TOP 10 Medical News Stories
Mon, March 25 – 10 Stories of The Day!
25 Mar, 2019 | 01:00h | UTC
1 – World Tuberculosis Day | 24 March 2019 – World Health Organization (free resources)
See also: Cochrane Library releases Special Collection on diagnosing tuberculosis for World Tuberculosis Day (free collection) AND Global Epidemiology of Tuberculosis and Progress Toward Achieving Global Targets — 2017 – Centers for Disease Control and Prevention (free) AND Building a Tuberculosis-free World: The Lancet Commission on Tuberculosis (free report – registration required) AND WHO Consolidated Guidelines on Drug-resistant Tuberculosis Treatment (free)
News Release: Treating diabetes in older adults requires simpler medication regimens, looser glycemic targets – The Endocrine Society (free)
Source: EvidenceAlerts
5 – Perspective: Why you should be a “medical conservative” – Lown Institute (free)
Original Article: Perspective: The Case for Being a Medical Conservative (free article and twitter thread)
“being a medical conservative means being skeptical about new medical advances until unbiased and high-quality evidence shows a clear benefit”
6 – Physicians’ Trust in One Another – JAMA (free for a limited period)
Related Article: Why Physicians Should Trust in Patients – JAMA (free for a limited period)
Commentary: JAMA viewpoint: Physicians’ trust in one another is a care safety and quality issue – Regenstrief Institute (free)
7 – Are the Risks Of Drugs That Enhance Imaging Tests Overblown? – NPR (free)
Related: Meta-analysis: Acute Kidney Injury After Computed Tomography (link to abstract and commentaries) AND Reviews: Post-Contrast Acute Kidney Injury (free) AND Review: Does contrast cause kidney injury? (free)
8 – Opinion: Things We Do for No Reason: Neuroimaging for Hospitalized Patients with Delirium – Journal of Hospital Medicine (free)
See Complete Series: Things We Do For No Reason (free articles)
9 – Opinion: Things We Do For No Reason: Use of Antipsychotic Medications in Patients with Delirium – Journal of Hospital Medicine (free)
See Complete Series: Things We Do For No Reason (free articles)
Related: Automated Triaging of Adult Chest Radiographs with Deep Artificial Neural Networks (free) AND Deep Learning for Chest Radiograph Diagnosis (free)
Fri, March 22 – 10 Stories of The Day!
22 Mar, 2019 | 07:42h | UTC
Commentaries: Bacteria in urine doesn’t always indicate infection – Infectious Diseases Society of America (free) AND Most Urinary Bacteria Do Not Require Antibiotics – MedicalResearch.com (free)
“Home blood pressure should be measured for 3 days, increased to 7 only when mean blood pressure is close to a diagnostic or treatment threshold.”
3 – Building a tuberculosis-free world: The Lancet Commission on tuberculosis (free articles – registration required)
Commentaries: Experts set out targets to eliminate tuberculosis within a generation – The Lancet (free) AND A human-rights approach is essential to end the global TB epidemic – The Conversation (free) AND A Roadmap for Ending the Moral Catastrophe of TB – Global Health NOW (free)
“A collaborative approach using a quality improvement methodology and a care bundle appeared to be effective in reducing mortality and length of stay in emergency laparotomy”.
5 – OBesity Treatment, Beyond the Guidelines: Practical Suggestions for Clinical Practice – JAMA (free for a limited period)
Related: European Practical and Patient-Centred Guidelines for Adult Obesity Management in Primary Care – Obesity Facts (free)
7 – Opting Out of Vaccines Should Opt You Out of American Society – Scientific American (free)
“Although you have a right to your own body, your choice to willfully be sick ends where another’s right to be healthy begins.”
Commentaries: Expert reaction to research on hot tea and oesophageal cancer – Science Media Centre (free) AND Drinking hot tea linked with elevated risk of esophageal cancer – Wiley (free) AND Drinking very hot tea almost doubles risk of cancer, new study says – CNN (free) AND Hot tea linked to increased risk of esophageal cancer – UPI (free)
10 – Performance of Screening Ultrasonography as an Adjunct to Screening Mammography in Women Across the Spectrum of Breast Cancer Risk – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: Breast Screening: Adding Ultrasonography Doesn’t Seem Worth Associated Harms – NEJM Journal Watch (free) AND Does supplemental whole-breast ultrasound provide significant value? – Radiology Business (free)
Thu, March 21 – 10 Stories of The Day!
21 Mar, 2019 | 07:25h | UTC
1 – WHO consolidated guidelines on drug-resistant tuberculosis treatment – World Health Organization (free PDF)
News Release: New WHO recommendations to accelerate progress on TB – World Health Organization (free)
Commentaries: World Health Organization advisers call for registry of studies on human genome editing – STAT (free) AND W.H.O. Panel Demands a Registry for Human Gene Editing – The New York Times (10 articles per month are free) AND World Health Organization panel weighs in on CRISPR-babies debate – Nature (free)
3 – Vitamin K for reversal of excessive vitamin K antagonist anticoagulation: a systematic review and meta-analysis – Blood Advances (free)
“Our findings indicate that patients on VKA therapy who have an INR between 4.5 and 10.0 without bleeding are not likely to benefit from vitamin K administration in addition to temporary VKA cessation.”
4 – Podcast: Update on Atrial Fibrillation: Review of the New AHA/ACC/HRS Treatment Guidelines (free)
5 – Perspective: Mesh Implants for Women: Scandal or Standard of Care? – JAMA (free for a limited period)
“Urogyne mesh implants have been called the “biggest medical scandal” since thalidomide and the “gold standard” treatment for stress urinary incontinence. These divergent views illustrate the complexity of the ongoing debate over their safety and efficacy.” (via @JAMA_current see Tweet)
6 – Clinical practice guidelines and the overuse of health care services: need for reform – Canadian Medical Association Journal (free for a limited period)
“Specialty bias and fee-for-service conflicts of interest threaten the validity of clinical practice guidelines and may lead to overdiagnosis, overtreatment and increasing health care costs.”
7 – Scientists rise up against statistical significance – Nature (free)
Editorial: It’s time to talk about ditching statistical significance – Nature (free)
Related: What a nerdy debate about p-values shows about science — and how to fix it – VOX (free) AND Big names in statistics want to shake up much-maligned P value – Nature News (free) AND ‘One-size-fits-all’ threshold for P values under fire – Nature News (free) AND Statisticians issue warning over misuse of P values – Nature News (free) AND Understanding common misconceptions about p-values – The 20% Statistician (free) AND PulmCrit- .050 shades of grey in p-value cutoffs (free) AND Statistical tests, P values, confidence intervals, and power: a guide to misinterpretations – European Journal of Epidemiology(free)
“We are not calling for a ban on P values. . . Rather, and in line with many others over the decades, we are calling for a stop to the use of P values in the conventional, dichotomous way.” (via @ericmjohnson)
Commentaries: Cannabis and psychosis: triangulating the evidence – The Lancet Psychiatry (free) AND Expert reaction to daily cannabis use, potency and psychosis – Science Media Centre (free) AND Daily or high-potency cannabis increases risk of psychotic disorder, study finds – CNN (free) AND Daily cannabis and skunk users run higher psychosis risk – Reuters (free)
9 – Psychosis with Methylphenidate or Amphetamine in Patients with ADHD – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Some ADHD medicines may increase psychosis more than others, ‘real-world’ data show – STAT (free) AND With ADHD, amphetamine has double the psychosis risk of methylphenidate – Reuters (free) AND Big data study identifies drugs that increase risk of psychosis in youth with ADHD – McLean Hospital (free)
Commentaries: ‘Just one sugary drink a day’ linked to health problems – NHS Choices (free) AND Sugary drinks linked to higher risk of premature death, especially for women, study says – CNN (free) AND Sugary drinks could raise risk of early deaths finds study – News Medical (free)
Wed, March 20 – 10 Stories of The Day!
