonsmokers – HealthDay (free)
9 – A Mysterious Infection, Spanning the Globe in a Climate of Secrecy – The New York Times (10 articles per month are free)
Related: CDC Guideline: Candida auris (free) AND A ‘perfect storm’ superbug: How an invasive fungus got health officials’ attention (free) AND Review: Candida auris: A rapidly emerging cause of hospital-acquired multidrug-resistant fungal infections globally (free) AND Epidemiology, Clinical Characteristics, Resistance, and Treatment of Infections by Candida Auris (free)
“The rise of Candida auris embodies a serious and growing public health threat: drug-resistant germs.”
Commentaries: Unite for a Framework Convention for Alcohol Control – The Lancet (free) AND Even one alcoholic drink a day can raise risk of stroke, study says – CNN (free) AND Expert reaction to research on alcohol intake and stroke – Science Media Centre (free) AND Major study debunks myth that moderate drinking can be healthy – Reuters (free)
Related: Alcohol Use and Burden for 195 Countries and Territories (free study and commentaries) AND WHO Global Status Report on Alcohol and Health 2018 (free study and commentaries)
Fri, April 5 – 10 Stories of The Day!
5 Apr, 2019 | 01:14h | UTC
Commentaries: What is the most effective way to deliver subcutaneous insulin—pumps or injections? – The BMJ Opinion (free) AND Randomized trial questions superiority of insulin pumps over injections in children – MedWire News (free)
Related: Insulin pumps not much better than multiple injections for intensive control of type 1 diabetes (free study and commentary)
Commentaries: Screening interval: a public health blind spot – The Lancet Public Health (free) AND The screen interval for high cardiovascular disease risk should be individual – University of Helsinki (free)
3 – Report: State of Global Air / 2019 – Health Effects Institute (free PDF)
News Release: State of Global Air 2019 Report – Institute for Health Metrics and Evaluation (free)
See also: State of Global Air Website (free resources)
Commentary: Toxic air will shorten children’s lives by 20 months, study reveals – The Guardian (free)
“A Special Report on Global Exposure to Air Pollution and Its Disease Burden”
Editorial: The remarkable impact of bivalent HPV vaccine in Scotland (free)
Commentaries: Tim Palmer: Bivalent HPV vaccine in Scotland is having a considerable and sustained effect – The BMJ Opinion (free) AND HPV Vaccination Program Brings Lower Rates of Cervical Disease in Scotland – NEJM Journal Watch (free) AND HPV programme linked to dramatic fall in cervical disease – OnMedica (free)
5 – Viewpoint: The Importance of Predefined Rules and Prespecified Statistical Analyses: Do Not Abandon Significance – JAMA (free)
Original Article: Scientists Rise Up Against Statistical Significance (free)
Related: Retire Statistical Significance? Really? – Unboxing Evidence Based Medicine (free)
Commentary: FDA is investigating reports of seizures after vaping – STAT (free) AND Seizures After E-Cigarette Use Prompt FDA Investigation – NEJM Journal Watch (free)
7 – Texting-While-Driving Bans and Motor Vehicle Crash–Related Emergency Department Visits in 16 US States: 2007–2014 – American Journal of Public Health (link to abstract – $ for full-text)
Commentaries: Bans on texting while driving tied to drop in ER visits for crash injuries – Reuters (free) AND Car crash ER visits fell in states that ban texting while driving, study says – CNN (free) AND Fewer car crash victims at ERs after texting while driving bans – UPI (free)
Commentary: Shift Work Is Tough on Workers’ Hearts, Study Shows – HealthDay (free)
9 – Automated insulin dosing guidance to optimise insulin management in patients with type 2 diabetes: a multicentre, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Commentaries: Promoting Better Glucose Management for Type 2 Diabetes – NEJM Journal Watch (free for a limited period) AND Automated insulin system improves glycemic control – MedicalXpress (free)
10 – Use of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Commentary: Well-known drug has less risk for preterm delivery in PCOS – Norwegian University of Science and Technology (free)
Thu, April 4 – 10 Stories of The Day!
