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Randomized Trials

RCT | Durvalumab with or without Tremelimumab plus chemotherapy for metastatic non–small-cell lung cancer.

14 Dec, 2022 | 14:47h | UTC

Durvalumab With or Without Tremelimumab in Combination With Chemotherapy as First-Line Therapy for Metastatic Non–Small-Cell Lung Cancer: The Phase III POSEIDON Study – Journal of Clinical Oncology

Commentary: Adding Tremelimumab and Durvalumab to Chemo Improves PFS, OS in mNSCLC – Cancer Therapy Advisor

 

Commentary on Twitter

 

RCT | Rogaratinib vs. chemotherapy in patients with advancer urothelial carcinoma selected based on FGFR1/3 mRNA expression.

14 Dec, 2022 | 14:45h | UTC

FORT-1: Phase II/III Study of Rogaratinib Versus Chemotherapy in Patients With Locally Advanced or Metastatic Urothelial Carcinoma Selected Based on FGFR1/3 mRNA Expression – Journal of Clinical Oncology

Commentary: Rogaratinib Is Noninferior to Chemo in Pretreated FGFR1/3 mRNA+ Locally Advanced or Metastatic Urothelial Carcinoma – OncLive

 

Commentary on Twitter

 

RCT | Ropivacaine perineal infiltration after episiotomy did not reduce postpartum pain.

13 Dec, 2022 | 14:16h | UTC

Ropivacaine perineal infiltration for postpartum pain management in episiotomy repair: a double-blind, randomised, placebo-controlled trial – BJOG (link to abstract – $ for full-text)

 

RCT | Twice-daily oral zinc in the treatment of patients with COVID-19.

12 Dec, 2022 | 12:48h | UTC

Twice-Daily Oral Zinc in the Treatment of Patients With Coronavirus Disease 2019: A Randomized Double-Blind Controlled Trial – Clinical Infectious Diseases

 

RCT | Mepitel film for the prevention of acute radiation dermatitis in breast cancer.

12 Dec, 2022 | 12:40h | UTC

Mepitel Film for the Prevention of Acute Radiation Dermatitis in Breast Cancer: A Randomized Multicenter Open-Label Phase III Trial – Journal of Clinical Oncology (link to abstract – $ for full-text)

Post-trial follow-up | Bursectomy vs. omentectomy alone for resectable gastric cancer.

12 Dec, 2022 | 12:26h | UTC

Five-year follow-up of a randomized clinical trial comparing bursectomy and omentectomy alone for resectable gastric cancer (JCOG1001) – British Journal of Surgery (link to abstract – $ for full-text)

 

RCT | Tumor-infiltrating lymphocyte therapy vs. Ipilimumab in advanced melanoma.

8 Dec, 2022 | 12:51h | UTC

Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Patient’s own immune cells effective as living medicine for melanoma – Netherlands Cancer Institute

 

RCT | Bimekizumab in patients with psoriatic arthritis, naive to biologic treatment.

7 Dec, 2022 | 14:29h | UTC

Bimekizumab in patients with psoriatic arthritis, naive to biologic treatment: a randomised, double-blind, placebo-controlled, phase 3 trial (BE OPTIMAL) – The Lancet

 

RCT | Iron chelation with Deferiprone fails to improve outcomes in Parkinson’s Disease.

6 Dec, 2022 | 13:46h | UTC

Trial of Deferiprone in Parkinson’s Disease – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Deferiprone Not Beneficial for Newly Diagnosed Parkinson Disease – HealthDay

 

Commentary on Twitter

 

RCT | Lecanemab slows cognitive decline in early Alzheimer’s disease but raises safety concerns.

2 Dec, 2022 | 14:40h | UTC

Lecanemab in Early Alzheimer’s Disease – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

Heralded Alzheimer’s drug works — but safety concerns loom – Nature

Lecanemab and Alzheimer’s: More Data – Science

Expert reaction to phase 3 trial results of lecanemab for early Alzheimer’s disease – Science Media Centre

Alzheimer’s Drug is Hailed Amid Safety Concerns – Health Policy Watch

Related: Second death linked to potential antibody treatment for Alzheimer’s disease – Science

 

Commentary on Twitter

 

RCT | Effects of internet-delivered cognitive behavioral therapy on use of child sexual abuse material.

2 Dec, 2022 | 14:38h | UTC

Effects of internet-delivered cognitive behavioral therapy on use of child sexual abuse material: A randomized placebo-controlled trial on the Darknet – Internet Interventions

News Release: Reduced use of child sexual abuse material after online CBT – Karolinska Institutet

 

Commentary on Twitter (thread – click for more)

https://twitter.com/NiklasLangstrom/status/1598206403294171138

 

RCT | Single-dose Acoziborole is effective and safe for patients with sleeping sickness.

2 Dec, 2022 | 14:35h | UTC

Efficacy and safety of acoziborole in patients with human African trypanosomiasis caused by Trypanosoma brucei gambiense: a multicentre, open-label, single-arm, phase 2/3 trial – The Lancet Infectious Diseases

News Release: New single-dose treatment for sleeping sickness could help eliminate transmission of the disease by 2030 – The Lancet

Commentary: Single dose of acoziborole 95% effective in treating sleeping sickness – CIDRAP

 

Phase 2b RCT | Cannabidiol oil failed to relieve symptoms in advanced cancer.