20 Mar, 2019 | 03:39h | UTC
2 – Comparison of Dual Therapies for Lowering Blood Pressure in Black Africans – New England Journal of Medicine (free for a limited period)
Commentary: Two-Drug Combos Using Popular Calcium Channel Blocker Show Superiority in Lowering Blood Pressure – American College of Cardiology (free)
3 – High-Dose Nifedipine Tied to Higher Cardiac Arrest Risk – TCTMD (free)
See also: Nifedipine linked with cardiac arrest – Pharmacy News (free) AND Common blood pressure drug may increase cardiac arrest risk – Medical News Today (free)
4 – Diagnostic Test Interpretation: Evaluating the Erythrocyte Sedimentation Rate – JAMA (free for a limited period)
5 – Outpatient treatment for people with cancer who develop a low‐risk febrile neutropaenic event – Cochrane Library (free)
Summary: Outpatient treatment for cancer patient with low-risk febrile neutropaenic event is effective – Cochrane Library (free)
Related Guideline: Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy: American Society of Clinical Oncology and Infectious Diseases Society of America Clinical Practice Guideline Update – Journal of Clinical Oncology (free)
6 – Pharmacologic and Nonpharmacologic Treatments for Urinary Incontinence in Women: A Systematic Review and Network Meta-analysis of Clinical Outcomes – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Behavioral therapy appears more effective than pharmacologic therapy for urinary incontinence outcomes – ACP Internist (free) AND For Urinary Incontinence, Behavioral Therapies Outperform Meds – NEJM Journal Watch (free)
Commentaries: A Rise In Depression Among Teens And Young Adults Could Be Linked To Social Media Use – NPR (free) AND Mental health issues increased significantly in young adults over last decade – American Psychological Association (free)
9 – Levels of Evidence Supporting American College of Cardiology/American Heart Association and European Society of Cardiology Guidelines, 2008-2018 – JAMA (link to abstract – $ for full-text)
Commentaries: Many Guidelines For Heart Care Rely On Weak Evidence – NPR (free) AND Few heart care recommendations are based on rigorous study – News Medical (free)
“The findings suggest that Lung Ultrasonography is more sensitive than Chest Radiography in detecting pulmonary edema in ADHF”
Tue, March 19 – 10 Stories of The Day!
19 Mar, 2019 | 03:54h | UTC
1 – Coronary Angiography after Cardiac Arrest without ST-Segment Elevation – New England Journal of Medicine (free for a limited period)
Editorial: Coronary Angiography after Cardiac Arrest — The Right Timing or the Right Patients? (free for a limited period)
Commentaries: Angiography timing does not impact survival after cardiac arrest for NSTEMI patients – American College of Cardiology (free) AND COACT: Delayed Angiography Does Not Compromise Survival in Cardiac Arrest Patients Without STEMI – TCTMD (free)
2 – Early or Delayed Cardioversion in Recent-Onset Atrial Fibrillation – New England Journal of Medicine (free for a limited period)
Editorial: The RACE to Treat Atrial Fibrillation in the Emergency Department (free for a limited period)
Commentary: For Acute A-fib, Wait-and-See Approach May Spare Many Patients from Cardioversion – TCTMD (free)
Source: Critical Care Reviews Newsletter
Comprehensive guideline covering many common conditions in the Critical Care Unit.
Source: Critical Care Reviews Newsletter
6 – Multiple‐micronutrient supplementation for women during pregnancy – Cochrane Library (free)
Summary: Vitamin and mineral supplements for women during pregnancy – Cochrane Library (free)
Commentaries: Dietary interventions to prevent atopic disease: Updated recommendations – American Academy of Pediatrics (free) AND There’s new advice to prevent food allergies in children – CNN (free)
8 – Christopher Martyn’s research reviews, 18 March 2019 – The BMJ Opinion (free)
10 – BHIVA/BASHH guidelines on the use of HIV pre–exposure prophylaxis (PrEP) 2018 – HIV Medicine (free)
Related guidelines: WHO implementation tool for pre-exposure prophylaxis of HIV infection – World Health Organization (free) AND Draft Recommendation Statement: Prevention of Human Immunodeficiency Virus (HIV) Infection: Pre-Exposure Prophylaxis – U.S. Preventive Services Task Force (free) AND Canadian guideline on HIV pre-exposure prophylaxis and nonoccupational postexposure prophylaxis – Canadian Medical Association Journal (free) AND Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine HIV pre-exposure prophylaxis: clinical guidelines. Update April 2018 – Journal of Virus Eradication (free) AND Preexposure Prophylaxis for the Prevention of HIV Infection in the United States – 2017 Update: a Clinical Practice Guideline (free)
Mon, March 18 – 10 Stories of The Day!
18 Mar, 2019 | 00:17h | UTC
Guideline Hub: Primary Prevention of Cardiovascular Disease (free resources)
Executive Summary: 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease (free PDF)
Guidelines Made Simple: A Selection of Tables and Figures (free PDF)
Summary with Key Points to Remember: 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease – American College of Cardiology (free)
2 – Effect of Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial – JAMA (free for a limited period)
Related Study: Effect of Catheter Ablation vs Medical Therapy on Quality of Life Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial – JAMA (free for a limited period)
Video Summary: Catheter Ablation vs Drug Therapy for Patients With Atrial Fibrillation: The CABANA Trial (free)
Editorial: Catheter Ablation for Atrial Fibrillation: Lessons Learned From CABANA (free for a limited period)
Commentary: Surgery no better than medication at preventing serious complications of atrial fibrillation – NIH News Releases (free)
3 – Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients – New England Journal of Medicine (free for a limited period)
Commentary: In study, TAVR is superior to surgery for low-risk patients with aortic valve stenosis – Columbia University Irving Medical Center (free)
“”The main limitation of the study is that the current results reflect outcomes after one year, which isn’t long enough to assess the long-term durability of the replacement valve,” said Leon. “Patients in the study will be followed for at least 10 years so that we can measure their long-term outcomes and inform the medical community.” (from Columbia University)
See also: Beware the hype over the Apple Watch heart app. The device could do more harm than good – STAT (free) AND Apple Watch may spot heart problem but more research needed – Associated Press (free) AND Apple Watch May Detect A-fib in the General Population, but at What Cost? – TCTMD (free)
Related: Editorial: Downsides of Detecting Atrial Fibrillation in Asymptomatic Patients (free) AND USPSTF Statement: Screening with Resting or Exercise Electrocardiography (ECG) Not Recommended (free Guideline and commentaries) AND Wearable technology to screen for atrial fibrillation: does it raise more questions than it answers? (free commentaries) AND Get Ready For A Tsunami Of ECGs (free commentaries)
Commentaries: Evaluate Troponin Results Carefully, Researchers Warn – NEJM Journal Watch (free) AND Blood test to diagnose heart attacks is flawed, warn researchers – The BMJ (free) AND CHARIOT: 1 in 20 Hospitalized Patients Undergoing Blood Tests Have Elevated Troponin – TCTMD (free)
Related: Randomized Trial: High-Sensitivity Troponin in the Evaluation of Suspected Acute Coronary Syndrome (free study and commentaries) AND Cohort Study: The Introduction of High-sensitive Troponins Had No Impact on Survival (free study and commentaries)
6 – Patient Blood Management Recommendations From the 2018 Frankfurt Consensus Conference – JAMA (free for a limited period)
7 – Review: Acute Respiratory Distress Syndrome – Nature Reviews Disease Primer (free PDF)
8 – Associations of Dietary Cholesterol or Egg Consumption With Incident Cardiovascular Disease and Mortality – JAMA (free for a limited period)
Commentaries: Are Eggs Good Or Bad? How You Should Interpret This Latest Study – Forbes (free) AND Are eggs good or bad for you? New research rekindles the debate – STAT (free) AND Eggs are bad – then good – then bad again? What gives? – Diet Doctor (free)
9 – An environmental cleaning bundle and health-care-associated infections in hospitals (REACH): a multicentre, randomised trial – The Lancet Infectious Diseases (link to abstract – $ for full-text)
Commentary: Hospital cleaning trial cuts infections – Queensland University of Technology (free)
10 – Chlorhexidine versus routine bathing to prevent multidrug-resistant organisms and all-cause bloodstream infections in general medical and surgical units (ABATE Infection trial): a cluster-randomised trial – The Lancet (link to abstract – $ for full-text)
Commentaries: Results of Trial to Stem Hospital-Acquired Bacterial Infections Published – NIAID (free) Quick Take: Chlorhexidine Versus Routine Bathing to Prevent Multidrug-Resistant Organisms and All-Cause Bloodstream Infections in General Medical and Surgical Units (ABATE Infection Trial) – 2 Minute Medicine (free) AND Infection control technique may reduce infections in patients with catheters, drains – Rush University Medical Center (free)
“Decolonisation with universal chlorhexidine bathing and targeted mupirocin for MRSA carriers did not significantly reduce multidrug-resistant organisms in non-critical-care patients.”
Fri, March 15 – 10 Stories of The Day!
