Systematic Reviews & Meta-analysis
Meta-analysis: Oxytocin used as first‐line treatment of postpartum hemorrhage probably is more effective than misoprostol with less side‐effects. The evidence for most other uterotonic agents is limited.
3 Dec, 2020 | 08:31h | UTCSummary: Which drug is best for treating excessive bleeding after childbirth? – Cochrane Library
Systematic review: Peripheral nerve blocks for hip fractures reduce pain on movement, risk of acute confusional state, risk of chest infection, and time to first mobilization
27 Nov, 2020 | 08:37h | UTCPeripheral nerve blocks for hip fractures in adults – Cochrane Library
Meta-analysis: Among the treatment interventions to maintain abstinence from alcohol in primary care, acamprosate was the only intervention with enough evidence of benefit
26 Nov, 2020 | 08:55h | UTC
Commentary on Twitter
Acamprosate was the only intervention with enough evidence of benefit for maintaining alcohol abstinence and acceptability up to 12 months after detoxification in primary care settings, concludes new #BMJResearchhttps://t.co/K7FutIC3yd
— The BMJ (@bmj_latest) November 25, 2020
Cochrane review finds we are still uncertain about the effects of face masks to reduce the spread of respiratory viruses. Editorial: “Policy makers must act on incomplete evidence in responding to COVID‐19”
23 Nov, 2020 | 09:51h | UTCPhysical interventions to interrupt or reduce the spread of respiratory viruses – Cochrane Library
Editorial: Policy makers must act on incomplete evidence in responding to COVID‐19
Commentary: Face masks cut disease spread in the lab, but have less impact in the community. We need to know why – The Conversation
Systematic review: Ultra-long‐acting insulins provide modest benefit compared to NPH insulin for Type 2 DM, resulting in reduced risk of hypoglycemia but no difference in HbA1c
23 Nov, 2020 | 09:45h | UTC
Systematic review: Interventions for breathlessness in patients with advanced cancer
23 Nov, 2020 | 09:43h | UTCFull report: Interventions for breathlessness in patients with advanced cancer
Evidence Summary: Interventions for breathlessness in patients with advanced cancer
Systematic review: Management of primary headaches in pregnancy
18 Nov, 2020 | 09:00h | UTCManagement of Primary Headaches in Pregnancy – Agency for Healthcare Research and Quality
Full report: Management of Primary Headaches in Pregnancy
Evidence Summary: Management of Primary Headaches in Pregnancy
Systematic review: Evidence-based practices for acute respiratory failure and Acute Respiratory Distress Syndrome
17 Nov, 2020 | 09:37h | UTCCommentary: Best practices for mechanical ventilation in patients with ARDS, COVID-19 – University of Michigan
Sleep problems in dementia: Despite many drugs being widely prescribed, systematic review finds lack of evidence and no randomized controlled trials to guide decisions about drug treatment
17 Nov, 2020 | 09:29h | UTCPharmacotherapies for sleep disturbances in dementia – Cochrane Library
Systematic review: Inotropic agents and vasodilator strategies for the treatment of cardiogenic shock or low cardiac output syndrome. “At present, there are no convincing data supporting any specific inotropic or vasodilating therapy to reduce mortality in hemodynamically unstable patients with CS or LCOS.”
10 Nov, 2020 | 09:30h | UTC
Systematic Review: Little benefit from phlebotonics in patients with venous insufficiency
5 Nov, 2020 | 08:54h | UTCPhlebotonics for venous insufficiency – Cochrane Library
A systematic review of rehabilitation and exercise recommendations in oncology guidelines
29 Oct, 2020 | 09:02h | UTC
Commentary on Twitter
Improving the integration of rehabilitation into cancer care: A review of #oncology guidelines and their recommendations for #rehabilitation and #exercise https://t.co/QRerXhhGON #cancerehab #exerciseoncology @NicoleStoutPT @JulieSilverMD @KarenPhysio @DR_SantaMina @WVUCancer pic.twitter.com/kObsSMRN9A
— CA: A Cancer Journal for Clinicians (@CAonline) October 27, 2020
Systematic review: PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease
29 Oct, 2020 | 08:57h | UTCSummary: PCSK9 inhibitors for prevention of cardiovascular disease – Cochrane Library
Meta-analysis: Most therapies for fibromyalgia are not supported by high-quality evidence
28 Oct, 2020 | 08:52h | UTCAssociation of Therapies With Reduced Pain and Improved Quality of Life in Patients With Fibromyalgia: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free for a limited period)
Commentary: Evidence Lacking for Most Fibromyalgia Treatments, Meta-Analysis Finds – NEJM Journal Watch
Systematic review: Antithrombotic drugs for people with antiphospholipid syndrome
28 Oct, 2020 | 08:50h | UTC
