Randomized Trials
[News release – not published yet] RCT: Minimally invasive approach to hysterectomy in cervical cancer is associated with poorer disease-free survival than open surgery.
24 Mar, 2022 | 08:47h | UTC
RCT: Effect of a physical activity and behavior maintenance program on functional mobility decline in older adults.
22 Mar, 2022 | 09:47h | UTCInvited Commentary: Considerations for maintaining functional mobility in older populations – The Lancet Public Health
RCT: Levothyroxine is not beneficial for euthyroid thyroid peroxidase antibody positive women with recurrent pregnancy loss.
22 Mar, 2022 | 08:24h | UTCLevothyroxine in euthyroid thyroid peroxidase antibody positive women with recurrent pregnancy loss (T4LIFE trial): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Commentary: Levothyroxine No Boon for Birth Rates in Women With Possible Thyroid Disorder – MedPage Today (free registration required)
Phase 2 RCT: Repeated intravenous cardiosphere-derived cell therapy in late-stage Duchenne muscular dystrophy.
22 Mar, 2022 | 07:59h | UTC
Commentary on Twitter
In patients with late-stage Duchenne muscular dystrophy, CAP-1002 cell therapy appears safe & effective in reducing deterioration of upper limb & cardiac function, trial suggests. Longer-term extension studies needed.
Explore full findings: https://t.co/bCLtsbuJH3 pic.twitter.com/h7vareAMC7
— The Lancet (@TheLancet) March 21, 2022
RCT: Efficacy and acceptability of dietary therapies in non-constipated irritable bowel syndrome: a randomized trial of traditional dietary advice, the low FODMAP diet and the gluten-free diet.
21 Mar, 2022 | 08:53h | UTCCommentary: Traditional Dietary Advice Optimal as an Irritable Bowel Syndrome Therapy – HCPLivre
Related:
10 mistakes in dietary management of irritable bowel syndrome and how to avoid them.
Supplement: Irritable bowel syndrome and related conditions.
RCT: FODMAPs, but not gluten, elicit modest symptoms of irritable bowel syndrome.
British Society of Gastroenterology guidelines on the management of irritable bowel syndrome
Guidelines for the treatment of irritable bowel syndrome
ACG Clinical Guideline: Management of irritable bowel syndrome
M-A: Efficacy of a low-FODMAP diet in adult irritable bowel syndrome
RCT: Imaging modality (CT vs. MRI) and frequency (seven scans over 60 months vs. three scans over 36 months) in surveillance of Stage I Seminoma Testicular Cancer.
21 Mar, 2022 | 08:39h | UTCImaging Modality and Frequency in Surveillance of Stage I Seminoma Testicular Cancer: Results From a Randomized, Phase III, Noninferiority Trial (TRISST) – Journal of Clinical Oncology (link to abstract – $ for full-text)
RCT: Early symptomatic improvement after ustekinumab therapy in patients with ulcerative colitis.
21 Mar, 2022 | 08:26h | UTCEarly symptomatic improvement after ustekinumab therapy in patients with ulcerative colitis: 16-week data from the UNIFI trial – Clinical Gastroenterology and Hepatology (link to abstract – $ for full-text)
RCT: Nebulized Poractant Alfa in premature babies with respiratory distress syndrome.
21 Mar, 2022 | 08:25h | UTCCommentary: Should we give up on nebulised surfactant? – Neonatal Research
Commentary on Twitter
The CURONEB RCT by Dani et al. in @JPediatr stopped early, but showed that nebulised poractant alfa is safe but does not reduce respiratory failure within 72 hours in 28-33 weekers https://t.co/gW57rPTd4f #FOAMneo #EBNEOalerts #neoEBM #neotwitter pic.twitter.com/G5Cii33fRD
— Evidence-Based Neo (@EBNEO) March 8, 2022
RCT: Cocoa flavanol supplementation shows promise for the prevention of cardiovascular disease events.
18 Mar, 2022 | 08:54h | UTC
Commentary on Twitter (thread – click for more)
In @AJCNutrition: @HowardSesso, Dr. JoAnn Manson of @BWHDPM @BrighamWomens & colleagues report the main findings of the first ever randomized trial of a cocoa flavanol supplement on cardiovascular disease endpointshttps://t.co/0F5v8WqzdM and https://t.co/vA3wwT0Amw (1 of 5) pic.twitter.com/X08hiNUCzK
— BrighamResearch (@BrighamResearch) March 16, 2022
Phase 2 RCT: Prophylactic use of garadacimab in patients with hereditary angioedema.