15 Mar, 2019 | 04:29h | UTC
Related: SIGN Guideline: Risk Reduction and Management of Delirium (free)
2 – A Trial of a Shorter Regimen for Rifampin-Resistant Tuberculosis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: STREAM trial final results show 9-month treatment for multi-drug resistant TB is as effective as 24-month treatment – University College London (free) AND Trial data support shorter drug-resistant TB regimen – CIDRAP (free)
News Release: AGS releases new action steps to guide care for older adults with multiple chronic illnesses – American Geriatrics Society (free)
5 – Continuous Renal Replacement Therapy: Who, When, Why, and How – Chest (free)
6 – Perspective: The Case for Being a Medical Conservative – The American Journal of Medicine (free for a limited period)
Commentary: Lower BP Linked to Cognitive Decline in Frail Elderly – Medscape (free registration required)
Related: Cohort Study: Control of Blood Pressure and Risk of Mortality in a Cohort of Older Adults (link to abstract and commentary)
Commentaries: Advancing the repurposing of ivermectin for malaria – The Lancet (free) AND Mosquito-killing drug reduces malaria episodes by a fifth among children – expert comment – London School of Hygiene & Tropical Medicine (free)
10 – Adopt a moratorium on heritable genome editing – Nature (free)
Editorial: Germline gene-editing research needs rules (free)
Commentaries: Leading scientists, backed by NIH, call for a global moratorium on creating ‘CRISPR babies’ – STAT (free) AND Expert reaction to a call for a moratorium on heritable genome editing – Science Media Centre (free)
Related: Genome-Edited Baby Provokes International Outcry (free commentaries) AND Consensus Statement on the Reported Birth of Genome-Edited Babies in China (free)
Thu, March 14 – 10 Stories of The Day!
14 Mar, 2019 | 01:15h | UTC
1 – One Month of Rifapentine plus Isoniazid to Prevent HIV-Related Tuberculosis – New England Journal of Medicine (free for a limited period)
Editorial: Ending Tuberculosis through Prevention (free)
Commentary: Ultrashort TB Therapy Found Just As Effective as 6 Month Course – MedicalResearch.com (free)
2 – A Randomized Trial of Prophylactic Antibiotics for Miscarriage Surgery – New England Journal of Medicine (free for a limited period)
Video Summary: Prophylactic Antibiotics before Miscarriage Surgery (free)
Commentaries: Research shines light on preventing infection after miscarriage – University of Birmingham (free) AND Antibiotics before miscarriage surgery not tied to fewer infections – CIDRAP (free)
Commentaries: Improving adolescent health: an evidence-based call to action – The Lancet (free) AND The Lancet: Disease, violence and inequality threaten more adolescents worldwide than ever before – The Lancet (free) AND The world’s adolescents: large unmet needs and growing inequalities – University of Melbourne (free) AND Adolescent health, education needs unmet in many countries, study says – UPI (free)
Commentaries: Shedding light on a million annual deaths in mid-childhood – The Lancet (free) AND Most deaths in children aged 5 to 14 in India, China, Brazil, Mexico are preventable – St. Michael’s Hospital (free)
5 – Risk reduction and management of delirium – Scottish Intercollegiate Guidelines Network (SIGN) (free guideline and summary)
News Release: First delirium clinical guidelines for Scotland published on World Delirium Awareness Day (free)
6 – EAN guideline on trigeminal neuralgia – European Journal of Neurology (free PDF)
Related Research: Randomized Trial: Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels in Patients with Septic Shock (link to abstract $ for full-text)
8 – Pro/Con Debate: Should Asymptomatic Patients with Moderate-to-severe OSA be Treated?
Pro: should asymptomatic patients with moderate-to-severe OSA be treated? – Breathe (free)
Con: should asymptomatic patients with moderate-to-severe OSA be treated? – Breathe (free)
Related: Obstructive Sleep Apnea in Cardiovascular Disease: A Review of the Literature and Proposed Multidisciplinary Clinical Management Strategy (free reviews) AND Positive airway pressure doesn’t reduce cardiovascular events and death in adults with sleep apnea (link to abstract and commentaries)
9 – Ten myths around open scholarly publishing – PeerJ Preprints (free)
Related: UC Terminates Subscriptions with World’s Largest Scientific Publisher in Push for Open Access (several commentaries on the subject)
10 – Infectious Diseases in Transplantation Guidelines
– BK Polyomavirus in Solid Organ Transplantation
– Adenovirus in Solid Organ Transplant Recipients
– Mycobacterium tuberculosis Infections in Solid Organ Transplantation
– Nocardia Infections in Solid Organ Transplantation
– Urinary Tract Infections in Solid Organ Transplant Recipients
– Herpes Simplex Virus Infections in Solid Organ Transplantation
– RNA Respiratory Viral Infections in Solid Organ Transplant Recipients
– Interactions between Anti‐infective Agents and Immunosuppressants
– Travel Medicine, Transplant Tourism, and the Solid Organ Transplant Recipient
– Solid Organ Transplantation in the HIV‐Infected Patient
– Cytomegalovirus in Solid Organ Transplant Recipients
– Human Herpesvirus 6, 7 and 8 in Solid Organ Transplantation
– Strategies for Safe Living Following Solid Organ Transplantation
– Emerging Fungal Infections in Solid Organ Transplant Recipients
Wed, March 13 – 10 Stories of The Day!
13 Mar, 2019 | 06:15h | UTC
Commentaries: Air pollution causes 8.8 million extra early deaths a year – European Society of Cardiology (free) AND Air Pollution Causes 8.8 Million Extra Deaths a Year – U.S. News (free) AND Air pollution kills 8.8 million people per year globally, study says – UPI (free)
Related: 9 out of 10 people worldwide breathe polluted air, but more countries are taking action – World Health Organization (free) AND The cost of a polluted environment: 1.7 million child deaths a year, says WHO – World Health Organization (free) AND Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015 – The Lancet (free) AND Death in the Air: Air Pollution Costs Money and Lives – World Bank (free infographic and report)
2 – Evidence evolving on aspirin as prevention – ACP Internist (free)
Related: Randomized Trial: Aspirin for Primary Prevention of Cardiovascular Disease (link to abstract and commentaries) AND Randomized Trial: Effects of Aspirin for Primary Prevention in Persons with Diabetes (link to abstract and commentaries) AND Randomized Trial: Effect of Aspirin on All-Cause Mortality in the Healthy Elderly (link to abstract and commentaries) AND Meta-Analysis: Association of Aspirin Use for Primary Prevention with Cardiovascular Events and Bleeding Events (link to abstract and commentaries)
“In patients who have not had a prior cardiovascular event, aspirin’s protective effects are modest and may not necessarily outweigh its potential downsides (namely, risk of bleeding and hemorrhagic stroke).”
4 – Italy bans unvaccinated children from school – BBC (free)
5 – Randomized Trial of Four Treatment Approaches for Actinic Keratosis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Comparison of Four Treatments for Actinic Keratosis – NEJM Resident 360 (free) AND Actinic keratosis: fluorouracil cream tops other options in randomized trial – Univadis (free registration required)
6 – Podcast: #142 Cirrhosis TIPS for Acute Complications – The Curbsiders Internal Medicine Podcast (free)
See also: Episode List
See also: Largest ever HIV prevention study delivers sobering message – Science (free)
Commentary: The global burden of stroke: persistent and disabling – The Lancet Neurology (free)
Commentary: Navigating Allosensitization in Heart Transplant Candidates and Recipients – American Heart Association (free)
Top Ten Things to Know: Sensitization in Heart Transplantation: Emerging Knowledge – American Heart Association (free)
Tue, March 12 – 10 Stories of The Day!
12 Mar, 2019 | 03:00h | UTC
Commentary: The Heart-Kidney, Kidney-Heart Connection and Our Improving Understanding of a Complex and Intimate Relationship – American Heart Association (free)
Top Things to Know: Cardiorenal Syndrome: Classification, Pathophysiology, Diagnosis, and Treatment Strategies – American Heart Association (free)
2 – WHO launches new global influenza strategy – World Health Organization (free)
See Report: Global influenza strategy 2019-2030 – World Health Organization (free)
Commentaries: World must prepare for inevitable next flu pandemic, WHO says – Reuters (free) AND WHO launches strategy to fight ‘inevitable’ flu pandemics – MedicalXpress (free)
Adults with an acute respiratory infection who have normal vital signs (temperature < 37,8 / respiratory rate < 20 / heart rate < 100) and a normal pulmonary examination are very unlikely to have CAP.
Related: 2018 ESC Guidelines for the diagnosis and management of syncope (free) AND 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope (free) AND Review: The Management of Vasovagal Syncope (free)
5 – Reexamining Recommendations for Treatment of Hypercholesterolemia in Older Adults – JAMA (free for a limited period)
“This Viewpoint discusses the 2018 ACC/AHA cholesterol management guideline recommendation to consider statin treatment in adults aged >75 years with LDL levels 70-189 mg/dL, arguing that trial evidence does not support it…”
6 – Guide to Statistics and Methods: Overview of Cost-effectiveness Analysis – JAMA (free for a limited period)
7 – FDA Safety Alert: Safe Use of Surgical Staplers and Staples – Letter to Health Care Providers – U.S Food & Drug Administration (free)
Commentary: FDA Alerts Clinicians About Surgical Staple Risks – NEJM Journal Watch (free)
Related: Hidden FDA Reports Detail Harm Caused By Scores Of Medical Devices – Kaiser Health News (free)
8 – Review: Three neglected numbers in the CBC: The RDW, MPV, and NRBC count – Cleveland Clinic Journal of Medicine (free)
9 – Christopher Martyn’s research reviews, 11 March 2019 – The BMJ Opinion (free)
Christopher Martyn reviews the latest research from the top medical journals.
