Systematic Reviews & Meta-analysis
M-A: Offspring’s risk for suicidal behavior in relation to parental death by suicide – “the experience of losing a parent to suicide is a strong and independent risk factor for suicidal behavior in offspring”.
11 Nov, 2021 | 08:39h | UTC
Commentary on Twitter
Crucial question to ask all patients:
"Has anyone in your family committed suicide?"Review of studies shows why: https://t.co/QIysuw9DoX
— Allen Frances (@AllenFrancesMD) November 10, 2021
Systematic Review: Beta‐blockers in patients without heart failure after myocardial infarction.
11 Nov, 2021 | 08:25h | UTCOriginal Study: Beta‐blockers in patients without heart failure after myocardial infarction – Cochrane Library
Systematic Review: Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility.
11 Nov, 2021 | 08:23h | UTCOriginal Study: Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility – Cochrane Library
Systematic Review: Prevention of dementia and decline in cognition by using multi-domain interventions.
11 Nov, 2021 | 08:27h | UTCOriginal Study: Multi‐domain interventions for the prevention of dementia and cognitive decline – Cochrane Library
M-A: In adults with sepsis or septic shock, metabolic resuscitation with vitamin C, glucocorticoids, vitamin B1, or combinations of these drugs was not associated with decreased long-term mortality. Adding glucocorticoid to other treatments shortened the duration of vasopressor therapy and ICU stay.
10 Nov, 2021 | 06:52h | UTCRelated:
Commentary on Twitter
Metabolic resuscitation in sepsis/septic shock with
💉vitamin C
💉glucocorticoids
💉vitamin B1
or their combinations not proven to⬇️long-term mortality.
NMA suggests association high dose/very high dose vit C & decreased mortality (low certainty).#FOAMcc https://t.co/tB2KKRjtzc pic.twitter.com/uns9rcmDbA— Intensive Care Medicine (@yourICM) November 9, 2021
Systematic Review: Exercise‐based cardiac rehabilitation for coronary heart disease.
9 Nov, 2021 | 01:21h | UTCSummary: Exercise-based rehabilitation for coronary heart disease – Cochrane Library
Original Study: Exercise‐based cardiac rehabilitation for coronary heart disease – Cochrane Library
Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain.
9 Nov, 2021 | 01:17h | UTCSee also:
Related:
Cannabis products are being sold as sleep remedies – here’s the evidence about their effectiveness.
Guideline: Medical cannabis or cannabinoids for chronic pain.
NICE Guideline: Cannabis-Based Medicinal Products
Short Review: Drug Interactions with Cannabinoids
Meta-Analysis: Cannabinoids Not Effective for Cancer-Related Pain
M-A: Comparison of outcomes between neoadjuvant chemoradiotherapy and neoadjuvant chemotherapy in patients with locally advanced esophageal cancer.
7 Nov, 2021 | 20:07h | UTC
M-A: Renal denervation for hypertension is associated with a modest reduction in ambulatory blood pressure control (3.61 mm Hg reduction in ambulatory systolic BP and 1.85 mm Hg reduction in ambulatory diastolic BP).
5 Nov, 2021 | 09:46h | UTCCommentaries:
Meta-Analysis of Renal Denervation for Hypertension – American College of Cardiology
Is Renal Denervation a Useful Strategy in BP Management? – American College of Cardiology
Related:
Systematic Review: Not enough evidence to inform the decision to either interrupt or continue anticoagulation before catheter ablation in patients with arrhythmia.
29 Oct, 2021 | 09:50h | UTC
Systematic Review: GLP-1 receptor agonists and SGLT-2 inhibitors are likely to reduce the risk of death from cardiovascular disease and death from any cause in people with both diabetes and established cardiovascular disease.
29 Oct, 2021 | 09:52h | UTC
Commentary on Twitter
The effects of DPP‐4 inhibitors, GLP‐1 receptor agonists and SGLT‐2 inhibitors for people with #CardiovascularDisease https://t.co/0FwffSCqbC New @CochraneHeart network meta-analysis looks at evidence from 31 studies. #CardiovascularResearch
— The Cochrane Library (@CochraneLibrary) October 27, 2021
Systematic Review: Prophylactic antibiotics for preventing gram‐positive infections associated with long‐term central venous catheters in adults and children receiving treatment for cancer.
28 Oct, 2021 | 09:58h | UTC
Systematic Review: Avoidance of bottles during the establishment of breastfeeds in preterm infants – “Avoiding the use of bottles when preterm infants need supplementary feeds probably increases the extent of any breastfeeding at discharge”.
28 Oct, 2021 | 09:56h | UTCAvoidance of bottles during the establishment of breastfeeds in preterm infants – Cochrane Library
Summary: Avoidance of bottles during the establishment of breastfeeds in preterm infants – Cochrane Library
Systematic Review: Antibiotics for the treatment of COVID‐19 – “We are certain that risk of death in hospitalized COVID‐19 patients is not reduced by treatment with azithromycin after 28 days”.
26 Oct, 2021 | 02:07h | UTCAntibiotics for the treatment of COVID‐19 – Cochrane Library
Commentary on Twitter
JUST PUBLISHED – Are #antibiotics an effective treatment for #COVID19 & do they cause unwanted effects? https://t.co/EVHduxmtdD New Cochrane Review looked at evidence from 11 studies: ❌ antibiotic azithromycin is not an effective treatment, 🤔not enough research on other types.
— The Cochrane Library (@CochraneLibrary) October 22, 2021
M-A: The efficacy of pharmacotherapies for the treatment of borderline personality disorder is limited.
