Systematic Reviews & Meta-analysis
Systematic Review: In patients with intermittent claudication, Propionyl‐L‐carnitine may improve walking distance when compared to placebo (moderate overall certainty of evidence).
14 Jan, 2022 | 08:02h | UTCPropionyl‐L‐carnitine for intermittent claudication – Cochrane Library
Summary: Propionyl-L-carnitine for intermittent claudication – Cochrane Library
M-A: Combined oral contraceptives may improve overall premenstrual symptomatology but are not helpful for premenstrual depressive symptoms.
14 Jan, 2022 | 07:49h | UTCCommentary: ‘Optimal’ treatment for premenstrual depressive symptoms remains elusive – Healio (free registration required)
Systematic Review: Chemotherapy for the treatment of oral cavity and oropharyngeal cancer.
13 Jan, 2022 | 08:14h | UTCSummary: Chemotherapy for mouth and throat cancer – Cochrane Library
Systematic Review: In patients who are about to undergo noncardiac surgery, biomarkers (BNP/NT‐proBNP, troponin or their combination) may provide added prognostic value to the Revised Cardiac Risk Index for preoperative prediction of major adverse cardiac events and all‐cause mortality. The results cannot be interpreted as conclusive due to the high risks of bias in most papers.
13 Jan, 2022 | 08:15h | UTC
Systematic Review: Antecolic vs. retrocolic reconstruction after partial pancreaticoduodenectomy.
12 Jan, 2022 | 08:38h | UTCAntecolic versus retrocolic reconstruction after partial pancreaticoduodenectomy – Cochrane Library
Systematic Review: First-generation cephalosporins for the treatment of complicated upper urinary tract infection in adults.
11 Jan, 2022 | 02:23h | UTC
Commentary on Twitter
Interesting! Why not?
🆕💥Systematic literature review First-generation cephalosporins mainly Cefazolin and one study Cefadroxil for the treatment of complicated upper urinary tract infection in adults
Comparators mainly 3d G
Old studies
No meta-analysis https://t.co/EHamKpfKZQ— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) January 10, 2022
Systematic Review: The effectiveness and safety of treatments for recurrent vulvovaginal candidiasis.
11 Jan, 2022 | 02:24h | UTCTreatment for recurrent vulvovaginal candidiasis (thrush) – Cochrane Library
M-A: Fecal immunochemical test to triage patients with possible colorectal cancer symptoms.
11 Jan, 2022 | 02:18h | UTC
Commentary on Twitter
🆕#CuttingEdgeBlog Plain English summary📰
"Worried about symptoms of bowel cancer? A simple stool test may help."@ian_bissett @SawKS88 @ChenLiu_NZ @williamxu_98 @chrisvarghese98
Blog🔗: https://t.co/Pb7zfsfWT3
Based on the paper 🔗: https://t.co/20proTApNd pic.twitter.com/IAUsHIqUrn
— BJS (@BJSurgery) January 10, 2022
M-A: Fatigue and cognitive impairment in Post-COVID-19 Syndrome.
11 Jan, 2022 | 01:28h | UTC
M-A of two randomized trials: Among men with high-risk non-metastatic prostate cancer, adding abiraterone and prednisolone to standard androgen-deprivation therapy was associated with improved 6-year metastasis-free survival (82% vs. 69% in the control group).
8 Jan, 2022 | 22:42h | UTCAbiraterone acetate and prednisolone with or without enzalutamide for high-risk non-metastatic prostate cancer: a meta-analysis of primary results from two randomised controlled phase 3 trials of the STAMPEDE platform protocol – The Lancet (link to abstract – $ for full-text)
Related Audio: Key messages of the recent report from the STAMPEDE trial platform
Systematic Review: Active surveillance for clinically localized prostate cancer to develop recommendations regarding inclusion of intermediate-risk disease, biopsy characteristics at inclusion and monitoring, and surveillance repeat biopsy strategy.