4 Apr, 2019 | 02:29h | UTC
1 – REPORT – Medication Overload: America’s Other Drug Problem – Lown Institute (free PDF)
Executive Summary: Medication Overload: America’s Other Drug Problem – Lown Institute (free PDF)
Press Release: Growing epidemic of medication overload impacting millions of older Americans (free)
Commentaries: Medication Overload: How the drive to prescribe is harming older Americans – Lown Institute (free) AND Overprescribed: High cost isn’t America’s only drug problem – STAT (free)
Related: Reducing Inappropriate Medication Use & Polypharmacy (several articles and commentaries on the subject)
2 – Heart and Lung Transplants from HCV-Infected Donors to Uninfected Recipients – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Hepatitis C-infected hearts and lungs safely transplanted – Brigham and Women’s Hospital (free) AND Hepatitis C Not A Barrier For Organ Transplantation, Study Finds – NPR (free) AND Hepatitis C-infected hearts and lungs can be safely transplanted, study says, opening way to more donors – STAT (free)
Related: Study: Transplant of Hepatitis C–Infected Kidneys Into Uninfected Recipients (link to abstract and commentaries)
Commentaries: Global diet and health: old questions, fresh evidence, and new horizons – The Lancet (free) AND Globally, 1 in 5 deaths are associated with poor diet – The Lancet (free) AND Bad diets killing more people globally than tobacco, study finds – The Guardian (free)
Related: ACG Guideline: Ulcerative Colitis in Adults (free Guidelines)
5 – European S2k Guideline on Chronic Pruritus – Acta Dermato Venerealogica (free)
6 – Treatment of Multiple Myeloma: ASCO and CCO Joint Clinical Practice Guideline (free)
7 – Preventing heart disease requires more than medicine – STAT (free)
9 – Management Options for Gastric Variceal Hemorrhage – JAMA Surgery (free for a limited period)
10 – Long-term Effects of Metformin on Diabetes Prevention: Identification of Subgroups That Benefited Most in the Diabetes Prevention Program and Diabetes Prevention Program Outcomes Study – Diabetes Care (free for a limited period)
Commentaries: Safe and Cheap Metformin Prevents Type 2 Diabetes Over 15 Years – Medscape (free registration required) AND Long-term metformin offsets diabetes in patients with higher glucose/HbA1c, history of gestational diabetes – MDedge (free)
Wed, April 3 – 10 Stories of The Day!
3 Apr, 2019 | 01:16h | UTC
Related Guidelines: WHO Consolidated Guidelines on Drug-resistant Tuberculosis Treatment (free) AND WHO Guideline: Latent TB Infection (free) AND WHO Guidelines for treatment of drug-susceptible tuberculosis and patient care (free)
3 – JCS 2018 Guideline on Diagnosis and Treatment of Acute Coronary Syndrome – Circulation Journal (free)
4 – Bypass Surgery or Stenting for Left Main Coronary Artery Disease in Patients With Diabetes – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: CABG or Stenting for Left Main CAD in Diabetes – American College of Cardiology (free) AND Similar Composite Endpoints With Everolimus DES, CABG for LMCAD With Diabetes – Cardiology Advisor (free)
5 – Cerebral Intraparenchymal Hemorrhage: A Review – JAMA (free for a limited period)
6 – Highly Profitable Medical Journal Says Open Access Publishing Has Failed. Right. – Forbes (free)
Original Article: No Free Lunch — What Price Plan S for Scientific Publishing? – New England Journal of Medicine (free)
Related: Will the world embrace Plan S, the radical proposal to mandate open access to science papers? – Science (free) AND The costs of academic publishing are absurd. The University of California is fighting back – VOX (free) AND Ten myths around open scholarly publishing – PeerJ Preprints (free PDF) AND The world debates open-access mandates (free) AND China Backs Bold Plan to Tear Down Journal Paywalls (free) AND Europe’s Bold Open-Access Plan Detailed (free) Groundbreaking deal makes large number of German studies free to public – Science (free) AND Open Access 2018: A Year of Funders and Universities Drawing Lines in the Sand – Absolutely Maybe Blog (free)
8 – Ann Robinson’s weekly research reviews, 2 April 2019 – The BMJ Opinion (free)
Ann Robinson reviews the latest research from the top medical journals.
