TOP 10 Medical News Stories
Fri May 31 – 10 Stories of The Day!
31 May, 2019 | 08:37h | UTC
1 – The ABCs of Primary Cardiovascular Prevention: 2019 Update – American College of Cardiology (free) (via @paomorejon)
Original Guideline: 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease (free guideline and related resources)
Commentary: IDSA Issues Updated Statement on Use of Telemedicine and Telehealth Technologies – Clinical Advisor (free)
4 – Bioethics – “The surgeon had a dilemma only a Nazi medical text could resolve. Was it ethical to use it? – STAT” (free)
5 – Menopausal Hormone Therapy – JAMA (free for a limited period)
Podcast: Menopausal Hormone Therapy (free audio)
Commentaries: Investigating the causes of death attributable to use of proton pump inhibitors – The BMJ Opinion (free) AND Heartburn drugs linked to fatal heart and kidney disease, stomach cancer – Washington University in St. Louis (free) AND Overuse of heartburn drugs linked to heart, kidney disease, cancer – UPI (free) AND Proton-pump inhibitors (PPIs) Linked to Increased Risk of Death – MedicalResearch.com (free)
Related Study: Ultra-processed food intake and risk of cardiovascular disease: prospective cohort study (NutriNet-Santé) – The BMJ (free)
Editorial: Ultra-processed food and adverse health outcomes (free)
Commentaries: Does ‘ultra-processed’ food cause earlier death? – NHS Behind the Headlines (free) AND Warning on link between processed foods and health risks – OnMedica (free) AND New evidence links ultra-processed foods with a range of health risks – The BMJ (free)
8 – Antidepressants and weight gain: long-term population impact #SUSANAsurvey – The Mental Elf (free)
Original Study: Cohort Study: Weight Gain with Antidepressant Utilization (free study and commentaries)
News Release: Updated Guidelines on Dental Sedation Address Concerns Over Safety for Pediatric Patients – American Academy of Pediatrics (free)
Thu May 30 – 10 Stories of The Day!
30 May, 2019 | 08:34h | UTC
News Release: What is known — and not known — about heart muscle diseases in children – American Heart Association (free)
Original Guideline: Anticonvulsant Prophylaxis and Steroid Use in Adults With Metastatic Brain Tumors: ASCO and SNO Endorsement of the Congress of Neurological Surgeons Guidelines – Journal of Clinical Oncology (free)
3 – Tramadol for osteoarthritis – Cochrane Library (free)
Summary: Tramadol for osteoarthritis – Cochrane Library (free)
“tramadol alone or in combination with acetaminophen probably has no important benefit on mean pain or function in people with osteoarthritis, although slightly more people in the tramadol group report an important improvement”
5 – Open versus Endovascular Repair of Abdominal Aortic Aneurysm – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Endovascular Aneurysm Procedure as Effective as Open Surgery, Study Finds – Wake Forest Baptist Medical Center (free)
7 – Rethinking impact factors: better ways to judge a journal – Nature (free)
“We need a broader, more-transparent suite of metrics to improve science publishing, say Paul Wouters, colleagues and co-signatories.”
8 – Alex Nowbar’s journal reviews, 29 May 2019 – The BMJ Opinion (free)
Alex Nowbar reviews the latest research from the top medical journals.
Original Article: BMJ Guideline: Treatment of Subclinical Hypothyroidism (free)
10 – Association of Step Volume and Intensity With All-Cause Mortality in Older Women – JAMA Internal Medicine (free for a limited period)
Commentaries: 10,000 Steps A Day? How Many You Really Need To Boost Longevity – NPR (free) AND Among older women, 10,000 steps per day not needed for lower mortality – Brigham and Women’s Hospital (Free)
Wed May 29 – 10 Stories of The Day!
29 May, 2019 | 02:09h | UTC
1 – Compendium: The Medical and Device-Related Treatment of Heart Failure – Circulation Research (free articles)
Editorial: The Medical and Device-Related Treatment of Heart Failure
– Medical Therapy for Heart Failure Caused by Ischemic Heart Disease
– Novel Therapies for Prevention and Early Treatment of Cardiomyopathies: Now and in the Future
– Medical Therapy for Heart Failure Associated With Pulmonary Hypertension
– Management of Myocarditis-Related Cardiomyopathy in Adults
– Cardiac Implantable Electronic Device Therapy in Heart Failure
– Heart Failure With Preserved Ejection Fraction In Perspective
– Anthracycline and Peripartum Cardiomyopathies: Predictably Unpredictable
– Stimulating Cardiogenesis as a Treatment for Heart Failure
2 – Association of Nonfasting vs Fasting Lipid Levels With Risk of Major Coronary Events in the Anglo-Scandinavian Cardiac Outcomes Trial–Lipid Lowering Arm – JAMA Internal Medicine (free for a limited period)
Commentaries: New evidence: It’s not necessary to fast before complete cholesterol test – Brigham and Women’s Hospital (free) AND More Evidence That Fasting Isn’t Necessary Before Lipid Tests – NEJM Journal Watch (free)
3 – Assessment of the Clinical Benefit of Cancer Drugs Receiving Accelerated Approval – JAMA Internal Medicine (free for a limited period)
Related Study: An Overview of Cancer Drugs Approved by the US Food and Drug Administration Based on the Surrogate End Point of Response Rate – JAMA Internal Medicine (free for a limited period)
Invited Commentaries: An International Perspective on Drugs for Cancer: The Best of Times, the Worst of Times (free for a limited period) AND Accelerated Approval of Cancer Drugs—Righting the Ship of the US Food and Drug Administration (free for a limited period)
Commentaries: Cancer Drugs Approved Quickly Often Fail To Measure Up Later – NPR (free) AND Questions raised over cancer drugs in FDA’s accelerated approval program – CNN (free)
4 – WHO Redefines Burnout As A ‘Syndrome’ Linked To Chronic Stress At Work – NPR (free)
See also: Burn-out an “occupational phenomenon”: International Classification of Diseases – World Health Organization (free)
5 – Estimating the Attributable Cost of Physician Burnout in the United States – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Physician burnout costs the US health care system approximately $4.6 billion a year – American College of Physicians (free) AND Doctors are burning out twice as fast as other workers. The problem’s costing the US $4.6 billion each year. – Business Insider (free) AND Physician Burnout Costs the U.S. Billions of Dollars Each Year – TIME (free)
Related: Physician Burnout Costs up to $17B a Year, Task Force Says (articles and commentaries on the subject)
7 – Opinion – “Should the US Government Pay People For Their Kidneys? – Forbes” (free)
“the placement of priority on early detection cannot be assumed to be effective in LMICs, where limited downstream resources may be overwhelmed by the inevitable increases in number of diagnoses.”
9 – Effect of Laparoscopic vs Open Distal Gastrectomy on 3-Year Disease-Free Survival in Patients With Locally Advanced Gastric Cancer: The CLASS-01 Randomized Clinical Trial – JAMA (free for a limited period)
Commentaries: Hospitals fall short in teaching fall prevention to departing patients – University of Michigan (free) AND Fall Injuries Top Cause of Hospital Readmission in Elderly – Medscape (free registration required)
Tue May 28 – 10 Stories of The Day!