Commentaries: Laser trabeculoplasty as first-line glaucoma treatment – The Lancet (free) AND 15-minute laser is best treatment for glaucoma patients, says study – The Guardian (free) AND 15-minute laser treatment best for glaucoma – OnMedica (free)
Mon, March 11 – 10 Stories of The Day!
11 Mar, 2019 | 04:16h | UTC
1 – Guidelines for Malaria Vector Control – World Health Organization (free)
See also: Cochrane Infectious Disease Group works with WHO on latest guidelines for malaria vector control – Cochrane Library (free) AND Current vector control challenges in the fight against malaria in Brazil – Revista da Sociedade Brasileira de Medicine Tropical (free)
2 – Selected Articles from the Annual Update in Intensive Care and Emergency Medicine 2019 – Critical Care (free articles)
– Sleep and Circadian Rhythm in Critical Illness
– Iron Metabolism: An Emerging Therapeutic Target in Critical Illness
– Heterogeneity in sepsis: new biological evidence with clinical applications
– Multidrug Resistant Gram-Negative Bacteria in Community-Acquired Pneumonia
– Uncovering Consciousness in Unresponsive ICU Patients: Technical, Medical and Ethical Considerations
– Mechanical Circulatory Support Devices for Cardiogenic Shock: State of the Art
– Physiological and Technical Considerations of Extracorporeal CO2 Removal
– ARDS in Obese Patients: Specificities and Management
– Recruitment Maneuvers and Higher PEEP, the So-Called Open Lung Concept, in Patients with ARDS
3 – Antiplatelet Therapy vs Anticoagulation Therapy in Cervical Artery Dissection: The Cervical Artery Dissection in Stroke Study (CADISS) Randomized Clinical Trial Final Results – JAMA Neurology (link to abstract – $ for full-text)
Commentaries: Antiplatelet and Anticoagulation Therapy May Equally Reduce Stroke Risk in Cervical Artery Dissection Patients – NeurologyToday (free) AND Stroke Prevention Agents on Par After Cervical Artery Dissection: Antiplatelet or anticoagulant treatment performed equally well in 1-year follow-up in CADISS trial – MedPage Today (free registration required)
Related Guidelines: Clinical Practice Guidelines for Enhanced Recovery After Colon and Rectal Surgery From the American Society of Colon and Rectal Surgeons and Society of American Gastrointestinal and Endoscopic Surgeons (free) AND Guidelines for Perioperative Care in Elective Colorectal Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations: 2018 (free)
5 – Man told he’s going to die by doctor on video-link robot – BBC (free)
See also: California family furious after hospital uses video call to tell grandfather he’s dying – The Guardian (free) AND Doctor on Video Screen Told a Man He Was Near Death, Leaving Relatives Aghast – The New York Times (10 articles per month are free)
6 – Overdiagnosis of pulmonary embolism: definition, causes and implications – Breathe (free)
Related: Time Trends in Pulmonary Embolism in the United States: Evidence of Overdiagnosis – JAMA Internal Medicine (free)
7 – Laboratory tests in rheumatology: A rational approach – Cleveland Clinical Journal of Medicine (free)
Source: Hospital Medicine Virtual Journal Club
Commentaries: E-cigarettes linked to heart attacks, coronary artery disease and depression – American College of Cardiology (free) AND E-cigarettes raise risk of heart attacks, strokes, depression, study says – UPI (free) AND e-Cigarettes Boost Heart Attack Risk, Emotional Stress, Findings Show – AJMC (free)
Editorial: Menopausal hormone therapy and cognition (free)
Commentaries: Systemic Hormone Therapy Tied to Small Increase in Alzheimer’s Risk – NEJM Journal Watch (free) AND ‘Small’ increase in risk of Alzheimer’s disease with HRT use, study suggests – NHS Choices (free)
“The findings of this case-control study, with the modest effect sizes and substantial potential for bias, will not change how I counsel patients regarding benefits and risks of HT.” (from Journal Watch)
“Evidence is reassuring for women needing a few years’ treatment for menopausal symptoms” (from Editorial)
Fri, March 8 – 10 Stories of The Day!
8 Mar, 2019 | 06:22h | UTC
1 – Patient Safety Outcomes under Flexible and Standard Resident Duty-Hour Rules – New England Journal of Medicine (link to abstract – $ for full-text)
Related Study: Sleep and Alertness in a Duty-Hour Flexibility Trial in Internal Medicine – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Longer shifts do not create chronic sleep loss in first-year doctors or reduce safety for patients, study finds – University of Pennsylvania School of Medicine (free) AND Flexible Medical Resident Duty Hours Did Not Pose Risks To Patients – MedicalResearch.com (free)
2 – Opinion: The war on ‘prediabetes’ could be a boon for pharma—but is it good medicine? – Science (free)
3 – Outpatient versus inpatient treatment for acute pulmonary embolism – Cochrane Library (free)
Summary: Outpatient versus inpatient treatment for acute pulmonary embolism – Cochrane Library (free)
Related: British Thoracic Society Guideline for the initial outpatient management of pulmonary embolism (free)
4 – Once daily long‐acting beta2‐agonists and long‐acting muscarinic antagonists in a combined inhaler versus placebo for chronic obstructive pulmonary disease – Cochrane Library (free)
Summary: Once daily long-acting beta2-agonists and long-acting muscarinic antagonists in a combined inhaler versus placebo for COPD – Cochrane Library (free)
6 – Medical-ethical guidelines: Management of dying and death – Swiss Medical Weekly (free)
Among other topics, this comprehensive guideline discusses assisted suicide in patients not facing imminent death. Under the Swiss Criminal Code, assisting suicide is not an offence.
Related: Research: Percutaneous coronary intervention in stable angina (ORBITA) (link to abstract and commentaries) AND Research: Physiology-Stratified Analysis of ORBITA (free study and commentaries)
9 – Control of blood pressure and risk of mortality in a cohort of older adults: the Berlin Initiative Study – European Heart Journal (link to abstract – $ for full-text)
Commentary: Blood Pressure Control and Mortality Risk in Older Adults – American College of Cardiology (free)
10 – Prospective associations between television in the preschool bedroom and later bio-psycho-social risks – Pediatric Research (link to abstract – $ for full-text)
Commentary: A television in the bedroom? – University of Montreal (free)
Related Guidelines: Media devices in pre-school children: the recommendations of the Italian pediatric society – Italian Journal of Pediatrics (free) AND Media and Young Minds – Recommendations from The American Academy of Pediatrics (free)
See also: Children, Adolescents and Screens: What We Know and What We Need To Learn (Pediatrics Supplement with free articles)
Thu, March 7 – 10 Stories of The Day!
7 Mar, 2019 | 03:23h | UTC
1 – NICE Guideline: Intrapartum care for women with existing medical conditions or obstetric complications and their babies – National Institute for Health and Care Excellence (free)
Related: Observational Study: β-Blocker Therapy Reduces the Risk for COPD Hospitalization (free study and reviews on the subject) AND β‐Blocker Use and Mortality in COPD Patients After Myocardial Infarction: A Swedish Nationwide Observational Study (free – similar study from Sweden)
Source: Hospital Medicine Virtual Journal Club
Commentary: ECG rhythm and airway management make all the difference during a heart attack – Osaka University (free)
Commentaries: Statins associated with 38 per cent increased risk of type 2 diabetes – Diabetes.co.uk (free) AND Cholesterol-lowering drugs linked to higher risk for developing type 2 diabetes – News Medical (free)
5 – Diagnosis and Outpatient Management of Chronic Obstructive Pulmonary Disease: A Review – JAMA (free for a limited period)
Podcast: COPD: All You Need to Know in 20 Minutes – JAMA (free)
6 – An ultrasound scan is not as useful as a CT scan in assessing trauma – NIHR Signal (free)
Original Article: Point‐of‐care ultrasonography for diagnosing thoracoabdominal injuries in patients with blunt trauma – Cochrane Library (free)
7 – Choosing Wisely Canada: Five Things Physicians and Patients Should Question in Otolaryngology – Rhinology – Canadian Society of Otolaryngology – Head & Neck Surgery (free)
See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada
8 – Inclusion body myositis: clinical features and pathogenesis – Nature Reviews Rheumatology (free)
9 – What do the people of the world die from? – BBC (free)
Commentaries: Study confirms and quantifies Zika-microcephaly link in Brazil – PLOS (free) AND Study highlights early pregnancy Zika microcephaly risk – CIDRAP (free)
Wed, March 6 – 10 Stories of The Day!