Commentaries: What’s bad for the heart is also bad for the brain – Reuters (free) AND Smoking, high blood pressure, diabetes and obesity each linked to unhealthy brains – European Society of Cardiology (free)
Related Meta-Analysis with Somewhat Conflicting Conclusions: Effects of spironolactone in heart failure with preserved ejection fraction – Medicine (free) AND Effects of mineralocorticoid receptor antagonists in patients with preserved ejection fraction: a meta-analysis of randomized clinical trials – BMC Medicine (free)
Related Randomized Trial: Spironolactone for Heart Failure with Preserved Ejection Fraction – New England Journal of Medicine (free)
Tue, April 2 – 10 Stories of The Day!
2 Apr, 2019 | 02:24h | UTC
Commentaries: Compression-only CPR increases survival of out-of-hospital cardiac arrest – American Heart Association (free) AND More people might survive cardiac arrest if more bystanders tried hands-only CPR – Reuters (free) AND Hands-only CPR doubles survival, boosts bystander intervention rates – Cardiovascular Business (free) AND Hands-Only CPR for Out-of-Hospital Cardiac Arrest Gaining Traction, With Good Results – TCTMD (free)
Related Guidelines: Antibiotics after incision and drainage for uncomplicated skin abscesses: a clinical practice guideline – The BMJ (free text and infographics) AND Clinical Guidelines for the Antibiotic Treatment for Community-Acquired Skin and Soft Tissue Infection – Korean Society of Infectious Diseases and Korean Society for Chemotherapy (free) AND 2018 WSES/SIS-E consensus conference: recommendations for the management of skin and soft-tissue infections – World Journal of Emergency Surgery (free)
3 – American College of Radiology Releases Update to ACR Appropriateness Criteria – ACR (free)
See the complete list of ACR Appropriateness Criteria topics and ratings tables (free)
4 – Management of Small Kidney Tumors in 2019 – JAMA (free for a limited period)
See also other Enhanced Recovery After Surgery (ERAS) Guidelines (free)
6 – How Can Doctors Be Sure A Self-Taught Computer Is Making The Right Diagnosis? – NPR (free)
7 – Arrhythmogenic cardiomyopathies (ACs): diagnosis, risk stratification and management – Heart (free)
9 – Hypertension Management in Older and Frail Older Patients – Circulation Research (free)
Commentaries: Increased Odds of Survival or Prevention of Severe Neurological Injury in Extremely Low-Gestational-Age Neonates: Including Placental Transfusion as the First Step to Improve Outcomes in Preterm Newborns – JAMA Network Open (free) AND Extremely Low Gestational Age Neonates May Benefit From Delayed Cord Clamping – MedicalResearch.com (free)
Mon, April 1 – 10 Stories of The Day!