28 May, 2019 | 01:36h | UTC
Related Reviews: Acute Respiratory Distress Syndrome – Nature Reviews Disease Primer (free PDF) AND Acute Respiratory Distress Syndrome – European Respiratory Review (free)
Related Guidelines: The clinical practice guideline for the management of ARDS in Japan – Journal of Intensive Care (free) AND An Official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome (free)
Source: Critical Care Reviews Newsletter
Original Guideline: New AHA/ACC Guideline on the Management of Blood Cholesterol (free guideline and resources)
4 – Head‐to‐head oral prophylactic antibiotic therapy for chronic obstructive pulmonary disease – Cochrane Library (free)
Summary: Prophylactic antibiotic therapy for people with chronic obstructive lung disease (COPD) – Cochrane Library (free)
Related Cochrane Review: Prophylactic Antibiotic Therapy for COPD (free)
5 – Mixed exercise training for adults with fibromyalgia – Cochrane Library (free)
Summary: Mixed exercise programmes for adults with fibromyalgia – Cochrane Library (free)
6 – Inpatient Management of Acute Severe Ulcerative Colitis – Journal of Hospital Medicine (free PDF via Unpaywall)
Source: Hospital Medicine Virtual Journal Club
7 – Preventing Delirium Takes a Village: Systematic Review and Meta-Analysis of Delirium Preventive Models of Care – Journal of Hospital Medicine (free PDF via Unpaywall)
Source: Hospital Medicine Virtual Journal Club
8 – Advances in the management of acute cholecystitis – Annals of Gastroenterological Surgery (free)
9 – Gentamicin compared with ceftriaxone for the treatment of gonorrhoea (G-ToG): a randomised non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Commentaries: Clinical trial finds gentamicin inferior to ceftriaxone for gonorrhea – CIDRAP (free) AND Drug combination could be effective for treatment resistant gonorrhea – NIHR (free) AND New drug combination could be effective for treatment-resistant gonorrhea – OnMedica (free) AND Quick Take: Gentamicin compared with ceftriaxone for the treatment of gonorrhoea (G-ToG) – 2 Minute Medicine (free)
10 – Preventable Cancer Burden Associated with Poor Diet in the United States – JNCI Cancer Spectrum (free PDF)
Commentaries: New study estimates preventable cancer burden linked to poor diet in the US – Tufts University (free) AND Poor diet may increase risk for preventable cancers – UPI (free)
Mon May 27 – 10 Stories of The Day!
27 May, 2019 | 00:01h | UTC
1 – Deprescribing in Older Adults with Cardiovascular Disease – Journal of the American College of Cardiology (free for a limited period)
Related: Position Statement: Reducing Inappropriate Medication Use & Polypharmacy (several articles and commentaries on the subject)
3 – Solutions for non-communicable disease prevention and control – The BMJ / World Health Organization (free articles)
Editorial: Mobilising society to implement solutions for non-communicable diseases
– National action plans to tackle NCDs: role of stakeholder network analysis
– Medical education must change if we are to tackle the causes of non-communicable diseases
– Tackling NCDs in humanitarian settings is a growing challenge
– Social determinants and non-communicable diseases: time for integrated action
– Integrating mental health with other non-communicable diseases
– Environmental risks and non-communicable diseases
– A life-course approach to the prevention and control of noncommunicable diseases
– Transforming the food system to fight non-communicable diseases
4 – Daily Self‐Weighing to Prevent Holiday‐Associated Weight Gain in Adults – Obesity (free)
Commentaries: Daily self-weighing can prevent holiday weight gain – University of Georgia (free) AND Researchers reveal new strategy for preventing holiday weight gain – The Obesity Society (free) AND Weighing yourself every day could prevent weight gain – Medical News Today (free)
6 – Evolving Issues in the Treatment of Depression – JAMA (free for a limited period)
Author Interview: New Approaches to Management of Depression (free audio)
7 – Trends in Incidence and Stage at Diagnosis of Colorectal Cancer in Adults Aged 40 Through 49 Years, 1975-2015 – JAMA (free for a limited period)
Commentaries: CRC rates appear to be rising among younger adults in U.S., Europe – ACP Gastroenterology (free) AND More Younger People Getting Later Stage Colon Cancer – MedicalResearch.com (free)
Related: Two Studies Point to Increase in Colorectal Cancer Incidence in Young Adults (link to abstracts and commentaries)
8 – At $2.1 Million, New Gene Therapy Is The Most Expensive Drug Ever – NPR (free)
See also: No Miracle Drug Should Cost $2.1 Million – Bloomberg Opinion (free) AND This New Treatment Could Save the Lives of Babies. But It Costs $2.1 Million. – The New York Times (10 articles per month are free)
“The price set by the Swiss drugmaker Novartis may be the world’s highest for a single treatment — prompting renewed debate about how society will pay for gene-therapy breakthroughs.” (from the New York Times)
Commentaries: Diabetes patients at higher risk of deadly liver disease, finds study of 18 million people – Queen Mary University of London (free) AND Diabetes patients at high risk of serious NAFLD outcomes – Medwire News (free) AND Cirrhosis and liver cancer risk higher in people with type 2 diabetes – Medical News Today (free)
Fri May 24 – 10 Stories of The Day!
24 May, 2019 | 05:29h | UTC
Commentary: Only a third of people have hypertension under control – OnMedica (free)
4 – Eosinophil-guided corticosteroid therapy in patients admitted to hospital with COPD exacerbation (CORTICO-COP): a multicentre, randomised, controlled, open-label, non-inferiority trial – The Lancet Respiratory Medicine (link to abstract – $ for full-text)
Commentary: 2 Minute Medicine Rewind May 20, 2019 (4th Summary)
See also: Video Summary – Medwire News (free audio)
Invited Commentary: Global palliative care: from need to action – The Lancet Global Health (free)
“Immediate global action to integrate palliative care into health systems is an ethical and economic imperative.”
7 – Neutrophil-Lymphocyte Ratio (NLR): Free upgrade to your WBC – PulmCrit (free)
9 – Recommendations for the Management of the Incidental Renal Mass in Adults: Endorsement and Adaptation of the 2017 ACR Incidental Findings Committee White Paper by the Canadian Association of Radiologists Incidental Findings Working Group – Canadian Association of Radiologists Journal (free)
Commentaries: Breast cancer risk in transgender people: the value of gaining new insights from other sources – The BMJ Opinion (free) AND Risk of Breast Cancer Among Transgender People – The ASCO Post (free) AND Transgender women have increased risk of breast cancer compared to cisgender men – Cancer Research UK (free)
Thu May 23 – 10 Stories of The Day!
23 May, 2019 | 10:36h | UTC
Commentaries: Restarting antiplatelet therapy after intracerebral haemorrhage – The Lancet (free) AND Aspirin unlikely to cause more brain bleeds for stroke patients – UPI (free) AND Aspirin green light for brain bleed stroke patients, study suggests – University of Edinburgh (free)
“The risk of recurrent intracerebral hemorrhage is probably too small to exceed the established benefits of antiplatelet therapy for secondary prevention.”
2 – Extending thrombolysis to 4·5–9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data – The Lancet (link to abstract – $ for full-text)
“Patients with ischemic stroke 4·5–9 h from stroke onset or wake-up stroke with salvageable brain tissue who were treated with alteplase achieved better functional outcomes than did patients given placebo. The rate of symptomatic intracerebral hemorrhage was higher with alteplase, but this increase did not negate the overall net benefit of thrombolysis.”
Commentaries: Making the case for a world without guns – The Lancet Public Health (free) AND Firearm mortality highest in young men, and is associated with race and education – The Lancet (free)
4 – Association of Changes in Air Quality With Incident Asthma in Children in California, 1993-2014 – JAMA (free for a limited period)
Editorial: Air Pollution Exposure and Asthma Incidence in Children: Demonstrating the Value of Air Quality Standards (free)
Commentary: When LA’s Air Got Better, Kids’ Asthma Cases Dropped – NPR (free)
Related Guidelines: IDSA Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children (free) AND 2019 update of the WSES guidelines for management of Clostridioides (Clostridium) difficile infection in surgical patients – World Journal of Emergency Surgery (free) AND The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications (free) AND Guideline for the Management of Clostridium Difficile Infection in Children and Adolescents With Cancer and Pediatric Hematopoietic Stem-Cell Transplantation Recipients (free) AND Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection and Other Conditions in Children (free)
6 – Recommendations on the diagnosis and treatment of urinary tract infection – Anales de Pediatría (free)
8 – Alex Nowbar’s journal reviews, 22 May 2019 – The BMJ Opinion (free)
See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada
1 – Don’t order serum ammonia to diagnose or manage hepatic encephalopathy (HE).
2 – Don’t routinely transfuse fresh frozen plasma, platelets or give Vitamin K to reverse abnormal tests of coagulation in patients with cirrhosis prior to abdominal paracentesis, endoscopic variceal band ligation, or any other minor invasive procedures.
