TOP 10 Medical News Stories

“GINA no longer recommends treating adults/adolescents with asthma with short-acting bronchodilators alone. Instead, they should receive symptom-driven (in mild asthma) or a daily corticosteroid-containing inhaler, to reduce risk of severe exacerbations.”

Thu July 4 – 10 Stories of The Day!

4 Jul, 2019 | 11:15h | UTC

1 – School-based violence prevention: a practical handbook – World Health Organization (free PDF)

News Release: New handbook promotes schools as an ideal setting for violence prevention (free)

2 – WHO draft guidelines on dietary saturated and trans fatty acids: time for a new approach? – The BMJ (free)

Commentary: Expert reaction to opinion piece questioning WHO draft guidance on saturated fat – Science Media Centre (free)

Original Draft Guideline: Saturated fatty acid and trans-fatty acid intake for adults and children – World Health Organization (free PDF)

3 – The Zika Virus Is Still a Threat. Here’s What the Experts Know. – The New York Times (10 articles per month are free)

Related WHO Report: Zika epidemiology update – July 2019 (free PDF)

4 – Rituximab or Cyclosporine in the Treatment of Membranous Nephropathy – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Study Finds Rituximab Noninferior to Cyclosporine for Membranous Nephropathy – Center for Biosimilars (free)

5 – Nonnarcotic Methods of Pain Management – New England Journal of Medicine (free)

6 – Wide Interest in a Vitamin C Drug Cocktail for Sepsis Despite Lagging Evidence – JAMA (free for a limited period)

7 – Ann Robinson’s journal review, 3 July 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

8 – Suicide amongst anaesthetists – an Association of Anaesthetists survey – Anaesthesia (free)

News Release: Survey highlights need for improved mental health guidance & support for anaesthetists – Association of Anaesthetists (free)

9 – Heart disease and pregnancy: State of the art – Revista Portuguesa de Cardiologia (free)

10 – Association of Initiation of Maintenance Dialysis with Functional Status and Caregiver Burden – Clinical Journal of the American Society of Nephrology (free)

Commentaries: Functional Decline Seen in Many Older Adults Initiating Dialysis – Renal & Urology News (free) AND Many Older Patients Initiating Dialysis Experience Functional Decline – American Society of Nephrology (free) AND Starting Dialysis Worse Than ‘Being Hit by a Silent Freight Train’ – Medscape (free registration required)

Wed July 3 – 10 Stories of The Day!

3 Jul, 2019 | 07:01h | UTC

1 – Evaluation and Management of the Child and Adult With Fontan Circulation: A Scientific Statement From the American Heart Association – Circulation (free PDF)

News Release: More people born with a single lower heart chamber survive, but face challenges in quality and length of life (free)

Top Ten Things to Know: Evaluation and Management of the Child and Adult With Fontan Circulation (free)

2 – Prevention of Early-Onset Group B Streptococcal Disease in Newborns – American College of Obstetricians and Gynecologists (free)

3 – Association of Carpal Tunnel Syndrome With Amyloidosis, Heart Failure, and Adverse Cardiovascular Outcomes – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Carpal Tunnel Linked to Higher Rates of Amyloidosis and HF – TCTMD (free) AND Carpal Tunnel Syndrome and Amyloidosis, HF, and Adverse CV Outcomes – American College of Cardiology (free)

4 – Dietary fats and mortality among patients with type 2 diabetes: analysis in two population based cohort studies – The BMJ (free)

Commentary: Polyunsaturated Fatty Acid Intake Linked to Lower Mortality Risk in Diabetes – NEJM Journal Watch (free)

5 – A user’s guide to inflated and manipulated impact factors – European Journal of Clinical Investigation (free)

6 – Immune Checkpoint Inhibitor Toxicities – Mayo Clinic Proceedings (free)

7 – Ulcerative Colitis – Mayo Clinic Proceedings (free)

Related: NICE Guideline: Management of Ulcerative Colitis (free guidelines on the subject)

8 – Infections in the Elderly Critically-Ill Patients – Frontiers in Medicine (free)

9 – Current guidelines in peritoneal dialysis – Part I – Portuguese Journal of Nephrology & Hypertension (free PDF)

Part II: Current guidelines in peritoneal dialysis (free PDF)

10 – EAES and SAGES 2018 consensus conference on acute diverticulitis management: evidence-based recommendations for clinical practice – Surgical Endoscopy (free)

Tue July 2 – 10 Stories of The Day!

2 Jul, 2019 | 07:29h | UTC

1 – The Real Deal on Brain Health Supplements: GCBH Recommendations on Vitamins, Minerals, and Other Dietary Supplements – Global Council on Brain Health (free PDF)

Commentaries: On supplements preventing cognitive decline, ‘science says that doesn’t work’ – University of Pennsylvania (free) AND Supplements for Brain Health Panned – Medscape (free registration required)

Related Cochrane Review: Supplements for Preventing Cognitive Decline in People with Mild Cognitive Impairment (free)

2 – Moving Matters – Interventions to Increase Physical Activity – National Institute for Health Research (NIHR) (free)

3 – Association of Radioactive Iodine Treatment With Cancer Mortality in Patients With Hyperthyroidism – JAMA Internal Medicine (free)

Commentaries: NIH study finds long-term increased risk of cancer death following common treatment for hyperthyroidism – NIH News Releases (free) AND Treatment for overactive thyroid linked to increased risk of dying from cancer – CNN (free) AND Expert reaction to study looking at radioactive iodine treatment for overactive thyroid and risk of cancer – Science Media Centre (free)

4 – Association of Weight Loss Interventions With Changes in Biomarkers of Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free)

Author Interview: Association of Weight Loss Interventions With Changes in NAFLD Biomarkers (free audio)

Commentaries: Treatment of Fatty Liver Disease—Time to Implement Common Sense Measures – JAMA Internal Medicine (free for a limited period) AND Doctors should offer structured weight loss programmes as treatment for non-alcoholic fatty liver disease – University of Oxford (free)

5 – Alcohol’s Secondhand Harms in the United States: New Data on Prevalence and Risk Factors – Journal of Studies on Alcohol and Drugs (link to abstract – $ for full-text)

Commentaries: The secondhand harms of drinking impact 1 in 5 adults, study says – CNN (free) AND Alcohol’s secondhand harms prevalent among U.S. women and men – Reuters (free)

6 – 10 Medical Myths We Should Stop Believing. Doctors, Too. – The New York Times (10 articles per month are free)

Original Study: Meta-Research: A Comprehensive Review of Randomized Trials Leading to “Medical Reversals” in Three Medical Journals (free)

7 – Effects of continuous positive airway pressure on depression and anxiety symptoms in patients with obstructive sleep apnoea: results from the sleep apnoea cardiovascular Endpoint randomised trial and meta-analysis – EClinicalMedicine (free)

Commentaries: Mood After CPAP: Fewer Patients With Depression, but not Fewer With Anxiety – EClinicalMedicine (free) AND CPAP provides relief from depression – Flinders University (free)

8 – Gastrointestinal Tract Disorders in Older Age – Canadian Journal of Gastroenterology and Hepatology (free)

9 – Adapting diabetes medication for low carbohydrate management of type 2 diabetes: a practical guide – British Journal of General Practice (free)

10 – Association between regional body fat and cardiovascular disease risk among postmenopausal women with normal body mass index – European Heart Journal (free)

Commentaries: Pear-shaped is better for postmenopausal women, even if they are normal weight – European Society of Cardiology (free) AND Pear shaped women are healthier than apple shaped women, study finds – CNN (free)

Mon July 1 – 10 Stories of The Day!