1 Apr, 2019 | 02:33h | UTC
Related Guidelines: Clinical Practice Guidelines for the Treatment of Systemic Lupus Erythematosus by the Mexican College of Rheumatology – Reumatología Clinica (free) AND The British Society for Rheumatology guideline for the management of systemic lupus erythematosus in adults (free) AND First Latin American clinical practice guidelines for the treatment of systemic lupus erythematosus (free) AND Canadian Rheumatology Association Recommendations for the Assessment and Monitoring of Systemic Lupus Erythematosus – The Journal of Rheumatology (free PDF)
Related: Pharmacokinetics–pharmacodynamics issues relevant for the clinical use of beta-lactam antibiotics in critically ill patients – Critical Care (free) AND Extended antibiotic infusions could save lives: Here’s how to do it – PulmCCM (free) AND Mortality lower with prolonged vs. short-term IV infusion of antipseudomonal beta-lactams (link to abstract and commentary)
Related Meta-analysis: Efficacy and Safety of Adjunctive Corticosteroids Therapy for Severe Community-Acquired Pneumonia in Adults: An Updated Systematic Review and Meta-Analysis – PLOS One (free) AND Adjunctive Systemic Corticosteroids for Hospitalized Community-Acquired Pneumonia: Systematic Review and Meta-Analysis 2015 Update – Scientific Reports (free)
Related Cochrane Review: Is Treatment With Corticosteroids Beneficial for People With Pneumonia? (free)
Commentaries: Artificial intelligence can predict premature death, study finds – University of Nottingham (free) AND Using artificial intelligence to predict mortality – Medical News Today (free)
5 – Report: A Heavy Burden: The Productivity Cost of Illness in Africa – World Health Organization (free)
News Release: Diseases cost the African Region $2.4 trillion a year, says WHO – World Health Organization (free)
6 – Valproate Use In Women and Girls Of Childbearing Years (free PDF)
News Release: Thirteen UK healthcare bodies launch ‘pragmatic’ guidance on valproate use – Royal College of General Practitioners (free)
Commentary: New guidance on valproate use in women – OnMedica (free)
Commentary: Are preventive drugs overused at the end of life in older adults with cancer? – Wiley (free)
8 – Screening for ‘hidden’ pancreatic cancer can put people in jeopardy – STAT (free)
Related: Overdiagnosis: Causes and Consequences in Primary Health Care (free reviews and opinions)
9 – Obesity Hypoventilation Syndrome – European Respiratory Review (free)
Related Review: Obesity hypoventilation syndrome: a current review – Jornal Brasileiro de Pneumologia (free)
10 – Maternal and perinatal mortality and complications associated with caesarean section in low-income and middle-income countries: a systematic review and meta-analysis – The Lancet (free registration required)
Commentaries: Death rates from caesarean section far higher in developing countries, finds major global study – Queen Mary, University of London (free) AND C-section death rates highest in low-income countries – OnMedica (free)
Review: Management of hypothalamic disease in patients with craniopharyngioma
30 Mar, 2019 | 17:31h | UTCManagement of hypothalamic disease in patients with craniopharyngioma – Clinical Endocrinology (free)
Fri, March 29 – 10 Stories of The Day!
29 Mar, 2019 | 07:57h | UTC
1 – Lung cancer: diagnosis and management – National Institute for Health and Care Excellence (free)
Related Quality Standard: Lung cancer in adults – National Institute for Health and Care Excellence (free)
Commentary: Consider non-surgical brain stimulation for severe depression, say experts – The BMJ (free)
See also: Full Report (free PDF) AND Evidence Summary (free PDF)
Related: Complex regional pain syndrome in adults (2nd edition) – UK guidelines for diagnosis, referral and management in primary and secondary care 2018 – Royal College of Physicians (free PDF)
Commentaries: Does prolonged sitting really kill 70,000 people a year in the UK? – NHS Choices (free) AND Queen’s research shows sedentary lifestyle linked to 70,000 deaths per year in the UK – Queen’s University Belfast (free) AND Expert reaction to study looking at sitting down and death – Science Media Centre (free)
Commentaries: How many cigarettes are there in a bottle of wine? – BMC Series Blog (free) AND Cigarettes and alcohol: should we be communicating cancer risk in terms of cigarettes smoked? – Cancer Research UK (free)
Commentaries: CHART: Where Disease-Carrying Mosquitoes Will Go In The Future – NPR (free) AND Mosquito-spread diseases may endanger millions in new places due to climate change – The Guardian (free)
Related: Climate Change — A Health Emergency (free reports and commentaries on the subject)
Thu, March 28 – 10 Stories of The Day!