3 – Don’t order HFE genotyping based on serum ferritin values alone to diagnose hereditary hemochromatosis.
4 – Don’t perform computed tomography (CT) or magnetic resonance imaging (MRI) routinely to monitor benign focal liver lesions (ex. focal nodal hyperplasia, hemangioma).
5 – Don’t repeat hepatitis C viral load testing in an individual who has established chronic infection, outside of antiviral treatment.
(Under a Creative Commons license)
Wed May 22 – 10 Stories of The Day!
22 May, 2019 | 06:19h | UTC
1 – Mucolytic agents versus placebo for chronic bronchitis or chronic obstructive pulmonary disease – Cochrane Library (free)
Summary: Mucolytic agents for chronic bronchitis or chronic obstructive pulmonary disease – Cochrane Library (free)
2 – Galactomannan detection in broncho‐alveolar lavage fluid for invasive aspergillosis in immunocompromised patients – Cochrane Library (free)
Summary: Measuring galactomannan in lung-washing fluid to diagnose invasive aspergillosis in patients with an impaired immune system – Cochrane Library (free)
3 – A Contrarian View of Digital Health – Quillette (free)
6 – Current concepts in acute liver failure – Annals of Hepatology (free)
7 – What’s new in oxygen therapy? – Intensive Care Medicine (free)
Related: Guideline: Oxygen Therapy for Acutely Ill Medical Patients (free) AND Review: Oxygen Treatment in Intensive Care and Emergency Medicine (free) AND Meta-Analysis: Liberal vs Conservative Oxygen Therapy in Acutely ill Adults (link to abstract and commentary)
Source: Critical Care Reviews Newsletter
8 – Eight things we would never do regarding end-of-life care in the ICU – Intensive Care Medicine (free)
Related: Limitation of Life-Sustaining Care in the Critically Ill: A Systematic Review of the Literature – Journal of Hospital Medicine (free PDF) AND Dying with Dignity in the Intensive Care Unit – New England Journal of Medicine (free) AND Palliative care in intensive care units: why, where, what, who, when, how – BMC Anesthesiology (free) AND Ten key points about ICU palliative care – Intensive Care Medicine (free) AND Guidelines for the withdrawal of life-sustaining measures – Intensive Care Medicine (free) AND End-of-life in the ICU: moving from ‘withdrawal of care’ to a palliative care, patient-centred approach – British Journal of Anaesthesia (free) AND New concepts in palliative care in the intensive care unit – Revista Brasileira de Terapia Intensiva (free) AND The Changing Role of Palliative Care in the ICU – Critical Care Medicine (free)
Source: Critical Care Reviews Newsletter
9 – Infant Deaths in Sitting Devices – Pediatrics (link to abstract – $ for full-text)
News Release: Large study sheds light infant deaths in sitting devices – American Academy of Pediatrics (free)
Commentaries: Car seat danger: Babies shouldn’t sleep in car seats when not traveling – Today (free) AND Sleep-Related Car Seat Deaths Occur Most Often Outside of Travel – NEJM Journal Watch (free)
Commentaries: Increasing Suicide Rates in Early Adolescent Girls in the United States and the Equalization of Sex Disparity in Suicide: The Need to Investigate the Role of Social Media – JAMA Network Open (free) AND Suicide Rate For Girls Has Been Rising Faster Than For Boys, Study Finds – NPR (free) AND Suicide rates in girls are rising, study finds, especially in those age 10 to 14 – CNN (free)
Tue May 21 – 10 Stories of The Day!
21 May, 2019 | 06:23h | UTC
#ATS2019 – Highlights from the 2019 Meeting of the American Thoracic Society
1 – Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis – JAMA (free for a limited period)
Editorial: New Phenotypes for Sepsis: The Promise and Problem of Applying Machine Learning and Artificial Intelligence in Clinical Research (free for a limited period)
Commentary: Big data reveals hidden subtypes of sepsis – University of Pittsburgh (free)
Just Presented at the 2019 Meeting of the American Thoracic Society.
2 – Early Sedation with Dexmedetomidine in Critically Ill Patients – New England Journal of Medicine (link to abstract – $ for full-text)
Just Presented at the 2019 Meeting of the American Thoracic Society.
3 – Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Sedation and controlled paralysis do not improve survival of ICU patients with ARDS – University of Pittsburgh (free)
Just Presented at the 2019 Meeting of the American Thoracic Society.
4 – Controlled Trial of Budesonide–Formoterol as Needed for Mild Asthma – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Treatment Changes for Mild Asthma? – NEJM Journal Watch (free)
Just Presented at the 2019 Meeting of the American Thoracic Society.
5 – Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Large portion of patients with mild persistent asthma and low sputum eosinophils respond equally well to inhaled corticosteroids as placebo – NIH News Releases (free)
Just Presented at the 2019 Meeting of the American Thoracic Society.
6 – Nintedanib for Systemic Sclerosis–Associated Interstitial Lung Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Nintedanib slows lung function decline in SSc-associated interstitial lung disease – Medicine Matters (free)
Just Presented at the 2019 Meeting of the American Thoracic Society.
7 – Google’s AI improves accuracy of lung cancer diagnosis, study shows – STAT (free)
See also: A.I. Took a Test to Detect Lung Cancer. It Got an A. – The New York Times (10 articles per month are free)
Original Article: End-to-end lung cancer screening with three-dimensional deep learning on low-dose chest computed tomography – Nature Medicine (link to abstract – $ for full-text)
8 – Viewpoint: Millions Take Gabapentin for Pain. But There’s Scant Evidence It Works. – The New York Times (10 articles per month are free)
Related: Meta-Analysis: Anticonvulsants in the Treatment of Low Back Pain and Lumbar Radicular Pain (free) AND Benefits and safety of gabapentinoids in chronic low back pain (free) AND Less is More: A Clinical Overview of Off-label Use of Gabapentinoid Drugs (link to abstract)
9 – Viewpoint: Artificial Intelligence in Health Care: Will the Value Match the Hype? – JAMA (free for a limited period)
10 – SCAI clinical expert consensus statement on the classification of cardiogenic shock – Catheterization Cardiovascular Interventions (free) (via @paomorejon)
Commentaries: SCAI releases multi-society endorsed consensus on the classification stages of cardiogenic shock – Society for Cardiovascular Angiography and Interventions (free) AND SCAI Clinical Expert Consensus Statement on Cardiogenic Shock – American College of Cardiology (free)
“Endorsed by the American College of Cardiology (ACC), the American Heart Association (AHA), the Society of Critical Care Medicine (SCCM), and the Society of Thoracic Surgeons (STS) in April 2019”
Mon May 20 – 10 Stories of The Day!
20 May, 2019 | 00:01h | UTC
Related: Diagnosing and treating antiphospholipid syndrome: a consensus paper – The Netherlands Journal of Medicine (free PDF) AND Guidelines on the investigation and management of antiphospholipid syndrome – British Journal of Haematology (free)
2 – ACSM Scientific Pronouncements: Physical Activity Guidelines for Americans – American College of Sports Medicine (free articles)
News Release: ACSM Publishes Science Behind the Updated Physical Activity Guidelines for Americans – American College of Sports Medicine (free)
Original Guideline: Physical Activity Guidelines for Americans (free resources)
3 – New-onset atrial fibrillation in adult critically ill patients: a scoping review – Intensive Care Medicine (free) (via @AndersPerner)
4 – Management of Hepatitis C in 2019 – JAMA (free for a limited period)
5 – Digital Medicine: A Primer on Measurement – Digital Biomarkers (free)
6 – Hospitals look to computers to predict patient emergencies before they happen – STAT (free)
7 – Optimizing cancer pain management in resource-limited settings – Supportive Care in Cancer (free)
8 – Evaluation of the Solitary Pulmonary Nodule – Internal Medicine Journal (free)
Related: Guidelines for Management of Incidental Pulmonary Nodules Detected on CT Images: From the Fleischner Society 2017 – Radiology (free) AND Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (free) AND British Thoracic Society guidelines for the investigation and management of pulmonary nodules (free) AND Management pathways for solitary pulmonary nodules – Journal of Thoracic Disease (free)
9 – Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source – New England Journal of Medicine (link to abstract – $ for full-text)
Related Study: Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined Source – New England Journal of Medicine (free)
Commentary: Dabigatran After Embolic Stroke of Undetermined Source – American College of Cardiology (free)
Commentaries: Are Fruit Juices Just as Unhealthy as Sugar-Sweetened Beverages? – JAMA Network Open (free) AND Fruit juice may increase death risk as much as sugary drinks – UPI (free) AND Expert reaction to study looking at sugary drinks, fruit juice and risk of premature death in US adults – Science Media Centre (free)
Author Interview: Association of Sugary Beverage Consumption With Mortality Risk in US Adults; Trends in Suicide Among US Youth Aged 10 to 19 Years, 1975 to 2016 (free audio)
Fri May 17 – 10 Stories of The Day!
