TOP 10 Medical News Stories
Mon August 12 – 10 Stories of The Day!
12 Aug, 2019 | 00:01h | UTC
1 – Management of acute liver failure. Clinical guideline from the Catalan Society of Digestology – Gastroenterología y Hepatología (free for a limited period)
Related Guideline: American Gastroenterological Association Institute Guidelines for the Diagnosis and Management of Acute Liver Failure – Gastroenterology (free)
Source: Critical Care Reviews Newsletter
“α-Glucosidase inhibitors, angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, metformin, orlistat, phentermine/topiramate, and pioglitazone significantly reduced the risk of biochemical conversion to T2DM, whereas statins and nateglinide increased the risk”
Commentary: Alcohol exposure during pregnancy linked with dose-dependent increase in miscarriage risk – News Medical (free)
5 – Making Machine Learning Models Clinically Useful – JAMA (free for a limited period)
Related JAMA Viewpoints: Artificial Intelligence in Health Care: Will the Value Match the Hype? (free for a limited period) AND Questions for Artificial Intelligence in Health Care (free for a limited period) AND Deep Learning in Medicine—Promise, Progress, and Challenges (free for a limited period)
Related: ESPEN guideline on clinical nutrition and hydration in geriatrics (free)
7 – Too Much Medicine: Not Enough trust? – Journal of Medical Ethics (free)
8 – Study: many of the “oldest” people in the world may not be as old as we think – Vox (free)
Commentary: Does metformin treatment for GDM adversely affect offspring? – Univadis (free registration required)
10 – Mechanical and oral antibiotic bowel preparation versus no bowel preparation for elective colectomy (MOBILE): a multicentre, randomised, parallel, single-blinded trial – The Lancet (link to abstract – $ for full-text)
Commentaries: Bowel preparation not needed before colon surgery, study says – UPI (free) AND A Finnish study finds bowel preparation for colon surgery unnecessary – University of Helsinki (free)
Fri August 9 – 10 Stories of The Day!
9 Aug, 2019 | 08:26h | UTC
Related Guidelines: WHO Guidelines for the pharmacological and radiotherapeutic management of cancer pain in adults and adolescents – World Health Organization (free PDF) AND Management of cancer pain in adult patients: ESMO Clinical Practice Guidelines – Annals of Oncology (free) AND Optimal pain management for patients with cancer in the modern era – CA: A Cancer Journal of Clinicians (free) AND 2017 SEOM clinical guideline for treatment of cancer pain – Clinical and Translational Oncology (free)
Commentaries: Pre-eclampsia increases risk of end stage kidney disease, study finds – PLOS (free) AND Preeclampsia Increases Kidney Failure Risk, Study Finds – Renal & Urology News (free)
5 – Post-surgical pain management: time for a paradigm shift – British Journal of Anaesthesia (free)
Related Guidelines: Standards for the diagnosis and management of complex regional pain syndrome: Results of a European Pain Federation task force – European Journal of Pain (free) AND Complex regional pain syndrome in adults (2nd edition) – UK guidelines for diagnosis, referral and management in primary and secondary care 2018 – Royal College of Physicians (free PDF)
7 – Chronic pain in critical care survivors: a narrative review – British Journal of Anaesthesia (free)
Related: Recovery after critical illness: putting the puzzle together—a consensus of 29 – Critical Care (free) AND Surviving critical illness: what is next? An expert consensus statement on physical rehabilitation after hospital discharge – Critical Care (free)
Invited Commentary: Ironing out frequent blood donation (free)
Original Study: Efficiency and safety of varying the frequency of whole blood donation (free)
Commentaries: Major surgery associated with small, long term decline in brain functioning – The BMJ (free) AND Major surgeries linked to small decline in mental functioning in older age – Reuters (free)
Editorial: The determinants of cognitive decline and dementia (free)
Commentaries: Good heart health at age 50 linked to lower dementia risk later in life – The BMJ (free) AND The implications of cardiovascular health for dementia – The BMJ Opinion (free)
Thu August 8 – 10 Stories of The Day!
8 Aug, 2019 | 08:43h | UTC
See also: Video Abstract (free)
Related Reviews: Palliative Care for Patients With Heart Failure – American College of Cardiology (free) AND Approach to advanced heart failure at the end of life – Canadian Family Physician (free) AND Palliative Care in Heart Failure: Rationale, Evidence, and Future Priorities – Journal of the American College of Cardiology (free) AND How Medicine Has Changed the End of Life for Patients With Cardiovascular Disease – Journal of the American College of Cardiology (free) AND Dilemmas in end-stage heart failure – Journal of Geriatric Cardiology (free) AND It’s Time to Talk: Challenges in Providing Integrated Palliative Care in Advanced Congestive Heart Failure. A Narrative Review – Cardiology Reviews (free) AND Palliative Care Interventions for Patients with Heart Failure: A Systematic Review and Meta-Analysis (free)
Related Randomized Trial: Palliative Care in Heart Failure (link to abstract and commentaries)
3 – White coats should no longer be worn by physicians – KevinMD (free)
Related guideline: Healthcare Personnel Attire in Non-Operating-Room Settings – Infection Control and Hospital Epidemiology (free) AND Commentaries: Goodbye to the Doctor’s White Coat? – The New York Times (10 articles per month are free) AND New infection control recommendations could make white coats obsolete – ScienceDaily (free) AND Should Doctors Still Be Allowed to Wear White Coats? You Decide – HIV and ID Observations (free)
See also: Long Sleeves on Doctors’ White Coats May Spread Germs – Scientific American (free) AND Why Your Doctor’s White Coat Can Be a Threat to Your Health – The New York Times (10 articles per month are free)
Commentaries: The Evolving Paradigm of Prostate Cancer Screening – JAMA Network Open (free) AND MRIs Improve Targeting of Biopsies for Prostate Cancer Diagnosis – MedicalResearch.com (free)
Related Cochrane Review: MRI Pathway vs. Systematic Biopsy for Detecting Prostate Cancer (free)
“Prebiopsy magnetic resonance imaging combined with targeted biopsy is associated with improved detection of clinically significant prostate cancer and reduced numbers of biopsy cores per procedure, while potentially avoiding unnecessary biopsies.”
5 – Diagnostic Imaging in Pregnant Patients With Suspected Appendicitis – JAMA (free for a limited period)
6 – Dysproteinemia and the Kidney: Core Curriculum 2019 – American Journal of Kidney Diseases (free)
Related Reviews: Dysproteinemias and Glomerular Disease – Clinical Journal of the American Society of Nephrology (free) AND Paraprotein–Related Kidney Disease: Kidney Injury from Paraproteins—What Determines the Site of Injury? – Clinical Journal of the American Society of Nephrology (free) AND Paraprotein–Related Kidney Disease: Glomerular Diseases Associated with Paraproteinemias – Clinical Journal of the American Society of Nephrology (free)
7 – ANCA-Associated Vasculitis: Core Curriculum 2020 – American Journal of Kidney Diseases (free)
Related Guidelines: EULAR/ERA-EDTA recommendations for the management of ANCA-associated vasculitis – Annals of Rheumatic Diseases (free) AND BSR and BHPR guideline for the management of adults with ANCA-associated vasculitis – Rheumatology (free) AND Comparisons of Guidelines and Recommendations on Managing Antineutrophil Cytoplasmic Antibody–Associated Vasculitis – Kidney International Reports (free)
Commentaries: Eating more plant-based foods may be linked to better heart health – American Heart Association (free) AND Healthy plant-based diet tied to lowered heart risk – Reuters (free)
10 – Association between meat consumption and risk of breast cancer: Findings from the Sister Study – International Journal of Cancer (link to abstract – $ for full-text)
Commentaries: Substituting poultry for red meat may reduce breast cancer risk – Wiley (free) AND Expert reaction to study looking at red meat and poultry consumption and breast cancer risk – Science Media Centre (free)
Wed August 7 – 10 Stories of The Day!