1 Jul, 2019 | 00:01h | UTC

1 – Pediatric Post–Cardiac Arrest Care: A Scientific Statement From the American Heart Association – Circulation (free PDF)

Top Ten Things to Know: Pediatric Post–Cardiac Arrest Care (free)

Podcast: Care Considerations for the Pediatric Post-Cardiac Arrest Patient (free)

2 – 2019 European guideline on the management of lymphogranuloma venereum – Journal of the European Academy of Dermatology and Venereology (free)

3 – Syphilis – The BMJ (free)

4 – Duration of dual antiplatelet therapy after percutaneous coronary intervention with drug-eluting stent: systematic review and network meta-analysis – The BMJ (free)

Related Randomized Trials: Shorter Duration of Dual Antiplatelet Therapy May be an Option for Patients Undergoing Percutaneous Coronary Intervention (free studies and commentaries)

5 – Causes of severe pneumonia requiring hospital admission in children without HIV infection from Africa and Asia: the PERCH multi-country case-control study – The Lancet (free)

Commentaries: What the PERCH study means for future pneumonia strategies – The Lancet (free) AND Study: Viruses cause most global pediatric pneumonia – CIDRAP (free)

6 – A Practical Approach to Low-Dose Aspirin for Primary Prevention – JAMA (free for a limited period)

7 – IDSA/AAN/ACR Draft Lyme Disease Guidelines – Infectious Diseases Society of America (free PDF)

Commentary: New Draft Lyme Disease Guidelines Issued – NEJM Journal Watch (free)

8 – Estimation of Kidney Function in Oncology: Implications for Anticancer Drug Selection and Dosing – Clinical Journal of the American Society of Nephrology (free)

“In one retrospective study, approximately one half of kidney function–impaired patients with solid tumors who were receiving a drug that necessitated dose adjustments for kidney function received almost 50% of their prescriptions at standard doses”.

9 – The Use of Activated Charcoal to Treat Intoxications – Deutsches Arzteblatt International (free)

10 – Effects of the DASH Diet and Sodium Intake on Bloating: Results From the DASH–Sodium Trial – The American Journal of Gastroenterology (link to abstract – $ for full-text)

Commentary: Higher salt intake can cause gastrointestinal bloating – Johns Hopkins University Bloomberg School of Public Health (free)

Fri June 28 – 10 Stories of The Day!

28 Jun, 2019 | 07:49h | UTC

1 – Pathophysiology, diagnosis and management of peripartum cardiomyopathy: a position statement from the Heart Failure Association of the European Society of Cardiology Study Group on peripartum cardiomyopathy – European Journal of Heart Failure (free)

2 – Guidelines for the Provision of Intensive Care Services – Edition 2 – Intensive Care Society (free PDF)

3 – Application of High-Sensitivity Troponin in Suspected Myocardial Infarction – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: High-Sensitivity Troponin in Suspected MI – American College of Cardiology (free) AND Risk Stratification Using Serial High-Sensitivity Troponin Measurements – NEJM Journal Watch (free)

See also: Compass MI Calculator

4 – Mass Drug Administration for Scabies — 2 Years of Follow-up – New England Journal of Medicine (free)

Commentaries: New Australian-Pacific scabies treatment has lasting results, study finds – Murdoch Childrens Research Institute (free) AND Scabies Means Misery. This Pill Can End It. – The New York Times (10 articles per month are free)

5 – Survey Snapshot: Challenging the Resistance to “Palliative” – NEJM Catalyst (free)

6 – Antiretroviral treatment can reduce the risk of HIV transmission between male partners to ‘zero’ – NIHR Signal (free)

Original Study: Undetectable = Untransmittable: Risk of HIV Transmission in Serodifferent Gay Couples (free study and commentaries)

7 – The Influence of Inpatient Physician Continuity on Hospital Discharge – Journal of General Internal Medicine (free)

Commentary: Inpatient physician continuity associated with speedier discharge at one hospital – ACP Hospitalist (free)

8 – Dietary carbohydrate restriction improves metabolic syndrome independent of weight loss – JCI Insight (free)

Commentary: Low-carb diet may reduce diabetes risk independent of weight loss – Ohio State University (free)

9 – Association between urinary triclosan with bone mass density and osteoporosis in the US adult women, 2005-2010 – The Journal of Clinical Endocrinology & Metabolism (free)

Commentaries: Triclosan Exposure May Lower Bone Mineral Density in Women – MPR (free) AND Osteoporosis: Investigating the role of a common antibacterial chemical – Medical News Today (free) AND Chemical in soaps, hand sanitizers tied to osteoporosis – Reuters (free)

10 – Types of Sedentary Behavior and Risk of Cardiovascular Events and Mortality in Blacks: The Jackson Heart Study – Journal of the American Heart Association (free)

Commentary: Sitting in front of TV may be worse for health than desk job – Reuters (free) AND Heart risk raised by sitting in front of the TV, not by sitting at work, finds study – Columbia University Irving Medical Center (free)

Thu June 27 – 10 Stories of The Day!

27 Jun, 2019 | 10:55h | UTC

1 – Diagnosing and managing work‐related mental health conditions in general practice: new Australian clinical practice guidelines – The Medical Journal of Australia (free)

2 – Same‐Day Discharge After Elective Percutaneous Coronary Interventions in Ontario, Canada – Journal of the American Heart Association (free)

Editorial: Same‐Day Discharge After Elective Uncomplicated Percutaneous Coronary Interventions (free)

Commentaries: Same-Day Discharge Safe After Elective PCI, Canadian Study Affirms – TCTMD (free) AND New study suggests same-day discharge after non-surgical heart procedure could save money and free up hospital beds – ICES (free)

Related Study: Same-Day Discharge After Elective PCI Seems Safe and Reduce Costs (free)

3 – New Guidelines Aim to Expand Palliative Care Beyond Specialists – JAMA (free for a limited period)

Audio Summary: New Guidelines Aim to Expand Palliative Care Beyond Specialists (free)

Original Guideline: Clinical Practice Guidelines for Quality Palliative Care (free article and commentaries)

Related: Building a Better Death, One Conversation at a Time – JAMA (free for a limited period)

4 – Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: updated systematic review and meta-analysis – The Lancet (link to abstract – $ for full-text)

Commentaries: Vaccination programs substantially reduce HPV infections and precancerous cervical lesions – Laval University (free) AND Hopes raised of cervical cancer eradication – BBC (free) AND Study shows major real-world impact of cervical cancer vaccines – Reuters (free)

5 – Amisulpride for the Rescue Treatment of Postoperative Nausea or Vomiting in Patients Failing Prophylaxis: A Randomized, Placebo-controlled Phase III Trial – Anesthesiology (free)

