M-A: In adults with sepsis or septic shock, metabolic resuscitation with vitamin C, glucocorticoids, vitamin B1, or combinations of these drugs was not associated with decreased long-term mortality. Adding glucocorticoid to other treatments shortened the duration of vasopressor therapy and ICU stay.

Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis – Intensive Care Medicine

Related:

Sepsis treatment: Another trial shows no benefit from the combination of Vitamin C, Thiamine, and Hydrocortisone

The VITAMINS Randomized Clinical Trial: Vitamin C, Hydrocortisone, and Thiamine Not beneficial for Patients with Sepsis

Commentary on Twitter

Metabolic resuscitation in sepsis/septic shock with
?vitamin C
?glucocorticoids
?vitamin B1
or their combinations not proven to⬇️long-term mortality.
NMA suggests association high dose/very high dose vit C & decreased mortality (low certainty).#FOAMcc https://t.co/tB2KKRjtzc pic.twitter.com/uns9rcmDbA

— Intens Care Med (@yourICM) November 9, 2021