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Randomized Trials

RCT | New defibrillation strategies increased the rates of survival to hospital discharge in patients with refractory ventricular fibrillation.

8 Nov, 2022 | 12:27h | UTC

Defibrillation Strategies for Refractory Ventricular Fibrillation – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: “Double shock” from two defibrillators could save more lives – Heart & Stroke

 

Commentary on Twitter

 

RCT | Rapid up-titration of guideline-directed medical therapies for acute heart failure reduced readmissions and deaths.

8 Nov, 2022 | 12:24h | UTC

Safety, tolerability and efficacy of up-titration of guideline-directed medical therapies for acute heart failure (STRONG-HF): a multinational, open-label, randomised, trial – The Lancet (free registration required)

News Release: Maximizing heart failure meds within 2 weeks reduced risk of hospital readmission, death – American Heart Association

Commentary: STRONG-HF: Rapid Uptitration of GDMT After Acute HF Pays Dividends – TCTMD

 

RCT | After an out-of-hospital cardiac arrest, fever prevention for 36 vs. 72 hours resulted in similar outcomes.

8 Nov, 2022 | 12:23h | UTC

Duration of Device-Based Fever Prevention after Cardiac Arrest – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

RCT | Efficacy of a targeted-release formulation of budesonide for treating primary immunoglobulin A nephropathy.

8 Nov, 2022 | 12:14h | UTC

Results from part A of the multi-center, double-blind, randomized, placebo-controlled NefIgArd trial evaluated targeted-release formulation of budesonide for the treatment of primary immunoglobulin A nephropathy – Kidney International

Commentary: Oral Steroid Safely Treats IgA Nephropathy: Trial Published – Medscape (free registration required)

 

Commentary on Twitter (thread – click for more)

https://twitter.com/hswapnil/status/1582685958881021952

 

RCT | Precuneus magnetic stimulation for Alzheimer’s disease.

8 Nov, 2022 | 12:12h | UTC

Precuneus magnetic stimulation for Alzheimer’s disease: a randomized, sham-controlled trial – Brain

Commentary: Novel Approach to TMS May Slow Cognitive Decline in Alzheimer’s – Medscape (free registration required)

 

Commentary on Twitter

 

RCT | Effects of combination treatment with tezepelumab and allergen immunotherapy on nasal responses to allergen.

8 Nov, 2022 | 12:06h | UTC

Effects of combination treatment with tezepelumab and allergen immunotherapy on nasal responses to allergen: a randomized controlled trial – Journal of Allergy and Clinical Immunology (link to abstract – $ for full-text)

News Release: Monoclonal antibody improves cat allergen immunotherapy – National Institutes of Health 

Commentaries: Study explores the potential use of anti-thymic stromal lymphopoietin monoclonal antibody as an adjuvant in allergic immunotherapy – News Medical

 

RCT | Efficacy of an eye-tracking-based dichoptic home treatment for amblyopia.

8 Nov, 2022 | 12:04h | UTC

An eye-tracking-based dichoptic home treatment for amblyopia: a multicenter randomized clinical trial – Ophthalmology 

 

RCT | In patients with CKD (eGFR 20-45 mL/min per 1.73 m2), Empagliflozin reduced the risk of progression of kidney disease.

7 Nov, 2022 | 12:56h | UTC

Empagliflozin in Patients with Chronic Kidney Disease – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: EMPA-KIDNEY supports SGLT2 inhibition for chronic kidney disease – medwire News

Video Summary: EMPA-KIDNEY results: Empagliflozin reduces kidney disease progression and cardiovascular deaths

 

Commentary on Twitter

 

RCT | Early amino acids in extremely preterm infants did improve neurodisability at 2 Years.

7 Nov, 2022 | 12:52h | UTC

Early Amino Acids in Extremely Preterm Infants and Neurodisability at 2 Years – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Extra Parenteral Amino Acids No Benefit for Extremely Preterm Infants – HealthDay

 

Commentary on Twitter

 

RCT | Chlortalidone and Hydrochlorothiazide resulted in similar reductions of CVD in older patients with hypertension.

7 Nov, 2022 | 12:50h | UTC

News Release (not published yet): No difference in heart outcomes found in use of two diuretics to treat blood pressure – American Heart Association

Commentaries:

In High BP, Chlorthalidone and Hydrochlorothiazide Have Similar Impact on MACE – TCTMD

Diuretic Comparison Project – DCP – American College of Cardiology

 

RCT | Intravenous iron did not significantly reduce hospital admissions in patients with heart failure and iron deficiency.

7 Nov, 2022 | 12:48h | UTC

Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial – The Lancet

Commentaries:

Effectiveness of Intravenous Iron Treatment Versus Standard Care in Patients With Heart Failure and Iron Deficiency – IRONMAN – American College of Cardiology

IRONMAN Misses but Lends Support to IV Iron Repletion in HF – TCTMD

 

RCT | Efficacy of a digital behavioral therapeutic application to improve glycemic control in adults with Type 2 DM.

7 Nov, 2022 | 12:33h | UTC

Randomized, Controlled Trial of a Digital Behavioral Therapeutic Application to Improve Glycemic Control in Adults With Type 2 Diabetes – Diabetes Care

Commentary: Smartphone-delivered CBT improves glycemic control in people with type 2 diabetes – medwire News

 

RCT | Efficacy of prune juice containing sorbitol, pectin, and polyphenol in chronic constipation.

7 Nov, 2022 | 12:34h | UTC

Prune Juice Containing Sorbitol, Pectin, and Polyphenol Ameliorates Subjective Complaints and Hard Feces While Normalizing Stool in Chronic Constipation: A Randomized Placebo-Controlled Trial – American Journal of Gastroenterology (free for a limited period)

 

Commentary on Twitter

 

RCT | Naltrexone-bupropion and behavior therapy, alone and combined, for binge-eating disorder.