6 – Performance of a Deep-Learning Algorithm vs Manual Grading for Detecting Diabetic Retinopathy in India – JAMA Ophthalmology (free)

Related: Google Launches Program in India to Screen Diabetics for Eye Conditions (studies and commentaries on the subject)

7 – Second International Consensus Conference on lesions of uncertain malignant potential in the breast (B3 lesions) – Breast Cancer Research and Treatment (free)

8 – Newer-Generation Antidepressants and Suicide Risk in Randomized Controlled Trials: A Re-Analysis of the FDA Database – Psychotherapy and Psychosomatics (free)

Commentary: New study: antidepressants significantly raise the risk of suicide in the treatment of depression for adults (free)

9 – Impact of sugar‐sweetened beverage taxes on purchases and dietary intake: Systematic review and meta‐analysis – Obesity Reviews (free)

Related: Cochrane Review: Environmental Interventions to Reduce the Consumption of Sugar‐sweetened Beverages and Their Effects on Health (free study and commentaries) AND Soda Tax Linked to a 50 Percent Reduction in Sugary Drink Consumption (link to abstract and several resources on the subject) AND AAP/AHA Policy Statement: Public Policies to Reduce Sugary Drink Consumption in Children and Adolescents (free statement and commentaries) AND Taxes on Sugar-Sweetened Beverages Associated with Reduced Consumption (link to abstract and commentaries)

10 – Statin users have an elevated risk of dysglycemia and new‐onset‐diabetes – Diabetes Metabolism Research and Reviews (free PDF)

Commentaries: Statins may double the risk of type 2 diabetes – Medical News Today (free) AND Cholesterol Medication Could Invite Diabetes, Study Suggests – Ohio State University (free)

Related Studies: Another Observational Study Showing Association of Statin Use with Risk of New‐Onset Diabetes Mellitus (free study and commentaries) AND Cohort Study: Statin Use Associated with a 38% Higher Risk of Incident Type 2 Diabetes (free study and commentaries)

Wed June 26 – 10 Stories of The Day!

26 Jun, 2019 | 08:00h | UTC

1 – Hypertension in pregnancy: diagnosis and management – National Institute for Health and Care Excellence (free)

2 – Depression in children and young people: identification and management – National Institute for Health and Care Excellence (free)

3 – Discriminative Accuracy of FEV₁:FVC Thresholds for COPD-Related Hospitalization and Mortality – JAMA (free for a limited period)

Editorial: Accuracy of Airflow Obstruction Thresholds for Predicting COPD-Related Hospitalization and Mortality: Can Simple Diagnostic Thresholds Be Used for a Complex Disease? (free)

Commentary: Study funded by NIH supports optimal threshold for diagnosing COPD – NIH News Releases (free)

“These results support the use of FEV₁:FVC less than 0.70 to identify individuals at risk of clinically significant COPD.”

4 – Effect of 1-Month Dual Antiplatelet Therapy Followed by Clopidogrel vs 12-Month Dual Antiplatelet Therapy on Cardiovascular and Bleeding Events in Patients Receiving PCI: The STOPDAPT-2 Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Dual Antiplatelet Therapy: Is It Time to Cut the Cord With Aspirin? (free for a limited period)

Audio Summary: Reducing the Intensity of Antithrombotic Therapy Following Coronary Stent Procedures (free)

Commentaries: Shorter Dual Antiplatelet Therapy May Be an Option for Patients Undergoing PCI – NEJM Journal Watch (free) AND Short and Optimal Duration of Dual Antiplatelet Therapy After Everolimus-Eluting Cobalt-Chromium Stent-2 – STOPDAPT-2 – American College of Cardiology (free)

5 – Did This Patient Have Cardiac Syncope? The Rational Clinical Examination Systematic Review – JAMA (free for a limited period)

6 – Choosing Wisely: Case Studies from the Top 10 Recommendations Across Campaigns – The Commonwealth Fund (free case studies)

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada

7 – Incidence of New Onset Diabetes Mellitus Secondary to Acute Pancreatitis: A Systematic Review and Meta-Analysis – Frontiers in Physiology (free)

8 – Alex Nowbar’s journal reviews, 25 June 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

9 – Risk of ESKD in Older Live Kidney Donors with Hypertension – Clinical Journal of the American Society of Nephrology (link to abstract – $ for full-text)

Commentary: Higher Risk of Kidney Failure in Older Donors With Hypertension – Medscape (free registration required)

10 – Cognitive Decline Before and After Incident Coronary Events – Journal of the American College of Cardiology (free)

Commentaries: Cognitive decline may accelerate after heart attack, angina – American College of Cardiology (free) AND Ischemic Events Worsen Long-term Cognitive Decline – TCTMD (free) AND Heart problems may hasten cognitive decline – Reuters (free)

Tue June 25 – 10 Stories of The Day!

25 Jun, 2019 | 07:23h | UTC

1 – WHO consolidated guideline on self-care interventions for health: sexual and reproductive health and rights – World Health Organization (free PDF)

News release: Expanding access to health services with self-care interventions – World Health Organization (free)

Related BMJ Supplement: Self care interventions for sexual and reproductive health and rights (free articles)

2 – Alcohol Use by Youth – Pediatrics (free)

Technical Report: Alcohol Use by Youth – Pediatrics (free)

News Release: American Academy of Pediatrics Emphasizes Dangers of Alcohol to Children, Teens and Young Adults – American Academy of Pediatrics (free)

3 – Anticholinergic Drug Exposure and the Risk of Dementia: A Nested Case-Control Study – JAMA Internal Medicine (free)

Commentaries: Preventing Alzheimer Disease by Deprescribing Anticholinergic Medications – JAMA Internal Medicine (free for a limited period) AND Commonly prescribed anticholinergic drugs linked to dementia risk – UPI (free) AND Expert reaction to anticholinergic drug exposure and risk of dementia – Science Media Centre (free) Commonly prescribed drugs are tied to nearly 50% higher dementia risk in older adults, study says – CNN (free)

4 – Coagulation Testing in Patients Taking Direct Oral Anticoagulants: A Teachable Moment – JAMA Internal Medicine (free for a limited period)

5 – Natural History of Adrenal Incidentalomas With and Without Mild Autonomous Cortisol Excess: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Incidentally discovered adrenal tumors rarely grow or affect hormonal function, review finds – ACP Internist (free) AND Healthcare guidelines should be updated for patients with certain adrenal tumors – University of Birmingham (free)

6 – Physiology and Pathophysiology of Potassium Homeostasis: Core Curriculum 2019 – American Journal of Kidney Diseases (free)

7 – A systematic review of infectious illness Presenteeism: prevalence, reasons and risk factors – BMC Public Health (free)

Infectious illness presenteeism (working while sick) prevalence ranged from 35 to 97%.

8 – Heart failure and sepsis: practical recommendations for the optimal management – Heart Failure Reviews (free)

9 – Expiratory muscle dysfunction in critically ill patients: towards improved understanding – Intensive Care Medicine (free)

10 – The geriatric patient: special aspects of peri-operative management – Effort Open Reviews (free)

Mon June 24 – 10 Stories of The Day!

