Systematic Reviews & Meta-analysis
M-A (mostly observational studies): Comparison of gastrojejunostomy to endoscopic stenting for gastric outlet obstruction.
30 Nov, 2021 | 10:08h | UTC
Systematic Review: Anticoagulants for acute ischemic stroke.
30 Nov, 2021 | 10:01h | UTCSummary: Early treatment with blood-thinning drugs for people who have had a stroke – Cochrane Library
Original Study: Anticoagulants for acute ischaemic stroke – Cochrane Library
M-A: Association of Glucagon-like Peptide 1 Analogs and agonists administered for obesity with weight loss and adverse events.
28 Nov, 2021 | 21:09h | UTC
Systematic Review: Quantifying anticholinergic burden and sedative load in older adults with polypharmacy.
26 Nov, 2021 | 09:58h | UTC
Commentary on Twitter
Systematic review of risk scales for anticholinergic burden and sedative overload – authors developed a comprehensive table on anticholinergics & sedatives (with potency). Check Table 2 and Table S2 (supplementary) for usable info to guide decision-making!https://t.co/JYaSuOeHqv
— deprescribing.org (@deprescribing) November 25, 2021
Systematic Review: Reducing medication errors for adults in hospital settings.
26 Nov, 2021 | 09:56h | UTCReducing medication errors for adults in hospital settings – Cochrane Library
Commentary on Twitter
Reducing medication errors for adults in hospital.
New review of 65 studies involving over 100,000 participantshttps://t.co/yxGKxumZP0#MedicationErrors #PatientSafety@aciapponi pic.twitter.com/4lb9NNxtpo— Cochrane EPOC (@CochraneEPOC) November 25, 2021
M-A: Treatment for gastrointestinal and pancreatic neuroendocrine tumors.
26 Nov, 2021 | 09:53h | UTCSummary: Treatment options for neuroendocrine tumours – Cochrane Library
Systematic Review: Insufficient evidence to recommend Omega‐3 fatty acids for depression in adults.
26 Nov, 2021 | 09:54h | UTCOmega‐3 fatty acids for depression in adults – Cochrane Library
Commentary on Twitter
'At present, we do not have sufficient high‐certainty evidence to determine the effects of Omega‐3 fatty acids as a treatment for depression in adults' – updated @Cochrane_CCMD systematic review https://t.co/Bg9VNMnyGx
— The Cochrane Library (@CochraneLibrary) November 25, 2021
M-A: Comparing the clinical efficacy of COVID-19 vaccines.
26 Nov, 2021 | 08:37h | UTC
Systematic Review: Macrolides versus placebo for chronic asthma.
25 Nov, 2021 | 10:14h | UTCMacrolides versus placebo for chronic asthma – Cochrane Library
Commentary on Twitter
Graphical abstract for #Cochrane Review on #Macrolides versus placebo for chronic #asthma Full review here https://t.co/SrHacxWoNr pic.twitter.com/0YCd9Xptlz
— CochraneAirways (@CochraneAirways) November 24, 2021
M-A: Incidence, prevalence and determinants of discomfort in inflammatory bowel disease.
25 Nov, 2021 | 09:54h | UTC
Review: The value of systematic reviews and meta-analyses in surgery.
25 Nov, 2021 | 10:11h | UTCThe Value of Systematic Reviews and Meta-Analyses in Surgery – European Surgical Research
Systematic Review: Renal denervation may have a modest effect in improving 24h ambulatory blood pressure monitoring (reduction in SBP by 5.29 mmHg and DBP by 3.75 mmHg) but does not improve major cardiovascular outcomes and renal function.
24 Nov, 2021 | 08:33h | UTCOriginal Review: Renal denervation for resistant hypertension – Cochrane Library
Commentary on Twitter
https://twitter.com/CochraneHTN/status/1462979551558995971
Systematic Review: Vaccines for preventing rotavirus diarrhea.
24 Nov, 2021 | 08:20h | UTCVaccines for preventing rotavirus diarrhoea: vaccines in use – Cochrane Library
Commentary: Vaccines for preventing rotavirus diarrhoea: an updated Cochrane review – Cochrane Library
M-A: Antiemetics for adults for prevention of nausea and vomiting caused by moderately or highly emetogenic chemotherapy.