27 Oct, 2021 | 01:11h | UTC
Systematic Review: Virtual care in patients with cancer.
27 Oct, 2021 | 01:04h | UTCVirtual Care in Patients with Cancer: A Systematic Review – Current Oncology
M-A: Strategies for antibiotic administration for bowel preparation among patients undergoing elective colorectal surgery – “the addition of oral antibiotics to intravenous antibiotics was associated with a reduction in the incidence of incisional surgical site infection by more than 50%”.
26 Oct, 2021 | 01:42h | UTCStrategies for Antibiotic Administration for Bowel Preparation Among Patients Undergoing Elective Colorectal Surgery: A Network Meta-analysis – JAMA Surgery (free for a limited period)
Commentaries:
Bowel Preparation for Colorectal Surgery: Have All Questions Been Answered? – JAMA Surgery (free for a limited period)
Oral Abx Cut Surgical Site Infections in Colorectal Surgeries — Network meta-analysis finds over 50% SSI reduction with addition of oral to IV antibiotics – MedPage Today (free registration required)
Commentary on Twitter
Network meta-analysis demonstrates that use of oral antibiotics in addition to IV antibiotics greatly reduce the incidence of incisional SSI in elective colorectal surgery https://t.co/pUoWzsmm56
— JAMA Surgery (@JAMASurgery) October 22, 2021
M-A: Data from randomized trials showed nonfatal myocardial infarction cannot be established as a good surrogate for all-cause and cardiovascular mortality.
26 Oct, 2021 | 01:36h | UTCAssessment of Nonfatal Myocardial Infarction as a Surrogate for All-Cause and Cardiovascular Mortality in Treatment or Prevention of Coronary Artery Disease: A Meta-analysis of Randomized Clinical Trials – JAMA Internal Medicine (free for a limited period)
Editorial: Nonfatal Myocardial Infarction—Poor Surrogate for Mortality – JAMA Internal Medicine (free for a limited period)
M-A: Clinical interventions for adults with comorbid alcohol use and depressive disorders.
24 Oct, 2021 | 23:39h | UTC
Degree of Myopia and Glaucoma Risk: A Dose-Response Meta-Analysis.
22 Oct, 2021 | 10:17h | UTC
Systematic Review: anti-interleukin-13 or anti-interleukin-4 agents may be appropriate for adults with moderate-to-severe uncontrolled asthma who have not responded to other treatments.
20 Oct, 2021 | 10:19h | UTC
Commentary on Twitter (thread – click for more)
Lead author David Evans said “Approximately five to ten percent of people with asthma experience symptoms that are severe or difficult-to-treat… [1/3] pic.twitter.com/Nw606oSrX0
— CochraneAirways (@CochraneAirways) October 19, 2021
Systematic Review: Colchicine for the treatment of COVID‐19 – not beneficial for hospitalized patients; inconclusive evidence for the treatment of non-hospitalized patients, “probably slightly reduces the need for hospitalization or death within 28 days compared to placebo”.
19 Oct, 2021 | 10:13h | UTCColchicine for the treatment of COVID‐19 – Cochrane Library
Related:
Commentary on Twitter
JUST PUBLISHED – Is #colchicine (often used to treat #gout) an effective treatment for people with #COVID19? ➡️ https://t.co/IF1enksFpn New @CochraneHaem systematic review includes evidence from 4 RCTS with 11,525 hospitalised & 4488 non‐hospitalised people.
— The Cochrane Library (@CochraneLibrary) October 18, 2021
Systematic Review: Calcium channel blockers versus other classes of drugs for hypertension – “there is moderate certainty evidence that diuretics reduce major cardiovascular events and congestive heart failure more than CCBs”.
19 Oct, 2021 | 08:56h | UTCSummary: Calcium channel blockers versus other classes of drugs for hypertension – Cochrane Library
Original Study: Calcium channel blockers versus other classes of drugs for hypertension – Cochrane Library
Commentary on Twitter
How do calcium channel blockers compare to other #antihypertensive drugs for #hypertension?💊
Our @CochraneLibrary systematic review looks at evidence from 23 RCTs involving 153,849 participants with #highbloodpressure
👉🏾https://t.co/dDLCY1RoOT#SystematicReviews #SysRev pic.twitter.com/zJ4JNRRf0L
— Cochrane Hypertension (@CochraneHTN) October 17, 2021
M-A: Effectiveness and safety of non-steroidal anti-inflammatory drugs and opioid treatment for knee and hip osteoarthritis – although Etoricoxib 60 mg/day and diclofenac 150 mg/day seem to be most effective treatments, topical diclofenac 70-81 mg/day is safer and should be considered as first line treatment.
17 Oct, 2021 | 21:14h | UTCNews release: Topical pain-killers more effective, safer than opioids for knee osteoarthritis pain – St. Michael’s Hospital
Commentary: Network meta-analysis compares analgesic regimens for osteoarthritis – medwire News
Commentary on Twitter
Etoricoxib 60 mg/day and diclofenac 150 mg/day seem to be the most effective oral NSAIDs for knee and hip osteoarthritis pain and physical function, but might not be appropriate in the presence of comorbidities or for long term use, concludes #BMJResearchhttps://t.co/rrtX3BnQE5
— The BMJ (@bmj_latest) October 16, 2021
Serious injury risk higher for horse riding than for football, motor racing, or skiing – “Chest most common site of injury, but head and neck injuries most lethal”.
17 Oct, 2021 | 21:08h | UTCNews release: Serious injury risk higher for horse riding than for football, motor racing, or skiing – BMJ
Commentary: Horse Riding More Dangerous Than Skiis And Motorcycles, Injury Data Reveal – Science Alert