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Randomized Trials

RCT | In hypoxemic patients after extubation, high-flow vs. Venturi mask oxygen therapy resulted in similar re-intubation rates.

1 Nov, 2022 | 12:11h | UTC

High-Flow Versus VenturiMask Oxygen Therapy to Prevent Re-Intubation in Hypoxemic Patients After Extubation: A Multicenter, Randomized Clinical Trial – American Journal of Respiratory and Critical Care Medicine

 

M-A | The success rate of cardioversion for AF was similar between anterior-posterior vs. anterior-lateral electrodes position.

1 Nov, 2022 | 12:09h | UTC

Anterior-Posterior versus anterior-lateral electrodes position for electrical cardioversion of atrial fibrillation: A meta-analysis of randomized controlled trials – IJC Heart & Vasculature

 

Phase 2/3 RCT | Zavegepant nasal spray for the acute treatment of migraine.

1 Nov, 2022 | 12:01h | UTC

Zavegepant nasal spray for the acute treatment of migraine: A Phase 2/3 double-blind, randomized, placebo-controlled, dose-ranging trial – Headache

 

RCT | Photodynamic vs. white-light-guided resection of first-diagnosis non-muscle-invasive bladder cancer.

31 Oct, 2022 | 13:51h | UTC

Photodynamic versus white-light-guided resection of first-diagnosis non-muscle-invasive bladder cancer: PHOTO RCT – Health Technology Assessment

 

RCT | Effectiveness of rTMS vs. bilateral Theta burst stimulation in older adults with depression.

31 Oct, 2022 | 13:38h | UTC

Effectiveness of Standard Sequential Bilateral Repetitive Transcranial Magnetic Stimulation vs Bilateral Theta Burst Stimulation in Older Adults With Depression: The FOUR-D Randomized Noninferiority Clinical Trial – JAMA Psychiatry

Commentary: Neurostimulation Methods Compared for Treating Depression in Seniors – HealthDay

 

Commentary on Twitter

 

RCT | Sutimlimab in patients with cold agglutinin disease without recent transfusion.

31 Oct, 2022 | 13:37h | UTC

Sutimlimab in patients with cold agglutinin disease: results of the randomized placebo-controlled phase 3 CADENZA trial – Blood

Editorial: A virtuosic CADENZA played by sutimlimab – Blood

Commentary: Sutimlimab Shows Efficacy in Patients With CAD Without Recent Transfusion – AJMC

 

Commentary on Twitter

 

RCT | Early active mobilization during mechanical ventilation in the ICU did not improve outcomes and increased adverse events.

28 Oct, 2022 | 13:28h | UTC

Early Active Mobilization during Mechanical Ventilation in the ICU – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

https://twitter.com/NEJM/status/1585246120963604481

 

RCT | Haloperidol for the treatment of delirium in ICU patients did not significantly improve outcomes.

28 Oct, 2022 | 13:29h | UTC

Haloperidol for the Treatment of Delirium in ICU Patients – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

RCT | Spontaneous-breathing trials performed with pressure-support ventilation are no better than trials using a T-piece.

28 Oct, 2022 | 13:25h | UTC

Spontaneous-Breathing Trials with Pressure-Support Ventilation or a T-Piece – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

RCT | Pulmonary vein isolation plus individualized substrate ablation of atrial low-voltage myocardium reduced A-fib recurrence.

28 Oct, 2022 | 13:24h | UTC

Low-Voltage Myocardium-Guided Ablation Trial of Persistent Atrial Fibrillation – NEJM Evidence

 

Commentary on Twitter

 

RCT | Selective decontamination of the GI tract did not significantly reduce mortality in ICU patients on mechanical ventilation.

27 Oct, 2022 | 12:40h | UTC

Effect of Selective Decontamination of the Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial – JAMA (free for a limited period)

See also: Visual Abstract

Related study: Association Between Selective Decontamination of the Digestive Tract and In-Hospital Mortality in Intensive Care Unit Patients Receiving Mechanical Ventilation: A Systematic Review and Meta-analysis – JAMA (free for a limited period)

 

RCT | Continuous enzalutamide after progression of metastatic castration-resistant prostate cancer treated with docetaxel.

27 Oct, 2022 | 12:23h | UTC

Continuous enzalutamide after progression of metastatic castration-resistant prostate cancer treated with docetaxel (PRESIDE): an international, randomised, phase 3b study – The Lancet Oncology (link to abstract – $ for full-text)

Commentary: PRESIDE Trial Meets Primary End Point With Continuous Enzalutamide After Progression of mCRPC – Cancer Network

 

RCT | Intraoperative electrocorticography using high-frequency oscillations or spikes to tailor epilepsy surgery.

26 Oct, 2022 | 14:34h | UTC

Intraoperative electrocorticography using high-frequency oscillations or spikes to tailor epilepsy surgery in the Netherlands (the HFO trial): a randomised, single-blind, adaptive non-inferiority trial – The Lancet Neurology

 

Phase 2 RCT | Immunoglobulin has no corticosteroid-sparing effects in Myasthenia Gravis.

