Randomized Trials
RCT | Follow-up schedule for patients with sentinel node negative cutaneous melanoma.
25 Jul, 2022 | 12:43h | UTCFollow-up Schedule for Patients with Sentinel Node Negative Cutaneous Melanoma: an International Phase III Randomised Clinical Trial – Annals of Surgery (link to abstract – $ for full-text)
RCT | Flexible buprenorphine/naloxone model of care for reducing opioid use in individuals with prescription-type opioid use disorder.
22 Jul, 2022 | 11:38h | UTCNews Release: Opioid use disorder: Flexible treatment at home proves effective – University of Montreal Hospital Research Centre
RCT | Effect of intramuscular midazolam premedication on patient satisfaction in women undergoing general anesthesia.
22 Jul, 2022 | 11:35h | UTC
RCT | In patients undergoing cardiac surgery with cardiopulmonary bypass, using a 4% albumin solution for volume expansion did not reduce adverse events compared to ringer acetate.
21 Jul, 2022 | 13:32h | UTCEffect of 4% Albumin Solution vs Ringer Acetate on Major Adverse Events in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Albumin vs Crystalloid Fluid for Resuscitation in Cardiac Surgery: New Evidence and Arguments in the Timeless Debate – JAMA (free for a limited period)
Commentary: Trial does not support albumin as primer, volume replacement solution in CABG – Healio (free registration required)
Commentary on Twitter
https://twitter.com/JAMA_current/status/1549424077298868225
RCT | Pembrolizumab plus chemotherapy in advanced triple-negative breast cancer.
21 Jul, 2022 | 13:25h | UTCPembrolizumab plus Chemotherapy in Advanced Triple-Negative Breast Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Among patients with triple-negative breast cancer and high expression of PD-L1, pembrolizumab plus chemotherapy resulted in longer overall survival than chemotherapy alone. https://t.co/5urffgHdFb pic.twitter.com/2GlmJuYZJz
— NEJM (@NEJM) July 20, 2022
RCT | Effect of Nintedanib on progression of systemic sclerosis-associated interstitial lung disease over 100 weeks.
21 Jul, 2022 | 13:03h | UTCCommentary: Durable Efficacy for Drug Preventing Lung Progression in Systemic Sclerosis — One-year results sustained over another 48 weeks – MedPage Today (free registration required)
M-A | Risk and benefit for umbrella trials in oncology.
21 Jul, 2022 | 12:27h | UTC
Open-label RCT | Moderate-intensity statin plus ezetimibe is noninferior to high-intensity statin monotherapy in patients with atherosclerotic cardiovascular disease.
20 Jul, 2022 | 12:32h | UTCLong-term efficacy and safety of moderate-intensity statin with ezetimibe combination therapy versus high-intensity statin monotherapy in patients with atherosclerotic cardiovascular disease (RACING): a randomised, open-label, non-inferiority trial – The Lancet (link to abstract – $ for full-text)
RCT | Therapist-guided internet-based psychodynamic therapy vs. cognitive behavioral therapy for adolescent depression.
20 Jul, 2022 | 11:54h | UTC
Commentary on Twitter
NEW Research: "Therapist-guided internet-based #psychodynamic therapy versus #cognitivebehaviouraltherapy for adolescent #depression in Sweden: a randomised, clinical, non-inferiority trial". @Stockholm_Unihttps://t.co/wZ15f80VSg pic.twitter.com/B78TJlrDVL
— The Lancet Digital Health (@LancetDigitalH) July 6, 2022
RCT | Intranasal corticosteroids not beneficial for children with obstructive sleep apnea.
