Randomized Trials
RCT: Erythropoietin not beneficial for patients with acute kidney injury.
6 Apr, 2022 | 10:02h | UTCErythropoietin in Acute Kidney Injury (EAKI): a pragmatic randomized clinical trial – BMC Nephrology
RCT: Higher vs. Standard Adalimumab induction and maintenance dosing regimens for treatment of ulcerative colitis.
6 Apr, 2022 | 09:56h | UTC
RCT: Efficacy and safety of Daprodustat (oral drug) for treating anemia of chronic kidney disease in incident dialysis patients.
5 Apr, 2022 | 08:34h | UTCRelated:
Commentary on Twitter
In this RCT, daprodustat was noninferior to darbepoetin alfa in treating anemia of chronic kidney disease. Daprodustat represents an oral alternative treatment to a conventional erythropoiesis-stimulating agent in the incident dialysis population. https://t.co/uoYOcpSam6
— JAMA Internal Medicine (@JAMAInternalMed) April 4, 2022
RCT: Routine lung volume recruitment is not beneficial for boys with Duchenne muscular dystrophy.
5 Apr, 2022 | 08:04h | UTC
#ACC22 – RCT: Diltiazem did not significantly improve coronary vasomotor dysfunction in angina and nonobstructive coronary arteries.
4 Apr, 2022 | 01:09h | UTCEfficacy of Diltiazem to improve coronary vasomotor dysfunction in angina and nonobstructive coronary arteries (ANOCA): Results of the EDIT-CMD randomized clinical trial – JACC: Cardiovascular Imaging (link to abstract – $ for full-text)
Commentaries:
In ANOCA, Diltiazem Fails to Improve Vasomotor Function: EDIT-CMD – TCTMD
Commentary on Twitter
#ACC22 #JACCIMG SimPub: In this first performed RCT in pts w/ ANOCA, authors show that 6 weeks therapy w/ #diltiazem didn't substantially improve CVDys, symptoms or #QoL when compared w/ placebo, but did ⬇️ prevalence of epicardial spasm. https://t.co/An8v4JHkl4 #CardioTwitter pic.twitter.com/D0fRG0PewG
— JACC Journals (@JACCJournals) April 2, 2022
RCT: Pembrolizumab vs. placebo as adjuvant therapy in completely resected stage IIB or IIC melanoma.
4 Apr, 2022 | 00:56h | UTCPembrolizumab versus placebo as adjuvant therapy in completely resected stage IIB or IIC melanoma (KEYNOTE-716): a randomised, double-blind, phase 3 trial – The Lancet (link to abstract – $ for full-text)
RCT: Shockwave lithotripsy compared with ureteroscopic stone treatment for adults with ureteric stones.
1 Apr, 2022 | 10:02h | UTCDownload: Full Report
RCT: Amisulpride and olanzapine combination treatment versus each monotherapy in acutely ill patients with schizophrenia.
1 Apr, 2022 | 09:47h | UTCAmisulpride and olanzapine combination treatment versus each monotherapy in acutely ill patients with schizophrenia in Germany (COMBINE): a double-blind randomised controlled trial – The Lancet Psychiatry (link to abstract – $ for full-text)
Commentary on Twitter
RCT: At 8 weeks, PANSS total score improved more with amisulpride + olanzapine (−29·6) than with olanzapine + placebo (−24·1, p=0·049, d=0·396), but not vs. amisulpride + placebo (−25·2, p=0·095, d=0·29) in acutely ill patients with schizophrenia https://t.co/Se75PJ3a0N
— PfOL (@psychopharmacol) March 18, 2022
RCT: Effect of tacrolimus vs. intravenous cyclophosphamide on complete or partial response in patients with lupus nephritis.
31 Mar, 2022 | 08:18h | UTC
Commentary on Twitter
In this RCT, oral tacrolimus was noninferior to intravenous cyclophosphamide for initial therapy of active lupus nephritis, with a more favorable safety profile. https://t.co/scz7lahVRU
— JAMA Network Open (@JAMANetworkOpen) March 30, 2022
Cluster RCT: A household salt substitution intervention is a cost-effective intervention for preventing stroke and improving quality of life.
29 Mar, 2022 | 10:16h | UTCCommentary: ACC: Use of Salt Substitute to Prevent Stroke Is Cost-Saving – HealthDay
Related:
Former CDC director: Low sodium salt could save millions of lives – CNN
Is salt good for you after all? The evidence says no.