17 May, 2019 | 07:04h | UTC
Commentaries: Low birthweight: will new estimates accelerate progress? – The Lancet Global Health (free) AND AND Too many babies are born too small – World Health Organization (free) AND 1 in 7 babies worldwide born with a low birthweight – London School of Hygiene & Tropical Medicine (free) AND UNICEF-WHO Low Birthweight Estimates: Levels and trends 2000-2015 – UNICEF (free) AND Countries must up their game to reduce low birth weights, warns UN-backed report – UN News (free)
Summaries: Scientific Statement on Home-Based Cardiac Rehabilitation – American College of Cardiology (free) AND Top Things to Know:
Home-Based Cardiac Rehabilitation – American Heart Association (free)
News Releases: New Scientific Statement Explores Home-Based Cardiac Rehab Strategy – American College of Cardiology (free) AND Home-based cardiac rehabilitation is an option to overcome barriers of traditional cardiac rehabilitation – American Heart Association (free)
Commentaries: Home-based heart rehab may help patients who can’t get to clinics – Reuters (free) AND Home-Based Cardiac Rehab a “Reasonable Option” – NEJM Journal Watch (free)
See also: Healthy diet cuts risk of dying from breast cancer in older women – Reuters (free) AND Less fat, more fruit may cut risk of dying of breast cancer – Associated Press (free) AND Balanced, Low-Fat Diet Reduces Risk of Death From Breast Cancer in Postmenopausal Women – ASCO News Releases (free)
4 – Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake – Cell Metabolism (free for a limited period)
Commentaries: Controlled study links processed food to increased calorie consumption – Cell Press (free) AND NIH study finds heavily processed foods cause overeating and weight gain – NIH News Releases (free) AND Ultra-processed foods lead to higher calorie consumption and weight gain – Reuters (free) AND Expert reaction to study looking at processed food, calorie consumption and weight gain – Science Media Centre (free) AND Ultra-processed food causes weight gain – firm evidence at last – The Conversation (free)
5 – Five-Year Outcomes of Gastric Bypass in Adolescents as Compared with Adults – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Early weight-loss surgery may improve type 2 diabetes, blood pressure outcomes – NIH/National Institute of Diabetes and Digestive and Kidney Diseases (free) AND Obesity surgery benefits may be bigger for teens than adults – Associated Press (free)
6 – Does Atelectasis Cause Fever After Surgery? Putting a Damper on Dogma – JAMA Surgery (free for a limited period)
7 – How Much Alcohol Can You Drink Safely? – The New York Times Magazine (10 articles per month are free)
Related Articles: Alcohol Use and Burden for 195 Countries and Territories (free) AND Meta-analysis: Risk Thresholds for Alcohol Consumption (free )
“The efficacy and safety of NOACs as thromboprophylaxis for AF and VHD are similar to those of warfarin.”
9 – Normal Body Temperature: A Systematic Review – Open Forum Infectious Diseases (free) (via @PaulSaxMD see Tweet)
See also: Interest “Tweetorial” about the definition of a fever (twitter thread)
10 – Association Between Incident Exposure to Benzodiazepines in Early Pregnancy and Risk of Spontaneous Abortion – JAMA Psychiatry (free for a limited period)
Commentaries: Benzodiazepine Use in Early Pregnancy Increases Risk of Miscarriage, Study Suggests – Psychiatry News Alert (free) AND Assess benzodiazepines’ risk-benefit before use in early pregnancy – OnMedica (free) AND Benzodiazepine Use in Early Pregnancy Linked to Spontaneous Abortion – MPR (free)
Thu May 16 – 10 Stories of The Day!
16 May, 2019 | 05:29h | UTC
Commentaries: Experts advise against hormone treatment in adults with mild thyroid problems – The BMJ (free) AND Experts: Don’t Treat Subclinical Hypothyroidism – NEJM Journal Watch (free)
Related: Meta-Analysis: Treating Subclinical Hypothyroidism is Not Associated with Quality of Life and Thyroid-Related Symptoms (link to abstract and commentaries) AND Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism (free study and commentary)
2 – Management of Infertility – Agency for Healthcare Research and Quality (free)
See also: Full Report (free PDF) AND Evidence Summary (free PDF)
3 – Transition Planning for the Senior Surgeon: Guidance and Recommendations From the Society of Surgical Chairs – JAMA Surgery (free for a limited period)
Invited Commentary: Planning for Retiring From Operating (free for a limited period)
Author Interview: Transition Planning for the Senior Surgeon (free audio)
4 – Chronic use of tramadol after acute pain episode: cohort study – The BMJ (free)
Commentaries: Risk of Prolonged Use With Tramadol vs Other Short Acting Opioids Examined – MPR (free) AND ‘There really is no safe opioid’: Study finds tramadol isn’t a less addictive painkiller – CBC (free)
5 – Familial Hypercholesterolemia Among Young Adults With Myocardial Infarction – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Familial Hypercholesterolemia Seen in 10% of Young MI Patients – TCTMD (free) AND Familial Hypercholesterolemia Among Young Adults With MI – American College of Cardiology (free)
6 – Otitis Externa: Investigation and Evidence-Based Treatment – Deutsches Ärzteblatt International (free)
7 – Bowel obstruction: a narrative review for all physicians – World Journal of Emergency Surgery (free)
8 – Mapping HIV prevalence in sub-Saharan Africa between 2000 and 2017 – Nature (free)
Commentaries: ‘Striking’ differences in rates of HIV/AIDS within African nations – Institute for Health Metrics and Evaluation (free) AND New HIV Map Offers Most Detailed Look Yet At The Epidemic – NPR (free)
9 – Association of a Beverage Tax on Sugar-Sweetened and Artificially Sweetened Beverages With Changes in Beverage Prices and Sales at Chain Retailers in a Large Urban Setting – JAMA (free for a limited period)
Editorial: Sugar-Sweetened Beverage Taxes: Emerging Evidence on a New Public Health Policy (free)
Commentaries: Soda Taxes Are a ‘No-Brainer’ for Public Health, Says the Author of a New Study on Them – TIME (free) AND Sales of Sweetened Drinks Fell 38% After Philadelphia Beverage Tax – AJMC (free)
Related: Soda Tax Linked to a 50 Percent Reduction in Sugary Drink Consumption (several policies, guidelines, studies and commentaries on the subject) AND AAP/AHA Policy Statement: Public Policies to Reduce Sugary Drink Consumption in Children and Adolescents (free statement and commentaries)
The aggregate prevalence of burnout was 51.0% among residents. Subgroup analysis by specialty showed that radiology (77.16%), neurology (71.93%), and general surgery (58.39%) were the top three specialties with the highest prevalence of burnout.
Wed May 15 – 10 Stories of The Day!
