Randomized Trials
Phase 2 RCT | Efficacy of adjunctive D-Cycloserine to intermittent theta-burst stimulation for major depressive disorder.
19 Oct, 2022 | 14:16h | UTCEfficacy of Adjunctive D-Cycloserine to Intermittent Theta-Burst Stimulation for Major Depressive Disorder: A Randomized Clinical Trial – JAMA Psychiatry (link to abstract – $ for full-text)
Commentaries:
Commentary on Twitter
In this RCT w 50 participants, those receiving intermittent theta-burst stimulation w adjunctive D-Cycloserine had significantly greater improvements in depressive symptoms compared to stimulation w placebo. https://t.co/AnP93WnkdG #Research
— JAMA Psychiatry (@JAMAPsych) October 12, 2022
RCT | Vonoprazan noninferior to Lansoprazole for healing and maintenance of healing of erosive esophagitis.
19 Oct, 2022 | 14:08h | UTC
Cluster RCT | Primary prophylaxis with CSFs fails to improve outcomes in patients at intermediate risk for febrile neutropenia.
18 Oct, 2022 | 12:58h | UTC
RCT | Two-year effects of Semaglutide in adults with overweight or obesity.
18 Oct, 2022 | 12:53h | UTCCommentary: STEP 5: Sustained semaglutide treatment maintains weight loss – medwire News
Related:
RCT: Effect of high-dose subcutaneous Semaglutide vs. placebo in adults with overweight or obesity
Commentary on Twitter
Results from the STEP 5, testing #semaglutide as an adjuct to behavioral interventions in adults with #overweight or #obesity, demonstrate sustained #weightloss over a period of 104 weeks. @ProfBatterhamMD @seanwharton @DrGeorgiaRigas https://t.co/0mBtzhCYID
— Nature Medicine (@NatureMedicine) October 11, 2022
Perspective | Reducing bureaucracy in clinical trials.
18 Oct, 2022 | 12:41h | UTCReducing bureaucracy in clinical trials – UEG Journal
RCT | Adjuvant capecitabine following concurrent CTX-RT in locoregionally advanced nasopharyngeal carcinoma.
17 Oct, 2022 | 12:15h | UTC
RCT | A low-intensity psychosocial intervention improved recovery from depression in older adults in Brazil.
14 Oct, 2022 | 14:09h | UTCInvited Commentary: Empowering older adults and their communities to cope with depression in resource-limited settings – The Lancet Health Longevity
Commentary on Twitter
Empowering older adults and their communities to cope with #depression in resource-limited settings https://t.co/8GShpxpcOX@clausuemoto #Geriatrics
Our commentary @LancetLongevity about the incredible PRO-ACTIVE intervention by @scazufca & cols https://t.co/x2UerUFAYY pic.twitter.com/IP0DqTmGdP
— Marlon Aliberti (@marlon_aliberti) October 3, 2022
Under a Creative Commons Attribution (CC BY 4.0) License
RCT | In abortion surgery, Esketamine plus Propofol can reduce hypotension compared to Fentanyl plus Propofol.
14 Oct, 2022 | 13:58h | UTCCommentary: Esketamine as an adjunct with propofol and fentanyl to avoid perioperative hypotension – Physician’s Weekly
RCT | No difference in cardiovascular outcomes with evening vs. morning dosing of usual antihypertensives.
12 Oct, 2022 | 14:01h | UTCRelated Consensus Statement: Bedtime dosing of antihypertensive medications: systematic review and consensus statement: International Society of Hypertension position paper endorsed by World Hypertension League and European Society of Hypertension – Journal of Hypertension
Related study (conflicting results): Bedtime Hypertension Treatment Improves Cardiovascular Risk Reduction in Randomized Trial
RCT | Toripalimab plus chemotherapy for patients with treatment-naive advanced non–small-cell lung cancer.
11 Oct, 2022 | 13:31h | UTC
RCT | Riociguat improved hemodynamics but increased dropouts in pulmonary hypertension and HFpEF.
11 Oct, 2022 | 13:26h | UTC
Commentary on Twitter
Riociguat in pulmonary hypertension and heart failure with preserved ejection fraction: results of randomized, double-blind, placebo-controlled, multicentre trial out.https://t.co/FYmorikQR5#HFpEF #HF #cardiotwitter @ESC_Journals @escardio pic.twitter.com/4sSeYt7Adq
— EHJ Editor-in-Chief (@ehj_ed) October 7, 2022
Under a https://creativecommons.org/licenses/by-nc/4.0/ license
RCT | Cefepime/Enmetazobactam vs. Piperacillin/Tazobactam in patients with complicated urinary tract infections.
6 Oct, 2022 | 13:49h | UTCEffect of Cefepime/Enmetazobactam vs Piperacillin/Tazobactam on Clinical Cure and Microbiological Eradication in Patients With Complicated Urinary Tract Infection or Acute Pyelonephritis: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Cefepime/Enmetazobactam for Complicated Urinary Tract Infections – JAMA (free for a limited period)
Commentary on Twitter
https://twitter.com/JAMA_current/status/1577372986188906522
RCT | Intravenous immune globulin reduces disease activity in dermatomyositis.