18 Mar, 2022 | 08:09h | UTCProphylactic use of an anti-activated factor XII monoclonal antibody, garadacimab, for patients with C1-esterase inhibitor-deficient hereditary angioedema: a randomised, double-blind, placebo-controlled, phase 2 trial – The Lancet (link to abstract – $ for full-text)
Commentary: Garadacimab significantly reduces frequency of hereditary angioedema exacerbations – Physician’s Weekly
RCT: Oral contezolid vs. linezolid in adults with complicated skin and soft tissue infections.
18 Mar, 2022 | 07:54h | UTCA Phase III multicentre, randomized, double-blind trial to evaluate the efficacy and safety of oral contezolid versus linezolid in adults with complicated skin and soft tissue infections – Journal of Antimicrobial Therapy (link to abstract – $ for full-text)
Commentary on Twitter
Phase III efficacy & safety of oral contezolid Vs linezolid in adults with c.SSTIs
?Non inferior
?Interestingly:Contezolid demonstrated significant lower incidence thrombocytopenia (0% Wow vs 2.3%) & leucopenia (0.3% vs 3.4%) than linezolid
?QIDP https://t.co/wSvxUInnkZ— Antibiotic Steward Bassam Ghanem (@ABsteward) March 11, 2022
RCT: Short-term radiotherapy plus chemotherapy vs. long-term chemoradiotherapy in locally advanced rectal cancer.
18 Mar, 2022 | 07:39h | UTC
RCT: In women undergoing cytoreductive surgery for ovarian cancer, the addition of hyperthermic intraperitoneal chemotherapy did not improve progression-free and overall survival.
16 Mar, 2022 | 09:41h | UTCRelated:
M-A: Secondary cytoreductive surgery in platinum-sensitive recurrent ovarian cancer.
RCT: Cytoreductive surgery for relapsed ovarian cancer.
Open Label RCT: Azithromycin for poorly controlled asthma in children.
15 Mar, 2022 | 08:39h | UTCAzithromycin for Poorly Controlled Asthma in Children: A randomized controlled trial – CHEST (link to abstract – $ for full-text)
Commentary: Adding azithromycin to standard care improves asthma control, exacerbations in children – Healio
RCT: Vortioxetine 5, 10, and 20 mg significantly reduces the risk of relapse compared with placebo in patients with remitted major depressive disorder.
14 Mar, 2022 | 01:03h | UTC
Commentary on Twitter
RCT: In patients with remitted MDD with 10 mg/day of vortioxetine, time to relapse was longer and cumulative relapse rates were lower for vortioxetine 5 mg (19.3%), 10 mg (17.9%), and 20 mg (17.4%) versus placebo (32.5%) over 28 weeks (p<0.05 for all) https://t.co/LzwFaxVt4d pic.twitter.com/Gq3lLTtVcS
— PfOL (@psychopharmacol) March 11, 2022
RCT: Methenamine Hippurate (a non-antibiotic preventive treatment) is noninferior to prophylactic antibiotics for treating recurrent urinary tract infections in women.
11 Mar, 2022 | 10:21h | UTCNews Release: Antiseptic drug as good as antibiotics for preventing recurrent urinary tract infections – BMJ Newsroom
Editorial: Methenamine hippurate for recurrent urinary tract infections – The BMJ
Commentaries:
Trial supports antibiotic alternative for recurrent urinary infections – CIDRAP
Nonantibiotic Prophylaxis Noninferior for Recurrent UTI – HealthDay
Commentary on Twitter
The antiseptic drug methenamine hippurate is as good as antibiotics for preventing recurrent urinary tract infections in women, finds this trial
Includes a visual abstract displaying the findings #BMJInfographic https://t.co/LJNx2OEKhO @chrisharding123 pic.twitter.com/CjxWtjao6r
— The BMJ (@bmj_latest) March 10, 2022
RCT: Overall survival with Ribociclib plus Letrozole in advanced breast cancer.
11 Mar, 2022 | 09:47h | UTCOverall Survival with Ribociclib plus Letrozole in Advanced Breast Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
Adding Ribociclib to Letrozole Prolongs Survival in Advanced Breast Cancer – HealthDay
RCT: In pediatric ICUs, a bundled intervention that emphasized a physiologically focused cardiopulmonary resuscitation training did not improve outcomes in cardiac arrest.