15 May, 2019 | 07:05h | UTC
1 – Risk reduction of cognitive decline and dementia – World Health Organization (free PDF)
News Release: Adopting a healthy lifestyle helps reduce the risk of dementia – World Health Organization (free)
Commentaries: WHO issues first advice on dementia: exercise and don’t smoke – Reuters (free) AND Eat well, exercise more: New global guidelines to reduce risk of dementia – CNN (free) AND Expert reaction to WHO Guidelines on risk reduction of cognitive decline and dementia – Science Media Centre (free)
3 – Association of Unrecognized Obstructive Sleep Apnea With Postoperative Cardiovascular Events – JAMA (free for a limited period)
Editorial: Unrecognized Obstructive Sleep Apnea and Postoperative Cardiovascular Complications: A Wake-up Call – JAMA (free for a limited period)
Video Summary: Association of Undiagnosed Obstructive Sleep Apnea With Postoperative Cardiovascular Complications (free)
Commentary: Sleep apnea tied to heart problems after surgery – Reuters (free)
4 – Same-Day vs Different-Day Elective Upper and Lower Endoscopic Procedures by Setting – JAMA Internal Medicine (free for a limited period)
Commentaries: Improving the Delivery of Common Medical Procedures to Achieve Value-Based Care – JAMA Internal Medicine (free for a limited period) AND When possible, upper and lower GI endoscopies should be done on same day – Johns Hopkins University School of Medicine (free)
5 – The Dangers of Ignoring the Beers Criteria—The Prescribing Cascade – JAMA Internal Medicine (free for a limited period)
Original Article: AGS 2019 Updated Beers Criteria for Potentially Inappropriate Medication Use in Older Adults (link to abstract – $ for full-text)
News Release: Inappropriate prescribing can lead to adverse outcomes – American Academy of Family Physicians (free)
7 – Alex Nowbar’s journal reviews, 14 May 2019 – The BMJ Opinion (free)
Alex Nowbar reviews the latest research from the top medical journals.
8 – The Development of Pathways in Palliative Medicine: Definition, Models, Cost and Quality Impact – Healthcare (free) (via @Abraham_RMI)
Commentary: Methotrexate Use Not Linked to Interstitial Lung Disease in RA – RheumNow (free)
10 – News Release: Whole body MRI may help to detect spread of cancers more quickly – The Lancet (free)
MRI for Lung Cancer Staging: Diagnostic accuracy of whole-body MRI versus standard imaging pathways for metastatic disease in newly diagnosed non-small-cell lung cancer: the prospective Streamline L trial – The Lancet Respiratory Medicine (free) AND Commentary: Whole-body MRI for lung cancer staging: a step in the right direction – The Lancet Respiratory Medicine (free)
MRI for Colorectal Cancer Staging: Diagnostic accuracy of whole-body MRI versus standard imaging pathways for metastatic disease in newly diagnosed colorectal cancer: the prospective Streamline C trial – The Lancet Gastroenterology & Hepatology (free) AND Commentary: Thinking outside the box: a more efficient diagnostic approach in metastatic colorectal cancer – The Lancet Gastroenterology & Hepatology (free)
Tue May 14 – 10 Stories of The Day!
14 May, 2019 | 06:16h | UTC
Commentary: HRS releases consensus statement on arrhythmogenic cardiomyopathy: 5 things to know – Cardiovascular Business (free)
3 – Obesity in the critically ill: a narrative review – Intensive Care Medicine (free)
Related Reviews: The Crashing Obese Patient – West Journal of Emergency Medicine (free) AND ARDS in Obese Patients: Specificities and Management – Critical Care (free)
Source: Critical Care Reviews Newsletter
Invited Commentary: Antibiotics for operative vaginal delivery: practice-changing data – The Lancet (free)
5 – Estimated Quality of Life and Economic Outcomes Associated With 12 Cervical Cancer Screening Strategies: A Cost-effectiveness Analysis – JAMA Internal Medicine (free for a limited period)
Invited Commentary: Screening Options for Preventing Cervical Cancer (free for a limited period)
Author Interview: Estimated Quality of Life and Economic Outcomes Associated With Cervical Cancer Screening (free audio)
“Cytologic testing every 3 years and low-cost high-risk human papillomavirus testing every 5 years both may be considered reasonable cervical cancer screening options.”
6 – Spreading and scaling up innovation and improvement – The BMJ (free)
7 – Thyroid and Cardiovascular Disease Research Agenda for Enhancing Knowledge, Prevention, and Treatment – Circulation (free PDF) (via @paomorejon see Tweet)
Commentary: New recommendations for a thyroid and cardiovascular disease research agenda – Mary Ann Liebert, Inc (free)
8 – Frequency of Intracranial Hemorrhage With Low-Dose Aspirin in Individuals Without Symptomatic Cardiovascular Disease: A Systematic Review and Meta-analysis – JAMA Neurology (free for a limited period)
Commentaries: Low-dose aspirin linked to bleeding in the skull, new report says – CNN (free) AND Study links low-dose aspirin to bleeding inside the skull – UPI (free)
9 – Speaking up to prevent harm: A systematic review of the safety voice literature – Safety Science (free)
Mon May 13 – 10 Stories of The Day!
13 May, 2019 | 02:14h | UTC
See also: Executive Summary (free)
Commentary: Deep kissing – a neglected route for throat gonorrhea – OnMedica (free) AND Deep Kissing Might Spread Oropharyngeal Gonorrhea in MSM – NEJM Journal Watch (free)
4 – “The Case of the Magician’s Sleight” – EMNerd (free)
See also: EXTEND Alteplase Shenanigans! – Emergency Medicine Literature of Note (free)
Original Study: Randomized Trial: Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke (free)
Related Cochrane Review: Thrombolysis for acute ischaemic stroke (free)
Related Opinion: Thrombolytics for stroke: The evidence – First10Em (free)
“Using statistical magic to extend the time window for IV tPA” (via @emcrit see Tweet)
5 – Targeting Huntingtin Expression in Patients with Huntington’s Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Experimental Drug For Huntington’s Disease Jams Malfunctioning Gene – NPR (free) AND Huntington drug successfully lowers levels of disease-causing protein, study shows – University of British Columbia (free)
6 – Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus – Nature Medicine (link to abstract – $ for full-text)
Commentaries: Viruses genetically engineered to kill bacteria rescue girl with antibiotic-resistant infection – Science (free) AND Genetically Modified Viruses Help Save A Patient With A ‘Superbug’ Infection – NPR (free) AND Genetically Tweaked Viruses Just Saved A Very Sick Teen – Wired (a few articles per month are free) AND Phage therapy’s latest makeover – Nature Biotechnology (free) AND Genetically modified virus saves teen’s life, offers hope in fight against antibiotic resistance – CNN (free) AND Scientists use engineered phages to help save teen – CIDRAP (free)
Commentaries: One in five people in England harmed by others’ drinking over past year – Blog BMJ Open (free) AND One in five people harmed by other people’s drinking – OnMedica (free) AND One in five harmed by others drinking alcohol over past year, survey finds – The Guardian (free) AND Expert reaction to study quantifying the harm of other people’s drinking – Science Media Centre (free)
Commentary: Meta-analysis: high intake of sugary drinks, juice tied to gout – Univadis (free registration required)
Fri May 10 – 10 Stories of The Day!
10 May, 2019 | 05:12h | UTC
1 – Prostate cancer: diagnosis and management – National Institute for Health and Care Excellence (free)
See also: NICE Quality Standard: Prostate Cancer (free)
Commentaries: The Apgar score and association with neonatal mortality and morbidity – The BMJ Opinion (free) AND Lower ‘normal’ Apgar scores linked to poorer outcomes – OnMedica (free)
“Vasopressin therapy in septic shock had no effect on 28-day mortality”
4 – A Deep Learning Mammography-based Model for Improved Breast Cancer Risk Prediction – Radiology (free)
Commentaries: Using AI to predict breast cancer and personalize care – MIT News (free) AND Novel artificial intelligence method predicts future risk of breast cancer – Radiological Society of North America (free)
Commentary: Patients with late-onset type 1 diabetes commonly treated as having type 2 diabetes – ACP Diabetes (free)
6 – Management of perinatal depression with non-drug interventions – The BMJ (free)
Commentaries: Rural Areas Drive Increases in Global Obesity – Scientific American (free) AND Obesity rising faster in rural areas than cities – Imperial College London (free)
8 – Global alcohol exposure between 1990 and 2017 and forecasts until 2030: a modelling study – The Lancet (link to abstract – $ for full-text)
Commentaries: Targets to reduce harmful alcohol use are likely to be missed as global alcohol intake increases – The Lancet (free) AND Increases in Drinking Worldwide (1990-2017) – Psychology Today (free) AND Alcohol use soaring worldwide: The average adult now consumes about 1.7 gallons of pure alcohol per year – USA Today (free)
Related: Alcohol Use and Burden for 195 Countries and Territories (free) AND The Global Burden of Disease Attributable to Alcohol and Drug Use (free)
9 – Snakebite: WHO targets 50% reduction in deaths and disabilities – World Health Organization (free)
Executive Summary: A strategy for prevention and control – World Health Organization (free PDF)
WHO Fact Sheet: Snakebite envenoming (free)
See also: New WHO Strategy Aims to Halve the Global Impact of Snakebite (report and resources) AND Study: Global Mapping of Vulnerability to Snakebite Envenoming (free) AND Snakebites Make The List Of ‘Neglected Tropical Diseases’ – NPR Goats and Soda (free)
10 – Access Barriers to Antibiotics – Center for Disease Dynamics, Economics & Policy (free PDF)
News Release: Lack of Access to Antibiotics is a Major Global Health Challenge (free PDF)
Commentary: Report highlights lack of access to antibiotics – CIDRAP (free)
Thu May 9 – 10 Stories of The Day!
