Randomized Trials
RCT | Effect of Dimethyl Fumarate vs. Interferon Beta-1a in patients with pediatric-onset multiple sclerosis.
29 Sep, 2022 | 13:29h | UTCInvited Commentary: Considering the Future of Pediatric Multiple Sclerosis Trials After the CONNECT Open-Label Randomized Trial – JAMA Network Open
See also: Visual Abstract
RCT | ShangRing vs. Mogen clamp for early infant male circumcision in eastern sub-Saharan Africa.
29 Sep, 2022 | 13:23h | UTCInvited Commentary: Can the ShangRing bring us closer to endorsing early infant male circumcision in sub-Saharan Africa? – The Lancet Global Health
RCT | Pembrolizumab vs. placebo as adjuvant therapy for completely resected stage IB–IIIA non-small-cell lung cancer.
29 Sep, 2022 | 13:22h | UTCPembrolizumab versus placebo as adjuvant therapy for completely resected stage IB–IIIA non-small-cell lung cancer (PEARLS/KEYNOTE-091): an interim analysis of a randomised, triple-blind, phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)
Commentaries:
Adjuvant Pembrolizumab in Patients With Completely Resected Stage IB to IIIA NSCLC – The ASCO Post
Adjuvant Pembrolizumab Prolongs DFS in Resected Non-Small Cell Lung Cancer – Cancer Therapy Advisor
Commentary on Twitter
New Research in @TheLancetOncol—Pembrolizumab improves disease-free survival vs placebo in completely resected, PD-L1-unselected, stage IB–IIIA #NSCLC
From Prof Mary O’Brien & colleagues https://t.co/Azqb8WTOwp pic.twitter.com/141bhAPtg5
— The Lancet Respiratory Medicine (@LancetRespirMed) September 13, 2022
RCT | Cyclosporine A (0.05%) ophthalmic gel in the treatment of dry eye disease.
28 Sep, 2022 | 13:42h | UTC
RCT | First-Line Serplulimab vs. placebo added to chemotherapy in patients with extensive-stage small cell lung cancer.
28 Sep, 2022 | 13:41h | UTCEffect of First-Line Serplulimab vs Placebo Added to Chemotherapy on Survival in Patients With Extensive-Stage Small Cell Lung Cancer: The ASTRUM-005 Randomized Clinical Trial – JAMA (free for a limited period)
See also: Visual Abstract
RCT | Paromomycin and Miltefosine combination as an alternative to treat patients with visceral leishmaniasis.
28 Sep, 2022 | 13:43h | UTC
RCT | Early initiation of short-term emollient use for the prevention of atopic dermatitis in high-risk infants.
28 Sep, 2022 | 13:35h | UTCCommentary: Early Use of Short-term Emollients Linked With Reduced Incidence of AD in High-risk Infants – AJMC
Commentary on Twitter
Can early barrier targeted interventions prevent development of #atopicdermatitis ?
Here’s our contribution.
After negative signals in BEEP and PreventADALL. We suggest earlier intervention with specific emollients may have a role.
More work neededhttps://t.co/GDscCeD1LS pic.twitter.com/ZqEqHMyhcW
— Alan Irvine (@irvinederm) August 27, 2022
RCT | Effectiveness of a stand-alone telephone-delivered intervention for reducing problem alcohol use.
28 Sep, 2022 | 13:34h | UTCEffectiveness of a Stand-alone Telephone-Delivered Intervention for Reducing Problem Alcohol Use: A Randomized Clinical Trial – JAMA Psychiatry (link to abstract – $ for full-text)
Commentary: Telephone Intervention May Reduce Risky Alcohol Consumption – Psychiatric News Alert
Commentary on Twitter
The Ready2Change telephone-delivered intervention is a highly scalable model of alcohol treatment shown in a recent RCT to reduce hazardous drinking levels. Alcohol problem severity reduced when people received ≥2 sessions. https://t.co/6npUvAQwku pic.twitter.com/vbcF0zavMO
— JAMA Psychiatry (@JAMAPsych) September 21, 2022
RCT | Incisional hernia following colorectal cancer surgery according to suture technique.
27 Sep, 2022 | 13:18h | UTC
RCT | Routine pressure wire assessment vs. conventional angiography in patients with coronary artery disease.
27 Sep, 2022 | 13:19h | UTCRelated:
RCT | Postoperative packing of perianal abscess cavities increases pain and does not reduce fistula and recurrence rates.
27 Sep, 2022 | 13:17h | UTC
RCT | Intrathecal Tofersen did not improve clinical endpoints in patients with amyotrophic lateral sclerosis with mutations in SOD1.
27 Sep, 2022 | 13:09h | UTCTrial of Antisense Oligonucleotide Tofersen for SOD1 ALS – New England Journal of Medicine (link to abstract – $ for full-text)
RCT | Efficacy of a commercial weight management program compared with a do-it-yourself approach.
27 Sep, 2022 | 13:05h | UTCCommentary: Weight Loss Greater With Commercial Weight Management Program – HealthDay
Commentary on Twitter
In this RCT, a commercial weight management program resulted in more weight reduction than a do-it-yourself approach at 3 months and 1 year. https://t.co/N8HAr7uw3p pic.twitter.com/UbvA1i8Kam
— JAMA Network Open (@JAMANetworkOpen) August 16, 2022
RCT | Pelvic floor rehabilitation after rectal cancer surgery.