11 Mar, 2022 | 09:37h | UTCEffect of Physiologic Point-of-Care Cardiopulmonary Resuscitation Training on Survival With Favorable Neurologic Outcome in Cardiac Arrest in Pediatric ICUs: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentary: CPR Intervention Failed to Improve Survival in Kids With Cardiac Arrest — Physiologically focused CPR training did not lead to difference in survival to discharge – MedPage Today (free registration required)
Commentary on Twitter
Among patients in pediatric ICUs, a bundled intervention that emphasized physiologically focused CPR training and structured clinical event debriefing did not significantly improve patient survival to hospital discharge with favorable neurologic outcome. https://t.co/MbmmSM0Xrt
— JAMA (@JAMA_current) March 8, 2022
RCT: In patients with refractory out-of-hospital cardiac arrest, a strategy of intra-arrest transport, extracorporeal cardiopulmonary resuscitation, and immediate invasive assessment did not significantly improve survival with a favorable neurological outcome (OR 1.63; 95% CI 0.93 to 2.85; P = .09).
10 Mar, 2022 | 10:57h | UTCEffect of Intra-arrest Transport, Extracorporeal Cardiopulmonary Resuscitation, and Immediate Invasive Assessment and Treatment on Functional Neurologic Outcome in Refractory Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentary: Early Invasive Therapy for Out-of-Hospital Cardiac Arrest – American College of Cardiology
Commentary on Twitter
In this randomized clinical trial, early intra-arrest transport, extracorporeal CPR, and invasive assessment and treatment did not significantly improve survival with neurologically favorable outcome at 180 days compared with standard resuscitation. https://t.co/qSqWSFFpOF pic.twitter.com/SLu0bGHhq8
— JAMA (@JAMA_current) February 22, 2022
RCT: Comparing methotrexate monotherapy with methotrexate plus leflunomide combination therapy in psoriatic arthritis.
10 Mar, 2022 | 10:27h | UTCComparing methotrexate monotherapy with methotrexate plus leflunomide combination therapy in psoriatic arthritis (COMPLETE-PsA): a double-blind, placebo-controlled, randomised, trial – The Lancet Rheumatology (link to abstract – $ for full-text)
Commentary: COMPLETE-PsA: Adding leflunomide to methotrexate may improve outcomes – medwireNews
Commentary on Twitter
NEW RESEARCH—A double-blind, placebo-controlled, randomised, trial comparing #methotrexate monotherapy with methotrexate plus #leflunomide combination therapy in psoriatic arthritis (COMPLETE-PsA) https://t.co/Fln7RlNl36 #LancetRheumatology pic.twitter.com/EqWSeHZQA2
— The Lancet Rheumatology (@TheLancetRheum) March 3, 2022
RCT: Reliever-triggered inhaled glucocorticoid reduces severe exacerbations in black and latinx adults with moderate-to-severe asthma.
9 Mar, 2022 | 10:06h | UTCReliever-Triggered Inhaled Glucocorticoid in Black and Latinx Adults with Asthma – New England Journal of Medicine (link to abstract – $ for full-text)
RCT: Combination treatment with Varenicline and Nicotine patch may increase smoking cessation rates among smokers who drink heavily.
9 Mar, 2022 | 08:44h | UTC
Commentary on Twitter
In this RCT, the combination of varenicline + nicotine patch was superior to placebo + nicotine patch in increasing smoking quit rates in smokers who drink heavily. https://t.co/UbekBdEjyA
— JAMA Network Open (@JAMANetworkOpen) March 4, 2022
RCT: Elective upper-neck vs. whole-neck irradiation of the uninvolved neck in patients with nasopharyngeal carcinoma.
9 Mar, 2022 | 08:17h | UTCElective upper-neck versus whole-neck irradiation of the uninvolved neck in patients with nasopharyngeal carcinoma: an open-label, non-inferiority, multicentre, randomised phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)
Commentaries:
Elective Upper-Neck vs Whole-Neck Irradiation in Nasopharyngeal Carcinoma – The ASCO Post
Lower Neck-Sparing RT Succeeds in Nasopharyngeal Carcinoma— Phase III trial also shows that upper-neck irradiation leads to fewer late toxicities – MedPage Today (link to abstract – $ for full-text)
RCT: Little long-term benefit from a small change approach to prevent weight gain in adults with overweight and obesity.
8 Mar, 2022 | 08:37h | UTC
RCT: Efficacy and safety of switching to the 2-drug regimen Dolutegravir/Lamivudine vs. continuing a 3- or 4-Drug regimen for maintaining virologic suppression in adults living with HIV-1.
7 Mar, 2022 | 00:32h | UTC