7 Aug, 2019 | 08:36h | UTC
See also: Summary of Recommendations (free PDF) AND Visual Abstract (free PDF)
Evidence Report: Screening for Pancreatic Cancer: Systematic Review for the US Preventive Services Task Force (free)
Editorials: Screening for Pancreatic Cancer – JAMA (free for a limited period) AND Screening for Pancreatic Cancer—Is There Hope? – JAMA Internal Medicine (free for a limited period) AND Screening for Pancreatic Cancer Gets a D, But the Student Is Improving – JAMA Surgery (free for a limited period)
3 – Transfusion Volume for Children with Severe Anemia in Africa – New England Journal of Medicine (free)
Commentary: Larger blood transfusions could halve deaths of children with severe anaemia – Imperial College London (free)
Related Study: Immediate Transfusion in African Children with Uncomplicated Severe Anemia – New England Journal of Medicine (free)
4 – Association of Office and Ambulatory Blood Pressure With Mortality and Cardiovascular Outcomes – JAMA (free for a limited period)
Editorial: Effective Use of Ambulatory Blood Pressure Monitoring (free)
Commentaries: Blood pressure recording over 24 hours is the best predictor of heart and vascular disease – KU Leuven (free) AND Nighttime, 24-Hour BP Readings Have Strongest Link to Poor Outcomes – TCTMD (free)
5 – Metformin Use and Clinical Outcomes among Patients with Diabetes with or without Heart Failure or Kidney Dysfunction: Observations from the SAVOR-TIMI 53 Trial – Circulation (link to abstract – $ for full-text)
Commentaries: Metformin Use and CV Outcomes Among Diabetes Patients – American College of Cardiology (free) AND Support for metformin cardioprotective effect – Medicine Matters (free) AND Metformin Use Associated With Lower Death Risk in Type 2 Diabetes – Renal & Urology News (free)
6 – These Medical Devices Are Inserted Into 500,000 Patients Each Year — but Are Tough to Sterilize – The New York Times (10 articles per month are free)
Related: Prevention of multidrug-resistant infections from contaminated duodenoscopes: Position Statement of the European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Gastroenterology Nurses and Associates (ESGENA) (free) AND An update on gastrointestinal endoscopy-associated infections and their contributing factors – Annals of Clinical Microbiology and Antimicrobials (free) AND Carbapenem Resistant Enterobacteriaceae and Endoscopy: An Evolving Threat – American Journal of Infection Control (free) AND Hygiene: The Looming Achilles Heel in Endoscopy – Visceral Medicine (free) AND Superbugs on Duodenoscopes: the Challenge of Cleaning and Disinfection of Reusable Devices – Journal of Clinical Microbiology (free)
Commentary: New Choosing Wisely List Tackles Opioid Prescribing, Lyme Testing – NEJM Journal Watch (free)
See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada
Related: ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes (free)
9 – Series from the Lancet journals: Genomic medicine – The Lancet (free articles – registration required)
Related Guidelines: Formal guidelines: management of acute respiratory distress syndrome – Annals of Intensive Care (free) AND Guidelines on the management of acute respiratory distress syndrome – BMJ Open Respiratory Research (free) AND Guidelines On The Management Of Acute Respiratory Distress Syndrome – Intensive Care Society (free PDF) AND The clinical practice guideline for the management of ARDS in Japan – Journal of Intensive Care (free) AND An Official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome (free)
Related Review: Acute Respiratory Distress Syndrome – Nature Reviews Disease Primer (free PDF)
“This network meta-analysis supports the use of prone positioning and venovenous extracorporeal membrane oxygenation in addition to lung protective ventilation in patients with ARDS.”
Tue August 6 – 10 Stories of The Day!
6 Aug, 2019 | 08:17h | UTC
2 – Perioperative Management of Patients With Atrial Fibrillation Receiving a Direct Oral Anticoagulant – JAMA Internal Medicine (free for a limited period)
Commentary: Study Sheds Light on Stopping and Resuming DOACs in Afib Patients Undergoing Surgery – NEJM Journal Watch (free)
“The DOAC regimens were omitted for 1 day before a low–bleeding-risk procedure and 2 days before a high–bleeding-risk procedure. The DOAC regimens were resumed 1 day after a low–bleeding-risk procedure and 2 to 3 days after a high–bleeding-risk procedure.”
3 – Potential Medicare Savings From Generic Substitution and Therapeutic Interchange of ACE Inhibitors and Angiotensin-II-Receptor Blockers – JAMA Internal Medicine (free for a limited period)
“By maximizing generic substitution and therapeutic interchange, Medicare could have saved approximately $676 million (89.6%) in 2016 and 2017 of the total $754 million spent on these brand-name ACEIs and ARBs during those 2 years”.
4 – #164 Stroke and TIA Deconstructed – The Curbsiders Internal Medicine Podcast (free audio)
Commentaries: Expert reaction to study reporting ‘spin’ in abstracts of psychiatry and psychology journals – Science Media Centre (free) AND ‘Spin’ found in over half of clinical trial abstracts published in top psychiatry journals – The British Medical Journal (free)
Related: Systematic Review: Spin in Published Cardiovascular Randomized Trials with Statistically Nonsignificant Primary Outcomes (free study and editorial) AND ‘Spin’ in published biomedical literature: A methodological systematic review – PLOS Biology (free)
6 – Alex Nowbar’s journal review, 5 August 2019 – The BMJ Opinion (free)
Alex Nowbar reviews the latest research from the top medical journals.
Commentaries: Global burden of childhood cancer: growing, but controllable – The Lancet Oncology (free) AND Globally, more than 11 million years of healthy life lost due to childhood cancer in 2017 – The Lancet (free)
Summary: Financial conflicts of interests and results, conclusions, and quality of systematic reviews – Cochrane Library (free)
10 – Renin-Angiotensin System Inhibition Following Transcatheter Aortic Valve Replacement – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: RAS Inhibition After TAVR Gains More Support, but RCT Still Needed – TCTMD (free) AND Renin-angiotensin system inhibition following transcatheter aortic valve replacement linked with lower cardiac mortality – 2 Minute Medicine (free)
Mon August 5 – 10 Stories of The Day!
5 Aug, 2019 | 02:38h | UTC
1 – Preterm labour and birth – National Institute for Health and Care Excellence (free)
Related Guideline: Practice Bulletin: Management of Preterm Labor – Obstetrics & Gynecology (free)
Related Review: Preterm Labor: One Syndrome, Many Causes – Science (free)
Commentary: Oral regimen management of acute hypertension in pregnancy – The Lancet (free)
Commentary: Ursodeoxycholic acid for intrahepatic cholestasis in pregnancy – The Lancet (free)
4 – An artificial intelligence-enabled ECG algorithm for the identification of patients with atrial fibrillation during sinus rhythm: a retrospective analysis of outcome prediction – The Lancet (link to abstract – $ for full-text)
Commentaries: Deep learning AI may identify atrial fibrillation from a normal rhythm ECG – The Lancet (free) AND AI may help detect atrial fibrillation from a normal rhythm ECG – OnMedica (free) AND Expert reaction to a study looking at an AI algorithm to identify atrial fibrillation – Science Media Centre (free) AND AI-Trained EKG Can Detect New or Impending Atrial Fibrillation – MedicalResearch.com (free) AND AI could enable accurate screening for atrial fibrillation – Mayo Clinic (free)
5 – Meta-Analysis of Oral Anticoagulant Monotherapy as an Antithrombotic Strategy in Patients With Stable Coronary Artery Disease and Nonvalvular Atrial Fibrillation – The American Journal of Cardiology (link to abstract – $ for full-text)
Source: EvidenceAlerts
6 – High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis – Neurology (link to abstract – $ for full-text)
Commentaries: Blood test may accurately identify people with early Alzheimer’s brain changes – Washington University School of Medicine in St. Louis (free) AND The new blood test for Alzheimer’s disease: developed in a study without patients – Medium (free)
7 – A Brain Scan May Predict Alzheimer’s. Should You Get One? – The New York Times (10 articles per month are free)
8 – Breastfeeding: A round up of Cochrane evidence – Evidently Cochrane (free)
9 – Celiac disease: a comprehensive current review – BMC Medicine (free)
Related Guidelines: European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders (free) AND ACG Clinical Guidelines: Diagnosis and Management of Celiac Disease (free) AND Coeliac Disease: Recognition, Assessment and Management – NICE Guideline (free)
10 – If You Smoke Pot, Your Anesthesiologist Needs To Know – Kaiser Health News (free)
Related: Perioperative care of cannabis users: A comprehensive review of pharmacological and anesthetic considerations – Journal of Clinical Anesthesia (free)
“One small study of Colorado patients published in May found marijuana users required more than triple the amount of one common sedation medicine, propofol, as did nonusers.”
Fri August 2 – 10 Stories of The Day!
2 Aug, 2019 | 03:19h | UTC
Commentary: ATS Publishes Clinical Guideline on Obesity Hypoventilation Syndrome – American Thoracic Society (free)
2 – Clinical Practice Guideline: Sudden Hearing Loss – Otolaryngology-Head and Neck Surgery (free)
News Release: Sudden hearing loss: Update to guideline to improve implementation and awareness – American Academy of Otolaryngology–Head and Neck Surgery (free)
Commentaries: Older adults should be regularly screened for heart disease, diabetes risk – The Endocrine Society (free) AND Why older adults need regular metabolic risk screening – Medical News Today (free)
“These findings support the use of fractional-dose vaccination for outbreak control.”
5 – Human placenta has no microbiome but can contain potential pathogens – Nature (link to abstract – $ for full-text)
Commentaries: No bacteria found in healthy placentas – Nature News (free) AND Babies get critical gut bacteria from their mother at birth, not from placenta, study suggests – Science (free)
6 – Effect of Standard vs Intensive Blood Pressure Control on the Risk of Recurrent Stroke: A Randomized Clinical Trial and Meta-analysis – JAMA Neurology (free for a limited perido)
Editorial: Challenges to Realizing Benefits From More Intensive Blood Pressure Control for Preventing Recurrent Stroke – JAMA Neurology (free for a limited period)
Commentary: Medical journal editors expect authors to disclose conflicts of interest—but don’t disclose their own – Science (free)
Related: Why we should care that many editors of top medical journals get healthcare industry payments (free study and commentary)
Commentary: Coronary Artery Calcium and Long-Term, Cause-Specific Mortality in Young Adults – American College of Cardiology (free)
10 – Pharmacotherapy Approaches in Nontuberculous Mycobacteria Infections – Mayo Clinic Proceedings (free)
Related: British Thoracic Society Guideline for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD) (free) AND Pulmonary Disease Due to Nontuberculous Mycobacteria: Current State and New Insights – Chest (free) AND Update on pulmonary disease due to non-tuberculous mycobacteria – International Journal of Infectious Diseases (free) AND Nontuberculous mycobacterial (NTM) lung disease: The top ten essentials – Respiratory Medicine (free) AND Pulmonary Disease Caused by Non-Tuberculous Mycobacteria – Respiration (free)
Thu August 1 – 10 Stories of The Day!