8 Jan, 2022 | 22:41h | UTC
Commentary on Twitter
Systematic Review of AS for Clinically Localised PCa to Develop Recommendations Regarding Inclusion of Intermediate-risk Disease, Biopsy Characteristics at Inclusion and Monitoring, and Surveillance Repeat Biopsy Strategyhttps://t.co/U9mA5KqStX@Dr_Willemse @thomas_b_lam pic.twitter.com/j6dgTaqaZs
— European Urology (@EUplatinum) January 3, 2022
Opinion: Decision makers need constantly updated evidence synthesis.
16 Dec, 2021 | 08:39h | UTCDecision makers need constantly updated evidence synthesis – Nature
Management of patellar tendinopathy: a systematic review and network meta-analysis of randomized studies.
16 Dec, 2021 | 08:35h | UTC
M-A: Intravenous diltiazem vs. metoprolol for atrial fibrillation with rapid ventricular rate.
10 Dec, 2021 | 10:05h | UTCIntravenous diltiazem versus metoprolol for atrial fibrillation with rapid ventricular rate: A meta-analysis – The American Journal of Emergency Medicine (link to abstract – $ for full-text)
Systematic Review: Antibiotics for adults and children with sore throats.
10 Dec, 2021 | 10:02h | UTCSummary: Antibiotics for adults and children with sore throats – Cochrane Library
Original Research: Antibiotics for treatment of sore throat in children and adults – Cochrane Library
Bronchiolitis: evidence and guidance for practice.
8 Dec, 2021 | 09:55h | UTCBronchiolitis: evidence and guidance for practice – Evidently Cochrane
M-A: Efficacy and safety associated with immune checkpoint inhibitors in unresectable hepatocellular carcinoma.
8 Dec, 2021 | 09:48h | UTC
Commentary on Twitter
This meta-analysis of RCTs shows immune checkpoint inhibitors are associated with demonstrated the superior efficacy and safety of versus standard systemic therapies in patients with unresectable hepatocellular carcinoma. https://t.co/fJdFng69qH
— JAMA Network Open (@JAMANetworkOpen) December 6, 2021
M-A: Major adverse events related to endoscopic or laparoscopic procedures in achalasia.
7 Dec, 2021 | 08:33h | UTC
Systematic Review: What are the benefits and risks of electrical spinal cord and dorsal root ganglion stimulation for the treatment of chronic pain in adults?
7 Dec, 2021 | 08:31h | UTCOriginal study: Implanted spinal neuromodulation interventions for chronic pain in adults – Cochrane Library
Systematic Review: Phototherapy for atopic eczema.
3 Dec, 2021 | 10:03h | UTCPhototherapy for atopic eczema – Cochrane Library
Commentary on Twitter
https://twitter.com/CochraneUK/status/1457046637134630920
M-A: Efficacy of non-invasive and invasive respiratory management strategies in adult patients with acute hypoxemic respiratory failure.
1 Dec, 2021 | 08:44h | UTC
Systematic Review: Late (after 6 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants.
1 Dec, 2021 | 08:32h | UTC
Systematic Review: Early (started within six days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants.
1 Dec, 2021 | 08:33h | UTCOriginal Study: Early (< 7 days) systemic postnatal corticosteroids for prevention of bronchopulmonary dysplasia in preterm infants – Cochrane Library
Commentary on Twitter
Early (started within six days) systemic #postnatal #corticosteroids for preventing bronchopulmonary dysplasia in #preterm #infants https://t.co/Ui6xZPoTj1 Updated @CochraneNeonate systematic review looks at evidence from 32 studies with 4395 infants.
— The Cochrane Library (@CochraneLibrary) October 29, 2021
M-A: Minimally invasive treatments for lower urinary tract symptoms in men with benign prostatic hyperplasia.
30 Nov, 2021 | 10:06h | UTC
Systematic Review: Are there ways to improve stop-smoking treatment in primary care to help more people quit smoking?
30 Nov, 2021 | 10:03h | UTCOriginal Study: Strategies to improve smoking cessation rates in primary care – Cochrane Library