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Systematic Reviews & Meta-analysis

Meta-analysis of mortality risk in octogenarians undergoing emergency general surgery operations

14 Jan, 2021 | 01:36h | UTC

Meta-analysis of mortality risk in octogenarians undergoing emergency general surgery operations – Surgery (link to abstract – $ for full-text)

 


Systematic review: Immunotherapy vs. chemotherapy for people with advanced non-small cell lung cancer who have not been previously treated

14 Jan, 2021 | 01:30h | UTC

Single or combined immune checkpoint inhibitors compared to first-line platinum-based chemotherapy with or without bevacizumab for people with advanced non-small cell lung cancer – Cochrane Library

Summary: Immunotherapy versus chemotherapy for people with advanced non-small cell lung cancer who have not been not previously been treated – Cochrane Library

 

 


Systematic review: Acute treatments for episodic migraine

13 Jan, 2021 | 01:56h | UTC

Acute Treatments for Episodic Migraine – Agency for Healthcare Research and Quality

Full text: Acute Treatments for Episodic Migraine

Evidence summary: Acute Treatments for Episodic Migraine

 


Systematic review: Treatments for acute pain

13 Jan, 2021 | 01:55h | UTC

Treatments for Acute Pain: A Systematic Review – Agency for Healthcare Research and Quality

Full text: Treatments for Acute Pain

Evidence summary: Treatments for Acute Pain

 


Systematic review: There is no evidence that Souvenaid is useful for preventing dementia or provide benefit for patients with Alzheimer’s disease

13 Jan, 2021 | 01:47h | UTC

Souvenaid for Alzheimer’s disease – Cochrane Library

 


Systematic review: Treatment with antenatal corticosteroids in women at risk of preterm birth reduces the risk of perinatal death, neonatal death, respiratory distress syndrome, and the risk of intraventricular hemorrhage

13 Jan, 2021 | 01:46h | UTC

Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth – Cochrane Library

Summary: What are the benefits and risks of giving corticosteroids to pregnant women at risk of premature birth? – Cochrane Library

 


Systematic review: Primary prophylaxis for venous thromboembolism in ambulatory cancer patients receiving chemotherapy

13 Jan, 2021 | 01:37h | UTC

Primary prophylaxis for venous thromboembolism in ambulatory cancer patients receiving chemotherapy – Cochrane Library

Summary: Prevention of blood clots in non-hospitalised cancer patients receiving chemotherapy – Cochrane Library

 


Systematic Review: “For the general population of persons with elevated blood pressure, the benefits of trying to achieve a lower blood pressure target rather than a standard target (140/90 mm Hg or less) do not outweigh the harms associated with that intervention.”

12 Jan, 2021 | 01:30h | UTC

Blood pressure targets in adults with hypertension – Cochrane Library

Summary: The use of lower blood pressure targets for people with hypertension – Cochrane Library

Related systematic review: Blood pressure targets in people with cardiovascular disease – Cochrane Library

 

Commentary on Twitter

 


Systematic review: Prevention of childhood unintentional injuries in low- and middle-income countries

12 Jan, 2021 | 01:23h | UTC

Prevention of childhood unintentional injuries in low- and middle-income countries: A systematic review – PLOS One

Related: World report on child injury prevention – World Health Organization

 


[Abstract Only] Meta-Analysis: Not enough evidence to recommend the use of a prosthetic Mesh for prevention of parastomal hernia

12 Jan, 2021 | 01:18h | UTC

Meta-Analysis and Systematic Review of the Use of a Prosthetic Mesh for Prevention of Parastomal Hernia – Annals of Surgery (link to abstract – $ for full-text)

 


Meta-analysis: Total neoadjuvant therapy vs. standard therapy in locally advanced rectal cancer

12 Jan, 2021 | 01:10h | UTC

Total Neoadjuvant Therapy vs Standard Therapy in Locally Advanced Rectal Cancer: A Systematic Review and Meta-analysis – JAMA Network Open

Commentaries: Personalizing Treatment for Rectal Cancer: Total Neoadjuvant Therapy Is Leading the Way AND Total Neoadjuvant Therapy Improves Rectal Cancer Pathologic Response – Physician’s Weekly

Related meta-analysis (just published): Impact of Total Neoadjuvant Therapy vs. Standard Chemoradiotherapy in Locally Advanced Rectal Cancer: A Systematic Review and Meta-Analysis of Randomized Trials – Cancers

 

Commentary on Twitter

 


Systematic review: Effectiveness of hospital clowns for symptom management in pediatrics

10 Jan, 2021 | 20:24h | UTC

Effectiveness of hospital clowns for symptom management in paediatrics: systematic review of randomised and non-randomised controlled trials – The BMJ