28 Mar, 2019 | 07:42h | UTC
Related: Review: Management of Myocardial Infarction with Nonobstructive Coronary Arteries (free) AND Cohort Study: Presentation, Clinical Profile, and Prognosis of Young Patients with Myocardial Infarction with Nonobstructive Coronary Arteries (free)
2 – Combined Surgery and Extensive Intraoperative Peritoneal Lavage vs Surgery Alone for Treatment of Locally Advanced Gastric Cancer: The SEIPLUS Randomized Clinical Trial – JAMA Surgery (free for a limited period)
Invited Commentary: Extensive Intraoperative Peritoneal Lavage to Prevent Metastases From Gastric Cancer: The Elegance of Simplicity (free)
Commentary: High Marks for EIPL After Gastric Ca Surgery: No deaths, fewer complications, less pain with extended intraperitoneal lavage – MedPage Today (free registration required)
3 – Overall Survival with Fulvestrant plus Anastrozole in Metastatic Breast Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Gain in Survival with Fulvestrant plus Anastrozole in Metastatic Breast Cancer – MedicalResearch.com (free) AND Fulvestrant plus anastrozole extends lives of women with advanced HR+ breast cancer – SWOG (free)
4 – In-Hospital Cardiac Arrest: A Review – JAMA (free for a limited period)
6 – The measles virus was down and out. Now it’s primed for a comeback – STAT (free)
Original Article: Randomized Trial: Marine n−3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer (free)
Related Meta-Analysis: Omega-3 Fatty Acid Supplements Don’t Reduce Cardiovascular Risk (free article and commentary)
Related Systematic Review: Omega-3 fatty Acids for the Prevention of Cardiovascular Disease (free review and commentaries)
9 – Prostate Imaging Reporting & Data System – American College of Radiology (free PDF)
News Release: PI-RADS Steering Committee Releases New Version of the Prostate Imaging Reporting and Data System (v2.1 2019) – American College of Radiology (free)
Commentary: Study: Research ties common heartburn medications to kidney disease and failure – University at Buffalo (free)
Related: Meta-Analysis of Observational Studies: Proton Pump Inhibitors are Associated with Increased Risk of Kidney Disease (link to abstract – $ for full-text) AND Proton Pump Inhibitors: Review of Emerging Concerns (free reviews) AND Deprescribing Proton Pump Inhibitors (free guidelines and reviews)
Wed, March 27 – 10 Stories of The Day!
27 Mar, 2019 | 06:26h | UTC
2 – Clinical guideline for the diagnosis and management of work-related mental health conditions in general practice – National Health and Medical Research Council, Australian Government (NHMRC) (free PDF)
See also: Short Form Guideline (free PDF) AND GP Summary (free PDF)
Commentary: Managing work-related mental health conditions in family medicine – Canadian Medical Association Journal (free for a limited period)
3 – Pregnancy-Adapted YEARS Algorithm for Diagnosis of Suspected Pulmonary Embolism – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: YEARS algorithm adaptation for pregnant women helped avoid CT scans for suspected PE – ACP Hospitalist (free) AND Pregnancy-adapted algorithm avoids diagnostic imaging for PE – MedicalXpress (free) AND PE in Pregnancy & YEARS Protocol – Emergency Medicine Literature of Note (free)
4 – Antithrombotic Therapy after Acute Coronary Syndrome or PCI in Atrial Fibrillation – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Atrial Fibrillation: Antithrombotic Therapy after Acute Coronary Syndrome or PCI – MedicalResearch.com (free) AND Antithrombotic Regimens Evaluated in Patients With Nonvalvular Atrial Fibrillation After ACS or PCI – MPR (free)
5 – Evidence Review: Tranexamic Acid (TXA) for Everything that Bleeds? – REBEL EM (free)
Related: Meta-analysis – Tranexamic acid: is it about time? (free study and commentaries) AND Randomized Controlled Trial: Tranexamic Acid for Hyperacute Primary Intracerebral Hemorrhage (free) AND Systematic Review: Tranexamic Acid for Patients with Epistaxis (free) AND Systematic Review: Antifibrinolytic drugs for treating primary postpartum haemorrhage (free) AND WHO Recommendation on Tranexamic Acid for the Treatment of Postpartum Haemorrhage (free) AND Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (free) AND Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial (landmark trial on the subject)
6 – Alex Nowbar’s research reviews, 26 March 2019 – The BMJ Opinion (free)
Alex Nowbar reviews the latest research from the top medical journals.