24 Jun, 2019 | 01:21h | UTC

1 – Progress on drinking water, sanitation and hygiene: 2000-2017: Special focus on inequalities – World Health Organization / UNICEF (free PDF)

News Releases: 1 in 3 people globally do not have access to safe drinking water – UNICEF, WHO (free) AND Billions globally lack ‘water, sanitation and hygiene’, new UN report spells out – United Nations (free)

See also: JMP Website (free resources)

2 – Epilepsy: a public health imperative – World Health Organization (free PDF)

News Releases: WHO highlights scarcity of treatment for epilepsy in low-income countries – World Health Organization (free) AND First-ever WHO global report on epilepsy highlights care gap in poorer countries – United Nations (free)

3 – Heart Failure Association of the European Society of Cardiology practical guidance on the use of natriuretic peptide concentrations – European Journal of Heart Failure (free) (via @paomorejon)

4 – A Clinical Reference Guide on Sexual Devices for Obstetrician–Gynecologists – Obstetrics & Gynecology (free)

Commentary: A Clinician’s Guide to Sexual Devices: What We Didn’t Learn in School – NEJM Journal Watch (free for a limited period)

5 – Practical guide to the management of chronic pancreatitis – Frontline Gastroenterology (free)

6 – Effects of Treatment of Metabolic Acidosis in CKD: A Systematic Review and Meta-Analysis – Clinical Journal of the American Society of Nephrology (free)

7 – Metabolic Acidosis in CKD: Core Curriculum 2019 – American Journal of Kidney Diseases (free)

8 – Band ligation versus no intervention for primary prevention of upper gastrointestinal bleeding in adults with cirrhosis and oesophageal varices – Cochrane Library (free)

Summary: Band ligation versus no intervention for primary prevention of upper gastrointestinal bleeding in people with cirrhosis and oesophageal varices – Cochrane Library (free)

9 – Adrenal crisis: prevention and management in adult patients – Therapeutic Advances in Endocrinology and Metabolism (free)

10 – Effect of a Home-Based Exercise Program on Subsequent Falls Among Community-Dwelling High-Risk Older Adults After a Fall: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Home exercise program reduces rate of falling in at-risk seniors – University of British Columbia (free) AND Home Based Physical Therapy Can Help Prevent Falls in the Elderly – MedicalResearch.com (free)

Fri June 21 – 10 Stories of The Day!

21 Jun, 2019 | 09:26h | UTC

1 – Mapping the global prevalence, incidence, and mortality of Plasmodium falciparum, 2000–17: a spatial and temporal modelling study – The Lancet (free)

Invited Commentary: New malaria maps (free)

News Release: New High-Resolution Global Maps Show How to Defeat Malaria – The Malaria Atlas Project (free)

See also: The Malaria Atlas Project Website (free resources) AND Explorer Tool (free)

2 – Magnetic Resonance Perfusion or Fractional Flow Reserve in Coronary Disease – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Cardiac MRI Safely Reduces Invasive Tx for Stable Angina – MedPage Today (free registration required)

3 – Association of Coworker Reports About Unprofessional Behavior by Surgeons With Surgical Complications in Their Patients – JAMA Surgery (free for a limited period)

Commentaries: When Surgeons Are Abrasive To Co-Workers, Patients’ Health May Suffer – NPR (free) AND Unprofessional Behavior by Surgeons Linked to Surgical Complications in Their Patients – MedicalResearch.com (free) AND After surgery, how patients fare may depend on how their doctor behaves, study says – CNN (free)

4 – Prevalence of Chronic Pain and High-Impact Chronic Pain in Cancer Survivors in the United States – JAMA Oncology (free for a limited period)

Commentaries: Nearly 5.4 million cancer survivors suffer chronic pain – American Cancer Society (free) AND One-third of cancer survivors experiences chronic pain, study says – UPI (free)

5 – Trends in the Laboratory Detection of Rotavirus Before and After Implementation of Routine Rotavirus Vaccination — United States, 2000–2018 – Centers for Disease Control and Prevention (free)

Commentary: Rotavirus Vaccination Tied to Large Drop in Infections – NEJM Journal Watch (free)

6 – Safety of a Restrictive versus Liberal Approach to Red Blood Cell Transfusion on the Outcome of AKI in Patients Undergoing Cardiac Surgery: A Randomized Clinical Trial – Journal of the American Society of Nephrology (link to abstract – $ for full-text)

Commentary: Restrictive Approach to Blood Cell Transfusions Safe for Heart Surgery Patients – American Society of Nephrology (free)

7 – Alex Nowbar’s journal reviews, 20 May 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

8 – Negative Pressure Wound Therapy for Surgical-site Infections: A Randomized Trial – Annals of Surgery (link to abstract – $ for full-text)

Related Cochrane Review: Negative pressure wound therapy for surgical wounds healing by primary closure (free)

Source: EvidenceAlerts

9 – Associations of genetically determined iron status across the phenome: A mendelian randomization study – PLOS Medicine (free)

Commentary: High on iron? It stops anaemia but has a downside – University of South Australia (free)

10 – Association Between Reported Long Working Hours and History of Stroke in the CONSTANCES Cohort – Stroke (free)

Commentaries: Long work hours associated with increased risk of stroke – American Heart Association (free) AND Longer work hours may raise stroke risk – UPI (free) AND Long working hours ‘linked to stroke risk’ – BBC (free)

Thu June 20 – 10 Stories of The Day!

20 Jun, 2019 | 09:33h | UTC

1 – Wellcome Global Monitor How does the world feel about science and health? (free PDF)

Report Summary: Wellcome Global Monitor 2018 (free)

News Release: How much does the world trust medical experts and vaccines? (free)

Commentaries: Japan and Ukraine most likely to doubt safety of vaccines – Nature (free) AND Global trust strong in healthcare, scientists, vaccines—with exceptions – CIDRAP (free) AND Eroding trust in vaccines leaves populations vulnerable, global study finds – Reuters (free) AND Vaccines: Low trust in vaccination ‘a global crisis’ – BBC (free)

2 – Adopt AWaRe Website: Handle antibiotics with care – World Health Organization (free)

News Release: In the face of slow progress, WHO offers a new tool and sets a target to accelerate action against antimicrobial resistance (free)

Commentaries: UN health agency steps up fight against ‘invisible pandemic’ of antimicrobial resistance – United Nations (free) AND New AWaRe tool aims to guide antibiotic use globally – CIDRAP (free)

3 – Canadian consensus statement: enhanced recovery after surgery in bariatric surgery – Surgical Endoscopy (free)

Related: Enhanced Recovery After Surgery (ERAS) Society Guidelines (free articles)

4 – Debating Whether Checkups Are Time Wasted or Time Misused – JAMA (free for a limited period)

Related Cochrane Review: General Health Checks for Reducing Illness and Mortality (free)

5 – Vitamin D Supplementation and Cardiovascular Disease Risks in More Than 83 000 Individuals in 21 Randomized Clinical Trials: A Meta-analysis – JAMA Cardiology (free for a limited period)

Commentaries: The Demise of Vitamin D for Cardiovascular Prevention – JAMA Cardiology (free for a limited period) AND Does Vitamin D Supplementation Provide Cardiovascular Protection? – MPR (free)

