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Randomized Trials

Long-term follow-up of a RCT | Percutaneous coronary intervention vs. bypass surgery for multivessel coronary artery disease.

20 Sep, 2022 | 13:34h | UTC

Everolimus-Eluting Stents or Bypass Surgery for Multivessel Coronary Artery Disease: Extended Follow-up Outcomes of Multicenter Randomized Controlled BEST Trial – Circulation

Commentary: 10-Year Data From BEST Trial Find No Significant Safety or MACE Differences Between PCI With EES Versus CABG – Cardiac Interventions Today

Original Study: Trial of Everolimus-Eluting Stents or Bypass Surgery for Coronary Disease – New England Journal of Medicine

 

Long-term follow-up of a RCT | Outcomes after catheter-based renal artery denervation for resistant hypertension.

20 Sep, 2022 | 13:33h | UTC

Long-term outcomes after catheter-based renal artery denervation for resistant hypertension: final follow-up of the randomised SYMPLICITY HTN-3 Trial – The Lancet (free registration required)

Commentary: SYMPLICITY HTN-3’s Late Surprise: Sustained BP Drop at 3 Years Despite Earlier Miss – TCTMD

Original Study: A Controlled Trial of Renal Denervation for Resistant Hypertension – New England Journal of Medicine

 

RCT | Myopia control effect of repeated low-level red-light therapy in children.

20 Sep, 2022 | 13:31h | UTC

Myopia Control Effect of Repeated Low-Level Red-Light Therapy in Chinese Children: A Randomized, Double-Blind, Controlled Clinical Trial – Ophthalmology

Commentary: Repeated Low-Level Red-Light Therapy Reduces Myopia Progression in Children – HCP Live

 

Preliminary results of a RCT | Once-only colonoscopy vs. two rounds of fecal immunochemical testing 2 years apart for colorectal cancer screening.

20 Sep, 2022 | 13:29h | UTC

Once-only colonoscopy or two rounds of faecal immunochemical testing 2 years apart for colorectal cancer screening (SCREESCO): preliminary report of a randomised controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)

Commentary: Two Rounds of FIT vs Single Colonoscopy as a One-time CRC Screening – Medscape (free registration required)

 

RCT | Dupilumab in children aged 6 months to younger than 6 years with uncontrolled atopic dermatitis.

20 Sep, 2022 | 13:20h | UTC

Dupilumab in children aged 6 months to younger than 6 years with uncontrolled atopic dermatitis: a randomised, double-blind, placebo-controlled, phase 3 trial – The Lancet

Commentary: Dupilumab Eases Atopic Dermatitis in Children Younger Than 6 Years – HealthDay

 

RCT | Deucravacitinib vs. placebo and Apremilast in moderate to severe plaque psoriasis.

20 Sep, 2022 | 13:16h | UTC

Deucravacitinib versus placebo and apremilast in moderate to severe plaque psoriasis: efficacy and safety results from the 52-week, randomized, double-blinded, phase 3 POETYK PSO-2 trial – Journal of the American Academy of Dermatology

 

RCT | Cerebral embolic protection during transcatheter aortic-valve replacement did not significantly reduce the incidence of periprocedural stroke.

19 Sep, 2022 | 12:49h | UTC

Cerebral Embolic Protection during Transcatheter Aortic-Valve Replacement – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

PROTECTED TAVR: No Less Stroke With Embolic Protection, but Some See Hope – TCTMD

Stroke PROTECTion With SEntinel During Transcatheter Aortic Valve Replacement – PROTECTED TAVR – American College of Cardiology

Presumed Clinical Benefits of TAVR Cerebral Protection Remain Unproven — Large trial comes up short in proving a definitive benefit to debris filters – MedPage Today (free registration required)

News Release: Cerebral Embolic Protection During Transcatheter Aortic-Valve Replacement – Cedars-Sinai

 

Commentary on Twitter

 

RCT | Methotrexate may increase response rates in patients with uncontrolled gout receiving Pegloticase.

