RCT | In patients undergoing cardiac surgery with cardiopulmonary bypass, using a 4% albumin solution for volume expansion did not reduce adverse events compared to ringer acetate.

Effect of 4% Albumin Solution vs Ringer Acetate on Major Adverse Events in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Albumin vs Crystalloid Fluid for Resuscitation in Cardiac Surgery: New Evidence and Arguments in the Timeless Debate – JAMA (free for a limited period)

Commentary: Trial does not support albumin as primer, volume replacement solution in CABG – Healio (free registration required)

Commentary on Twitter

#OriginalInvestigation: Clinical trial findings do not support the use of 4% albumin solution in cardiac surgery with cardiopulmonary bypass. @EeroJPesonen https://t.co/uyWQRdxfuJ pic.twitter.com/RJ5M9NBb9x

— JAMA (@JAMA_current) July 19, 2022