26 Sep, 2022 | 12:04h | UTC
RCT | Outpatient vs. inpatient preinduction cervical ripening using a synthetic osmotic dilator.
26 Sep, 2022 | 11:58h | UTC
RCT | 6-year results of primary selective laser trabeculoplasty vs. eye drops for glaucoma and ocular hypertension.
23 Sep, 2022 | 13:06h | UTCOriginal Study: Randomized Trial: Selective Laser Trabeculoplasty vs. Eye Drops for First-line Treatment of Ocular Hypertension and Glaucoma
Secondary analysis of a RCT | Complete revascularization vs. culprit lesion–only PCI for angina-related quality of life in patients with STEMI.
22 Sep, 2022 | 13:17h | UTCComplete Revascularization vs Culprit Lesion–Only Percutaneous Coronary Intervention for Angina-Related Quality of Life in Patients With ST-Segment Elevation Myocardial Infarction: Results From the COMPLETE Randomized Clinical Trial – JAMA Cardiology (link to abstract – $ for full-text)
Related meta-analysis:
Study: Nonculprit-lesion PCI Timing in Patients With ST-Segment Elevation Myocardial Infarction
Studies in patients with cardiogenic shock:
One-Year Outcomes after PCI Strategies in Cardiogenic Shock – New England Journal of Medicine
RCTs | Effect of Roflumilast cream vs. vehicle cream on chronic plaque psoriasis.
22 Sep, 2022 | 13:06h | UTCEffect of Roflumilast Cream vs Vehicle Cream on Chronic Plaque Psoriasis: The DERMIS-1 and DERMIS-2 Randomized Clinical Trials – JAMA (free for a limited period)
Editorial: Roflumilast for Chronic Plaque Psoriasis – JAMA
Commentary: Study Suggests Roflumilast May Be Effective As Treatment For Plaque Psoriasis – HCPLive
Commentary on Twitter
Roflumilast cream resulted in better chronic plaque psoriasis clinical status compared with vehicle cream at 8 weeks; further research is needed to compare efficacy with other active treatments and to assess longer-term efficacy and safety. https://t.co/DyGNNjr5ea #Research pic.twitter.com/QnMcChnht6
— JAMA (@JAMA_current) September 21, 2022
RCT | Effect of Tocilizumab on disease activity in patients with active polymyalgia rheumatica receiving glucocorticoid therapy.
22 Sep, 2022 | 13:06h | UTCEffect of Tocilizumab on Disease Activity in Patients With Active Polymyalgia Rheumatica Receiving Glucocorticoid Therapy: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Tocilizumab as a Novel Therapy for Steroid-Dependent Polymyalgia Rheumatica – JAMA (free for a limited period)
Video Editor’s Note: Tocilizumab and Disease Activity in Patients With Polymyalgia Rheumatica Receiving Glucocorticoid Therapy – JAMA
RCT | Effect of clinical decision support with audit and feedback on prevention of acute kidney injury in patients undergoing coronary angiography.
22 Sep, 2022 | 13:04h | UTCEffect of Clinical Decision Support With Audit and Feedback on Prevention of Acute Kidney Injury in Patients Undergoing Coronary Angiography: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentary: Intervention Cuts Risk for AKI After Coronary Angiography – HealthDay
Commentary on Twitter
This multifaceted intervention led to a lower risk of acute kidney injury in patients undergoing coronary angiography, percutaneous coronary intervention, or both. #Research https://t.co/rKVBsRxHy7
— JAMA (@JAMA_current) September 7, 2022
RCT | Effect of the family-centered advance care planning for teens with cancer intervention on sustainability of congruence about end-of-life treatment preferences.
22 Sep, 2022 | 13:02h | UTCNews Release: Advance care planning for adolescents with cancer – University of Minnesota
Commentary: Study Examines Effects of Advance Care Planning for Adolescents With Cancer – The ASCO Post
Commentary on Twitter
Results of this trial showed that, for those who received the FACE®-TC intervention, the families’ knowledge of their adolescents’ end-of-life treatment preferences was sustained for 1 year, suggesting yearly follow-up sessions. @ChildrensNatl #EOL https://t.co/dngUhFQ5vQ
— JAMA Network Open (@JAMANetworkOpen) July 12, 2022
RCT | Routine ultrasonography guidance for femoral vascular access for cardiac procedures improved first-pass success but did not reduce complications.
22 Sep, 2022 | 13:01h | UTCRoutine Ultrasonography Guidance for Femoral Vascular Access for Cardiac Procedures: The UNIVERSAL Randomized Clinical Trial – JAMA Cardiology (free for a limited period)
RCT | Circular stapled technique vs. modified collard technique for cervical esophagogastric anastomosis after esophagectomy.
21 Sep, 2022 | 13:08h | UTCCircular Stapled Technique Versus Modified Collard Technique for Cervical Esophagogastric Anastomosis After Esophagectomy: A Randomized Controlled Trial – Annals of Surgery (link to abstract – $ for full-text)
RCT | Efficacy and safety of Rituximab for new onset generalized Myasthenia Gravis.
21 Sep, 2022 | 13:04h | UTC
Commentary on Twitter
Treatment with #rituximab shortly after onset of #myastheniagravis was effective, a placebo-controlled randomized study showed. https://t.co/wdUzx7yOq6 #Research
— JAMA Neurology (@JAMANeuro) September 19, 2022
RCTs | Crenezumab not beneficial for patients with early Alzheimer Disease.
21 Sep, 2022 | 13:03h | UTC