1 Aug, 2019 | 10:31h | UTC
2 – Yellow Book 2020 – Centers for Disease Control and Prevention (free chapters)
See also: CDC Travelers’ Health Website (free resources) AND Table of Contents (free Chapters)
3 – The Mexican consensus on non-cardiac chest pain – Revista de Gastroenterología de México (free)
Related Reviews: Non-Cardiac Chest Pain – Visceral Medicine (free) AND Review article: the current treatment of non‐cardiac chest pain – Alimentary Pharmacology and Therapeutics (free)
4 – 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Part 1, Lifestyle and Behavioral Factors – JAMA Cardiology (free for a limited period)
Original Guideline: 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease (free guideline and related resources)
Related Summaries: The ABCs of Primary Cardiovascular Prevention: 2019 Update – American College of Cardiology (free) AND Key Points From the 2019 ACC/AHA Guidelines on the Primary Prevention of Cardiovascular Disease – American College of Cardiology (free)
5 – Digoxin Discontinuation and Outcomes in Patients With Heart Failure With Reduced Ejection Fraction – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Stopping digoxin after a heart failure exacerbation associated with risk of readmission – ACP Hospitalist (free) AND Digoxin Swings Toward Benefit in HFrEF, But Lack of Clarity Remains – Medscape (free registration required)
6 – The addition of fluoxetine to cognitive behavioural therapy for youth depression (YoDA-C): a randomised, double-blind, placebo-controlled, multicentre clinical trial – The Lancet Psychiatry (link to abstract – $ for full-text)
Commentaries: Psychotherapy should be first-line treatment for depression in young people, trial finds – by Orygen, the National Centre of Excellence in Youth Mental Health (free) AND Psychotherapy should be first option to treat depression in young people, study says – UPI (free)
7 – A clinically applicable approach to continuous prediction of future acute kidney injury – Nature (link to abstract – $ for full-text)
Commentaries: DeepMind AI predicts acute loss of kidney function two days in advance, study shows – STAT (free) AND Deep learning detects impending organ injury in the clinic – Nature News (free) AND Expert reaction to study on a deep learning approach to predicting acute kidney injury – Science Media Centre (free)
8 – Assessment of Publication Trends of Systematic Reviews and Randomized Clinical Trials, 1995 to 2017 – JAMA Internal Medicine (free for a limited period)
Invited Commentary: Meta-analysis Metastasis – JAMA Internal Medicine (free)
Related: The Mass Production of Redundant, Misleading, and Conflicted Systematic Reviews and Meta‐analyses – Milbank Quarterly (free PDF)
Commentaries: Stomach-protecting medicines can trigger allergies – Medical University of Vienna (free) AND Acid-Suppressing Drugs Tied to Later Use of Anti-Allergy Drugs – NEJM Journal Watch (free) AND Your heartburn drugs may be giving you allergies, study suggests – CNN (free)
10 – Cigarette Smoking, Smoking Cessation, and Long-Term Risk of 3 Major Atherosclerotic Diseases – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Smoking cessation study supports ‘never too early, never too late’ – ACP Internist (free) AND Study Quantifies Smoking’s Strong Link to Peripheral Artery Disease – Johns Hopkins Bloomberg School of Public Health (free)
Wed July 31 – 10 Stories of The Day!
31 Jul, 2019 | 02:14h | UTC
2 – New Protocol For HIV Prevention Drug Reduces The Number Of Pills Required – Kaiser Health News (free)
Related Guidelines: British Guidelines on the Use of HIV Pre–exposure Prophylaxis (PrEP) (several guidelines on the subject) AND USPSTF Statement: Preexposure Prophylaxis for the Prevention of HIV Infection (free guideline and commentaries)
“both organizations now endorse a strategy that requires taking just four pills timed to a specific sexual encounter — two within two to 24 hours before sex and one on each of the two following days… The new strategy, called “2-1-1” or “on-demand” PrEP, is becoming popular overseas but has gotten little traction in the United States thus far.”
Commentary: Expert reaction to study looking at acupuncture as an added treatment for angina – Science Media Centre (free)
4 – Doctors: How Job Stress Can Age Us – The New York Times (10 articles per month are free)
Related Study: Physician-Training Stress and Accelerated Cellular Aging – Biological Psychiatry (link to abstract – $ for full-text) AND Commentary: New doctors’ DNA ages six times faster than normal in first year – University of Michigan (free)
Commentaries: Placental growth factor testing for suspected pre-eclampsia – The Lancet (free) AND Placental growth factor testing can speed up diagnosis of pre-eclampsia – NIHR Signal (free)
7 – The impact of occupational shift work and working hours during pregnancy on health outcomes: a systematic review and meta-analysis – American Journal of Obstetrics & Gynecology (link to abstract – for full-text)
Commentary: Night shifts, long hours linked to miscarriages and preterm births – Reuters (free)
Related Systematic Review: Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion – Cochrane Library (free)
Related Guideline: Guidelines on the management of anaemia and red cell transfusion in adult critically ill patients – British Committee for Standards in Haematology (free)
Commentaries: In Noncardiac Surgery, the Post-Op Period Is Riskiest – NEJM Journal Watch (free) AND Most deaths related to noncardiac surgery occur after surgery and after discharge from hospital – Canadian Medical Association Journal (free) AND Riskiest time for surgery patients is not in the operating room – Reuters (free)
“Among adults undergoing noncardiac surgery, 99.3% of deaths occurred after the procedure and 44.9% of deaths were associated with 3 complications: major bleeding, myocardial injury and sepsis.”
Related Meta-Analysis: Efficacy comparisons of enteral nutrition and parenteral nutrition in patients with severe acute pancreatitis: a meta-analysis from randomized controlled trials – Bioscience Reports (free) AND Enteral nutrition provided within 48 hours after admission in severe acute pancreatitis: A systematic review and meta-analysis – Medicine (free)
Related Guidelines: 2019 WSES guidelines for the management of severe acute pancreatitis – World Journal of Emergency Surgery (free) AND American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis (free) AND Pancreatitis – National Institute for Health and Care Excellence (free) AND American College of Gastroenterology Guideline: Management of Acute Pancreatitis (free)
Tue July 30 – 10 Stories of The Day!
30 Jul, 2019 | 01:43h | UTC
Related: 2017 ACC Expert Consensus Decision Pathway on Management of Bleeding in Patients on Oral Anticoagulants (free guideline and summary)
3 – Comparison of the Harms, Advantages, and Costs Associated With Alternative Guidelines for the Evaluation of Hematuria – JAMA Internal Medicine (free for a limited period)
Commentaries: Hematuria Practice Guidelines That Explicitly Consider Harms and Costs – JAMA Internal Medicine (free for a limited period) AND Evaluating Hematuria: Uniform Use of CT Seen as Risky and Expensive – NEJM Journal Watch (free)
Commentary: A shorter course for anti-relapse therapy against vivax malaria – The Lancet (free)
5 – The management of diverticulitis: a review of the guidelines – Medical Journal of Australia (free for a limited period)
Related Guidelines: American Gastroenterological Association Institute Guideline on the Management of Acute Diverticulitis (free) AND EAES and SAGES 2018 consensus conference on acute diverticulitis management: evidence-based recommendations for clinical practice (free) AND Guidelines for Colonic Diverticular Bleeding and Colonic Diverticulitis: Japan Gastroenterological Association (free) AND Colorectal surgeon consensus with diverticulitis clinical practice guidelines (free) AND WSES Guidelines for the management of acute left sided colonic diverticulitis in the emergency setting (free) AND The Mexican Consensus on the Diagnosis and Treatment of Diverticular Disease of the Colon (free)
6 – White Paper: A Multilayered Analysis of Telehealth – FAIR Health (free PDF)
Commentaries: Use of Non-Hospital-Based Provider-to-Patient Telehealth Grew Nearly 1400% From 2014 to 2018, FAIR Health Finds – AJMC (free) AND Telemedicine use up 1,400 percent since 2014 – UPI (free) AND Use of Non-Hospital-Based Provider-to-Patient Telehealth Grew Nearly 1,400 Percent from 2014 to 2018 – PR Newswire (free)
7 – Prescriptions on Demand: The Growth of Direct-to-Consumer Telemedicine Companies – JAMA (free for a limited period)
8 – Choosing Wisely India: ten low-value or harmful practices that should be avoided in cancer care – The Lancet Oncology (free registration required)
Commentary: 10 Ways to Improve the Value of Cancer Care – Medscape (free registration required)
See other lists of low-value practices in oncology:
– American Society of Clinical Oncology
– Society of Surgical Oncology
– Society of Gynecologic Oncology
– American Society for Radiation Oncology
– Medical Oncology Group of Australia
– Oncology – Choosing Wisely Canada
See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada
9 – Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of hospital stay and postoperative complications – Cochrane Library (free)
Related Guidelines: Clinical Practice Guidelines for Enhanced Recovery After Colon and Rectal Surgery From the American Society of Colon and Rectal Surgeons and Society of American Gastrointestinal and Endoscopic Surgeons (free) AND Guidelines for Perioperative Care in Elective Colorectal Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations: 2018 (free) AND Enhanced recovery after surgery in emergency colorectal surgery: Review of literature and current practices – World Journal of Gastrointestinal Surgery (free)
“This review suggests that early enteral feeding may lead to a reduced postoperative length of stay, however cautious interpretation must be taken due to substantial heterogeneity and low-quality evidence.”