26 Oct, 2022 | 14:25h | UTC

A Randomized, Double-Blind, Placebo-Controlled Trial of the Corticosteroid-Sparing Effects of Immunoglobulin in Myasthenia Gravis – Neurology

 

RCT | Effect of a novel brief motivational intervention for alcohol-intoxicated young adults in the emergency department.

25 Oct, 2022 | 13:18h | UTC

Effect of a Novel Brief Motivational Intervention for Alcohol-Intoxicated Young Adults in the Emergency Department: A Randomized Clinical Trial – JAMA Network Open

See also: Visual Abstract

 

Post-trial follow-up | IV calcium does not improve long-term outcomes in patients with out-of-hospital cardiac arrest.

25 Oct, 2022 | 13:17h | UTC

Effect of calcium vs. placebo on long-term outcomes in patients with out-of-hospital cardiac arrest – Resuscitation

Original Study: RCT: Intravenous or intraosseous calcium does not improve the return of spontaneous circulation in adults with out-of-hospital cardiac arrest.

 

Commentary on Twitter

 

RCT | Transcutaneous Electrical Acustimulation (TEA) vs. sham-TEA for irritable bowel syndrome with constipation.

25 Oct, 2022 | 13:12h | UTC

Transcutaneous Electrical Acustimulation Improves Irritable Bowel Syndrome With Constipation by Accelerating Colon Transit and Reducing Rectal Sensation Using Autonomic Mechanisms – American Journal of Gastroenterology

 

RCT | Effect of pentaerythritol tetranitrate (PETN) in pregnancies with impaired uteroplacental perfusion at midgestation.

24 Oct, 2022 | 14:05h | UTC

Effect of pentaerythritol tetranitrate (PETN) on the development of fetal growth restriction in pregnancies with impaired uteroplacental perfusion at midgestation—a randomized trial – American Journal of Obstetrics & Gynecology

 

Commentary on Twitter

 

RCT | No benefit from an evidence-based educational intervention for reducing coercive measures in psychiatric hospitals.

24 Oct, 2022 | 13:57h | UTC

An Evidence-Based Educational Intervention for Reducing Coercive Measures in Psychiatric Hospitals: A Randomized Clinical Trial – JAMA Network Open

Commentary: Education Program Had Limited Effect on Coercive Practices in Psych Hospitals – MedPage Today (free registration required)

 

Commentary on Twitter

 

Two Phase 3, randomized, controlled trials of Ruxolitinib cream for vitiligo.

21 Oct, 2022 | 13:03h | UTC

Two Phase 3, Randomized, Controlled Trials of Ruxolitinib Cream for Vitiligo – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Ruxolitinib Cream Results in Greater Repigmentation in Vitiligo – HealthDay

 

RCT | Sugammadex vs. Neostigmine for neuromuscular block reversal in patients undergoing resection of lung cancer.

21 Oct, 2022 | 12:54h | UTC

Sugammadex Versus Neostigmine for Neuromuscular Block Reversal and Postoperative Pulmonary Complications in Patients Undergoing Resection of Lung Cancer – Journal of Cardiothoracic and Vascular Anesthesia

Editorial: Influence of Sugammadex in Decreasing Postoperative Pulmonary Complications in Thoracic Surgery, is There Evidence? – Journal of Cardiothoracic and Vascular Anesthesia

Related:

Systematic Review: Benefits and harms of sugammadex versus neostigmine in reversing induced paralysis

Reduction of Nonoperative Time Using the Induction Room, Parallel Processing, and Sugammadex: A Randomized Clinical Trial – Anesthesia & Analgesia

[News release – not published yet] Women not being routinely informed that a common anesthetic may lessen contraception effectiveness, doctors warn.

 

Caffeine to prevent intermittent hypoxemia in late preterm infants: randomized controlled dosage trial.

21 Oct, 2022 | 12:49h | UTC

Caffeine to prevent intermittent hypoxaemia in late preterm infants: randomised controlled dosage trial – ADC Fetal & Neonatal

Summary: What dose of caffeine to use? – Neonatal Research

 

Commentary on Twitter

 

RCT | The efficacy of bone wax in reduction of perioperative blood loss in total hip arthroplasty via direct anterior approach.

21 Oct, 2022 | 12:48h | UTC

The Efficacy of Bone Wax in Reduction of Perioperative Blood Loss in Total Hip Arthroplasty via Direct Anterior Approach: A Prospective Randomized Clinical Trial – The Journal of Bone and Joint Surgery (link to abstract – $ for full-text)

 

RCT | Evaluation of mRNA-1273 vaccine in children 6 months to 5 years of age.

20 Oct, 2022 | 12:35h | UTC

Evaluation of mRNA-1273 Vaccine in Children 6 Months to 5 Years of Age – New England Journal of Medicine

 

Commentary on Twitter

 

RCT | Etrolizumab as induction and maintenance therapy in patients with moderately to severely active Crohn’s disease.

20 Oct, 2022 | 12:26h | UTC

Etrolizumab as induction and maintenance therapy in patients with moderately to severely active Crohn’s disease (BERGAMOT): a randomised, placebo-controlled, double-blind, phase 3 trial – The Lancet Gastroenterology & Hepatology (free registration required)

Commentary: Etrolizumab Increases Chance of Clinical Remission for Crohn’s Disease – HCP Live

 

Commentary on Twitter

 

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