6 Mar, 2019 | 01:52h | UTC
1 – S2k guidelines for the diagnosis and treatment of type B aortic dissection – Gefässchirurgie (free)
Related Guidelines: 2014 ESC Guidelines on the diagnosis and treatment of aortic diseases: Document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult (free) AND 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the Diagnosis and Management of Patients With Thoracic Aortic Disease (free)
Related Guidelines: IDSA Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children (free) AND The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications (free) AND Guideline for the Management of Clostridium Difficile Infection in Children and Adolescents With Cancer and Pediatric Hematopoietic Stem-Cell Transplantation Recipients (free) AND Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection and Other Conditions in Children (free)
Related Guideline: Canadian Cardiovascular Society/Canadian Heart Rhythm Society Joint Position Statement on the Cardiovascular Screening of Competitive Athletes (free)
4 – Second patient free of HIV after stem-cell therapy – Nature News (free)
See also: Has a second person with HIV been cured? – Science (free) AND Expert reaction to HIV-1 remission in a second patient – Science Media Centre (free) AND Bone Marrow Transplant Renders Second Patient Free Of HIV – NPR (free) AND London patient might be second to be cured of HIV – CNN (free) AND H.I.V. Is Reported Cured in a Second Patient, a Milestone in the Global AIDS Epidemic – The New York Times (10 articles per month are free)
5 – Glucose control in the ICU – Current Opinion in Anesthesiology (free)
Source: Critical Care Reviews Newsletter
6 – Ann Robinson’s research reviews, 5 March 2019 – The BMJ Opinion (free)
Ann Robinson reviews the latest research from the top medical journals.
7 – Stand-Alone Artificial Intelligence for Breast Cancer Detection in Mammography: Comparison With 101 Radiologists – JNCI: Journal of the National Cancer Institute (link to abstract – $ for full-text)
Commentary: Robots can detect breast cancer as well as radiologists – Oxford University Press USA (free)
8 – Pro/Con Debate: Contact Precautions for MRSA and VRE
Con: Things We Do For No Reason: Contact Precautions for MRSA and VRE – Journal of Hospital Medicine (free)
Commentaries: Hospital and Time of Delivery May Affect Mother’s Health – The New York Times (10 articles per month are free) AND Study reveals that night and weekend births have substantially higher risk of delivery complications – Society for Risk Analysis (free)
10 – Fast-Food Offerings in the United States in 1986, 1991, and 2016 Show Large Increases in Food Variety, Portion Size, Dietary Energy, and Selected Micronutrients – Journal of the Academy of Nutrition and Dietetics (link to abstract – $ for full-text)
Commentaries: Bigger, Saltier, Heavier: Fast Food Since 1986 in 3 Simple Charts – The New York Times (10 articles per month are free) AND Thirty years of fast food: Greater variety, but more salt, larger portions, and added calories – Elservier (free) AND Fast Food Is Less Healthy Today Than 30 Years Ago, Analysis Finds – Forbes (free) AND Has fast food become worse for our health in the past 30 years? – Medical News Today (free)
Tue, March 5 – 10 Stories of The Day!
5 Mar, 2019 | 03:30h | UTC
News Release: New scientific statement on blood pressure measurement in people – American Heart Association (free) AND Heart Group Updates Statement on Blood Pressure Measurement – NEJM Journal Watch (free) AND AHA Details Accurate BP Measurement in Updated Scientific Statement – TCTMD (free)
2 – ACG Clinical Guideline: Ulcerative Colitis in Adults – American Journal of Gastroenterology (free PDF)
Commentary: Mucosal healing an emerging goal of ulcerative colitis treatment, guideline states – ACP Internist (free)
Related Guidelines: AGA Clinical Practice Guidelines on the Management of Mild-to-Moderate Ulcerative Colitis (free guideline and commentaries) AND Guideline: Management of Paediatric Ulcerative Colitis (free)
Commentaries: Doctors may be prescribing antibotics for longer than needed – The Conversation (free) AND UK primary care study finds overly long antibiotic courses – CIDRAP (free) AND Antibiotics courses often longer than guidelines – OnMedica (free)
4 – Javad Hekmat-panah: “Elderly”—an outdated and potentially harmful term – The BMJ Opinion (free)
5 – Management of hyperkalemia in the acutely ill patient – Annals of Intensive Care (free)
Related Reviews: Diagnosis and treatment of hyperkalemia – Cleveland Clinic Journal of Medicine (free) AND Potassium Disorders: Hypokalemia and Hyperkalemia – American Family Physician (free)
Source: Critical Care Reviews Newsletter
6 – Fibrosing interstitial lung diseases: knowns and unknowns – European Respiratory Review (free)
Related: Position Statement: Comprehensive Management of Fibrotic Interstitial Lung Diseases (free guidelines and reviews on the subject)
Source: Critical Care Reviews Newsletter
Commentaries: New sanitation system halves healthcare associated infections and cuts costs by 75 percent – Bocconi University (free) AND Study: Hospital sanitation system cuts infections by 52 percent – UPI (free)
Amazing results. Hopefully, a randomized trial will confirm these findings.
Commentary: A new machine learning model can classify lung cancer slides at the pathologist level – Dartmouth-Hitchcock Medical Center (free)
9 – Measles, Mumps, Rubella Vaccination and Autism: A Nationwide Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: It’s old news that vaccines don’t cause autism. But a major new study aims to refute skeptics again – STAT (free) AND Danish study finds no association between MMR vaccine and autism, even within high-risk subgroups – 2 Minute Medicine (free) AND A Large Study Provides More Evidence That MMR Vaccines Don’t Cause Autism – NPR (free)
10 – Impact of a Municipal Policy Restricting Trans Fatty Acid Use in New York City Restaurants on Serum Trans Fatty Acid Levels in Adults – American Journal of Public Health (link to abstract – $ for full-text)
Commentaries: Trans Fat Bans May Be Good for the Heart – The New York Times (10 articles per month are free) AND A ban on artificial trans fats in NYC restaurants appears to be working – ScienceNews (free)
Related: Action Package: WHO Plan to Eliminate Trans-fatty Acids from Global Food Supply (free report and commentaries) AND Systematic review of dietary trans-fat reduction interventions (free) AND Banning trans fats in New York prevented thousands of heart attacks (link to abstract and commentaries)
Mon, March 4 – 10 Stories of The Day!