6 – Safety and Efficacy of Antithrombotic Strategies in Patients With Atrial Fibrillation Undergoing Percutaneous Coronary Intervention: A Network Meta-analysis of Randomized Controlled Trials – JAMA Cardiology (free for a limited period)

Commentary: In High-Risk AF Patients, NOAC Plus P2Y₁₂Inhibitor Tied to Less Bleeding – NEJM Journal Watch (free)

7 – Septoplasty with or without concurrent turbinate surgery versus non-surgical management for nasal obstruction in adults with a deviated septum: a pragmatic, randomised controlled trial – The Lancet (link to abstract – $ for full-text)

Commentary: Surgery for Deviated Septum Linked to Better Quality of Life – NEJM Journal Watch (free)

8 – Extended Duration of Active Surveillance of Small Renal Masses: A Prospective Cohort Study – Journal of Urology (free)

Commentary: Active Surveillance Safe for Small Renal Tumors – MedPage Today (free registration required)

9 – Collateral Benefits of Preventive Chemotherapy — Expanding the War on Neglected Tropical Diseases – New England Journal of Medicine (free)

10 – Rapid initiation of antiretroviral therapy for people living with HIV – Cochrane Library (free)

Summary: Effects of starting antiretroviral therapy within one week of diagnosis on people living with HIV – Cochrane Library (free)

Wed June 19 – 10 Stories of The Day!

19 Jun, 2019 | 08:35h | UTC

1 – Screening for Abdominal Aortic Aneurism – U.S. Preventive Services Task Force (free)

Commentary: USPSTF Reaffirms Recommendations on AAA Screening in Draft Statement – NEJM Journal Watch (free)

2 – Management of suspected immediate perioperative allergic reactions: an international overview and consensus recommendations – British Journal of Anaesthesia (free)

Related Report: Anesthesia, Surgery and Life-Threatening Allergic Reactions (free)

Source: Critical Care Reviews Newsletter

3 – Management of a surgical patient with a label of penicillin allergy: narrative review and consensus recommendations – British Journal of Anaesthesia (free)

Source: Critical Care Reviews Newsletter

4 – Consensus clinical scoring for suspected perioperative immediate hypersensitivity reactions – British Journal of Anaesthesia (free)

Source: Critical Care Reviews Newsletter

5 – Systolic Blood Pressure and Outcomes in Patients With Heart Failure With Reduced Ejection Fraction – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Systolic Blood Pressure and Systolic Heart Failure Outcomes – American College of Cardiology (free) AND Lower Systolic BP in HFrEF Patients Linked to Mortality – NEJM Journal Watch (free)

“There is an urgent need for randomized controlled trials to evaluate optimal SBP reduction goals in patients with HFrEF.”

6 – Care of Women Presenting with Suspected Preterm Prelabour Rupture of Membranes from 24⁺⁰ Weeks of Gestation – BJOG (free)

News Release: RCOG provides new guidance for doctors and women on when to give birth if waters break early (free)

7 – When more is not better: 10 ‘don’ts’ in endometriosis man`Sagement. An ETIC^* position statement – Human Reproduction Open (free)

8 – Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Peptide Innovation for Early Diabetes Treatment 6 – PIONEER 6 – American College of Cardiology (free) AND Oral semaglutide falls just short of cardioprotection in event-driven PIONEER 6 – Medicine Matters (free) AND Oral Semaglutide Meets CV Safety Mark, Reduces Events in High-Risk T2D Patients – AJMC (free)

9 – Overall Survival with Ribociclib plus Endocrine Therapy in Breast Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: MONALEESA-7 Shows Overall Survival Benefit for Ribociclib/Endocrine Therapy – The ASCO Post (free)

10 – Homepage: Future of Critical Care Medicine (FCCM) 2018 – Critical Care (free articles)

– Thinking forward: promising but unproven ideas for future intensive care

– Science and fiction in critical care: established concepts with or without evidence?

– Evolving concepts for safer ventilation

– NIV through the helmet can be used as first-line intervention for early mild and moderate ARDS: an unproven idea thinking out of the box

– Extracorporeal gas exchange: when to start and how to end?

– Minimizing catecholamines and optimizing perfusion

– Physiology and technology for the ICU in vivo

– Sepsis: personalization v protocolization?

– Host-pathogen interaction during mechanical ventilation: systemic or compartmentalized response?

– Preserving the quality of life: nutrition in the ICU

– The continuum of critical care

Mon June 17 – 10 Stories of The Day!

17 Jun, 2019 | 01:57h | UTC

1 – Revision of expert panel’s guidelines on postoperative pain management – Anaesthesia Critical Care & Pain Medicine (free)

2 – Blood pressure in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference – Kidney International (free)

3 – Important Safety Alert Regarding Use of Fecal Microbiota for Transplantation and Risk of Serious Adverse Reactions Due to Transmission of Multi-Drug Resistant Organisms – U.S. Food & Drug Administration (free)

Commentaries: Fecal Transplant Is Linked to a Patient’s Death, the F.D.A. Warns – The New York Times (10 articles per month are free) AND This Poop Transplant Resulted In A Death, FDA Warning – Forbes (free) AND Be Careful Of Fecal Transplants, Warns FDA, After Patient Death – NPR (free) AND FDA issues alert after fecal microbiota transplant death – CIDRAP (free)

4 – Safety and efficacy of aspirin for primary prevention of cancer: a meta-analysis of randomized controlled trials – Journal of Cancer Research and Clinical Oncology (free)

“Our study did not find any significant reductions in cancer-related mortality or cancer incidence when compared aspirin use with placebo or no aspirin.”

5 – Adenosine Deaminase Diagnostic Testing in Pericardial Fluid – JAMA (free for a limited period)

6 – Comparison of the accuracy of human readers versus machine-learning algorithms for pigmented skin lesion classification: an open, web-based, international, diagnostic study – The Lancet Oncology (link to abstract- $ for full-text)

Commentary: Artificial intelligence for the diagnosis of skin lesions is superior to humans – Medical University of Vienna (free)

7 – Clinical Metagenomic Sequencing for Diagnosis of Meningitis and Encephalitis – New England Journal of Medicine (link to abstract $ for full-text)

Commentaries: Metagenomic Sequencing Enhanced Diagnosis of Meningitis and Encephalitis Infections – MedicalResearch.com (free) AND Superfast gene sequencing helps diagnose critically ill patients – University of California – San Francisco (free) AND Rapid DNA analysis helps diagnose mystery diseases – The Conversation (free)

8 – Cardiac Radiation Dose, Cardiac Disease, and Mortality in Patients With Lung Cancer – Journal of the American College of Cardiology (free for a limited period)

Commentaries: Radiation treatment increases cardiac risk for lung cancer patients – Brigham and Women’s Hospital (free) AND Study: Radiation drives up cardiac event risk for lung cancer patients – UPI (free) AND Cardiac Radiation Can Increase Mortality in Lung Cancer Patients – MedicalResearch.com (free)

9 – 6 versus 12 months of adjuvant trastuzumab for HER2-positive early breast cancer (PERSEPHONE): 4-year disease-free survival results of a randomised phase 3 non-inferiority trial – The Lancet (free)

Commentaries: Is the duration of adjuvant trastuzumab debate still clinically relevant? – The Lancet (free) AND 6 months treatment with Herceptin is as good as 12 months for preventing breast cancer return – University of Warwick (free)

10 – ASIPP Guidelines for Sedation and Fasting Status of Patients Undergoing Interventional Pain Management Procedures – Pain Physician (free PDF)

“Based on extensive literature and consensus, a minimum fasting period is established as 2 hours before a procedure for clear liquids and 4 hours before procedure for light meals, rather than having all patients fast for 8 hours or even fasting beginning at midnight the night before the procedure.”