10 – Continuous Anticoagulation and Cold Snare Polypectomy Versus Heparin Bridging and Hot Snare Polypectomy in Patients on Anticoagulants With Subcentimeter Polyps: A Randomized Controlled Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Trial demonstrates noninferiority of cold snare polyp removal for patients on anticoagulation – ACP Gastroenterologist (free) AND Cold snare polypectomy with continuous anticoagulant use does not increase bleeding risk – 2 Minute Medicine (free)
Mon July 29 – 10 Stories of The Day!
29 Jul, 2019 | 00:01h | UTC
1 – WHO report on the global tobacco epidemic 2019 – World Health Organization (free PDF)
News Release: WHO launches new report on the global tobacco epidemic (free)
Commentaries: UN sees progress in fight against tobacco, warns more action needed to help people quit deadly product – United Nations (free) AND Battle against tobacco epidemic is far from won, WHO report finds – The Guardian (free) AND Expanding tobacco control measures to reach 5 billion people – Bloomberg Philanthropies (free) AND WHO Says e-Cigarettes,’ Smoke-Free’ Products Do Not Help Reduce Cancer – Reuters (free)
Related Guideline: Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the treatment of panic disorder, social anxiety disorder and generalised anxiety disorder (free)
3 – Multiple sclerosis in adults: management – National Institute for Health and Care Excellence (free)
Related Guidelines: AAN Guideline: Disease-modifying Therapies for Adults with Multiple Sclerosis (free guideline and commentaries) AND ECTRIMS/EAN guideline on the pharmacological treatment of people with multiple sclerosis – European Journal of Neurology (free) AND Brazilian Consensus for the Treatment of Multiple Sclerosis: Brazilian Academy of Neurology and Brazilian Committee on Treatment and Research in Multiple Sclerosis (free PDF) AND Diagnosis of Multiple Sclerosis: 2017 Revisions of the McDonald Criteria (free registration required)
Commentaries: Strategies to identify patients for antihypertensive treatment – The Lancet (free) AND Using cardiovascular risk to identify patients eligible for blood pressure treatment could prevent significantly more heart attacks and strokes – London School of Hygiene & Tropical Medicine (free) AND Expert reaction to paper on identifying those eligible for blood pressure treatment and subsequent burden of cardiovascular disease – Science Media Centre (free)
5 – The state of hypertension care in 44 low-income and middle-income countries: a cross-sectional study of nationally representative individual-level data from 1·1 million adults – The Lancet (link to abstract – $ for full-text)
Commentaries: Hypertension poorly managed in low- and middle-income countries – Harvard T.H. Chan School of Public Health (free) AND In the Global South less than one-third of high blood pressure patients treated – University of Göttingen (free) AND Two-Thirds Of People In Low & Middle-Income Countries With Hypertension Don’t Get Treatment – Health Policy Watch (free)
Commentary: CDC Updates Measles Prevention Guidelines for Healthcare Workers – NEJM Journal Watch (free)
7 – Moral injury and burnout in medicine: a year of lessons learned – STAT (free)
Original Perspective: Physicians aren’t ‘burning out.’ They’re suffering from moral injury – STAT (free)
Related: The Burnout Crisis in American Medicine (free commentaries on the subject)
8 – Alex Nowbar’s journal reviews, 25 July 2019 – The BMJ Opinion (free)
Alex Nowbar reviews the latest research from the top medical journals.
Editorial: Antiarrhythmic Drugs in Atrial Fibrillation: Is There Still a Role for Rhythm Control? (free)
Commentary: Medications used to treat atrial fibrillation may raise risk of falls – American Geriatrics Society (free)
10 – Fluoroquinolone use and serious arrhythmias: A nationwide case-crossover study – Resuscitation (link to abstract – $ for full-text)
Commentary: Fluoroquinolones and Sudden Death – JournalFeed (free)
Related: Committee Recommends New Restrictions on the use of Fluoroquinolones (free report and commentaries) AND FDA Safety Alert: Warnings for Fluoroquinolones on Risks of Mental Health and Low Blood Sugar Adverse Reactions (free statement and commentaries) AND FDA Warns About Increased Risk of Aortic Dissection and Ruptures of Aortic Aneurism with Fluoroquinolones (free report and commentaries)
Fri July 26 – 10 Stories of The Day!
26 Jul, 2019 | 09:46h | UTC
1 – ACG Clinical Guideline: Hereditary Hemochromatosis – The American Journal of Gastroenterology (free PDF)
Related Guidelines: Diagnosis and management of hemochromatosis: 2011 Practice Guideline by the American Association for the Study of Liver Diseases (free) AND Therapeutic recommendations in HFE hemochromatosis for p.Cys282Tyr (C282Y/C282Y) homozygous genotype – Hepatology International (free)
2 – Clinical Guide and Update on Porphyrias – Gastroenterology (free)
Related Reviews: Update review of the acute porphyrias – British Journal of Haematology (free) AND Acute Hepatic Porphyrias: Review and Recent Progress – Hepatology Communications (free) AND Acute hepatic porphyrias: Recommendations for evaluation and long‐term management – Hepatology (free) AND An overview of the cutaneous porphyrias – F1000 Research (free)
Commentary: Review examines methods for diagnosis of elevated ICP in critically ill – MedicalXpress (free)
Related Guidelines: Management of severe traumatic brain injury (first 24 hours) – Anaesthesia Critical Care & Pain Medicine (free) AND Consensus statement from the International Consensus Meeting on the Role of Decompressive Craniectomy in the Management of Traumatic Brain Injury – Acta Neurochirurgica (free)
Related Reviews: Emergency Neurological Life Support: Intracranial Hypertension and Herniation – Neurocritical Care (free) AND Acute Management of Traumatic Brain Injury – Surgical Clinics of North America (free)
Commentary: Long-Term Risk for Recurrent VTE Significant After Stopping Anticoagulation – NEJM Journal Watch (free)
“the risk of recurrent VTE was 10% in the first year after treatment, 16% at two years, 25% at five years, and 36% at 10 years, with 4% of recurrent VTE events resulting in death.”
5 – Harms from Uninformative Clinical Trials – JAMA (free for a limited period)
“An uninformative trial is one that provides results that are not of meaningful use for a patient, clinician, researcher, or policy maker.”
6 – Realizing Shared Decision-making in Practice – JAMA (free for a limited period)
Related Viewpoint: Shared Decision Making and the Importance of Time – JAMA (free)
9 – Interventions for preventing obesity in children – Cochrane Library (free)
Summary: Do diet and physical activity strategies help prevent obesity in children (aged 0 to 18 years)? – Cochrane Library (free)
10 – Rhythm control for patients with atrial fibrillation complicated with heart failure in the contemporary era of catheter ablation: a stratified pooled analysis of randomized data – European Heart Journal (link to abstract – $ for full-text)
Commentary: Rhythm Control for Atrial Fibrillation With Heart Failure – American College of Cardiology (free)
Related Meta-Analysis: Catheter Ablation for Atrial Fibrillation Improves Outcomes in Heart Failure with Reduced Ejection Fraction (free)
Thu July 25 – 10 Stories of The Day!
25 Jul, 2019 | 02:20h | UTC
1 – Preventing dementia by preventing stroke: The Berlin Manifesto – Alzheimer’s & Dementia (free)
Commentaries: Group calls on international community to prevent dementia by preventing stroke – University of Western Ontario (free) AND Stroke Prevention Best Path to Dementia Reduction, Experts Say – Medscape (free registration required)
Commentary: Baseline Ischemia Not Linked to 10-Year Events in Stable CAD: MASS II Analysis – TCTMD (free) AND Stress Testing–Induced Myocardial Ischemia and Clinical Events in Multivessel CAD – Latest in Cardiology (free)
3 – How a data detective exposed suspicious medical trials – Nature (free)
Related: Dozens of recent clinical trials may contain wrong or falsified data (free study by John Carlisle)
“Anaesthetist John Carlisle has spotted problems in hundreds of research papers — and spurred a leading medical journal to change its practice.”
4 – Allergan Recalls Textured Breast Implant Tied to Rare Cancer – Associated Press (free)
See also: FDA Requests Manufacturer Recall of Some Textured Breast Implants – The ASCO Post (free) AND FDA asks Allergan to recall textured breast implants worldwide – Reuters (free) AND Worldwide recall issued for textured breast implants tied to rare cancer – CNN (free)
Related: FDA Report: 660 Cases of Breast Implant-Associated Anaplastic Large Cell Lymphoma (link to statement and other studies)
Commentary: One dose of HPV vaccine may be enough, Australian research finds – University of Melbourne (free)
6 – Renal Replacement Therapy in the Critical Care Setting – Critical Care Research and Practice (free)
Related Meta-Analysis: Early Initiation of Renal Replacement Therapy in Critically Ill Patients (free)
Related Randomized Trial: Early vs. Delayed Dialysis in Acute Kidney Injury (link to abstract and commentaries)
Source: Critical Care Reviews Newsletter
Related Guideline: Investigation of a unilateral pleural effusion in adults: British Thoracic Society pleural disease guideline (free)
Related Reviews: Evaluation of the patient with pleural effusion – Canadian Medical Association Journal (free) AND Recommendations of Diagnosis and Treatment of Pleural Effusion. Update – Achivos de Broncopneumologia (free) AND State-of-the-art: Radiological investigation of pleural disease – Respiratory Medicine (free)
Source: Critical Care Reviews Newsletter
Commentaries: What’s New in Understanding the Risk Associated With Body Size and Shape? Pears, Apples, and Olives on Toothpicks – JAMA Network Open (free) AND Bellyfat in some postmenopausal women linked to higher death risk – UPI (free) AND Expert reaction to central obesity and mortality risk in postmenopausal women of normal weight – Science Media Centre (free)
Related Study: Distribution of Regional Body Fat and Cardiovascular Disease Risk Among Postmenopausal Women with Normal BMI (free study and commentaries)
Commentaries: Stricter Regulations Needed to Maximize Cuts in Sodium Intake, UK Study Suggests – TCTMD (free) AND Relaxed UK salt policy tied to more heart disease, cancers – Reuters (free)
Wed July 24 – 10 Stories of The Day!