19 Jul, 2022 | 13:27h | UTCA trial of intranasal corticosteroids to treat the childhood obstructive sleep apnea syndrome – CHEST (link to abstract – $ for full-text)
Commentaries:
Intranasal corticosteroids not recommended for most children with OSA: study – Medical Dialogues
Commentary on Twitter
In children with obstructive sleep apnea syndrome, treatment with intranasal corticosteroids did not result in significant polysomnographic, neurobehavioral, and symptom changes compared to placebo, according to research in @journal_CHEST. https://t.co/e4bt4NMv5Z pic.twitter.com/FrIBdoMABf
— American Academy of Sleep Medicine (@AASMorg) July 11, 2022
RCT | Effect of psychiatric advance directives facilitated by peer workers on compulsory admission among people with mental illness.
19 Jul, 2022 | 13:22h | UTCCommentary: Advance Directives for Psychiatric Care Reduce Compulsory Admissions – Medscape (free registration required)
Commentary on Twitter
A RCT found that psychiatric advance directives facilitated by peer-workers were associated with a significant decrease in compulsory readmission and an increase in recovery outcomes among adults living with SCZ, BP-I or SCZ-Aff. https://t.co/ICcwE1RYyJ #EPA2022
— JAMA Psychiatry (@JAMAPsych) June 6, 2022
RCT | Effect of Dextromethorphan plus Bupropion vs. Bupropion alone in major depressive disorder.
19 Jul, 2022 | 13:19h | UTCEffect of AXS-05 (Dextromethorphan-Bupropion) in Major Depressive Disorder: A Randomized Double-Blind Controlled Trial – American Journal of Psychiatry (link to abstract – $ for full-text)
Commentary: Dextromethorphan-Bupropion Significantly Improves Depression Symptoms, Study Finds – Psychiatry News Alert
RCT | Efficacy and safety of once-weekly Efpeglenatide monotherapy versus placebo in Type 2 Diabetes.
19 Jul, 2022 | 13:20h | UTC
RCT | Treat-to-target dose reduction and withdrawal strategy of TNF inhibitors in psoriatic arthritis and axial spondyloarthritis.
19 Jul, 2022 | 13:06h | UTCTreat-to-target dose reduction and withdrawal strategy of TNF inhibitors in psoriatic arthritis and axial spondyloarthritis: a randomised controlled non-inferiority trial – Annals of Rheumatic Diseases (link to abstract – $ for full-text)
Commentary: TNF inhibitor tapered T2T strategy feasible in PsA and axSpA – medwireNews
Commentary on Twitter
Treat-to-target (#T2T) tapering strategy is an effective and safe alternative to a T2T full dose continuation strategy in patients with #psoriatic #arthritis and axial #spondyloarthritis with stable low disease activity using TNF inhibitorshttps://t.co/YhurbawiTm pic.twitter.com/1jj4zuYkPf
— Annals of the Rheumatic Diseases (@eular_ARD) June 18, 2022
RCT | Aflibercept monotherapy or bevacizumab first for diabetic macular edema.
18 Jul, 2022 | 11:16h | UTCAflibercept Monotherapy or Bevacizumab First for Diabetic Macular Edema – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Some insurance companies mandate a form of step therapy, which involves a trial of an inexpensive drug, bevacizumab, to treat diabetic macular edema. This trial compared two treatments: step therapy and a more expensive drug. #ASRS2022 https://t.co/gOhFTw1C1T pic.twitter.com/8uN9WgmtkD
— NEJM (@NEJM) July 14, 2022
RCT | Overall survival with Brentuximab Vedotin in stage III or IV Hodgkin’s lymphoma.
18 Jul, 2022 | 11:13h | UTCOverall Survival with Brentuximab Vedotin in Stage III or IV Hodgkin’s Lymphoma – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: Brentuximab vedotin may improve overall survival in patients with Hodgkin Lymphoma – Mayo Clinic
RCT | Safety and efficacy of rituximab vs. dimethyl fumarate in patients with relapsing-remitting multiple sclerosis or clinically isolated syndrome.