Fri June 14 – 10 Stories of The Day!

14 Jun, 2019 | 07:27h | UTC

1 – 2019 WSES guidelines for the management of severe acute pancreatitis – World Journal of Emergency Surgery (free)

2 – Diagnosis, Treatment and Follow Up of Acute Pulmonary Embolism: Consensus Practice from the PERT Consortium – Clinical and Applied Thrombosis/Hemostasis (free)

3 – Formal guidelines: management of acute respiratory distress syndrome – Annals of Intensive Care (free)

Related: Guidelines on the Management of Acute Respiratory Distress Syndrome (free guidelines and reviews on the subject)

4 – Updated Geriatric Cardiology Guidelines of the Brazilian Society of Cardiology – 2019 – Arquivos Brasileiros de Cardiologia (free PDF)

5 – Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation – CREDENCE – American College of Cardiology (free)

6 – Risks of 23 specific malformations associated with prenatal exposure to 10 antiepileptic drugs – Neurology (link to abstract – $ for full-text)

Commentaries: Epilepsy drugs linked to higher risk of birth defects, study says – CNN (free) AND Study Confirms Teratogenicity of Valproic Acid, Topiramate – MPR (free)

7 – Higher doses of antidepressants “not optimal”, according to new review – The Mental Elf (free)

Original Article: Meta-analysis: Optimal Dose of Antidepressants in Major Depression (free study and commentaries)

8 – Influenza virus-related critical illness: prevention, diagnosis, treatment – Critical Care (free)

9 – Current guidelines on the management of gestational diabetes mellitus: a content analysis and appraisal – BMC Pregnancy and Childbirth (free)

10 – Associations between gabapentinoids and suicidal behaviour, unintentional overdoses, injuries, road traffic incidents, and violent crime: population based cohort study in Sweden – The BMJ (free)

Editorial: Gabapentinoids linked to new risks, including suicidal behavior (free)

Commentaries: Epilepsy drugs linked to increased risk of suicidal behavior, particularly in young people – The BMJ (free) AND Expert reaction to study on gabapentinoids and risk of suicidal behavior – Science Media Centre (free)

Thu June 13 – 10 Stories of The Day!

13 Jun, 2019 | 10:33h | UTC

1 – Examining Risk: A Systematic Review of Perioperative Cardiac Risk Prediction Indices – Mayo Clinic Proceedings (free)

2 – Infective Endocarditis in Patients With Positive Blood Cultures – American College of Cardiology (free)

Original Article: Prevalence of infective endocarditis in patients with positive blood cultures: a Danish nationwide study – European Heart Journal (link to abstract – $ for full-text)

3 – Cardiovascular Corner: Low Lipids, Metformin, and Plant-Based Diets – JAMA (free for a limited period)

4 – To Save The Science Poster, Researchers Want To Kill It And Start Over – NPR (free)

5 – Care Redesign Survey: The Power of Palliative Care – NEJM Catalyst (free)

6 – Never Say ‘Die’: Why So Many Doctors Won’t Break Bad News – Kaiser Health News (free)

7 – Ann Robinson’s journal review, 12 June 2019 – The BMJ Opinion (free)

8 – Environmental interventions to reduce the consumption of sugar‐sweetened beverages and their effects on health – Cochrane Library (free)

Summary: Cutting back on sugar-sweetened beverages: What works? – Cochrane Library (free)

Commentaries: New review suggests proven ways to cut back on sugary drinks – Reuters (free) AND Evidence on ways to reduce consumption of sugary drinks – Wiley (free)

9 – Diagnosis of obstructive coronary artery disease using computed tomography angiography in patients with stable chest pain depending on clinical probability and in clinically important subgroups: meta-analysis of individual patient data – The BMJ (free)

10 – Association of changes in red meat consumption with total and cause specific mortality among US women and men: two prospective cohort studies – The BMJ (free)

Commentaries: Increasing red meat consumption linked with higher risk of premature death – Harvard T.H. Chan School of Public Health (free) AND The Swap: Less Processed Meat, More Plant-Based Foods May Boost Longevity – NPR (free)

Wed June 12 – 10 Stories of The Day!

12 Jun, 2019 | 10:52h | UTC

1 – Screening for HIV Infection: US Preventive Services Task Force Recommendation Statement (free)

Editorials: HIV Screening and Preexposure Prophylaxis Guidelines: Following the Evidence (free) AND New USPSTF Guidelines for HIV Screening and Preexposure Prophylaxis (PrEP): Straight A’s (free)

Evidence Reports and Systematic Reviews: Screening for HIV Infection in Asymptomatic, Nonpregnant Adolescents and Adults (free) AND Screening for HIV Infection in Pregnant Women (free)

Author Interviews: Screening for HIV infection and Use of Preexposure Prophylaxis for Prevention of HIV Infection: US Preventive Services Task Force Recommendation Statements (free audio) AND HIV Screening and Preexposure Prophylaxis Guidelines (free audio)

2 – Preexposure Prophylaxis for the Prevention of HIV Infection: US Preventive Services Task Force Recommendation Statement (free)

Evidence Report and Systematic Review: Preexposure Prophylaxis for the Prevention of HIV Infection (free)

Commentaries: Expert Panel Recommends Wider Use Of Daily Pill To Prevent HIV Infections – NPR (free) AND HIV prevention pill recommended for healthy people at risk – Reuters (free)

Related: British Guidelines on the Use of HIV Pre–exposure Prophylaxis (PrEP) (several guidelines on the subject)

3 – Effect of Pressure Support vs T-Piece Ventilation Strategies During Spontaneous Breathing Trials on Successful Extubation Among Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Revisiting, Reframing, and Casting a New Light on Liberation From Mechanical Ventilation (free for a limited period)

See also: Visual Abstract (free)

4 – Meta-Research: A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals – eLife (free)

“A review of more than 3,000 randomized clinical trials in NEJM, Lancet and JAMA reveals 396 medical reversals (results later shown to be wrong, usually in systematic reviews). 22 studies in pulmonary diseases and 45 in critical care medicine were affected.” (via @ClaudiaCDobler see Tweet)

5 – The current and future global distribution and population at risk of dengue – Nature Microbiology (free)

Commentaries: More than six billion people at risk of dengue fever by 2080 – London School of Hygiene & Tropical Medicine (free) AND A new picture of dengue’s growing threat – Institute for Health Metrics and Evaluation (free) AND How Dengue, a Deadly Mosquito-Borne
Disease, Could Spread in a Warming World – The New York Times (10 articles per month are free)

6 – Effects of saline or albumin fluid bolus in resuscitation: evidence from re-analysis of the FEAST trial – The Lancet Respiratory Medicine (free)