8 – Evaluation of an Intervention to Reduce Low-Value Preoperative Care for Patients Undergoing Cataract Surgery at a Safety-Net Health System – JAMA Internal Medicine (free for a limited period)
Commentary: Cataract Surgery: QI Initiative Markedly Reduced Low-Value Preoperative Care – MedicalResearch.com (free)
Related: Systematic Review: Routine Preoperative Medical Testing for Cataract Surgery (free)
See Complete Series: Things We Do For No Reason (free articles)
Commentaries: Link Between Night Shift Work and Miscarriage – MedicalResearch.com (free) AND Miscarriage risk linked with night shift work – OnMedica (free) AND Night shift work linked to a higher risk of miscarriage – Reuters (free) AND Expert reaction to night shifts and miscarriage – Science Media Centre (free)
Tue, March 26 – 10 Stories of The Day!
26 Mar, 2019 | 02:16h | UTC
1 – Public Policies to Reduce Sugary Drink Consumption in Children and Adolescents – Pediatrics (free)
News Release: American Academy of Pediatrics and American Heart Association endorse suite of policies to reduce kids’ consumption of sugary drinks (free)
Commentaries: Tax on sugary drinks recommended by health organizations – UPI (free) AND AHA, AAP recommend policies to limit kids’ sugary drink consumption – Cardiovascular Business (free) AND To Curb Kids’ Sugary Drink Habits, Pediatricians Now Call For Soda Taxes – NPR (free) AND Physician groups call for taxes and regulations on kids’ access to sugary drinks – CNN (free)
Related: Soda Tax Linked to a 50 Percent Reduction in Sugary Drink Consumption (several policies, guidelines, studies and commentaries on the subject)
2 – Policy Statement: Prevention of Drowning – Pediatrics (free PDF)
News Release: AAP Updates Recommendations to Prevent Drowning in Children (free)
Related: Preventing drowning: an implementation guide – World Health Organization (free) AND Report: Open Water Drowning and Risks for Children (free)
News Release: Many postmenopausal women do not receive treatment for osteoporosis (free)
Commentary: Managing Osteoporosis in Postmenopausal Women: An Endocrine Society Guideline – Endocrinology Advisor (free)
See also: Point of Care Algorithm (free)
5 – Management of acute upper gastrointestinal bleeding – The BMJ (free for a limited period)
6 – Thyrotoxicosis: Diagnosis and Management – Mayo Clinic Proceedings (free)
Related: Thyroid Storm: A Japanese Perspective (free study and commentary)
7 – A Clinical Overview of Off-label Use of Gabapentinoid Drugs – JAMA Internal Medicine (free for a limited period)
“Clinicians who prescribe gabapentinoids off-label for pain should be aware of the limited evidence and should acknowledge to patients that potential benefits are uncertain for most off-label uses.”
8 – Health and Socioeconomic Inequities as Contributors to Brain Health – JAMA Neurology (free for a limited period)
10 – Differences in Parent-Toddler Interactions with Electronic Versus Print Books – Pediatrics (link to abstract – $ for full-text)
Commentaries: Does story time with an e-book change how parents and toddlers interact? – University of Michigan (free) AND Print Books Better Than E-Books for Parent-Toddler Interaction – NEJM Journal Watch (free) AND Reading to Your Toddler? Print Books Are Better Than Digital Ones – The New York Times (10 articles per month are free)