Narrative systematic review: Benefits of medication charts provided at transitions of care
25 Oct, 2020 | 23:29h | UTC
Systematic review: Laparoscopic surgery for pain and infertility associated with endometriosis
25 Oct, 2020 | 23:23h | UTCLaparoscopic surgery for pain and infertility associated with endometriosis – Cochrane Library
Original study: Laparoscopic surgery for endometriosis – Cochrane Library
Commentary on Twitter
Updated priority #Cochrane review published "Laparoscopic surgery for #endometriosis" Laparoscopic excision or ablation probably increases #pregnancy rate compared to diagnostic laparoscopy only. No data were reported on live birth. https://t.co/OaIduKN0B8 @JamesMNDuffy pic.twitter.com/C3EnffV4d3
— CochraneCGF (@CochraneCGF) October 25, 2020
Meta-analysis: Preventive malaria treatment among school-aged children in sub-Saharan Africa
25 Oct, 2020 | 23:22h | UTCCommentaries: Landmark Study Suggests Malaria-Preventive Drugs Dramatically Reduce Infections and Improve Health of School Children – University of Maryland AND Back to school for malaria prevention: a new tool in the era of malaria elimination? – The Lancet Global Health
Commentary on Twitter
Conclusion of a new systematic review and meta-analysis: "Preventive treatment of malaria among school-aged children reduces the burden of malaria in this age group and could be a key intervention to decrease P falciparum transmission…" https://t.co/UaNBdsKaze pic.twitter.com/82e1OMX7TF
— The Lancet Global Health (@LancetGH) October 23, 2020
Meta-analysis: Dual antiplatelet therapy after percutaneous coronary intervention and drug-eluting stents
22 Oct, 2020 | 09:29h | UTC
Meta-analysis: Evaluating prophylactic heparin in ambulatory patients with solid tumors
22 Oct, 2020 | 09:23h | UTCEvaluating prophylactic heparin in ambulatory patients with solid tumours: a systematic review and individual participant data meta-analysis – The Lancet Haematology (free registration required)
Meta-analysis: Drugs for preventing postoperative nausea and vomiting in adults after general anesthesia
21 Oct, 2020 | 09:13h | UTC
Commentary on Twitter
Very pleased to share our new #NMA on drugs for preventing #postoperative #nausea and #vomiting after general #anaesthesia: https://t.co/vwha2Vd3DL A huge effort (585 studies!), that involved assessing and ranking the effects of 28 drugs and 36 drug combinations from 6 classes.
— Cochrane Anaesthesia & Emergency and Critical Care (@Cochrane_ACE) October 20, 2020
Vertical transmission of Zika virus and its outcomes: a Bayesian synthesis of prospective studies
20 Oct, 2020 | 01:30h | UTCCommentary: Desideratum: a developmentalist view of Zika virus infection – The Lancet Infectious Diseases
[Abstract Only] Systematic review and meta-analysis of native kidney biopsy complications
20 Oct, 2020 | 01:26h | UTCSystematic Review and Meta-Analysis of Native Kidney Biopsy Complications – Clinical Journal of the American Society of Nephrology (link to abstract – $ for full-text)
Commentary on Twitter
A meta-analysis found that although native kidney biopsy is an invasive diagnostic procedure, the rates of bleeding complications are low. Complications are more frequently seen after kidney biopsies of hospitalized patients with AKI. https://t.co/kxK6qxX1fc pic.twitter.com/SgCoI505cc
— CJASN (@CJASN) October 15, 2020
Meta-analysis: Evidence-based prevention of Alzheimer’s disease
20 Oct, 2020 | 01:21h | UTCCommentaries: Biggest risk factors identified to try and prevent Alzheimer’s disease – BMJ AND Systematic review finds ten lifestyle factors that clearly impact the probability of developing Alzheimer’s disease (AD) – Sharp Brains
Commentary on Twitter
Evidence-based #prevention of #Alzheimers disease https://t.co/XOMiEoMlmI via @JNNP_BMJ #dementia @perryd43 @PennilessScribe @u3Y4BDE @SanWren @lfkraus @the_scholar1 @ktanimara @drsharwood @TargetLatino @LilithResists @Joseph_Santoro @liftdupbyangels @mrtom101 @SteveDitchfield pic.twitter.com/T5hqbzmIwi
— Ian Kremer (@LEAD_Coalition) July 24, 2020
[Abstract Only] Meta-analysis: Effect of urate-lowering therapy on cardiovascular and kidney outcomes
20 Oct, 2020 | 01:22h | UTCEffect of Urate-Lowering Therapy on Cardiovascular and Kidney Outcomes: A Systematic Review and Meta-Analysis – Clinical Journal of the American Society of Nephrology (link to abstract – $ for full-text)
Commentary on Twitter
Study found urate-lowering therapy didn't produce benefits on clinical outcomes including major adverse cardiovascular events, all-cause mortality & kidney failure. Insufficient evidence to support urate lowering to improve kidney & cardiovascular outcomes https://t.co/uifm4vikYe pic.twitter.com/3fV60V3Lcx
— CJASN (@CJASN) October 14, 2020