Systematic Review: Altered dietary salt intake for people with chronic kidney disease.
New WHO benchmarks help countries reduce salt intake and save lives.
RCT: Reduced-sodium added-potassium salt substitute reduces blood pressure in hypertensive patients
Potassium Enriched Salt Substitution Could Prevent a Large Number of Cardiovascular Deaths
Meta-Analysis: Effect of Reduction in Dietary Sodium on Blood Pressure Levels
RCT: Comparison of 3 different minimally invasive surgical techniques for lumbar spinal stenosis.
29 Mar, 2022 | 08:42h | UTC
Commentary on Twitter
A pragmatic randomized clinical trial of patients treated surgically for lumbar spinal stenosis found no difference in the clinical results from three minimally invasive decompression techniques at 2 years follow up. https://t.co/6b5J5RzKpF
— JAMA Network Open (@JAMANetworkOpen) March 28, 2022
Crossover RCT: Effects of experimental sleep restriction on energy intake, energy expenditure, and visceral obesity.
29 Mar, 2022 | 08:31h | UTCEffects of Experimental Sleep Restriction on Energy Intake, Energy Expenditure, and Visceral Obesity – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentary: Lack of sleep increases unhealthy abdominal fat, study finds – Mayo Clinic
Related: RCT: Advising overweight patients to increase sleep duration may reduce caloric intake.
RCT: Effect of induction chemotherapy with Paclitaxel, Cisplatin, and Capecitabine vs. Cisplatin and Fluorouracil on failure-free survival for patients with stage IVA to IVB Nasopharyngeal Carcinoma.
28 Mar, 2022 | 08:36h | UTCEffect of Induction Chemotherapy With Paclitaxel, Cisplatin, and Capecitabine vs Cisplatin and Fluorouracil on Failure-Free Survival for Patients With Stage IVA to IVB Nasopharyngeal Carcinoma: A Multicenter Phase 3 Randomized Clinical Trial – JAMA Oncology (link to abstract – $ for full-text)
Commentary: Triplet Induction Regimen Bests Doublet for Nasopharyngeal Carcinoma — Three drugs reduced risk of disease failure, but longer follow-up needed to assess OS – MedPage Today (free registration required)
Commentary on Twitter
Phase 3 randomized trial of paitents with stage IVA to IVB nasopharyngeal carcinoma shows that induction chemotherapy w 2 cycles of paclitaxel/cisplatin/capecitabine improved failure-free survival vs. cisplatin/5-FU before concurrent chemoradiation. https://t.co/YYEvFsTxgd pic.twitter.com/7qbSXLWCE1
— JAMA Oncology (@JAMAOnc) March 24, 2022
RCT: Nitroglycerin does not prevent radial occlusion after transradial access in the cath lab.
28 Mar, 2022 | 08:26h | UTCRandomized Clinical Trial on Prevention of Radial Occlusion After Transradial Access Using Nitroglycerin: PATENS Trial – JACC: Cardiovascular Interventions (link to abstract – $ for full-text)
Commentary: Nitroglycerin Given Early or Late Fails to Prevent Radial Artery Occlusion: PATENS – TCTMD
RCT: Among premature infants with a gestational age of less than 30 weeks and intubated for at least 7 days at 14 to 28 days, hydrocortisone did not improve survival without bronchopulmonary dysplasia.
24 Mar, 2022 | 09:58h | UTCHydrocortisone to Improve Survival without Bronchopulmonary Dysplasia – New England Journal of Medicine (link to abstract – $ for full-text)
See also: Visual Abstract
Related:
State of the Art Review: Diagnosis and management of bronchopulmonary dysplasia.
ERS Guideline on Long-term Management of Children with Bronchopulmonary Dysplasia
Commentary on Twitter
In this trial involving preterm infants, there was little difference in survival without bronchopulmonary dysplasia or in the occurrence of neurodevelopmental impairment with hydrocortisone as compared with placebo. https://t.co/wzGQ1gohjA pic.twitter.com/yfrIaG3JLv
— NEJM (@NEJM) March 23, 2022
RCT: Safety and efficacy of a third dose of the Pfizer Covid-19 vaccine during the Delta wave.