18 Jul, 2022 | 10:53h | UTCSafety and efficacy of rituximab versus dimethyl fumarate in patients with relapsing-remitting multiple sclerosis or clinically isolated syndrome in Sweden: a rater-blinded, phase 3, randomised controlled trial – The Lancet Neurology (link to abstract – $ for full-text)
News Release: Fewer relapses in MS with off-label drug – Karolinska Institutet
RCT | Tixagevimab-cilgavimab for treatment of patients hospitalized with COVID-19.
15 Jul, 2022 | 13:02h | UTCCommentary: The potential of tixagevimab–cilgavimab for treating hospitalized COVID-19 patients – News Medical
Related:
Commentary on Twitter
In pts hospitalised w/ COVID-19 receiving remdesivir and other standard care, tixagevimab–cilgavimab did not improve time to sustained recovery but was safe and mortality was lower vs placebo
From the ACTIV-3–TICO Study Group https://t.co/zaaXBQYl5t pic.twitter.com/xe0tmbFrZ9
— The Lancet Respiratory Medicine (@LancetRespirMed) July 11, 2022
RCT | Deucravacitinib vs. placebo vs. apremilast in moderate to severe plaque psoriasis.
15 Jul, 2022 | 12:26h | UTCDeucravacitinib versus placebo and apremilast in moderate to severe plaque psoriasis: efficacy and safety results from the 52-week, randomized, double-blinded, placebo-controlled phase 3 POETYK PSO-1 trial – Journal of the American Academy of Dermatology (link to abstract – $ for full-text)
Randomized trials in maternal and perinatal health in low and middle-income countries from 2010 to 2019: a systematic scoping review.
15 Jul, 2022 | 12:22h | UTC
RCT | Pharmacogenomic testing for drug-gene interactions provides little benefit for the remission of symptoms in major depressive disorder.
14 Jul, 2022 | 13:05h | UTCEffect of Pharmacogenomic Testing for Drug-Gene Interactions on Medication Selection and Remission of Symptoms in Major Depressive Disorder: The PRIME Care Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Pharmacogenomic Testing for Next-Step Antidepressant Selection: Still a Work in Progress – JAMA (free for a limited period)
Commentary: Does Pharmacogenomic Testing Improve Outcomes in Major Depressive Disorder? — The evidence is unclear – MedPage Today (free registration required)
Commentary on Twitter
In this randomized clinical trial, pharmacogenomic testing for drug-gene interactions in major depressive disorder reduced prescription of medications with predicted drug-gene interactions but had small and nonpersistent effects on symptom remission. https://t.co/Z2OIK3h1Bo pic.twitter.com/8eKSipfBFN
— JAMA (@JAMA_current) July 12, 2022
RCT | Erythropoietin not beneficial for hypoxic-ischemic encephalopathy in newborns.
14 Jul, 2022 | 12:42h | UTCTrial of Erythropoietin for Hypoxic–Ischemic Encephalopathy in Newborns – New England Journal of Medicine (link to abstract – $ for full-text)
Randomized crossover trial | AI reduces miss rate of precancerous polyps in colorectal cancer screening.
14 Jul, 2022 | 12:29h | UTCNews Release: AI reduces miss rate of precancerous polyps in colorectal cancer screening – Mayo Clinic
Original Study: Impact of Artificial Intelligence on Miss Rate of Colorectal Neoplasia – Gastroenterology
RCT | Effects of the short stitch technique for midline abdominal closure on incisional hernia.
14 Jul, 2022 | 12:27h | UTC
RCT | Effect of ultrasonography-guided corticosteroid injection vs. placebo added to exercise therapy for Achilles tendinopathy.
14 Jul, 2022 | 12:18h | UTCCommentary: Trial Backs Steroid Shots for Stubborn Achilles Tendon Pain — Corticosteroid bests placebo when combined with resistance exercise therapy – MedPage Today (free registration required)
Commentary on Twitter
In this RCT, corticosteroid injections + exercise therapy was more effective for patients with long-standing Achilles tendinopathy compared to placebo injections + exercise therapy. https://t.co/nkTH0OYL4a
— JAMA Network Open (@JAMANetworkOpen) July 11, 2022