Commentaries: Clowns may help children cope with the pain and anxiety of hospital treatment – The BMJ AND Clowns Make Hospitals Less Scary For Young Patients – Forbes AND Laughter As Medicine: Clowns Help Hospitalized Kids Cope – U.S News

 

Commentary on Twitter

 


Meta-analysis: Effectiveness of bundle interventions on ICU delirium

10 Jan, 2021 | 20:16h | UTC

Effectiveness of Bundle Interventions on ICU Delirium: A Meta-Analysis – Critical Care Medicine

Commentary: ICU bundles do not appear to improve delirium but may help other outcomes – ACP Hospitalist

 

Commentary on Twitter

 


Effects of low sodium diet vs. high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride

10 Jan, 2021 | 20:12h | UTC

Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride – Cochrane Library

Summary: The effect of a low salt diet on blood pressure and some hormones and lipids in people with normal and elevated blood pressure – Cochrane Library

 


Systematic review: Infection and mortality of healthcare workers worldwide from COVID-19

17 Dec, 2020 | 08:40h | UTC

Infection and mortality of healthcare workers worldwide from COVID-19: a systematic review – BMJ Global Health

 

Commentary on Twitter

 


Meta-analysis: Induction of labor at 41 weeks improves perinatal outcomes compared with expectant management until 42 weeks, without increasing the cesarean delivery rate

15 Dec, 2020 | 01:21h | UTC

Induction of labour at 41 weeks or expectant management until 42 weeks: A systematic review and an individual participant data meta-analysis of randomised trials – PLOS Medicine

Commentary: More support for induction at 41 weeks’ pregnancy, especially for first time mothers – University of Gothenburg

 


Meta-analysis: Efficacy and harms of remdesivir for the treatment of COVID-19. “Until stronger evidence emerges, we cannot conclude that remdesivir is efficacious for treating COVID-19”.

13 Dec, 2020 | 23:27h | UTC

Efficacy and harms of remdesivir for the treatment of COVID-19: A systematic review and meta-analysis – PLOS One

 


A systematic review of corticosteroid treatment for noncritically ill patients with COVID-19 – corticosteroid treatment is not recommended for patients with mild or moderate COVID-19

13 Dec, 2020 | 23:26h | UTC

A systematic review of corticosteroid treatment for noncritically ill patients with COVID-19 – Scientific Reports

 


Systematic review: Tourniquet use for knee replacement surgery is probably associated with an increased risk of serious adverse events

13 Dec, 2020 | 23:17h | UTC

Tourniquet use for knee replacement surgery – Cochrane Library

Commentary: Featured Review: Tourniquet in knee replacement surgery

 


Systematic review: Among patients with advanced chronic kidney disease and uremic pruritus, gabapentinoids are the most studied treatments and show the greatest reduction in itch scores

13 Dec, 2020 | 23:16h | UTC

Interventions for itch in people with advanced chronic kidney disease – Cochrane Library

Commentary: What is the best treatment for itch in people with chronic kidney disease? – Cochrane Library

 


Systematic Review: Financial conflicts of interest are associated with favorable recommendations of drugs and devices in clinical guidelines, advisory committee reports, opinion pieces, and narrative reviews

11 Dec, 2020 | 09:18h | UTC

Conflicts of interest in clinical guidelines, advisory committee reports, opinion pieces, and narrative reviews: associations with recommendations – Cochrane Library

Summary: Conflicts of interest and recommendations in clinical guidelines, advisory committee reports, opinion pieces, and narrative reviews – Cochrane Library

 


Meta-analysis: Respiratory function post-infection by COVID-19. Altered diffusion capacity, restrictive pattern, and obstructive pattern were found in 39%, 15% and 7% of patients, respectively

7 Dec, 2020 | 01:04h | UTC

Respiratory function in patients post-infection by COVID-19: a systematic review and meta-analysis – Pulmonology

 

Commentary on Twitter

 


Meta-analysis reinforces the safety of betablockers in patients with COPD and cardiovascular disease

6 Dec, 2020 | 23:30h | UTC

Association of β-blocker use with survival and pulmonary function in patients with chronic obstructive pulmonary and cardiovascular disease: a systematic review and meta-analysis – European Heart Journal

Commentary: Beta-Blockers in Patients With COPD and CVD – American College of Cardiology

 


Meta-analysis: High-quality evidence supports fecal microbiota transplantation is effective for recurrent Clostridioides difficile infection

6 Dec, 2020 | 23:35h | UTC

Faecal microbiota transplantation for recurrent Clostridioides difficile infection: An updated systematic review and meta-analysis – EClinicalMedicine

 


Meta-analysis: Epidural corticosteroid injections for sciatica are effective, although the effects are small and short-term

4 Dec, 2020 | 08:26h | UTC

Epidural Corticosteroid Injections for Sciatica: An Abridged Cochrane Systematic Review and Meta-Analysis – Spine

 


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