19 Sep, 2022 | 12:38h | UTC

A Randomized Placebo-Controlled Study of Methotrexate to Increase Response Rates in Patients with Uncontrolled GOut Receiving Pegloticase (MIRROR RCT): Primary Efficacy and Safety Findings – Arthritis & Rheumatology

Commentary: Data Now Out for Pegloticase-MTX Combo Gout Treatment – MedPage Today (free registration required)

 

RCT | Olokizumab, a monoclonal antibody against interleukin-6, in combination with methotrexate in patients with rheumatoid arthritis inadequately controlled by tumor necrosis factor inhibitor therapy.

19 Sep, 2022 | 12:35h | UTC

Olokizumab, a monoclonal antibody against interleukin-6, in combination with methotrexate in patients with rheumatoid arthritis inadequately controlled by tumour necrosis factor inhibitor therapy: efficacy and safety results of a randomised controlled phase III study – Annals of Rheumatic Diseases

 

RCT | Intensity-modulated radiotherapy vs. stereotactic body radiotherapy for prostate cancer.

19 Sep, 2022 | 12:31h | UTC

Intensity-modulated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): 2-year toxicity results from an open-label, randomised, phase 3, non-inferiority trial – The Lancet Oncology (link to abstract – $ for full-text)

 

Commentary from the author on Twitter (thread – click for more)

 

Phase 2 RCT | Combined nivolumab and ipilimumab with or without stereotactic body radiation therapy for advanced Merkel cell carcinoma.

19 Sep, 2022 | 12:32h | UTC

Combined nivolumab and ipilimumab with or without stereotactic body radiation therapy for advanced Merkel cell carcinoma: a randomised, open label, phase 2 trial – The Lancet (free registration required for full-text)

Commentary: Dual checkpoint inhibitor blockade shows promise as first-line and salvage therapy for Merkel cell carcinoma patients – H. Lee Moffitt Cancer Center & Research Institute

 

RCT | Short-term outcomes of laparoscopy-assisted vs. open surgery for patients with low rectal cancer.

16 Sep, 2022 | 12:58h | UTC

Short-term Outcomes of Laparoscopy-Assisted vs Open Surgery for Patients With Low Rectal Cancer: The LASRE Randomized Clinical Trial – JAMA Oncology

 

Commentary on Twitter

https://twitter.com/JAMAOnc/status/1570532915393744896

 

RCT | In patients with acute pancreatitis, early aggressive hydration resulted in a higher incidence of fluid overload without improvement in clinical outcomes.

15 Sep, 2022 | 13:15h | UTC

Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis – New England Journal of Medicine (link to abstract – $ for full-text)

 

RCT | Effects of cocoa extract and a multivitamin on cognitive function.

15 Sep, 2022 | 13:14h | UTC

Effects of cocoa extract and a multivitamin on cognitive function: A randomized clinical trial – Alzheimer’s & Dementia

Commentary: Daily multivitamins improved the brain function of seniors in a trial — but plenty of questions remain – STAT

 

RCT | Robotic vs. laparoscopic surgery for middle and low rectal cancer.

15 Sep, 2022 | 13:09h | UTC

Robotic versus laparoscopic surgery for middle and low rectal cancer (REAL): short-term outcomes of a multicentre randomised controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)

Commentaries:

Robotic Surgery Tops Laparoscopic Surgery for Middle and Low Rectal Cancer — Randomized trial shows fewer positive circumferential resection margins with robotic technique – MedPage Today (free registration required)

 

Commentaries on Twitter

 

RCT | Minocycline added to standard antidepressant treatment did not improve symptoms in patients with treatment-resistant depression.

15 Sep, 2022 | 13:04h | UTC

Effect of Minocycline on Depressive Symptoms in Patients With Treatment-Resistant Depression: A Randomized Clinical Trial – JAMA Network Open

See also: Visual Abstract

 

Study | Vitamin D3 and omega-3 fatty acids not helpful in reducing the risk of frailty.