23 Nov, 2021 | 08:21h | UTC
Antibiotic Awareness: a round-up of Cochrane evidence.
23 Nov, 2021 | 08:23h | UTCAntibiotic Awareness: a round-up of Cochrane evidence – Cochrane Library
Commentary on Twitter
@CochraneUK – excellent resources and collection of antibiotic evidence review. #tldr
Azithro doesn’t work for COVID; procalcitonin reduces antibiotic use effectively; short course durations have similar outcomes to long; & so much more— Susan Hopkins (@SMHopkins) November 21, 2021
M-A: Current evidence does not support intensive blood pressure reduction as a preventive strategy for cognitive decline and dementia.
23 Nov, 2021 | 08:26h | UTC
Commentary on Twitter
Meta-analysis found no associated reduction in the risk of cognitive decline with intensive as compared to standard blood pressure (BP) interventions. There is insufficient evidence to support intensive BP management to prevent cognitive impairment. https://t.co/2BEV1ywrCO
— JAMA Network Open (@JAMANetworkOpen) November 22, 2021
M-A: In patients with Non-ST Elevation Acute Coronary Syndromes, pretreatment with oral P2Y12 inhibitors prior to angiography was associated with increased risk of bleeding and no difference in cardiovascular outcomes.
21 Nov, 2021 | 22:58h | UTCInvited Commentary: Pretreatment in the Setting of Non–ST-Elevated Acute Coronary Syndrome—When It Is Time to Change – JAMA Network Open
Systematic Review | Integrated and comprehensive pain management programs: effectiveness and harms.
21 Nov, 2021 | 22:43h | UTCSee also:
Systematic Review | Prehabilitation and rehabilitation for major joint replacement.
21 Nov, 2021 | 22:41h | UTCSee also:
M-A: In patients with anterior circulation acute stroke and evidence of reversible cerebral ischemia across the 6–24 h time window, thrombectomy was associated with higher rates of independence in activities of daily living at 90 days than best medical therapy alone.
18 Nov, 2021 | 08:43h | UTCThrombectomy for anterior circulation stroke beyond 6 h from time last known well (AURORA): a systematic review and individual patient data meta-analysis – The Lancet (link to abstract – $ for full-text)
Real-world ethics in palliative care: A systematic review of the ethical challenges reported by specialist palliative care practitioners in their clinical practice.
17 Nov, 2021 | 08:18h | UTC
Commentary on Twitter
The range of ethical challenges faced by specialist palliative care practitioners exceeds the breadth of those detailed in palliative care textbooks and ethics resources. #hpm #hapc https://t.co/pvwkYrJmIo pic.twitter.com/qb5803oQg1
— Palliative Medicine (@PalliativeMedJ) March 3, 2021
#AHA21 – M-A: Among patients with left main coronary disease, there was no statistically significant difference in 5-year all-cause death between percutaneous coronary intervention with drug-eluting stents vs. coronary artery bypass grafting.
16 Nov, 2021 | 08:31h | UTCPercutaneous coronary intervention with drug-eluting stents versus coronary artery bypass grafting in left main coronary artery disease: an individual patient data meta-analysis – The Lancet (free registration required)
Commentary: No Mortality Difference Between PCI and CABG for Left Main PCI: Meta-analysis – TCTMD
Systematic Review: Immunosuppressive treatment for primary membranous nephropathy in adults with nephrotic syndrome.
16 Nov, 2021 | 08:25h | UTCSummary: Immunosuppressive treatment for adults with idiopathic membranous nephropathy – Cochrane Library
Original Study: Immunosuppressive treatment for primary membranous nephropathy in adults with nephrotic syndrome – Cochrane Library
M-A: Prediction of extubation outcome in critically ill patients.
16 Nov, 2021 | 08:27h | UTC
M-A: Low vitamin D levels do not aggravate COVID-19 risk or death, and vitamin D supplementation does not improve outcomes in hospitalized patients with COVID-19.
11 Nov, 2021 | 08:53h | UTC