9 May, 2019 | 08:16h | UTC
1 – Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: IV Thrombolysis Could Be Given Up to 9 Hours After Stroke Onset in Some – NEJM Journal Watch (free)
Related Randomized Trial: MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset (free study and commentaries)
2 – A Randomized Trial of Progesterone in Women with Bleeding in Early Pregnancy – New England Journal of Medicine (link to abstract – $ for full-text)
Related Study: A Randomized Trial of Progesterone in Women with Recurrent Miscarriages – New England Journal of Medicine (free)
Commentaries: Progesterone could increase births in women with early pregnancy bleeding and previous miscarriage – University of Birmingham (free) AND Progesterone Was Ineffective Against Threatened Miscarriage – NEJM Journal Watch (free) AND Vaginal Progesterone May Reduce Miscarriages in Women with Bleeding in Early Pregnancy – MedicalResearch.com (free) AND Progesterone only prevents miscarriage in women with history of pregnancy loss – Reuters (free) AND Progesterone Disappoints Again for Threatened Miscarriage – MedPage Today (free registration required)
Editorial: Filling in the Evidence About Sunscreen (free)
Commentaries: Expert reaction to study looking at sunscreen ingredients and bloodstream concentrations – Science Media Centre (free) AND High levels of sunscreen ingredients end up in the bloodstream: study – Reuters (free) AND How Sunscreen Chemicals Can Get Into Your Blood – Forbes (free) AND How Much of Your Sunscreen is Absorbed? – MedicalResearch.com (free)
4 – Prophylactic oxytocin for the third stage of labour to prevent postpartum haemorrhage – Cochrane Library (free)
Summary: Oxytocin to prevent excessive blood loss for women during the third stage of labour – Cochrane Library (free)
Related: WHO Guideline: Uterotonics for the Prevention of Postpartum Hemorrhage (free)
5 – State of the Art Review: Diagnosis and management of sensory polyneuropathy – The BMJ (free for a limited period)
6 – Acute Flaccid Myelitis: A Clinical Overview for 2019 – Mayo Clinic Proceedings (free)
7 – POEMS syndrome: clinical update – Journal of Neurology (free)
9 – Azithromycin during Acute COPD Exacerbations Requiring Hospitalization (BACE): a Multicentre, Randomized, Double-blind, Placebo-controlled Trial – American Journal of Respiratory and Critical Care Medicine (link to abstract – $ for full-text)
Commentaries: Azithromycin appears to reduce treatment failure in severe, acute COPD exacerbations – American Thoracic Society (free) AND Azithromycin May Reduce Treatment Failure in Patients With Acute Exacerbation of COPD – AJMC (free)
10 – Study Puts Eggs and Dietary Cholesterol Back on the Radar – JAMA (free for a limited period)
Podcast: Study Puts Eggs and Dietary Cholesterol Back on the Radar (free audio)
Original Study: Cohort Study: Associations of Dietary Cholesterol or Egg Consumption with Incident Cardiovascular Disease and Mortality (link to abstract and commentaries)
Wed May 8 – 10 Stories of The Day!
8 May, 2019 | 07:18h | UTC
Related: Stroke in Childhood: Clinical guideline for diagnosis, management and rehabilitation (free guideline and resources)
3 – Diagnosis and Treatment of Early Stage Testicular Cancer: AUA Guideline (2019) (free)
4 – Push-Dose Vasopressors: An Update for 2019 – emDocs (free)
Related: A Comparative Study of Bolus Norepinephrine, Phenylephrine, and Ephedrine for the Treatment of Maternal Hypotension in Parturients with Preeclampsia During Cesarean Delivery Under Spinal Anesthesia – Medical Science Monitor (free) AND Bolus-Dose Vasopressors in the Emergency Department: First, Do No Harm; Second, More Evidence Is Needed – Annals of Emergency Medicine (free PDF)
5 – Is Noise Pollution the Next Big Public-Health Crisis? – The New Yorker (3 articles per month are free)
Related: Environmental Noise Guidelines for the European Region (free) AND WHO Environmental Noise Guidelines for the European Region: A Systematic Review on Environmental Noise and Effects on Sleep (free) AND Review: Environmental Noise and the Cardiovascular System (free) AND Cross-sectional analysis: noise exposure in workplace tied to hypertension and high cholesterol (free)
6 – The world-wide burden of musculoskeletal diseases: a systematic analysis of the World Health Organization Burden of Diseases Database – Annals of Rheumatic Diseases (link to abstract – $ for full-text)
Commentaries: Musculoskeletal conditions now second global cause of years lived with disability – BMJ (free) AND Musculoskeletal conditions 2nd global cause of years with disability – OnMedica (free)
7 – Patent Foramen Ovale and Ischemic Stroke in Patients With Pulmonary Embolism: A Prospective Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: PFO Compounds Ischemic Stroke Risk Among Patients with Pulmonary Embolism – TCTMD (free) AND PFO Tied to Increased Stroke Risk in Patients with Pulmonary Embolism – NEJM Journal Watch (free)
8 – Association of Treatment With 5α-Reductase Inhibitors With Time to Diagnosis and Mortality in Prostate Cancer – JAMA Internal Medicine (free for a limited period)
Commentary: 5-ARIs Tied to Delayed Prostate Cancer Dx, Worse Outcomes – MedPage Today (free registration required)
9 – Association of Gestational Weight Gain With Adverse Maternal and Infant Outcomes – JAMA (free for a limited period)
Editorial: Prepregnancy Body Mass Index, Weight Gain During Pregnancy, and Health Outcomes (free for a limited period)
“Optimal gestational weight gain ranges were 14.0 kg to less than 16.0 kg for women categorized as underweight; 10.0 kg to less than 18.0 kg for normal weight; 2.0 kg to less than 16.0 kg for overweight; 2.0 kg to less than 6.0 kg for obesity grade 1; weight loss or gain of 0 kg to less than 4.0 kg for obesity grade 2; and weight gain of 0 kg to less than 6.0 kg for obesity grade 3.”
10 – Does Skipping Breakfast Lead to Weight Loss or Weight Gain? – JAMA (free for a limited period)
Related: Observational Study Suggests a Link Between Skipping Breakfast and Increased Cardiovascular Risk (link to abstract and commentaries) AND Meta-Analysis: Effect of Breakfast on Weight and Energy Intake (free study and commentary)
Tue May 7 – 10 Stories of The Day!