24 Jul, 2019 | 09:41h | UTC
Related Guideline: EFNS guidelines on the Clinical Management of Amyotrophic Lateral Sclerosis (MALS) – revised report of an EFNS task force (free)
3 – Intensive vs Standard Treatment of Hyperglycemia and Functional Outcome in Patients With Acute Ischemic Stroke: The SHINE Randomized Clinical Trial – JAMA (free for a limited period)
Commentaries: Researchers get a handle on how to control blood sugar after stroke – NIH News Releases (free) AND Study Doesn’t Support Intensive Glucose Control in Patients with Stroke and Hyperglycemia – NEJM Journal Watch (free)
4 – Screening for Hepatitis B Virus Infection in Pregnant Women – U.S Preventive Services Task Force (free)
See also: Evidence Report and Systematic Review (free) AND Editorial (free) AND Author Interview (free audio)
Commentary: USPSTF Reaffirms Benefit of Hep B Screening in Pregnant Women – Physician’s Briefing (free)
5 – Aspiration Pneumonia in Older Adults – Journal of Hospital Medicine (free PDF)
7 – Dietary and Pharmacological Treatment of Nonalcoholic Fatty Liver Disease – Medicina (free)
Related Guidelines: Non-Alcoholic Fatty Liver Disease: Assessment and Management – National Institute for Health and Care Excellence (NICE) (free) AND The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases (free) AND Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis – Japanese Society of Gastroenterology (free) AND Nonalcoholic Fatty Liver Disease Brazilian Society of Hepatology Consensus (free PDF) AND EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease (free)
Commentaries: Mediterranean diet during pregnancy reduces gestational diabetes and weight gain – Queen Mary University of London (free) AND Mediterranean Diet in Pregnancy Might Reduce Risk for Gestational Diabetes – NEJM Journal Watch (free)
9 – Prevalence of Aspirin Use for Primary Prevention of Cardiovascular Disease in the United States: Results From the 2017 National Health Interview Survey – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Widespread aspirin use despite few benefits, high risks – Beth Israel Deaconess Medical Center (free) AND Many Americans mistakenly use aspirin to prevent heart disease – Reuters (free) AND Older Adults Should Reevaluate Daily Aspirin – MedicalResearch.com (free) AND Millions still take aspirin for their heart without a doctor’s recommendation, research suggests – CNN (free)
10 – 2-cm versus 4-cm surgical excision margins for primary cutaneous melanoma thicker than 2 mm: long-term follow-up of a multicentre, randomised trial – The Lancet (link to abstract – $ for full-text)
Commentaries: Does Size of Surgical Excision Margins for Thick Localized Cutaneous Melanoma Affect Survival Outcomes? – The ASCO Post (free) AND Quick Take: 2-cm versus 4-cm surgical excision margins for primary cutaneous melanoma thicker than 2 mm – 2 Minute Medicine (free)
Tue July 23 – 10 Stories of The Day!
23 Jul, 2019 | 09:52h | UTC
Commentary: The evidence on travel bans for diseases like Ebola is clear: they don’t work – Vox (free)
Related: WHO Declares New Ebola Outbreak a Public Health Emergency of International Concern (free statement and commentaries)
6 – Recent trends in the age at diagnosis of colorectal cancer in the US National Cancer Data Base, 2004‐2015 – Cancer (link to abstract – $ for full-text)
Commentaries: Colon cancer cases rising among adults under 50 – UPI (free) AND More colorectal cancer cases are being diagnosed in younger patients – Wiley (free)
Related Studies: Another Study Shows Increased Incidence of Colorectal Cancer in Adults Aged 40 Through 49 Years (link to abstract and commentaries) AND Two Studies Point to Increase in Colorectal Cancer Incidence in Young Adults (link to abstract and commentaries)
7 – Diagnosing the Onset of Menopause – JAMA (free for a limited period)
Clinical Review Audio: Diagnosing Menopause (free)
8 – Association Between Plant-Based Dietary Patterns and Risk of Type 2 Diabetes: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free for a limited period)
Commentaries: Following a healthy plant-based diet may lower type 2 diabetes risk – JAMA Internal Medicine (free) Eating a plant-based diet might help prevent type 2 diabetes, study suggests – CNN (free) AND Healthy plant-based diets could reduce diabetes risk, study says – UPI (free) AND Expert reaction to study on the vegetarian diet and diabetes risk – Science Media Centre (free)
9 – Music versus midazolam during preoperative nerve block placements: a prospective randomized controlled study – Regional Anesthesia & Pain Medicine (link to abstract – $ for full-text)
Commentaries: Music may offer alternative to preoperative drug routinely used to calm nerves – BMJ (free) AND Music ‘calms nerves before surgery’ as well as sedative – BBC (free) AND Music could offer alternative to sedatives – OnMedica (free)
10 – Association of Genetic and Environmental Factors With Autism in a 5-Country Cohort – JAMA Psychiatry (free for a limited period)
Editorial: The Architecture of Autism Spectrum Disorder Risk: What Do We Know, and Where Do We Go From Here? (free for a limited period)
Commentaries: Genetic factors are primary cause of autism, study finds – UPI (free) AND Study provides ‘strongest evidence’ yet for autism being a genetic condition – News Medical (free) AND A new study reinforces the conclusion that autism is primarily genetic – Science Based Medicine (free)
Mon July 22 – 10 Stories of The Day!
21 Jul, 2019 | 22:14h | UTC
1 – Buffered solutions versus 0.9% saline for resuscitation in critically ill adults and children – Cochrane Library (free)
Summary: Buffered solutions versus 0.9% saline for resuscitation in critically ill adults and children – Cochrane Library (free)
Related Meta-Analysis: Choice of Intravenous Crystalloid Fluid and Mortality in Critically Ill Adult Patients – Southern Medical Journal (link to abstract – $ for full-text)
Related Randomized Trials: Balanced Crystalloids vs Saline in Hospitalized Patients (free studies and commentary)
“The three ongoing studies once published and assessed may alter the conclusions of the review.”
2 – Cancer and heart disease: associations and relations – European Journal of Heart Failure (free)
4 – Deep Learning to Assess Long-term Mortality from Chest Radiographs – JAMA Network Open (free)
Commentaries: Prediction and Prevention Using Deep Learning – JAMA Network Open (free) AND Chest X-rays contain information that can be harvested with AI – Massachusetts General Hospital (free)
6 – Distinguishing opinion from evidence in guidelines – The BMJ (free for a limited period)
7 – Evidence vs Consensus in Clinical Practice Guidelines – JAMA (free for a limited period)
9 – Series: Oral Health – The Lancet (free articles and commentaries – registration required)
10 – Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis – The Lancet (link to abstract – $ for full-text)
Commentaries: Study Distinguishes Schizophrenia Drug Effects Among Patients – MD Magazine (free) AND New Guidance on Antipsychotic Choice – Medscape (free registration required)
“These findings will aid clinicians in balancing risks versus benefits of those drugs available in their countries. They should consider the importance of each outcome, the patients’ medical problems, and preferences.”
Fri July 19 – 10 Stories of The Day!
19 Jul, 2019 | 09:56h | UTC
Related Guidelines: Crohn’s disease: management – National Institute for Health and Care Excellence (free) AND ACG Clinical Guideline: Management of Crohn’s Disease in Adults – The American Journal of Gastroenterology (free)
2 – Management of Patients with Acute Ischemic Stroke – JAMA (free for a limited period)
Original Guideline: 2018 AHA/ASA Guidelines for the Early Management of Patients With Acute Ischemic Stroke (free)
Related Guidelines: Stroke and transient ischaemic attack in over 16s: diagnosis and initial management – National Institute for Health and Care Excellence (free) AND Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke – The BMJ (free) AND Canadian Stroke Best Practice Recommendations for Acute Stroke Management (free)
3 – Effect of Systolic and Diastolic Blood Pressure on Cardiovascular Outcomes – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Hypertension From Top to Bottom: Don’t Ignore Diastolic BP – TCTMD (free) AND Both Systolic and Diastolic BP Affect CV Outcomes – NEJM Journal Watch (free)
4 – Incentives for smoking cessation – Cochrane Library (free)
Summaries: Can rewards help smokers to quit in the long term? – Cochrane Library (free) AND Featured Review: Incentives for smoking cessation – Cochrane Library (free)
Commentaries: Helping smokers quit: financial incentives work – The Conversation (free) AND NHS could save billions by offering cash reward to quit smoking – The Guardian (free)
5 – Association Between Electronic Cigarette Use and Smoking Reduction in France – JAMA Internal Medicine (free for a limited period)
Commentaries: No evidence that e-cigarettes help long-term smoking cessation – OnMedica (free) AND Study: E-cigarettes can help smokers quit, but have higher rate of relapse – UPI (free) AND Adults who vape are more likely to quit cigarettes, study finds – CNN (free)
Related Randomized Trial: E-Cigarettes vs. Nicotine-Replacement Therapy – New England Journal of Medicine (link to abstract and commentaries)
Related Guidelines and Reports: Public Health Consequences of E-Cigarettes – National Academies of Sciences, Engineering, and Medicine (free) AND E-cigarettes and heated tobacco products: evidence review – Public Health England (free) AND E-cigarettes: balancing risks and opportunities – British Medical Association (free PDF) AND Nicotine without smoke: Tobacco harm reduction – Royal College of Physicians(free summary and PDF)
6 – Perspective: The Promise and Price of Cellular Therapies – The New Yorker (a few articles per month are free)
“New “living drugs”—made from a patient’s own cells—can cure once incurable cancers. But can we afford them?”