7 Nov, 2022 | 12:27h | UTC

Naltrexone-Bupropion and Behavior Therapy, Alone and Combined, for Binge-Eating Disorder: Randomized Double-Blind Placebo-Controlled Trial – The American Journal of Psychiatry

News Release: People With Binge-eating Disorder Benefit From Specific Behavioral Therapy and Medication – Yale School of Medicine

Commentary: Behavioral Therapy Plus Naltrexone-Bupropion Combination May Reduce Binge Eating – Psychiatric News Alert

 

RCT | Efficacy of drug-eluting stent vs. bare metal stent for symptomatic femoropopliteal peripheral artery disease.

7 Nov, 2022 | 12:29h | UTC

Efficacy of a Drug-Eluting Stent Versus Bare Metal Stents for Symptomatic Femoropopliteal Peripheral Artery Disease: Primary Results of the EMINENT Randomized Trial – Circulation (free for a limited period)

 

Commentary on Twitter

https://twitter.com/CircAHA/status/1585005809955651584

 

Crossover RCT | Efficacy of low-dose Empagliflozin as an adjunct to hybrid closed-loop insulin therapy in adults with Type 1 DM.

7 Nov, 2022 | 12:24h | UTC

Low-Dose Empagliflozin as Adjunct to Hybrid Closed-Loop Insulin Therapy in Adults With Suboptimally Controlled Type 1 Diabetes: A Randomized Crossover Controlled Trial – Diabetes Care (link to abstract – $ for full-text)

 

Phase 2 RCT | Single-dose Psilocybin for a treatment-resistant episode of major depression.

4 Nov, 2022 | 13:57h | UTC

Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

Largest trial to date shows that psilocybin reduces depression symptoms – King’s College London

Expert reaction to Phase IIb Clinical Trial of Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression – Science Media Centre

Related:

RCT | In patients with alcohol use disorder, the percentage of heavy drinking days was reduced with a psychedelic drug.

Phase 2 RCT: Psilocybin, a psychedelic compound, shows promise for the treatment of depression in a study with 59 patients

Research: “Magic mushrooms” for treatment-resistant depression

 

Commentary on Twitter

RCT | Once-weekly Semaglutide effective for weight loss in adolescents with obesity.

4 Nov, 2022 | 13:59h | UTC

Once-Weekly Semaglutide in Adolescents with Obesity – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

STEP TEENS: High-dose semaglutide weight loss benefits shown in adolescents – medwire News

Trial Shows Weight-Loss Drug Works in Teens – HealthDay

 

Commentary on Twitter

 

RCT | Discontinuing RAS inhibitors in patients with advanced CKD did not result in a slower decline in eGFR.

4 Nov, 2022 | 13:55h | UTC

Renin–Angiotensin System Inhibition in Advanced Chronic Kidney Disease – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

RCT | Clinical and cost-effectiveness of single stage compared vs. two-stage revision for hip prosthetic joint infection.

4 Nov, 2022 | 13:49h | UTC

Clinical and cost effectiveness of single stage compared with two stage revision for hip prosthetic joint infection (INFORM): pragmatic, parallel group, open label, randomised controlled trial – The BMJ

 

RCT | Computerized games vs. crosswords training in mild cognitive impairment.

4 Nov, 2022 | 13:34h | UTC

Computerized Games versus Crosswords Training in Mild Cognitive Impairment – NEJM Evidence

News Release: Crossword puzzles beat computer video games in slowing memory loss – Columbia University Irving Medical Center

 

RCT | Effect of high-intensity interval training in patients with atrial fibrillation.

3 Nov, 2022 | 13:53h | UTC

Effect of High-Intensity Interval Training in Patients With Atrial Fibrillation: A Randomized Clinical Trial – JAMA Network Open

 

Commentary from the author on Twitter (thread – click for more)

Under a CC-BY License License

 

Phase 2 RCT | A single injection of a monoclonal antibody was 88% effective for malaria prevention over 6 months.

2 Nov, 2022 | 14:30h | UTC

Safety and Efficacy of a Monoclonal Antibody against Malaria in Mali – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Monoclonal antibody prevents malaria infection in African adults – National Institutes of Health

Commentary: Monoclonal antibody infusion 88% effective against malaria – CIDRAP

Related Study: Phase 1 Study | Low-dose subcutaneous or intravenous monoclonal antibody can prevent malaria in a human challenge model.

 

Commentary on Twitter

 

RCT | Intensive BP control after thrombectomy for ischemic stroke is associated with increased risk of poor functional outcomes.

2 Nov, 2022 | 14:26h | UTC

Intensive blood pressure control after endovascular thrombectomy for acute ischaemic stroke (ENCHANTED2/MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial – The Lancet (link to abstract – $ for full-text)

News Release: Large stroke trial finds intensive blood pressure lowering after clot removal worsens recovery – George Institute for Global Health

 

Commentary on Twitter (thread – click for more)

 

Post-trial follow-up | Endarterectomy vs. stenting vs. best medical treatment for asymptomatic carotid artery stenosis.

2 Nov, 2022 | 14:25h | UTC

Carotid endarterectomy or stenting or best medical treatment alone for moderate-to-severe asymptomatic carotid artery stenosis: 5-year results of a multicentre, randomised controlled trial – The Lancet Neurology (link to abstract – $ for full-text)

Original Study: Angioplasty in asymptomatic carotid artery stenosis vs. endarterectomy compared to best medical treatment: One-year interim results of SPACE-2 – International Journal of Stroke

 

Commentary on Twitter

 

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