7 May, 2019 | 02:24h | UTC
1 – Implementation manual to prevent and control the spread of carbapenem-resistant organisms at the national and health care facility level – World Health Organization (free PDF manual and resources)
Related Systematic Review: Control of Carbapenem-resistant Enterobacteriaceae, Acinetobacter baumannii, and Pseudomonas aeruginosa in Healthcare Facilities – Clinical Infectious Diseases (free)
See also: Prevention and Treatment of Surgical Site Infections (free guidelines on the subject)
Systematic review summary: Treatment of tics in people with Tourette syndrome and chronic tic disorders – Neurology (free)
Source: New Guideline Published on Tourette Syndrome, Other Tic Disorders – NEJM Journal Watch (free)
Related: Updates in Management and Timing of Dialysis in Acute Kidney Injury (free) AND Randomized Trial: Early vs. Delayed Dialysis in Acute Kidney Injury (free study and commentaries)
4 – Fournier Gangrene Associated With Sodium–Glucose Cotransporter-2 Inhibitors: A Review of Spontaneous Postmarketing Cases – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: SGLT2 inhibitors associated with rare, life-threatening necrotizing genital infections – ACP Internist (free) AND Potentiall fatal infection of genitals identified as rare side effect of SGLT2 Inhibitors – American College of Physicians (free) AND Postmarketing data support Fournier gangrene link with SGLT2 inhibitors – Medicine Matters (free)
Related: SGLT2 inhibitors: reports of Fournier’s gangrene (necrotising fasciitis of the genitalia or perineum) – GOV.UK (free)
5 – 80,000 Deaths. 2 Million Injuries. It’s Time for a Reckoning on Medical Devices – The New York Times (10 articles per month are free)
Related: Investigation: The Implant Files (free report and commentaries) AND It’s time to get serious about the safety of medical devices – STAT News (free)
6 – Here’s why moderate drinking is probably not good for you – The Guardian (free)
“The problem is that moderate drinking isn’t an isolated behaviour. You can’t easily separate moderate drinking from the people who drink moderately, which means that you can’t easily identify whether it’s actually the alcohol that’s improving people’s health or something more complex.”
7 – Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum Period – JAMA (free for a limited period)
Original Article: 2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum (free)
8 – Diagnostic Modalities for Acute Compartment Syndrome of the Extremities: A Systematic Review – JAMA Surgery (free for a limited period)
9 – Relationship Between Poor Olfaction and Mortality Among Community-Dwelling Older Adults: A Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Poor olfaction linked to increased mortality in older adults – 2 Minute Medicine (free) AND Declining sense of smell linked to premature mortality – OnMedica (free) AND Why a smell test could become part of a regular doctor visit – Michigan State University (free)
Mon May 6 – 10 Stories of The Day!
6 May, 2019 | 00:15h | UTC
1 – Ulcerative colitis: management – National Institute for Health and Care Excellence (free)
Related Guidelines: ACG Clinical Guideline: Ulcerative Colitis in Adults – American Journal of Gastroenterology (free) AND AGA Clinical Practice Guidelines on the Management of Mild-to-Moderate Ulcerative Colitis – Gastroenterology (free) AND Updated S3-Guideline Ulcerative Colitis. German Society for Digestive and Metabolic Diseases (DGVS) – Zeitschrift für Gastroenterologie (free) AND Management of Paediatric Ulcerative Colitis (free)
2 – Crohn’s disease: management – National Institute for Health and Care Excellence (free)
Related: ACG Clinical Guideline: Management of Crohn’s Disease in Adults – The American Journal of Gastroenterology (free)
3 – Guidelines for Perioperative Care in Cardiac Surgery: Enhanced Recovery After Surgery Society Recommendations – JAMA Surgery (free for a limited period)
Invited Commentary: The Enhanced Recovery After Surgery in Cardiac Surgery Revolution – JAMA Surgery (free)
Related: Enhanced Recovery After Surgery (ERAS) Society Guidelines (free articles)
See also: Measles & the MMR Vaccine: Recommendations Around Pregnancy, Including the Periconception and Postpartum Periods – University of Washington (free PDF)
Commentary: ACOG Practice Advisory: patient management during a measles outbreak – Univadis (free registration required)
5 – Should Adults Get a Measles Booster Shot? – The New York Times (10 articles per month are free)
See also: Measles Shots Aren’t Just For Kids: Many Adults Could Use A Booster Too – NPR (free) AND HHS, CDC Address Ongoing Measles Outbreaks – AAFP (free) AND Measles, Mumps, and Rubella (MMR) Vaccination: What Everyone Should Know – CDC (free)
6 – Podcast: Untangling the Future of Telehealth And How To Get There – The Curbsiders Internal Medicine Podcast (free audio and text)
7 – Early Norepinephrine Has Potential in Septic Shock – Emergency Medicine News (free)
Original Study: Randomized Trial: Early Use of Norepinephrine in Septic Shock Resuscitation (link to abstract and commentary)
8 – Urgent steps are needed to prevent Ebola from spinning out of control in the DRC – STAT (free)
See also: ‘The world has never seen anything like this’: WHO chief on battling Ebola in a war zone – Nature (free) AND Ebola deaths top 1,000 in increasingly dangerous outbreak – CIDRAP (free)
Commentaries: Predicting individual treatment response in diabetes – The Lancet Endocrinology & Diabetes (free) AND Simple clinical features can help personalise type 2 diabetes treatment – University of Exeter (free)
Related: Novel subgroups of adult-onset diabetes and their association with outcomes (link to abstract and commentaries)
Fri May 3 – 10 Stories of The Day!
3 May, 2019 | 07:47h | UTC
1 – Recurrent Uncomplicated Urinary Tract Infections in Women: AUA/CUA/SUFU Guideline (2019)
Commentary: Recommendations for the Evaluation, Management of Recurrent UTI in Women Released – MPR (free)
Commentary: Successful treatment of HIV eliminates sexual transmission – The Lancet (free)
Related: Systematic Review: Negligible Risk of Transmitting HIV During Sex When Viral Load is Suppressed (free study and commentaries) AND UNAIDS Explainer: UNDETECTABLE = UNTRANSMITTABLE (free)
Commentary: Towards a public health approach to psychotic disorders – The Lancet Public Health (free)
5 – The electrocardiogram in the athlete – free chapter from the new European Society of Cardiology Textbook of Sports Cardiology (via @gonzaeperez see Tweet)
6 – A Global Review of Food-Based Dietary Guidelines – Advances in Nutrition (free)
Related: Enhanced Recovery After Surgery (ERAS) Society Guidelines (free articles)
9 – Why Your Doctor’s White Coat Can Be a Threat to Your Health – The New York Times (10 articles per month are free)
Related: Long Sleeves on Doctors’ White Coats May Spread Germs (free commentaries)
10 – Diagnostic Performance of Creatinine-Based Equations for Estimating Glomerular Filtration Rate in Adults 65 Years and Older – JAMA Internal Medicine (free for a limited period)
Thu May 2 – 10 Stories of The Day!
2 May, 2019 | 04:41h | UTC
Related Guidelines: Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the AHA/ASA (free) AND Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke – The BMJ (free) AND Canadian Stroke Best Practice Recommendations for Acute Stroke Management (free)
Original Guideline: 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease (free guideline and resources)
For Consumers: Taking Z-drugs for Insomnia? Know the Risks – U.S. Food & Drug Administration (free)
Commentaries: Drug Agency Calls for Strong Warning Labels on Popular Sleep Aids – The New York Times (10 articles per month are free) AND FDA Requires Stronger Warnings for Common Insomnia Medications – Psychiatric News Alert (free)
4 – Chronic Constipation – Mayo Clinic Proceedings (free)
Related: Indian Consensus on Chronic Constipation in Adults (free guidelines and reviews on the subject)
5 – Positional therapy for obstructive sleep apnoea – Cochrane Library (free)
Summary: Are interventions to keep people sleeping on their side the best way to treat obstructive sleep apnoea? – Cochrane Library (free)
Commentaries: Guidelines proposed for newly defined Alzheimer’s-like brain disorder – NIH News Releases (free) AND Researchers define Alzheimer’s-like brain disorder: LATE symptoms resembles Alzheimer’s disease but has different cause – Rush University Medical Center (free) AND Form of dementia that ‘mimics’ Alzheimer’s symptoms discovered – The Guardian (free)
7 – As Artificial Intelligence Moves Into Medicine, The Human Touch Could Be A Casualty – NPR (free)
Related: AHA Scientific Statement on Cardio-Oncology: Vascular and Metabolic Perspectives (several guidelines on the subject)
9 – Pre-eclampsia and risk of later kidney disease: nationwide cohort study – The BMJ (free)
Commentary: Preeclampsia Tied to Later Risk for Chronic Kidney Disease – NEJM Journal Watch (free)
10 – Preterm birth and risk of chronic kidney disease from childhood into mid-adulthood: national cohort study – BMJ (free)
Commentary: Preterm Birth Tied to Long-Term Risk for CKD in the Child – NEJM Journal Watch (free)
Wed May 1 – 10 Stories of The Day!