4 Mar, 2019 | 00:54h | UTC
Commentary: Traumatic brain injury and kids: New treatment guidelines issued – Oregon Health & Science University (free)
2 – Preoperative evaluation of adult patients before elective, noncardiothoracic surgery – Der Anaesthesist (free for a limited period)
Related guidelines: 2014 ACC/AHA Guideline on Perioperative Cardiovascular Evaluation and Management of Patients Undergoing Noncardiac Surgery (free) AND 2014 ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management (free) AND Routine preoperative tests for elective surgery – NICE Guideline (free) AND Canadian Cardiovascular Society Guidelines on Perioperative Cardiac Risk Assessment and Management for Patients Who Undergo Noncardiac Surgery (free) AND 3rd Guideline for Perioperative Cardiovascular Evaluation of the Brazilian Society of Cardiology (free)
See also: Launching a powerful new screening tool for diabetic eye disease in India – Verily (free) AND Google, Verily develop AI algorithm to detect diabetic eye disease from imaging exams – HealthImaging (free)
Related Studies: Clinically Applicable Deep Learning for Diagnosis and Referral in Retinal Disease (free study and commentaries) AND Development and Validation of a Deep Learning System for Diabetic Retinopathy and Related Eye Diseases Using Retinal Images From Multiethnic Populations With Diabetes – JAMA (free) AND Prediction of cardiovascular risk factors from retinal fundus photographs via deep learning (link to abstract and commentaries)
4 – Preoperative Frailty Correlates with Surgical Outcomes across Diverse Surgical Subspecialties in a Large Health Care System – Journal of the American College of Surgeons (link to abstract – $ for full-text)
Commentary: Frailty may be a new screening criterion for fitness for an operation – American College of Surgeons (free)
5 – Alarming global surge of measles cases a growing threat to children – UNICEF (free)
Commentary: Measles cases at ‘alarmingly’ high levels around the world, UNICEF says – CNN (free)
Commentaries: The costs of academic publishing are absurd. The University of California is fighting back – VOX (free) AND University of California breaks up with major publisher over research access dispute – STAT (free)
Related: Will the world embrace Plan S, the radical proposal to mandate open access to science papers? – Science (free) AND The world debates open-access mandates (free) AND China Backs Bold Plan to Tear Down Journal Paywalls (free) AND Europe’s Bold Open-Access Plan Detailed (free) Groundbreaking deal makes large number of German studies free to public – Science (free) AND Open Access 2018: A Year of Funders and Universities Drawing Lines in the Sand – Absolutely Maybe Blog (free)
Editorial: Collective Intelligence for Clinical Diagnosis—Are 2 (or 3) Heads Better Than 1? (free)
Commentaries: Management of intrahepatic cholestasis in pregnancy – The Lancet (free) AND Simple bile acid blood test could tell risk of stillbirth – NIHR Biomedical Research Centre at Guy’s and St Thomas’ and King’s College London (free)
9 – Is interval training the magic bullet for fat loss? A systematic review and meta-analysis comparing moderate-intensity continuous training with high-intensity interval training (HIIT) – British Journal of Sports Medicine (link to abstract – $ for full-text)
Commentaries: The Best Type of Exercise to Burn Fat – The New York Times (10 articles per month are free) AND Short bursts of intense exercise ‘better for weight loss’ – BBC (free) AND Short intense exercise regimes may aid weight loss – OnMedica (free)
10 – Sugar-Sweetened Beverage Consumption 3 Years After the Berkeley, California, Sugar-Sweetened Beverage Tax – American Journal of Public Health (link to abstract – $ for full-text)
Commentaries: Sugary drink tax tied to drop in soda consumption – Reuters (free) AND Three years into soda tax, sugary drink consumption down more than 50 percent in Berkeley – University of California – Berkeley (free) AND U.S. Soda Taxes Work, Studies Suggest — But Maybe Not As Well As Hoped – NPR (free)
Related: Fiscal policies for diet and the prevention of noncommunicable diseases – World Health Organization (free) AND Policy lessons from health taxes (free research and commentaries) AND The Lancet taskforce on NCDs and economics (free series and commentaries) AND W.H.O. Urges Tax on Sugary Drinks to Fight Obesity – The New York Times (10 articles per month are free) AND Mexico’s sugar tax leads to fall in consumption for second year running – The Guardian (free) AND To improve global health, tax the things that are killing us – Financial Times (free policies, articles and commentaries) AND Reducing cardiovascular disease burden through targeted dietary policies (free study and commentaries) AND Fiscal policies for the prevention of diseases (free study and commentary) AND The potential impact of food taxes and subsidies on cardiovascular disease and diabetes burden and disparities (free) AND Sugar Tax: Why Health Experts Want it But Politicians and Industry are Resisting (free)
Fri, March 1 – 10 Stories of The Day!
1 Mar, 2019 | 07:23h | UTC
1 – WHO publishes new estimates on congenital syphilis – World Health Organization (free)
Original Article: Global burden of maternal and congenital syphilis and associated adverse birth outcomes—Estimates for 2016 and progress since 2012 – PLOS One (free)
Commentaries: Early use of antibiotics in elderly patients with UTIs associated with reduced risk of sepsis – Imperial College London (free) AND Delaying antibiotics in elderly with UTI linked to higher sepsis, death rates – MDedge (free) AND Withholding antibiotics from over-65s may increases cases of deadly sepsis, study shows – The Telegraph (free)
4 – Treatment of Anorexia Nervosa—New Evidence-Based Guidelines – Journal of Clinical Medicine (free)
5 – Ebola virus disease – The Lancet (free for a limited period)
Commentaries: Expert reaction to study looking at watching TV and memory in over 50s – Science Media Centre (free) AND TV Viewing Tied to Cognitive Decline in Those Over Age 50 – NEJM Journal Watch (free)
Commentary: FDA sounds an alarm on using robotic devices in cancer surgeries, citing concerns about safety and results – STAT (free)
“Our meta-analysis on higher versus lower doses of medications for heart failure just came out in PLOS ONE. You might be surprised at the magnitude of benefits vs harms of getting to “target doses” -always start with low doses and only increase if tolerated” (via @medmyths see Tweet)
News Release: Better options needed for children at higher risk of premature heart disease – American Heart Association (free)
10 – Special Issue: Initial Management of Thoracic Traumas – Journal of Thoracic Disease (free articles)
Diaphragm and transdiaphragmatic injuries
Thoracic damage control surgery
Management of traumatic esophageal injuries
Surgical management of chronic diaphragmatic hernias
Chest drain and thoracotomy for chest trauma
Thu, February 28 – 10 Stories of The Day!
28 Feb, 2019 | 06:07h | UTC
1 – A Randomized Trial of Lymphadenectomy in Patients with Advanced Ovarian Neoplasms – New England Journal of Medicine (link to abstract – $ for full-text)
Video Summary: Lymphadenectomy in Advanced Ovarian Cancer (free)
Commentaries: No survival benefit from systematic lymphadenectomy in ovarian cancer – MDedge Hematology & Oncology (free) AND ‘Meticulous’ Trial Overturns an Ovarian Cancer Practice – Medscape (free registration required)
2 – Paracetamol versus placebo for knee and hip osteoarthritis – Cochrane Library (free)
Summary: Paracetamol for treating people with hip or knee osteoarthritis – Cochrane Library (free)
Related: Paracetamol: widely used and largely ineffective (free)
3 – Policy Statement: 2019 Recommendations for Preventive Pediatric Health Care – American Academy of Pediatrics (free)
See Periodicity Schedule: Recommendations for Preventive Pediatric Health Care Bright Futures/American Academy of Pediatrics (free PDF)
4 – Association of Surgical Intervention for Adhesive Small-Bowel Obstruction With the Risk of Recurrence – JAMA Surgery (link to abstract – $ for full-text)
Commentaries: Surgery for adhesive small-bowel obstruction associated with lower recurrence risk – ACP Gastroenterology (free) AND Quick Take: Association of Surgical Intervention for Adhesive Small-Bowel Obstruction With the Risk of Recurrence – 2 Minute Medicine (free)
5 – Long-Term Risk of Heart Failure in Breast Cancer Patients After Adjuvant Chemotherapy With or Without Trastuzumab – JACC: Heart Failure (link to abstract – $ for full-text) (via @md_arianemacedo)
Commentary: Long-Term Risk of Heart Failure After Chemotherapy With Trastuzumab – American College of Cardiology (free)
“Trastuzumab treatment is associated with a 2-fold increased risk of late HF compared with chemotherapy treatment alone.”
Commentaries: Working long hours linked to depression in women – University College London (free) AND Long Works Hours May Hike Depression Risk in Women – PsychCentral (free) AND Are women who work long hours more likely to be depressed? – NHS (free)
7 – Clinics Aim to Improve Post-ICU Recovery – JAMA (free for a limited period)
Related: Post-intensive care outpatient clinic: is it feasible and effective? A literature review – Revista Brasileira de Medicina Intensiva (free) AND Impact of follow-up consultations for ICU survivors on post-ICU syndrome: a systematic review and meta-analysis – Intensive Care Medicine (free) AND Post-intensive Care Syndrome: an Overview – Journal of Translational Internal Medicine (free)
8 – Perspective: Telemedicine: The Latest Futuristic Tech Prediction From The Jetsons To Come True – Forbes (free)
Related: Why Your Next Doctor Visit Could Be Over The Phone – Forbes (free)
9 – Estimating the total incidence of global childhood cancer: a simulation-based analysis – The Lancet Oncology (link to abstract – $ for full-text)
Commentaries: Nearly half of childhood cancers worldwide undiagnosed – Harvard T.H. Chan School of Public Health (free) AND Nearly half of all children with cancer go undiagnosed and untreated – The Guardian (free)
Related: Early Detection for Colorectal Cancer: ASCO Resource-Stratified Guideline – Journal of Global Oncology (free)
Wed, February 27 – 10 Stories of The Day!