24 Mar, 2022 | 09:46h | UTCSafety and Efficacy of a Third Dose of BNT162b2 Covid-19 Vaccine – New England Journal of Medicine
Commentary on Twitter
A third dose of the BNT162b2 vaccine administered a median of 10.8 months after the second dose provided 95.3% efficacy against Covid-19 as compared with two doses. #COVID19 #IDTwitter https://t.co/IeHOgVhU8a pic.twitter.com/wValXSdyHX
— NEJM (@NEJM) March 23, 2022
RCT: Awake prone positioning did not improve outcomes in patients with moderate hypoxemia due to covid-19.
24 Mar, 2022 | 09:48h | UTCEditorial: Awake prone positioning for patients with covid-19
News Release: Lying prone long enough to improve outcomes is difficult for many covid-19 patients – BMJ
[News release – not published yet] RCT: Minimally invasive approach to hysterectomy in cervical cancer is associated with poorer disease-free survival than open surgery.
24 Mar, 2022 | 08:47h | UTC
RCT: Effect of a physical activity and behavior maintenance program on functional mobility decline in older adults.
22 Mar, 2022 | 09:47h | UTCInvited Commentary: Considerations for maintaining functional mobility in older populations – The Lancet Public Health
RCT: Levothyroxine is not beneficial for euthyroid thyroid peroxidase antibody positive women with recurrent pregnancy loss.
22 Mar, 2022 | 08:24h | UTCLevothyroxine in euthyroid thyroid peroxidase antibody positive women with recurrent pregnancy loss (T4LIFE trial): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Commentary: Levothyroxine No Boon for Birth Rates in Women With Possible Thyroid Disorder – MedPage Today (free registration required)
Phase 2 RCT: Repeated intravenous cardiosphere-derived cell therapy in late-stage Duchenne muscular dystrophy.
22 Mar, 2022 | 07:59h | UTC
Commentary on Twitter
In patients with late-stage Duchenne muscular dystrophy, CAP-1002 cell therapy appears safe & effective in reducing deterioration of upper limb & cardiac function, trial suggests. Longer-term extension studies needed.
Explore full findings: https://t.co/bCLtsbuJH3 pic.twitter.com/h7vareAMC7
— The Lancet (@TheLancet) March 21, 2022
RCT: Efficacy and acceptability of dietary therapies in non-constipated irritable bowel syndrome: a randomized trial of traditional dietary advice, the low FODMAP diet and the gluten-free diet.
21 Mar, 2022 | 08:53h | UTCCommentary: Traditional Dietary Advice Optimal as an Irritable Bowel Syndrome Therapy – HCPLivre
Related:
10 mistakes in dietary management of irritable bowel syndrome and how to avoid them.
Supplement: Irritable bowel syndrome and related conditions.
RCT: FODMAPs, but not gluten, elicit modest symptoms of irritable bowel syndrome.
British Society of Gastroenterology guidelines on the management of irritable bowel syndrome
Guidelines for the treatment of irritable bowel syndrome
ACG Clinical Guideline: Management of irritable bowel syndrome
M-A: Efficacy of a low-FODMAP diet in adult irritable bowel syndrome
RCT: Imaging modality (CT vs. MRI) and frequency (seven scans over 60 months vs. three scans over 36 months) in surveillance of Stage I Seminoma Testicular Cancer.
21 Mar, 2022 | 08:39h | UTCImaging Modality and Frequency in Surveillance of Stage I Seminoma Testicular Cancer: Results From a Randomized, Phase III, Noninferiority Trial (TRISST) – Journal of Clinical Oncology (link to abstract – $ for full-text)
RCT: Early symptomatic improvement after ustekinumab therapy in patients with ulcerative colitis.
21 Mar, 2022 | 08:26h | UTCEarly symptomatic improvement after ustekinumab therapy in patients with ulcerative colitis: 16-week data from the UNIFI trial – Clinical Gastroenterology and Hepatology (link to abstract – $ for full-text)
RCT: Nebulized Poractant Alfa in premature babies with respiratory distress syndrome.
21 Mar, 2022 | 08:25h | UTCCommentary: Should we give up on nebulised surfactant? – Neonatal Research
Commentary on Twitter
The CURONEB RCT by Dani et al. in @JPediatr stopped early, but showed that nebulised poractant alfa is safe but does not reduce respiratory failure within 72 hours in 28-33 weekers https://t.co/gW57rPTd4f #FOAMneo #EBNEOalerts #neoEBM #neotwitter pic.twitter.com/G5Cii33fRD
— Evidence-Based Neo (@EBNEO) March 8, 2022