Commentaries: Adverse effects of bolus fluid resuscitation—short-term benefit but long-term harm – The Lancet Respiratory Medicine (free) AND Doctors urge hospitals to reconsider the type of fluids used to treat children with sepsis – News Medical (free)

Original article: Mortality after Fluid Bolus in African Children with Severe Infection – New England Journal of Medicine (free)

7 – Dietary Glycemic Index and Load and the Risk of Type 2 Diabetes: A Systematic Review and Updated Meta-Analyses of Prospective Cohort Studies – Nutrients (free)

8 – Cancer treatment and survivorship statistics, 2019 – CA: A Cancer Journal for Clinicians (free)

Commentaries: Cancer survivors to reach 22 million by 2030 – UPI (free) AND Cancer survivors predicted to number over 22 million by 2030 – American Cancer Society (free)

9 – Aspirin for Primary Prevention of CV Events – American College of Cardiology (free)

Original Article: Aspirin for Primary Prevention of Cardiovascular Events – Journal of the American College of Cardiology (free)

Related: Aspirin for Primary Prevention: Is This the End of the Road? (selection of resources on the subject)

10 – Early Acid Suppression Therapy Exposure and Fracture in Young Children – Pediatrics (link to abstract – $ for full-text)

Commentary: Early exposure to antacids could put infants at risk for bone fractures during childhood – News Medical (free)

Tue June 11 – 10 Stories of The Day!

11 Jun, 2019 | 03:42h | UTC

1 – Three Public Health Interventions Could Save 94 Million Lives in 25 Years Global Impact Assessment Analysis – Circulation (free PDF)

Commentaries: Three public health interventions could prevent 94 million premature deaths – Harvard T.H. Chan School of Public Health (free) AND 3 simple steps could save 94 million lives – American Heart Association News (free) AND Lowering blood pressure, sodium intake may prevent 94 million early deaths – UPI (free)

2 – Cardiovascular Events and Mortality in White Coat Hypertension: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: People with Untreated “White Coat Hypertension” Twice as Likely to Die from Heart Disease – Penn Medicine (free) AND Untreated white-coat hypertension associated with increased cardiovascular and mortality risk – ACP Internist (free) AND Patients whose blood pressure only spikes at the doctor’s office are twice as likely to die of a heart attack or other cardiac event – STAT (free)

3 – Top 10 medical myths, busted – ACP Internist (free)

“Ten medical myths persist despite all the evidence.”

4 – Incidence of Herpes Zoster Among Children: 2003–2014 – Pediatrics (link to abstract – $ for full-text)

Commentaries: When kids are vaccinated against chickenpox, they’re less likely to get shingles, too – STAT (free) AND Decline in pediatric herpes zoster associated with varicella vaccine – 2 Minute Medicine (free)

5 – Editorial: ICD 11 – The Lancet (free)

Related: WHO: ICD-11 is Here! (free resources)

6 – Perspective: The war to free science – Vox (free)

“How librarians, pirates, and funders are liberating the world’s academic research from paywalls.”

7 – Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial – The Lancet (link to abstract – $ for full-text)

Commentary: Dulaglutide Cuts Cardiovascular Risk in Type 2 Diabetes – NEJM Journal Watch (free)

During a median follow-up of 5.4 years, the primary outcome (a composite endpoint of non-fatal myocardial infarction, non-fatal stroke, or death from cardiovascular causes) occurred in 12.0% of participants in the dulaglutide group and in 13.4% of participants in the placebo group (incidence rate of 2.4 per 100 person-years vs 2.7 per 100 person-years in the placebo group).

8 – Effect of a Self-management Support Intervention on Asthma Outcomes in Older Adults: The SAMBA Study Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)

Commentary: Study reports asthma control in older patients and shows lower ED visits – The Mount Sinai Hospital (free)

9 – Risk of Hospitalization for Serious Adverse Gastrointestinal Events Associated With Sodium Polystyrene Sulfonate Use in Patients of Advanced Age – JAMA Internal Medicine (free for a limited period)

Editorial: Sodium Polystyrene Sulfonate for Hyperkalemia (free)

Commentary: Sodium Polystyrene Sulfonate Tied to Increased Risk for Serious GI Events in Seniors – NEJM Journal Watch (free)

10 – Association of Exposure to Artificial Light at Night While Sleeping With Risk of Obesity in Women – JAMA Internal Medicine (free for a limited period)

Commentaries: Sleeping with artificial light at night associated with weight gain in women – NIH News Releases (free) AND Sleeping with lights or TV on tied to obesity – Reuters (free) AND Sleeping with the TV on may make you gain weight – Associated Press (free)

Mon June 10 – 10 Stories of The Day!

10 Jun, 2019 | 00:01h | UTC

1 – 2018 updated European League Against Rheumatism evidence-based recommendations for the diagnosis of gout – Annals of Rheumatic Disease (free)

2 – Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update – Hepatology International (free)

3 – Optimal dose of selective serotonin reuptake inhibitors, venlafaxine, and mirtazapine in major depression: a systematic review and dose-response meta-analysis – The Lancet Psychiatry (free)

Commentaries: Which antidepressant doses are optimal? – The Lancet Psychiatry (free) AND Expert reaction to systematic review and dose-response meta-analysis of antidepressants – Science Media Centre (free)

4 – Vitamin D Supplementation and Prevention of Type 2 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: NIH-funded trial finds vitamin D does not prevent type 2 diabetes in people at high risk – NIH News Releases (free) AND Vitamin D fails to prevent type 2 diabetes in large study – Reuters (free) AND Vitamin D Supplements Do Not Significantly Reduce Risk of Developing Type 2 Diabetes, According to Research Presented Today at the ADA’s Scientific Sessions – American Diabetes Association (free)

5 – Opinion: The Business of Health Care Depends on Exploiting Doctors and Nurses – The New York Times (10 articles per month are free)

“One resource seems infinite and free: the professionalism of caregivers.”

6 – New preprint server for medical research – The BMJ (free)

7 – Association of Net Ultrafiltration Rate With Mortality Among Critically Ill Adults With Acute Kidney Injury Receiving Continuous Venovenous Hemodiafiltration: A Secondary Analysis of the Randomized Evaluation of Normal vs Augmented Level (RENAL) of Renal Replacement Therapy Trial – JAMA Network Open (free)

Commentaries: Rapid Fluid Removal Tied to Worse Survival in ICU Patients With AKI – Renal & Urology News (free) AND Rapidly Removing Fluid from Critically Ill Patients in Kidney Failure Linked to Increased Risk of Death – University of Pittsburg (free)

8 – Statin Toxicity: Mechanistic Insights and Clinical Implications – Circulation Research (free)

9 – Individualised nutritional support in medical inpatients at nutritional risk: a randomised clinical trial – The Lancet (link to abstract – $ for full-text)

Commentaries: Quick Take: Individualised nutritional support in medical inpatients at nutritional risk – 2 Minute Medicine (free) AND Individual nutrition shows benefits in hospital patients – University of Basel (free)

10 – Aspirin has potential benefits for primary prevention of cardiovascular outcomes in diabetes: updated literature-based and individual participant data meta-analyses of randomized controlled trials – Cardiovascular Diabetology (free)

Commentary: Aspirin offers benefit for primary CVD prevention in DM – Univadis (free registration required)

Related Randomized Trial: Effects of Aspirin for Primary Prevention in Persons with Diabetes (free study and commentaries)

Fri June 7 – 10 Stories of The Day!