14 Sep, 2022 | 13:20h | UTC

News Release: Vitamin D3 and omega-3 fatty acids not helpful in reducing risk of frailty – Brigham and Women’s Hospital

Original Study: Effect of Vitamin D3 and Omega-3 Fatty Acid Supplementation on Risk of Frailty: An Ancillary Study of a Randomized Clinical Trial – JAMA Network Open

Invited Commentary: There Is No Magic Pill to Prevent Frailty—You Still Have to Eat Your Vegetables – JAMA Network Open

 

Commentary on Twitter

 

Long-term follow-up of a RCT | Endoscopic versus surgical step-up approach for infected necrotizing pancreatitis.

14 Sep, 2022 | 13:13h | UTC

Endoscopic Versus Surgical Step-Up Approach for Infected Necrotizing Pancreatitis (ExTENSION): Long-term Follow-up of a Randomized Trial – Gastroenterology

 

Commentary on Twitter

Under a Creative Commons Attribution (CC BY 4.0) License

 

Phase 2 RCT | Sequencing of Ipilimumab plus Nivolumab and Encorafenib plus Binimetinib for untreated BRAF-mutated metastatic melanoma.

14 Sep, 2022 | 13:01h | UTC

Sequencing of Ipilimumab Plus Nivolumab and Encorafenib Plus Binimetinib for Untreated BRAF-Mutated Metastatic Melanoma (SECOMBIT): A Randomized, Three-Arm, Open-Label Phase II Trial – Journal of Clinical Oncology (link to abstract – $ for full-text)

Commentary: Sequential Treatment With Immunotherapy and Targeted Therapy Denotes OS Benefit in BRAF-Mutant Melanoma – OncLive

 

Commentary on Twitter

 

RCT | Efficacy and safety of carboplatin with nab-paclitaxel vs. docetaxel in older patients with squamous non-small-cell lung cancer.

14 Sep, 2022 | 13:00h | UTC

Efficacy and safety of carboplatin with nab-paclitaxel versus docetaxel in older patients with squamous non-small-cell lung cancer (CAPITAL): a randomised, multicentre, open-label, phase 3 trial – The Lancet Health Longevity

 

Commentary on Twitter

 

RCT | A double-dose influenza vaccination during hospitalization for acute coronary syndrome did not improve outcomes compared to standard-dose outpatient vaccination.

13 Sep, 2022 | 13:19h | UTC

Influenza vaccination strategy in acute coronary syndromes: the VIP-ACS trial – European Heart Journal

 

Commentary on Twitter

 

RCT | Anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically ventilated patients with COVID-19.

13 Sep, 2022 | 13:16h | UTC

Anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically ventilated patients with COVID-19 (PANAMO): a multicentre, double-blind, randomised, placebo-controlled, phase 3 trial – The Lancet Respiratory Medicine

 

Commentaries on Twitter

 

RCT | Dipeptidyl peptidase-1 inhibition does not improve outcomes in patients hospitalized with COVID-19.

13 Sep, 2022 | 13:15h | UTC

Dipeptidyl peptidase-1 inhibition in patients hospitalised with COVID-19: a multicentre, double-blind, randomised, parallel-group, placebo-controlled trial – The Lancet Respiratory Medicine

 

Commentary on Twitter

 

RCT | Five-year analysis of adjuvant Pembrolizumab or placebo in stage III melanoma.

13 Sep, 2022 | 13:03h | UTC

Five-Year Analysis of Adjuvant Pembrolizumab or Placebo in Stage III Melanoma – NEJM Evidence

 

Phase 2b RCT | ABX464 (obefazimod) for moderate-to-severe, active ulcerative colitis.

13 Sep, 2022 | 13:01h | UTC

ABX464 (obefazimod) for moderate-to-severe, active ulcerative colitis: a phase 2b, double-blind, randomised, placebo-controlled induction trial and 48 week, open-label extension – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)

 

Commentary on Twitter

 

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