27 Feb, 2019 | 01:09h | UTC
1 – Rationalizing antimicrobial therapy in the ICU: a narrative review – Intensive Care Medicine (free)
Note: if the link above is paywalled, try this one
Commentary: New psoriasis guidelines emphasize management of comorbidities, use of biologics – ACP Internist (free)
Related Guidelines: Joint AAD-NPF guidelines of care for the management and treatment of psoriasis with biologics – Journal of the American Academy of Dermatology (free) AND French guidelines on the use of systemic treatments for moderate‐to‐severe psoriasis in adults – Journal of the European Academy of Dermatology and Venereology (free)
3 – Benefits of Sequentially Adding Cognitive-Behavioral Therapy or Antidepressant Medication for Adults With Nonremitting Depression – The American Journal of Psychiatry (link to abstract – $ for full-text)
Commentaries: Patients Not Fully Responsive to Antidepressants, CBT Alone Found to Improve With Combined Therapies – Psychiatric News Alert (free) AND What to Do When Depression Doesn’t Remit with Monotherapy – NEJM Journal Watch (free for a limited period)
4 – Alex Nowbar’s weekly research reviews, 26 February 2019 – The BMJ Opinion (free)
5 – Bundled Payments Are Moving Upstream – NEJM Catalyst (free)
“For bundled payments to fulfill their promise of delivering greater value to patients, bundling must shift toward the condition or person level rather than the procedure level”
6 – Association of Overlapping Surgery With Perioperative Outcomes – JAMA (link to abstract – $ for full-text)
Podcast: Is It Safe? What Happens When Your Surgeon Is Not Actually Doing Some of Your Operation? – JAMA (free)
Commentaries: How Safe Are Overlapping Surgeries? – Harvard Medical School (free) AND Double-Booked Surgeons: Study Raises Safety Questions For High-Risk Patients – NPR (free) AND ‘Overlapping surgery’ is safe for most patients, but not all – STAT (free)
7 – Association of Adolescent Hypertension with Future End-Stage Renal Disease – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentary: Adolescent Hypertension Linked to Later End-Stage Renal Disease – NEJM Journal Watch (free)
8 – 2018 Update on Pediatric Medical Overuse: A Review – JAMA Pediatrics (free for a limited period)
Related Guideline: American Gastroenterological Association Institute Guideline on the Medical Management of Opioid-Induced Constipation (free guideline and commentaries)
10 – Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Evaluation and Treatment of Patients with Thoracolumbar Spine Trauma – Neurosurgery (free articles)
– Prophylaxis and Treatment of Thromboembolic Events
– Operative Versus Nonoperative Treatment
– Timing of Surgical Intervention
Tue, February 26 – 10 Stories of The Day!
26 Feb, 2019 | 04:38h | UTC
Related Guidelines: SEOM clinical practice guideline: management and prevention of febrile neutropenia in adults with solid tumors (2018) – Clinical and Translational Oncology (free) AND Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy: American Society of Clinical Oncology and Infectious Diseases Society of America Clinical Practice Guideline Update – Journal of Clinical Oncology (free) AND Diagnosis and empirical treatment of fever of unknown origin (FUO) in adult neutropenic patients: guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO) (free) AND Management of febrile neutropaenia: ESMO Clinical Practice Guidelines (free) AND Guideline for the Management of Fever and Neutropenia in Children With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: 2017 Update (free)
3 – Distracted Driving, Visual Inattention, and Crash Risk Among Teenage Drivers – American Journal of Preventive Medicine (free for a limited period)
Commentary: Reaching for objects while driving may raise teen crash risk nearly sevenfold – NIH News Releases (free)
Commentary: Avoiding invasive treatment in dying patients may not shorten lifespan – Stanford Medicine (free)
5 – Limitation of Life-Sustaining Care in the Critically Ill: A Systematic Review of the Literature – Journal of Hospital Medicine (free PDF for a limited period)
Related: Dying with Dignity in the Intensive Care Unit – New England Journal of Medicine (free) AND Palliative care in intensive care units: why, where, what, who, when, how – BMC Anesthesiology (free) AND Ten key points about ICU palliative care – Intensive Care Medicine (free) AND Guidelines for the withdrawal of life-sustaining measures – Intensive Care Medicine (free) AND End-of-life in the ICU: moving from ‘withdrawal of care’ to a palliative care, patient-centred approach – British Journal of Anaesthesia (free) AND New concepts in palliative care in the intensive care unit – Revista Brasileira de Terapia Intensiva (free) AND The Changing Role of Palliative Care in the ICU – Critical Care Medicine (free)
6 – Clinical Guidelines on Chronic Rhinosinusitis in Children – Current Allergy and Asthma Reports (free for a limited period)
Note: if the above link is paywalled, try this one
Related Guideline: Clinical Consensus Statement: Pediatric Chronic Rhinosinusitis – Otolaryngology–Head and Neck Surgery (free)
7 – Stress Testing Versus CT Angiography in Patients With Diabetes and Suspected Coronary Artery Disease – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentary: CT Angiography Bests Functional Testing in Diabetic Patients With Chest Pain: PROMISE – TCTMD (free)
8 – Nuances to the Management of Febrile Patients: Non-Infectious Causes of Fever – emDocs (free)
Related: Pyrexia: aetiology in the ICU – Critical Care (free)
9 – Measuring Hospital-Acquired Complications Associated With Low-Value Care – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentary: Low-value procedures harm patients, consume hospital resources – HealthExec (free)
10 – Performance Characteristics of Fecal Immunochemical Tests for Colorectal Cancer and Advanced Adenomatous Polyps: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Annual noninvasive stool test effective for colon cancer screening – Regenstrief Institute (free) AND Annual FIT home stool test effective for CRC screening rates – American College of Physicians (free) AND Meta-Analysis Adds Support for FIT for Colorectal Cancer Screening – NEJM Journal Watch (free) AND One-Time FIT Adequately Detects CRC but Not Advanced Adenomas – MedPage Today (free registration required)
Mon, February 25 – 10 Stories of The Day!
25 Feb, 2019 | 01:32h | UTC
Related: ACG Clinical Guideline: Management of Patients With Acute Lower Gastrointestinal Bleeding (free)
Related Guideline: Evaluation and Management of Children and Adolescents With Acute Mental Health or Behavioral Problems. Part I: Common Clinical Challenges of Patients With Mental Health and/or Behavioral Emergencies – Pediatrics (free)
Commentaries: Push-up capacity linked with lower incidence of cardiovascular disease events among men – Harvard T.H. Chan School of Public Health (free) AND Struggling to do push-ups? You may be at risk of heart disease – NHS (free) AND How Many Push-Ups Can You Do? It May Be a Good Predictor of Heart Health – The New York Times (10 articles per month are free)
Commentaries: FDA Adds Boxed Warning About CV Risks to Gout Drug Febuxostat – TCTMD (free) AND FDA: Gout Drug Raises Death Risk – MedPage Today (free)
Related Research: Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout (free study and commentaries)
6 – Updates in Management and Timing of Dialysis in Acute Kidney Injury – Journal of Hospital Medicine (free PDF for a limited period)
Related Research: Early vs. Delayed Dialysis in Acute Kidney Injury (link to abstract and commentary)
7 – Pharmacological treatments for generalised anxiety disorder: a systematic review and network meta-analysis – The Lancet (link to abstract – $ for full-text)
Commentary: Pharmacotherapy for Generalized Anxiety: An Update – NEJM Journal Watch (free for a limited period)
News Release: New WHO strategy aims to halve the global impact of snakebite – The University of Melbourne (free)
Related: Global Mapping of Vulnerability to Snakebite Envenoming (free study and commentaries) AND Why Are So Many People Still Dying from Snake Bites? (free) AND Snakebite finally makes a WHO list of top global health priorities (free) AND Snakebites Make The List Of ‘Neglected Tropical Diseases’ (free)
9 – Management of Cardiovascular Disease in Women With Breast Cancer – Circulation (free)
Related: AHA Scientific Statement on Cardio-Oncology (several guidelines on the subject)
Commentary: Breast Calcifications May Hold Important Clues for CV Risk Stratification – TCTMD (free)
Fri, February 22 – 10 Stories of The Day!
22 Feb, 2019 | 01:44h | UTC
Commentary: Should HbA1c cutoffs for DM diagnosis be higher in older adults? – Univadis (free registration required)
Related Guidelines and Reviews: SEOM clinical guidelines on cardiovascular toxicity (2018) – Clinical and Translational Oncology (free) AND Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline (free) AND 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines (free) AND Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy (free) AND Cardio-Onco-Hematology in Clinical Practice. Position Paper and Recommendations – Revista Espanola de Cardiologia (free) AND Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management – CA: A Cancer Journal for Clinicians (free)
Editorial: Optimising the management of late term pregnancies (free for a limited period)
Commentaries: Small benefit of inducing labor over ‘wait and see’ approach for late-term pregnancies – MedicalXpress (free) AND To induce or not to induce pregnant women at 41 weeks – The BMJ Opinion (free)
Related: WHO Recommendations: Induction of Labor at or Beyond Term (free) AND Cochrane Review: Induction of Labor for Improving Birth Outcomes for Women at or Beyond Term (free)
Commentaries: Risks of shoulder replacement surgery higher than previously thought – The BMJ (free) AND Revision Surgery Common Among Middle-Aged Men with Shoulder Replacement – NEJM Journal Watch (free) AND Shoulder replacement surgery carries higher risk – OnMedica (free)
6 – Climate Change Is Having a Major Impact on Global Health – Scientific American (free)
Related: Climate Change — A Health Emergency (free reports and commentaries on the subject)
8 – Predictive Validity of a 2-Question Alcohol Screen at 1-, 2-, and 3-Year Follow-up – Pediatrics (free)
Commentaries: Alcohol Use Disorder: A Pediatric-Onset Condition Needing Early Detection and Intervention – Pediatrics (free) AND 2-Question Screen Identifies Adolescents at Risk for Future Alcohol Use Disorders – 2 Minute Medicine (free)
See Complete Series of Things We Do For No Reason (free articles)
10 – Impact of scaled up human papillomavirus vaccination and cervical screening and the potential for global elimination of cervical cancer in 181 countries, 2020–99: a modelling study – The Lancet Oncology (link to abstract – $ for full-text)
Commentaries: Rapid scale-up of HPV vaccine and screening could prevent up to 13 million cases of cervical cancer by 2050 – The Lancet (free) AND More Vaccination, Testing, Could Prevent Millions of Cervical Cancer Cases – Cleveland Clinic Newsroom (free)
See also: Human papillomavirus (HPV) and cervical cancer – World Health Organization (free)
Thu, February 21 – 10 Stories of The Day!