1 May, 2019 | 10:01h | UTC
Related: 10 Tips for Intensive Care Management of Transplanted Patients (free articles) AND Special Issue: Infections in Solid Organ Transplantation Guidelines (free articles)
Source: Critical Care Reviews Newsletter
Commentary: Shorter Treatment Succeeds in Septic Arthritis – RheumNow (free)
4 – Risk‐reducing medications for primary breast cancer: a network meta‐analysis – Cochrane Library (free)
Summary: Medicines to prevent breast cancer in women at above-average risk of developing breast cancer – Cochrane Library (free)
5 – Opinion: How to Make Doctors Think About Death – The New York Times (10 articles per month are free)
“End-of-life treatment guidelines would help families, physicians and nurses confront the inevitable with care and compassion.”
6 – Is It Time for Safeguards in the Adoption of Robotic Surgery? – JAMA (free for a limited period)
Related: FDA Cautions Patients, Providers About Using Robotically-assisted Surgical Devices for Mastectomy and Other Cancer-related Surgeries (free safety alert and commentary)
“To date, most studies demonstrating potential benefits of robotic-assisted surgery have been small, single-centered reports without rigorous controls.”
7 – Clinical Update: Active Surveillance of Low-Risk Thyroid Cancer – JAMA (free for a limited period)
“Individuals should also be aware that there are currently no head-to-head randomized trials that compared active surveillance of low-risk thyroid cancer with thyroid surgery, and that there remain uncertainties related to the risks and benefits of each approach.”
8 – Alex Nowbar’s research reviews, 30 April 2019 – The BMJ Opinion (free)
9 – Perioperative Fluid Therapy for Major Surgery – Anesthesiology (free)
Source: Critical Care Reviews Newsletter
10 – Effect of Initial Management With Aflibercept vs Laser Photocoagulation vs Observation on Vision Loss Among Patients With Diabetic Macular Edema Involving the Center of the Macula and Good Visual Acuity: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Patients With Good Vision and Diabetic Macular Edema Involving the Center of the Macula: To Treat or Not to Treat? (free)
Commentary: Watchful waiting reasonable for patients with diabetic macular edema and good vision – NIH News Releases (free)
See also: Visual Abstract
Tue April 30 – 10 Stories of The Day!
30 Apr, 2019 | 02:51h | UTC
1 – Report: No Time to Wait: Securing the future from drug-resistant infections – World Health Organization (free PDF)
News Release: New report calls for urgent action to avert antimicrobial resistance crisis – World Health Organization (free)
Commentary: UN report calls for urgent action against antimicrobial resistance – CIDRAP (free)
3 – Heart failure in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference – Kidney International (free) (via @paomorejon)
Commentaries: Childhood mortality declining globally but disability on the rise – Reuters (free) AND Child and adolescent deaths decreased by half worldwide since 1990 Journalist’s Resource (free)
5 – Association Between Peripheral Neuropathy and Exposure to Oral Fluoroquinolone or Amoxicillin-Clavulanate Therapy – JAMA Neurology (free for a limited period)
Editorial: On the Association Between Fluoroquinolones and Neuropathy (free)
Related: Committee Recommends New Restrictions on the use of Fluoroquinolones (free report and commentaries)
6 – Restrictive strategy versus usual care for cholecystectomy in patients with gallstones and abdominal pain (SECURE): a multicentre, randomised, parallel-arm, non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Commentary: Applying Strict Criteria for Gallbladder Removal Doesn’t Improve Pain – NEJM Journal Watch (free)
Source: EvidenceAlerts
“Our findings suggest that to provide clinical benefit with the least effect on growth, the number of repeat treatment courses should be limited to a maximum of three and the total dose to between 24 mg and 48 mg.”
Commentary: NNT with statins is 400 for lower risk eligible patients, researchers estimate – Pulse (free)
9 – Effect of Gastric Residual Evaluation on Enteral Intake in Extremely Preterm Infants: A Randomized Clinical Trial – JAMA Pediatrics (free for a limited period)
10 – Release of “13 Reasons Why” associated with increase in youth suicide rates – NIH News Releases (free)
Original Study: Association Between the Release of Netflix’s 13 Reasons Why and Suicide Rates in the United States: An Interrupted Times Series Analysis – Journal of the American Academy of Child and Adolescent Psychiatry (link to abstract – $ for full-text)
Related Study: Internet Searches for Suicide Following the Release of “13 Reasons Why” (free study and commentaries)
“NIH-supported study highlights the importance of responsible portrayal of suicide by the media.”
Mon April 29 – 10 Stories of The Day!
29 Apr, 2019 | 01:13h | UTC
Comprehensive resource on the subject with 9 guidelines covering important aspects of patient care.
3 – One-Year Mortality After Dialysis Initiation Among Older Adults – JAMA Internal Medicine (free for a limited period)
Commentaries: Older Adults Starting Dialysis Die at Higher Rates than Previously Thought – Harvard Medical School (free) AND More than half of older dialysis patients die within a year – UPI (free)
4 – Management of inflammatory rheumatic conditions in the elderly – Rheumatology (free)
5 – Treatment of Patients With Psychogenic Nonepileptic Attacks – JAMA (free for a limited period)
Author Interview: Treatment of Patients With Psychogenic Nonepileptic Attacks (free audio)
6 – Oral immunotherapy for peanut allergy (PACE): a systematic review and meta-analysis of efficacy and safety – The Lancet (link to abstract – $ for full-text)
Commentaries: Peanut allergy oral immunotherapy increases allergic reactions, compared with avoidance or placebo – The Lancet (free) AND Oral Immunotherapy for Peanut Allergy Linked to Increased Anaphylaxis Risk – NEJM Journal Watch (free) AND Experimental treatment for peanut allergy increases anaphylaxis risk, study finds – CNN (free) AND Expert reaction to study on peanut allergy oral immunotherapy and allergic reactions – Science Media Centre (free)
7 – Intravenous magnesium can reduce shivering in patients after surgery – NIHR Signal (free)
Original Study: Effectiveness of Magnesium in Preventing Shivering in Surgical Patients: A Systematic Review and Meta-analysis – Anesthesia & Analgesia (free)
8 – Prostate MRI, with or without MRI‐targeted biopsy, and systematic biopsy for detecting prostate cancer – Cochrane Library (free)
Summary: Is prostate MRI, with or without MRI-targeted biopsy, better than systematic biopsy for detecting prostate cancer in men? – Cochrane Library (free)
Related Randomized Trial: MRI-Targeted or Standard Biopsy for Prostate-Cancer Diagnosis (link to abstract and commentaries)
“The diagnostic workup of prostate cancer may benefit from including prostate MRI prior to biopsy.”
Commentaries: Substituting healthy plant proteins for red meat lowers risk for heart disease – Harvard T.H. Chan School of Public Health (free) AND Swapping red meat for healthy plant proteins may reduce heart disease risk – UPI (free) AND ‘Is red meat good or bad?’ Researchers say that’s the wrong question – CBC (free) AND It’s Not Just Avoiding Red Meat, It’s the Substitute Diet That Influences Heart Health – MedicalResearch.com (free)
10 – Association of Skipping Breakfast With Cardiovascular and All-Cause Mortality – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: People Who Forgo Breakfast May Carry a Higher Risk of CV Death – TCTMD (free) AND Skipping breakfast tied to higher risk of heart-related death, study finds – CNN (free) AND Skipping breakfast associated with higher risk of cardiovascular death – University of Iowa (free) AND Regularly skipping breakfast linked to increased risk of heart disease and stroke – NHS News (free)