Commentaries: Persistent HIV in central nervous system linked to cognitive impairment – NIH News Release (free) AND HIV-infected cells persist in cerebrospinal fluid, linked to poorer neurocognitive performance – University of North Carolina School of Medicine (free)
8 – Alex Nowbar’s journal reviews, 18 July 2019 – The BMJ Opinion (free)
Alex Nowbar reviews the latest research from the top medical journals.
9 – Anticoagulation in the cirrhotic patient – JHEP Reports (free)
Related: The Complex Role of Anticoagulation in Cirrhosis: An Updated Review of Where We Are and Where We Are Going – Digestion (free) AND Direct Oral Anticoagulants in Cirrhotic Patients: Current Evidence and Clinical Observations – Canadian Journal of Gastroenterology and Hepatology (free) AND Anticoagulation in cirrhosis: a new paradigm? – Clinical and Molecular Hepatology (free)
10 – Cardiovascular and Cerebrovascular Safety of Testosterone Replacement Therapy Among Aging Men with Low Testosterone Levels: A Cohort Study – American Journal of Medicine (link to abstract – $ for full-text)
Commentary: Testosterone replacement therapy (TRT) can increase men’s risk of stroke and heart attack – Elsevier (free)
Thu July 18 – 10 Stories of The Day!
18 Jul, 2019 | 11:18h | UTC
1 – News Release: Ebola outbreak in the Democratic Republic of the Congo declared a Public Health Emergency of International Concern – World Health Organization (free)
Commentaries: DR Congo Ebola outbreak now a Public Health Emergency, UN health agency declares – United Nations (free) AND WHO declares public health emergency over DRC Ebola – CIDRAP (free) AND WHO sounds Ebola alarm as risks intensify – Reuters (free) AND The WHO finally declared a public health emergency over Ebola – Vox (free)
See also: Statement by the Emergency Committee (free PDF)
Related: Special Report: The Ongoing Ebola Epidemic in the Democratic Republic of Congo, 2018–2019 – New England Journal of Medicine (free) AND Comprehensive Review: Ebola virus disease – The Lancet (free)
Editorial: Preventable harm: getting the measure right (free)
Commentaries: One in 20 patients exposed to preventable harm in medical care – OnMedica (free) AND Half of All Patient Harms ‘Preventable’ – Medscape (free registration required)
Commentary: The power of awareness – The BMJ Opinion (free)
Invited Commentary: Partial versus total knee replacement for knee osteoarthritis – The Lancet (free)
5 – Original Studies: Universal Testing, Expanded Treatment, and Incidence of HIV Infection in Botswana – New England Journal of Medicine (free) AND Effect of Universal Testing and Treatment on HIV Incidence — HPTN 071 (PopART) – New England Journal of Medicine (free) AND HIV Testing and Treatment with the Use of a Community Health Approach in Rural Africa – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Intensive Anti-H.I.V. Efforts Meet With Mixed Success in Africa – The New York Times (10 articles per month are free) AND HIV Incidence: Effect of Universal Testing and Treatment – MedicalResearch.com (free) AND New HIV program increased viral suppression, decreased new infections in Botswana – Harvard T.H. Chan School of Public Health (free)
Editorial: Is Transient Takotsubo Syndrome Associated With Cancer? Why, and With What Implications for Oncocardiology? (free)
Commentary: Cancer Rates High in Patients with Takotsubo Syndrome – NEJM Journal Watch (free)
Commentaries: Inserting informed choice into global menstrual product use and provision – The Lancet Public Health (free) AND Menstrual Cups: Study Finds They’re Safe To Use — And People Like Them – NPR (free) AND Menstrual cups ‘as reliable as tampons’ – BBC (free) AND A Better Way to Manage Your Period? Try the Menstrual Cup, Scientists Say – The New York Times (free)
8 – Association of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging – JAMA Neurology (free for a limited period)
Commentaries: Scientists close in on blood test for Alzheimer’s – STAT (free) AND Predicting Alzheimer’s – Blood markers close in on helping determine who will develop Alzheimer’s disease – MedPage Today (free registration required)
“What good will that do without a cure?” (from STAT)
9 – A multimodality test to guide the management of patients with a pancreatic cyst – Science Translational Medicine (link to abstract – $ for full-text)
Commentaries: Test shown to improve accuracy in identifying precancerous pancreatic cysts – Johns Hopkins Medicine (free) AND Machine Learning Guides Pancreatic Cyst Management in Patients – American Association for the Advancement of Science (free) AND An experimental AI system can predict when pancreatic cysts will become cancerous – STAT (free)
10 – The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness – The Lancet Psychiatry (free registration required)
Executive Summary and Podcast: A blueprint for protecting physical health in people with mental illness (free summary, audio and other resources)
Commentaries: Global commission into health inequities of mental illness gives blueprint for change – NICM Health Research Institute at Western Sydney University (free) AND People with mental illness experience poorer physical health, and the gap may be getting worse, experts say – ABC News (free) AND Why people with mental illness may face poorer physical health and early death – CNN (free)
Related WHO Guideline: Management of Physical Health Conditions in Adults with Severe Mental Disorders (free)
Wed July 17 – 10 Stories of The Day!
17 Jul, 2019 | 10:52h | UTC
Source: EvidenceAlerts
“Results favor clopidogrel and aspirin/dipyridamole combination for long-term secondary prevention after noncardioembolic stroke or transient ischemic attack”.
2 – Association Between Time to Treatment With Endovascular Reperfusion Therapy and Outcomes in Patients With Acute Ischemic Stroke Treated in Clinical Practice – JAMA (free for a limited period)
Editorial: Endovascular Therapy for Acute Ischemic Stroke Treated in Clinical Practice (free for a limited period)
Video Summary: Association Between Time to Treatment With Endovascular Reperfusion Therapy and Acute Ischemic Stroke Outcomes (free)
News Release: Treating stroke patients just 15 minutes earlier can save lives – UCLA (free)
3 – Association Between State-Mandated Protocolized Sepsis Care and In-hospital Mortality Among Adults With Sepsis – JAMA (free for a limited period)
Editorial: Government Regulation of Sepsis Care (free for a limited period)
Commentaries: First Ever State Sepsis Regulation in U.S. Tied to Lower Death Rates – University of Pittsburg (free) AND Regulations That Mandate Sepsis Care Appear To Have Worked In New York – NPR (free)
4 – Effect of Flexible Family Visitation on Delirium Among Patients in the Intensive Care Unit: The ICU Visits Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Psychological Consequences of Admission to the ICU: Helping Patients and Families (free for a limited period)
Author Interview: Do Flexible Family Visitation Hours Reduce Delirium in ICU Patients? – MedicalResearch.com (free)
Commentary: Sudden cardiac arrest in athletes: Prevention and management – Joule Inc. (free)
6 – Editorial: Lithium as the drug of choice for maintenance treatment in bipolar disorder – Acta Psychiatrica Scandinavica (free) (via @J_F_Hayes)
Original Article: A systematic review and meta‐analysis of clinical predictors of lithium response in bipolar disorder – Acta Psychiatrica Scandinavica (free)
7 – Editorial: The Challenge of Defining Alzheimer Disease Based on Biomarkers in the Absence of Symptoms – JAMA Neurology (free for a limited period)
Original Article: Prevalence of Biologically vs Clinically Defined Alzheimer Spectrum Entities Using the National Institute on Aging–Alzheimer’s Association Research Framework – JAMA Neurology (free)
“individuals with flushing reaction should maintain an alcohol consumption level half of that for non-flushers.”
9 – Post‐intensive care syndrome: its pathophysiology, prevention, and future directions – Acute Medicine & Surgery (free) (via @NydahlPeter)
Related Reviews: Post-intensive care outpatient clinic: is it feasible and effective? A literature review – Revista Brasileira de Medicina Intensiva (free) AND Post-intensive Care Syndrome: an Overview – Journal of Translational Internal Medicine (free) AND Optimizing Post-Intensive Care Unit Rehabilitation – Turkish Thoracic Journal (free)
See also: Acetylsalicylic acid for primary prevention of cardiovascular events – Canadian Family Physician (free)
Related: A Practical Approach to Low-Dose Aspirin for Primary Prevention (free) AND Aspirin for Primary Prevention: Is This the End of the Road? (free) AND Evidence evolving on aspirin as prevention – ACP Internist (free)
Tue July 16 – 10 Stories of The Day!