6 Oct, 2022 | 13:48h | UTCTrial of Intravenous Immune Globulin in Dermatomyositis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
NEJM: trial of IVIG for autoimmune disorder dermatomyositis – MedicalResearch.com
IV Immune Globulin Bests Placebo for Dermatomyositis – Drugs.com
RCT | Telmisartan did not improve walking performance in patients with lower extremity peripheral artery disease.
6 Oct, 2022 | 13:43h | UTCEffect of Telmisartan on Walking Performance in Patients With Lower Extremity Peripheral Artery Disease: The TELEX Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Telmisartan and Walking Performance in Peripheral Artery Disease – JAMA (free for a limited period)
Audio interview: Treatment of Peripheral Artery Disease – JAMA
Commentary on Twitter
Study results do not support #telmisartan for improving walking performance in patients with lower extremity #PeripheralArteryDisease https://t.co/QErZh3i3rO pic.twitter.com/nhthGoIQym
— JAMA (@JAMA_current) October 5, 2022
RCT | A postoperative multimodal opioid-sparing protocol can reduce opioid consumption after knee or shoulder arthroscopy.
5 Oct, 2022 | 13:57h | UTCEffect of a Postoperative Multimodal Opioid-Sparing Protocol vs Standard Opioid Prescribing on Postoperative Opioid Consumption After Knee or Shoulder Arthroscopy: A Randomized Clinical Trial – JAMA (free for a limited period)
News Release: Orthopedic surgery patients do fine without opioid painkillers – McMaster University
See also: Visual Abstract
Video Editor’s Note: Effect of an Opioid-Sparing Protocol vs Standard Prescribing on Opioid Consumption After Knee or Shoulder Arthroscopy
RCT | Analgesic efficacy of intravenous dexamethasone as an adjunct to paravertebral block in thoracoscopic surgery.
3 Oct, 2022 | 13:54h | UTC
RCT | Antibiotic prophylaxis vs. no prophylaxis in breast cancer surgery.
3 Oct, 2022 | 13:47h | UTCAntibiotic prophylaxis in breast cancer surgery (PAUS trial): randomised clinical double-blind parallel-group multicentre superiority trial – British Journal of Surgery (link to abstract – $ for full-text)
RCT | Selumetinib plus adjuvant radioactive iodine in patients with high-risk differentiated thyroid cancer.
3 Oct, 2022 | 13:42h | UTCCommentary: Selumetinib Does Not Improve CR Rate in Differentiated Thyroid Cancer – Cancer Therapy Adviser
Commentary on Twitter
❎ ASTRA trial: Radioactive iodine ± selumetinib doesn't improve remission rates for high-risk #thyroidcancer
✅ Postoperative pathologic risk stratification identified pts at risk of primary treatment failurehttps://t.co/kvakaMXtDh#JCO #thycsm @MSKCancerCenter pic.twitter.com/mvQwgzIjWh— Journal of Clinical Oncology (@JCO_ASCO) March 16, 2022
RCT | No benefit from hydrocortisone, vitamin C, and thiamine in adult patients with septic shock.
30 Sep, 2022 | 12:42h | UTCRelated:
Parenteral Vitamin C in Patients with Severe Infection: A Systematic Review – NEJM Evidence
RCT | Self-cut vs. Mesh-Kit titanium-coated polypropylene Mesh for transvaginal treatment of severe pelvic organ prolapse.
30 Sep, 2022 | 12:38h | UTCCommentary: Self-Cut Mesh Noninferior for Pelvic Organ Prolapse Procedure – HealthDay
Systematic Review | Randomized clinical trials of machine learning interventions in health care.
30 Sep, 2022 | 12:37h | UTC
RCT | Doxycycline vs. placebo in patients with mild thyroid-associated ophthalmopathy.
30 Sep, 2022 | 12:35h | UTCDoxycycline vs Placebo at 12 Weeks in Patients With Mild Thyroid-Associated Ophthalmopathy: A Randomized Clinical Trial – JAMA Ophthalmology (free for a limited period)
Invited commentary: Oral Doxycycline for Mild Thyroid Eye Disease – JAMA Opthalmology (free for a limited period)
RCT | Adjuvant Nivolumab plus Ipilimumab vs. Nivolumab alone in patients with resected Stage IIIB-D or Stage IV melanoma.
30 Sep, 2022 | 12:33h | UTC
RCT | In patients with Type 1 Diabetes, the use of a “bionic pancreas” reduced HbA1c without increasing hypoglycemia.
29 Sep, 2022 | 13:35h | UTCMulticenter, Randomized Trial of a Bionic Pancreas in Type 1 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)
RCT | Abbreviated antiplatelet therapy after coronary stenting in patients with myocardial infarction at high bleeding risk.
29 Sep, 2022 | 13:32h | UTC