7 Jun, 2019 | 07:31h | UTC

1 – More than 1 million new curable sexually transmitted infections every day – World Health Organization (free)

Read the Study: Estimates of four sexually transmitted infections, 2016 – World Health Organization (free)

Commentary: One million new STIs every day, says WHO – BBC (free)

2 – Hyperparathyroidism (primary): diagnosis, assessment and initial management – National Institute for Health and Care Excellence (free)

3 – Pain Management Best Practices Inter-Agency Task Force Report: Updates, Gaps, Inconsistencies, and Recommendations – U.S. Department of Health and Human Services (free PDF)

Commentary: Best Pain Management Practices Outlined in New HHS Report – Medscape (free registration required)

4 – Managing opioid use disorder in primary care: PEER simplified guideline – Canadian Family Physician (free)

5 – Durable Control of HIV Infection in the Absence of Antiretroviral Therapy: Opportunities and Obstacles – JAMA (free for a limited period)

Author Interview: Durable Control of HIV Infection in the Absence of Antiretroviral Therapy (free audio)

6 – Fluid Management in Septic Shock: A Review of Physiology, Goal-Directed Therapy, Fluid Dose, and Selection – Current Anesthesiology Reports (free)

7 – Ann Robinson’s journal review, 5 June 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

8 – Type 2 Diabetes Mellitus and Heart Failure: A Scientific Statement From the American Heart Association and the Heart Failure Society of America – Circulation (free PDF)

News Release: Diabetes and heart failure are linked; treatment should be too – American Heart Association (free)

9 – Pharmacotherapy for hypertension in adults 60 years or older – Cochrane Library (free)

Summary: Pharmacotherapy for hypertension in adults 60 years or older – Cochrane Library (free)

10 – Intensive care use and mortality among patients with ST elevation myocardial infarction: retrospective cohort study – The BMJ (free)

Commentary: Should STEMI patients recover in the ICU? – Michigan Medicine – University of Michigan (free) AND Mortality Lower When STEMI Patients Sent to the ICU, but Why? – TCTMD (free) AND ICU admission yields better results for STEMI patients—at a price – Cardiovascular Business (free)

Thu June 6 – 10 Stories of The Day!

6 Jun, 2019 | 06:36h | UTC

1 – Global vascular guidelines on the management of chronic limb-threatening ischemia – Journal of Vascular Surgery (free)

Editorial: Global Vascular Guidelines for patients with critical limb-threatening ischemia (free)

2 – Intensive Glucose Control in Patients with Type 2 Diabetes — 15-Year Follow-up – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Tight Diabetes Control Alone May Not Benefit the Heart Long-Term – HealthDay (free) AND Long-Term Follow-Up After Intensive Glucose-Lowering Treatment – NEJM Journal Watch (free)

3 – Longer-Term Assessment of Azithromycin for Reducing Childhood Mortality in Africa – New England Journal of Medicine (free)

4 – Mortality From Ischemic Heart Disease: Analysis of Data From the World Health Organization and Coronary Artery Disease Risk Factors From NCD Risk Factor Collaboration – Circulation: Cardiovascular Quality and Outcomes (free)

Related: Global, Regional, and National Burden of Cardiovascular Diseases (free study and commentaries)

5 – Surgical interventions for women with stress urinary incontinence: systematic review and network meta-analysis of randomised controlled trials – The BMJ (free)

6 – Taking Stock of Dietary Supplements’ Harmful Effects on Children, Adolescents, and Young Adults – Journal of Adolescent Health (link to abstract – $ for full-text)

Commentaries: Dietary supplements linked with severe health events in children, young adults – Harvard T.H. Chan School of Public Health (free) AND Harvard Study: Supplements For Energy, Weight Loss, Muscle-Building Carry Risk For Youth – CommonHealth (free) AND Study: Dietary supplements may raise death risk in children, teens – UPI (free)

7 – Reproducibility trial publishes two conclusions for one paper – Nature (free)

8 – EuGMS Task and Finish group on Fall-Risk-Increasing Drugs (FRIDs): Position on Knowledge Dissemination, Management, and Future Research – Drugs & Aging (free)

9 – Natural history of prediabetes in older adults from a population‐based longitudinal study – Journal of Internal Medicine (free)

Commentary: Study follows the health of older adults with prediabetes problems – Wiley (free)

10 – Use of Peripherally Inserted Central Catheters in Patients With Advanced Chronic Kidney Disease: A Prospective Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Peripherally inserted central catheters often used in CKD – HealthDay (free) AND Too Many CKD Patients Get Central Catheters Despite Warnings – Medscape (free registration required)

Wed June 5 – 10 Stories of The Day!

5 Jun, 2019 | 08:16h | UTC

1 – British HIV Association guidelines for the management of tuberculosis in adults living with HIV 2019 – HIV Medicine (free)

2 – British Society of Gastroenterology and UK-PSC guidelines for the diagnosis and management of primary sclerosing cholangitis – Gut (free)

3 – Effects of red meat, white meat, and nonmeat protein sources on atherogenic lipoprotein measures in the context of low compared with high saturated fat intake: a randomized controlled trial – American Journal of Clinical Nutrition (free)

Commentaries: Red and white meats are equally bad for cholesterol – University of California – San Francisco (free) AND Poultry may raise bad cholesterol the same as red meat – UPI (free)

4 – Protecting Sleep in the Hospital, for Both Patients and Doctors – The New York Times (10 articles per month are free)

5 – Lithium for acute mania – Cochrane Library (free)

Summary: Lithium for the treatment of acute mania – Cochrane Library (free)

6 – Randomized Trial of Lisinopril Versus Carvedilol to Prevent Trastuzumab Cardiotoxicity in Patients With Breast Cancer – Journal of the American College of Cardiology (link to abstract – $ for full-text)

“In patients with HER2-positive breast cancer treated with trastuzumab, both lisinopril and carvedilol prevented cardiotoxicity in patients receiving anthracyclines.”

7 – Effect of β-blockers on triggering of symptomatic atrial fibrillation by anger or stress – Heart Rhythm (link to abstract – $ for full-text)

Commentaries: Beta blockers can block the effects of stress and anger in patients prone to emotion-triggered atrial fibrillation – Elsevier (free) AND Beta-blockers mitigate emotionally triggered AFib – Cardiovascular Business (free)

8 – The Cardiovascular Effects of Noise – Deutsches Ärzteblatt international (free)

Related: Perspective: Is Noise Pollution the Next Big Public-Health Crisis? (resources on the subject)

9 – Safety of Opioids in Osteoarthritis: Outcomes of a Systematic Review and Meta-Analysis – Drugs & Aging (free)

10 – Prevalence and Cost of Care Cascades After Low-Value Preoperative Electrocardiogram for Cataract Surgery in Fee-for-Service Medicare Beneficiaries – JAMA Internal Medicine (free for a limited period)

Commentary: Cascades Of Care – American Council on Science and Health (free)