16 Jul, 2019 | 09:53h | UTC
1 – Healing the Professional Culture of Medicine – Mayo Clinic Proceedings (free)
Related: Understanding organisational culture for healthcare quality improvement – The BMJ (free)
2 – State of The Art Review: Pre-eclampsia: pathophysiology and clinical implications – The BMJ (free for a limited period)
Commentaries: Reduced work hours for trainee doctors not seen to compromise care – Reuters (free) AND Capping medical residency hours does not hamper new doctors’ quality of training – Harvard Medical School (free) AND Is an 80-Hour Workweek Enough to Train a Doctor? – Harvard Business Review (free)
Commentaries: New stillbirth risk figures help women’s decisions on timing delivery – Queen Mary University of London (free) AND Higher risk of stillbirth in longer pregnancies, study finds – PLOS (free) AND Expert reaction to study on longer pregnancies and risk of stillbirth – Science Media Centre (free)
Related Cochrane Review: Induction of Labor for Improving Birth Outcomes for Women at or Beyond Term (free)
Related Randomized Trials: Labor Induction vs. Expectant Management in Low-Risk Nulliparous Women (free) AND Induction of Labor at 41 Weeks vs. Expectant Management Until 42 Weeks (free)
Related WHO Recommendations: Induction of Labor at or Beyond Term (free)
5 – Hartmann’s procedure versus sigmoidectomy with primary anastomosis for perforated diverticulitis with purulent or faecal peritonitis (LADIES): a multicentre, parallel-group, randomised, open-label, superiority trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)
Commentary: Farewell to Hartmann’s Procedure? – MedPage Today (free registration required)
6 – Benefits and Harms of Oral Anticoagulant Therapy in Chronic Kidney Disease: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Non-vitamin K oral anticoagulants appear superior to vitamin K antagonists in early-stage CKD – ACP Internist (free) AND Evidence Favors NOACs for Anticoagulation in Early Chronic Kidney Disease – NEJM Journal Watch (free)
7 – Association of Lifestyle and Genetic Risk With Incidence of Dementia – JAMA (free for a limited period)
Commentaries: Healthy lifestyle reduces dementia risk even in those with genetic risk factors – NHS Choices (free) AND Healthy lifestyle may offset genetic risk of dementia – University of Exeter (free) AND Genes vs. lifestyle: Study ‘undermines fatalistic view of dementia’ – Medical News Today (free) AND Healthy living may help offset genetic risk of dementia: study – Reuters (free) AND Healthy lifestyle may cut risk of dementia regardless of genes – The Guardian (free)
8 – Viewpoint: The Ketogenic Diet for Obesity and Diabetes—Enthusiasm Outpaces Evidence – JAMA Internal Medicine (free for a limited period)
Related Consensus Statement: Very-low-calorie Ketogenic Diet (VLCKD) in the Management of Metabolic Diseases (free)
9 – Association of Screen Time and Depression in Adolescence – JAMA Pediatrics (free for a limited period)
Commentaries: Expert reaction to a study on screen time and depression in adolescents – Science Media Centre (free) AND Increasing social media use tied to rise in teens’ depressive symptoms, study says – CNN (free)
10 – Association of Silent Myocardial Infarction and Sudden Cardiac Death – JAMA Cardiology (free for a limited period)
Commentaries: Frequency of Left Ventricular Scars at Autopsy in Persons Dying Suddenly of Coronary Artery Disease With or Without Earlier Myocardial Infarction – JAMA Cardiology (free for a limited period) AND Nearly half of sudden cardiac death victims had prior, undetected MI – Cardiovascular Business (free) AND Silent MI Often Precedes Sudden Cardiac Death, Finnish Data Confirm – TCTMD (free)
Mon July 15 – 10 Stories of The Day!
14 Jul, 2019 | 20:09h | UTC
1 – Clinical Practice: Measles – New England Journal of Medicine (free)
2 – Optimized Treatment of ST-Elevation Myocardial Infarction: The Unmet Need to Target Coronary Microvascular Obstruction as Primary Treatment Goal to Further Improve Prognosis – Circulation Research (free) (via @gonzaeperez)
3 – For the sake of doctors and patients, we must fix hospital culture – The BMJ Opinion (free)
Related: Speaking up to prevent harm: A systematic review of the safety voice literature – Safety Science (free)
“When hospitals fail to create a culture where doctors and nurses can speak up patients pay the price.”
4 – 2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Commentaries: Moderate calorie restriction in young and middle-aged adults significantly reduces heart and metabolic risk factors independent of weight loss – NIH News Releases (free) AND Cutting calories improves health markers even in slim adults, study reports – Diabetes.co.uk (free) AND Cutting Just 300 Calories Per Day May Keep Your Heart Healthy – NPR (free) AND Cutting about 300 calories a day might benefit your heart, study finds – CNN (free)
5 – Viewpoint: Redefining the Physician’s Role in Cost-Conscious Care: The Potential Role of the Electronic Health Record – JAMA (free for a limited period)
“Displaying price information in EHRs could mark the next step in the transformation of the practice of medicine… The next generation of EHRs should include prices for the majority of medical products and services: medications, laboratory testing, surgical procedures, and physician visits.”
6 – Industry Payments and Physician Prescribing – JAMA Internal Medicine (free for a limited period)
Original Studies: Association of Biologic Prescribing for Inflammatory Bowel Disease With Industry Payments to Physicians – JAMA Internal Medicine (free for a limited period) AND Association Between Industry Payments to Physicians and Gabapentinoid Prescribing – JAMA Internal Medicine (free for a limited period)
7 – Urinary Tract Infections Affect Millions. The Cures Are Faltering. – The New York Times (10 articles per month are free)
“As the infections become increasingly resistant to antibiotics, some standard treatments no longer work for an ailment that was once easily cured.”
8 – Review: Diaphragmatic dysfunction – Pulmonology (free)
Source: Critical Care Reviews Newsletter
Related reviews: Toxicities of chimeric antigen receptor T cells: recognition and management – Blood (free) AND Toxicity and management in CAR T-cell therapy – Molecular Therapy Oncolytics (free) AND New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free) AND CAR T-Cell Therapy – What do you need to know for the ED? – emDocs (free) AND Managing the toxicities of CAR T‐cell therapy – Hematological Oncology (free)
Source: Critical Care Reviews Newsletter
Fri July 12 – 10 Stories of The Day!
12 Jul, 2019 | 08:23h | UTC
1 – Serious misdiagnosis-related harms in malpractice claims: The “Big Three” – vascular events, infections, and cancers – Diagnosis (free)
Commentaries: Diagnosis errors account for one-third of severe harm malpractice claims – Modern Healthcare (free) AND Study: 100k patients injured, die each year after misdiagnosis – UPI (free)
Related Report: Improving Diagnosis in Health Care – The National Academies of Sciences Engineering and Medicine (free)
2 – Time Course for Benefit and Risk of Clopidogrel and Aspirin after Acute Transient Ischemic Attack and Minor Ischemic Stroke: A Secondary Analysis from the POINT Randomized Trial – Circulation (link to abstract – $ for full-text)
Commentary: Clopidogrel-Aspirin in Minor Stroke/TIA of Maximum Benefit in First 21 Days – TCTMD (free)
Related Guideline: Dual Antiplatelet Therapy for Acute High-Risk TIA and Minor Ischemic Stroke – The BMJ (free)
3 – Editorial: Physician burnout: a global crisis – The Lancet (free)
Related Perspectives: Why Physician Burnout Is Endemic, and How Health Care Must Respond – NEJM Catalyst (free) AND Counting the costs: U.S. hospitals feeling the pain of physician burnout – Reuters (free) AND Panic, chronic anxiety and burnout: doctors at breaking point – The Guardian (free) AND The Burnout Crisis in American Medicine – The Atlantic (free) AND To Combat Physician Burnout and Improve Care, Fix the Electronic Health Record – Harvard Business Review (free commentaries) AND Physician burnout costs up to $17B a year, task force says – HealthcareDive (free)
Related Articles: Systematic Review: Prevalence of Burnout Among Physicians (free) AND Burnout syndrome among medical residents: A systematic review and meta-analysis – PLOS One (free) AND Prevalence of Burnout in Medical and Surgical Residents: A Meta-Analysis – International Journal of Environmental Research and Public Health (free) AND Physician Burnout Can Lead to Major Medical Errors (link to abstract and commentaries) AND Association Between Physician Burnout and Patient Safety, Professionalism, and Patient Satisfaction (link to abstract and commentaries)
Related Guidelines: Erectile Dysfunction: AUA Guideline (free) AND An Update of the International Society of Sexual Medicine’s Guidelines for the Diagnosis and Treatment of Premature Ejaculation – Sexual Medicine (free)
5 – Preclinical Alzheimer Disease—Early Diagnosis or Overdiagnosis? – JAMA Internal Medicine (free for a limited period)
6 – Association Between Blood Pressure Variability, Cardiovascular Disease And Mortality In Type 2 Diabetes: A Systematic Review And Meta‐Analysis – Diabetes, Obesity and Metabolism (link to abstract – $ for full-text)
Commentary: Systolic BP variability associated with increased risk of death, CV events in patients with type 2 diabetes, meta-analysis finds – ACP Diabetes (free)
Commentaries: No link between flu vaccine in pregnancy and later health problems in children – The BMJ (free) AND Swine flu jab in pregnancy safe for children as well as mothers – OnMedica (free)
8 – Perspective: New drugs: where did we go wrong and what can we do better? – The BMJ (free)
Commentary: No evidence of added benefit for most new drugs entering German healthcare system – The BMJ (free)
Commentaries: Possible link between sugary drinks and cancer – The BMJ (free) Sugary drinks linked to cancer – NHS Choices (free) AND A small glass of juice or soda a day is linked to increased risk of cancer, study finds – CNN (free) AND Are sugary drinks causing cancer? – BBC (free)
Commentary: Mentally stimulating activities linked to lower risk or delay of age-related memory loss – News Medical (free)
Thu July 11 – 10 Stories of The Day!