21 Feb, 2019 | 04:58h | UTC
1 – Current use of vasopressors in septic shock – Annals of Intensive Care (free)
Related Guidelines: Difficult Airway Society 2015 guidelines for management of unanticipated difficult intubation in adults – British Journal of Anaesthesia (free) AND Practice Guidelines for Management of the Difficult Airway: An Updated Report by the American Society of Anesthesiologists Task Force on Management of the Difficult Airway – Anesthesiology (free)
“Despite several national guidelines on management of the anticipated and unanticipated difficult airway, with separate guidelines for pediatric, obstetric, and intensive care settings, only limited effort has been directed towards developing specific suggestions regarding the contents of a Difficult Airway Trolley”
Related Summaries: Ten Commandments of the 2018 ESC/ESH Hypertension Guidelines (free) AND 2018 ESC/ESH Guidelines for Management of Arterial Hypertension – American College of Cardiology (free)
Original Guideline: ESC/ESH Guidelines for the Management of Arterial Hypertension (free)
4 – Association of Primary Care Physician Supply With Population Mortality in the United States, 2005-2015 – JAMA Internal Medicine (free for a limited period)
Commentaries: Primary care physicians associated with longevity, new research finds – Stanford Medicine (free) AND Greater primary care physician supply associated with longer life spans – News Medical (free)
5 – Dual Antiplatelet Therapy Duration Based on Ischemic and Bleeding Risks After Coronary Stenting – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: PRECISE-DAPT Score and Complex PCI – American College of Cardiology (free) AND After Stenting, Long-Term DAPT Benefits Those at Low Bleeding Risk More – NEJM Journal Watch (free)
Related Guidelines: 2018 Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology Focused Update of the Guidelines for the Use of Antiplatelet Therapy (free) AND 2017 European Society of Cardiology focused update on dual antiplatelet therapy in coronary artery disease (free) AND 2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease(free)
“Prospective studies are needed to verify whether patients at high bleeding risk derive net benefit from a shorter duration of DAPT after stenting, regardless of procedural complexity.” (from American College of Cardiology)
6 – Draft Recommendation Statement: BRCA-Related Cancer: Risk Assessment, Genetic Counseling, and Genetic Testing – U.S. Preventive Services Task Force (free)
Commentaries: USPSTF Issues Draft Recommendation on BRCA Risk Assessment and Testing – NEJM Journal Watch (free) AND New recommendations say not all women need genetic testing for cancer. Critics say it could cost lives – CNN (free)
8 – Understanding Lung Cancer Screening – BMJ EBM Spotlight (free)
See other reviews from the same Special Issue: Sudden Cardiac Death and Ventricular Arrhythmias – State of the Art (free articles)
Invited Commentary: An unparalleled assessment of the global burden of epilepsy (free)
Wed, February 20 – 10 Stories of The Day!
20 Feb, 2019 | 05:31h | UTC
1 – Bag-Mask Ventilation during Tracheal Intubation of Critically Ill Adults – New England Journal of Medicine (free for a limited period)
Editorial: Preventing Dogma from Driving Practice (free for a limited period)
Commentaries: Is pure RSI a failed paradigm in critical illness? The primacy of pressure – PulmCrit (free) AND Higher O2 Sats With Manual Vent During Intubation of Critically Ill – Drugs.com (free) AND Helping patients breathe during dangerous procedure prevents complications – Vanderbilt University Medical Center (free)
2 – Adjunctive Intermittent Pneumatic Compression for Venous Thromboprophylaxis – New England Journal of Medicine (free for a limited period)
3 – Challenges in the management of septic shock: a narrative review – Intensive Care Medicine (free)
Note: if the link above is paywalled, try this one
4 – Ann Robinson’s research reviews, 19 February 2019 – The BMJ Opinion (free)
Ann Robinson reviews the latest research from the top medical journals.
5 – Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicentre, randomised, controlled equivalence trial – The Lancet (link to abstract – $ for full-text)
Commentary: Having Anesthesia Once as a Baby Does Not Cause Learning Disabilities, New Research Shows – The New York Times (10 articles per month are free)
6 – Choosing Wisely Canada: Six Things Clinicians and Patients Should Question – Canadian Society of Hospital Pharmacists (free)
See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada
7 – A Clinical Prediction Rule to Identify Febrile Infants 60 Days and Younger at Low Risk for Serious Bacterial Infections – JAMA Pediatrics (free for a limited period)
Commentaries: New protocol could ease diagnosis of bacterial infections in infants – NIH News Release (free) AND Model derived to rule out bacteria in feverish infants – CIDRAP (free)
8 – Unresolved questions on venous thromboembolic disease. Consensus statement of the French Society for Vascular Medicine (SFMV) – JMV-Journal de Médecine Vasculaire (free for a limited period)
Commentaries: Risk of Spontaneous Abortion & Birth Defects with Oral Yeast Drug During Pregnancy – MedicalResearch.com (free) AND Common yeast infection pill tied to miscarriages – Reuters (free) AND Oral antifungal drug used to treat yeast infections linked to higher rates of miscarriage – CMAJ (free)
Related Research (just published): Analysis of postmarketing safety data for proton-pump inhibitors reveals increased propensity for renal injury, electrolyte abnormalities, and nephrolithiasis – Scientific Reports (free) AND Commentary: Common acid reflux medications linked to increased kidney disease risk – University of California (free)
See also: Proton Pump Inhibitors: Review of Emerging Concerns (free reviews) AND Deprescribing Proton Pump Inhibitors (free guidelines and reviews)
Tue, February 19 – 10 Stories of The Day!
19 Feb, 2019 | 00:15h | UTC
Commentary: Progressive Guidance on the Modern Management of Abdominal Aorto-iliac Artery Aneurysms – European Journal of Vascular and Endovascular Surgery (free)
See also: AGA Technical Review on the Management of Mild-to-Moderate Ulcerative Colitis – Gastroenterology (free)
Commentary: New guideline recommendations for the treatment of mild-to-moderate ulcerative colitis – American Gastroenterological Association (free)
3 – Effect of a Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels on 28-Day Mortality Among Patients With Septic Shock: The ANDROMEDA-SHOCK Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: How Best to Resuscitate Patients With Septic Shock? (free)
See also: Visual Abstract (free PDF)
Discussion Forum: ANDROMEDA-SHOCK (or, how to intepret HR 0.76, 95% CI 0.55-1.02, p=0.06) – Datamethods Discussion Forum (free)
4 – Hospital Wastes A Third Less Food After This One Change – Forbes (free)
Related Case Study: Mayo General Hospital Food Waste Prevention (free PDF)
5 – Podcast: #140 Psychopharmacology 2.0, Antidepressant Master Class – The Curbsiders Internal Medicine Podcast (free)
Commentary: Anaesthetists say patients at risk after flawed oxygen guidelines – The Guardian (free)
Related: Position Statement: Reducing Inappropriate Medication Use & Polypharmacy (several articles and commentaries on the subject)
8 – Subclinical hypothyroidism: When to treat – Cleveland Clinic Journal of Medicine (free)
Related: Thyroid Hormone Treatment Does Not Help Adults with Mildly Abnormal Thyroid Tests (link to abstract and commentaries) AND Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism (free study and commentary)
10 – What the Doctor Ordered: Improving the Use and Value of Laboratory Testing – CD Howe Institute (free PDF)
News Release: Lab Testing Misuse Costs Billions (free)
Commentary: Billions wasted annually on inappropriate lab tests, report finds – The Star (free)