11 Jul, 2019 | 11:20h | UTC
1 – C-Reactive Protein Testing to Guide Antibiotic Prescribing for COPD Exacerbations – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: CRP Testing Can Safely Reduce Antibiotic Use for COPD Exacerbations – NEJM Journal Watch (free) AND Fingerprick Biomarker Test Can Reduce Use of Antibiotics in COPD Flares – MedicalResearch.com (free)
Editorial: Myocardial Infarction With Nonobstructive Coronary Arteries: A Call for Individualized Treatment (free)
Related: Contemporary Diagnosis and Management of Patients With Myocardial Infarction in the Absence of Obstructive Coronary Artery Disease: A Scientific Statement From the American Heart Association (free) AND The What, When, Who, Why, How and Where of Myocardial Infarction With Non-Obstructive Coronary Arteries (MINOCA) – Circulation Journal (free) AND Systematic Review of Patients Presenting With Suspected Myocardial Infarction and Nonobstructive Coronary Arteries – Circulation (free) AND Nonobstructive Versus Obstructive Coronary Artery Disease in Acute Coronary Syndrome: A Meta‐Analysis – Journal of the American Heart Association (free)
“Patients with MINOCA and those with myocardial infarction with obstructive coronary artery disease had comparable clinical outcomes. Use of renin‐angiotensin system blockers and statins was associated with lower mortality in patients with MINOCA.”
3 – Microvascular Disease, Peripheral Artery Disease and Amputation – Circulation (free PDF)
Commentaries: Microvascular Disease Quadruples Risk of Leg Amputation – TCTMD (free) AND Microvascular Disease Anywhere in the Body May Be Linked to Higher Risk of Leg Amputations – American Heart Association (free)
“Quality Improvement Goals for Acute Kidney Injury: “The AKI care process starts with the community, continues in the hospital, and ends in community, and each of these phases requires specific intervention.”” (via @CCCNPitt see Tweet)
7 – Ann Robinson’s journal review, 10 July 2019 – The BMJ Opinion (free)
Ann Robinson reviews the latest research from the top medical journals.
8 – Effect of Aerobic and Resistance Exercise on Cardiac Adipose Tissues: Secondary Analyses From a Randomized Clinical Trial – JAMA Cardiology (free link for a limited period)
Commentaries: Weight Training, Aerobic Exercise Affect Cardiac Fat Mass in Different Ways – TCTMD (free) AND Aerobic, resistance exercise may reduce coronary risk for people with belly fat – UPI (free)
9 – Systolic Blood Pressure and Risk of Valvular Heart Disease: A Mendelian Randomization Study – JAMA Cardiology (free link for a limited period)
“Lifetime exposure to elevated systolic BP appears to be associated with an increased risk of major valvular heart disease.”
10 – Press Release: HPV vaccine could prevent over 100,000 cancers – Public Health England (free)
Commentaries: HPV vaccine for boys ‘will prevent thousands of cancers’ – BBC (free) AND Expert reaction to HPV vaccine, modelling of cancer prevention, and introduction in September of vaccine programme for boys – Science Media Centre (free) AND UK offers HPV vaccines to boys, aims to stop 100,000 cancer cases – Reuters (free)
Wed July 10 – 10 Stories of The Day!
10 Jul, 2019 | 10:28h | UTC
1 – News Release: WHO updates global guidance on medicines and diagnostic tests to address health challenges, prioritize highly effective therapeutics, and improve affordable access – World Health Organization (free)
Guidance: World Health Organization model list of essential medicines: 21st list 2019 (free PDF) AND Executive summary: the selection and use of essential medicines 2019 (free PDF) AND World Health Organization model list of essential medicines for children: 7th list 2019 (free PDF) AND Second WHO Model List of Essential In Vitro Diagnostics (free PDF)
Commentaries: WHO List of Essential Tests Gets An Upgrade – Forbes (free) AND WHO adds new antibiotics to essential medicines list – CIDRAP (free)
3 – Management of Infants at Risk for Group B Streptococcal Disease – Pediatrics (free)
News Releases: AAP Updates Guidance on Preventing, Managing Infants with Group B Strep Disease – American Academy of Pediatrics (free) AND Early-onset group B strep: New guidance includes changes in dosing, assessment – AAP News (free)
Related: ACOG Guideline: Prevention of Early-Onset Group B Streptococcal Disease in Newborns (free)
4 – Delayed childhood neurodevelopment and neurosensory alterations in the second year of life in a prospective cohort of ZIKV-exposed children – Nature Medicine (link to abstract – $ for full-text)
News Release: A third of children up to age 3 exposed to Zika in-utero have neurological problems – UCLA (free) AND Maternal Zika infection tied to poor development in 32% of tots – CIDRAP (free)
5 – Selective Referral Using CCTA Versus Direct Referral for Individuals Referred to Invasive Coronary Angiography for Suspected CAD: A Randomized, Controlled, Open-Label Trial – JACC: Cardiovascular Imaging (link to abstract – $ for full-text)
Commentary: Coronary Computed Tomographic Angiography for Selective Cardiac Catheterization – CONSERVE – American College of Cardiology (free)
Commentaries: Hormone therapy for prostate cancer may raise risk of Alzheimer’s, Dementia – Penn Medicine (free) AND Prostate cancer treatment linked to heightened Alzheimer’s risk – UPI (free) AND Men’s dementia risk higher after androgen deprivation therapy – OnMedica (free) AND Risk of dementia rises with prostate cancer hormone-blocking therapy – Reuters (free)
7 – Subclinical Hypothyroidism – A Review – JAMA (free link for a limited period)
Related: BMJ Guideline: Treatment of Subclinical Hypothyroidism (free guideline and commentaries)
8 – Evaluating and Managing Bradycardia – Trends in Cardiovascular Medicine (free)
Related: 2018 ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay (free guideline and resources)
9 – Management of acute variceal hemorrhage – F1000Research (free)
10 – Neuropsychiatric Sequelae in Adolescents With Acute Synthetic Cannabinoid Toxicity – Pediatrics (link to abstract – $ for full-text)
News Release: Study: Seizures, coma more common with synthetic cannabinoids than cannabis – American Academy of Pediatrics (free)
Commentary: Synthetic Cannabinoids Associated with More Comas and Seizures in Teens – NEJM Journal Watch (free)
Tue July 9 – 10 Stories of The Day!
9 Jul, 2019 | 10:33h | UTC
2 – ERS statement on chest imaging in acute respiratory failure – European Respiratory Journal (free PDF)
3 – Financial Implications of 12-Month Dispensing of Oral Contraceptive Pills in the Veterans Affairs Health Care System – JAMA Internal Medicine (free link for a limited period)
Commentaries: 12-month supply of birth control pills cuts unintended pregnancies, cost – Reuters (free) AND Expanding Access to Short-Acting Hormonal Contraceptive Methods in the United States – JAMA Internal Medicine (free link for a limited period) AND Yearlong birth control supply would cut unintended pregnancies, costs – University of Pittsburg (free) AND Giving women only 3 months of birth control at a time may waste millions of dollars and lead to hundreds of unintended pregnancies. Year-long prescriptions could fix that. – Business Insider (free)
4 – Effects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence Map – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Little evidence supports nutritional supplements for protection against cardiovascular disease, death – ACP Internist (free) AND Nutritional supplements and diets not always protective, WVU research suggests – West Virginia University (free) AND Supplements and Diets for Heart Health Show Limited Proof of Benefit – The New York Times (10 articles per month are free)
Related Study: Association of Multivitamin and Mineral Supplementation and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis – Circulation: Cardiovascular Quality and Outcomes (free) AND Editorial: Multivitamins Do Not Reduce Cardiovascular Disease and Mortality and Should Not Be Taken for This Purpose: How Do We Know That? (free)
5 – Excess Antibiotic Treatment Duration and Adverse Events in Patients Hospitalized With Pneumonia: A Multihospital Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary: Pneumonia patients get too many antibiotics – especially as they leave the hospital – University of Michigan (free)
6 – A Multicenter Trial of Vena Cava Filters in Severely Injured Patients – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Liberal IVC Filter Use Not Warranted in Severe Trauma Patients – TCTMD (free)
7 – Low-density lipoprotein cholesterol and risk of intracerebral hemorrhage: A prospective study – Neurology (link to abstract – $ for full-text)
Commentaries: Cholesterol that is too low may boost risk for hemorrhagic stroke – Penn State (free) AND Low cholesterol may increase risk for haemorrhagic stroke – OnMedica (free) AND Very low levels of ‘bad’ cholesterol may raise stroke risk – Medical News Today (free)
8 – #159 Atrial Fibrillation Review and Update – The Curbsiders Internal Medicine Podcast (free audio and summary)
Commentaries: Drinking less might be tied to higher quality of life – Reuters (free) AND Women’s mental health may improve after quitting alcohol – UPI (free) AND Quitting alcohol may improve mental well-being, health-related quality of life – EurekAlert (free)