1 Dec, 2022 | 14:04h | UTC

Phase IIb Randomized, Placebo-Controlled, Dose-Escalating, Double-Blind Study of Cannabidiol Oil for the Relief of Symptoms in Advanced Cancer (MedCan1-CBD) – Journal of Clinical Oncology

Commentary: Cannabis oil failed to improve pain or quality of life in palliative care cancer patients, study shows – The Guardian

Related:

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain – Agency for Healthcare Research and Quality

Systematic Review: Cannabis-based products for chronic pain.

Podcast: #338 LIVE! Medical Cannabis: Is it still dope? – The Curbsiders

Medicinal Cannabis for Chronic Pain: The Bermuda Triangle of Low Quality Studies, Countless Meta-analyses and Conflicting Recommendations – European Journal of Pain

RCT: Effect of medical marijuana card ownership on pain, insomnia, and affective disorder symptoms in adults. 

Cohort Study: Long-term cannabis use is associated with cognitive deficits and smaller hippocampal volume in midlife. 

AHA Scientific Statement | How does cannabis use affect brain health? Caution advised, more research needed.

M-A: Birth outcomes of neonates exposed to marijuana in utero. 

Cannabis-related allergies: an international overview and consensus recommendations.

Review: Cannabis-based medicines and medical cannabis for chronic neuropathic pain.

Cannabinoid metabolites as inhibitors of major hepatic CYP450 enzymes, with implications for cannabis-drug interactions.

The International Cannabis Toolkit (iCannToolkit): a multidisciplinary expert consensus on minimum standards for measuring cannabis use.

Cannabis products are being sold as sleep remedies – here’s the evidence about their effectiveness.

Guideline: Medical cannabis or cannabinoids for chronic pain.

Cannabis and Cannabinoid Analgesia position statement – “Due to the lack of high-quality clinical evidence, the IASP does not currently endorse general use of cannabis and cannabinoids for pain relief.”

NICE Guideline: Cannabis-Based Medicinal Products

Consensus recommendations for perioperative management of cannabis and cannabinoid-based medicine users

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain – Agency for Healthcare Research and Quality

Short Review: Drug Interactions with Cannabinoids

Meta-Analysis: Cannabinoids Not Effective for Cancer-Related Pain

Review: Considerations for cannabinoids in perioperative care by anesthesiologists.

Review: Cannabis-based Medicines and the Perioperative Physician

Study: Cannabis Use Disorder May Increase the Risk of Cardiovascular Events in Major Elective Surgeries

Perspective: If You Smoke Pot, Your Anesthesiologist Needs To Know

Perioperative Care of Cannabis Users: A Comprehensive Review of Pharmacological and Anesthetic Considerations

 

RCT | Combining loop with thiazide diuretics for decompensated heart failure.

1 Dec, 2022 | 14:02h | UTC

Combining loop with thiazide diuretics for decompensated heart failure: the CLOROTIC trial – European Heart Journal

 

Commentary on Twitter

 

RCT | Effect of irrigation fluid temperature on recurrence in the evacuation of chronic subdural hematoma.

30 Nov, 2022 | 13:45h | UTC

Effect of Irrigation Fluid Temperature on Recurrence in the Evacuation of Chronic Subdural Hematoma – JAMA Neurology

News Release: Warmer brain-irrigation fluid in surgery more efficacious – University of Gothenburg 

 

Commentary on Twitter

 

RCT | Remotely delivered cognitive behavioral and personalized exercise interventions for fatigue severity and impact in rheumatic diseases.

29 Nov, 2022 | 13:46h | UTC

Remotely delivered cognitive behavioural and personalised exercise interventions for fatigue severity and impact in inflammatory rheumatic diseases (LIFT): a multicentre, randomised, controlled, open-label, parallel-group trial – The Lancet Rheumatology

 

RCT | Rectal culture-based vs. empirical antibiotic prophylaxis to prevent infections in men undergoing transrectal prostate biopsy.

27 Nov, 2022 | 22:28h | UTC

Rectal culture-based versus empirical antibiotic prophylaxis to prevent infectious complications in men undergoing transrectal prostate biopsy: a randomized, non-blinded multicenter trial – Clinical Infectious Diseases (link to abstract – $ for full-text)

 

Commentary on Twitter

 

RCT | One-session treatment compared with multisession CBT in children aged 7-16 years with specific phobias.

27 Nov, 2022 | 22:07h | UTC

One-session treatment compared with multisession CBT in children aged 7 16 years with specific phobias: the ASPECT non-inferiority RCT – Health Technology Assessment

 

Commentary on Twitter

 

RCT | Opioid-reduced anesthesia based on esketamine in gynecological day surgery.

25 Nov, 2022 | 12:29h | UTC

Opioid-reduced anesthesia based on esketamine in gynecological day surgery: a randomized double-blind controlled study – BMC Anesthesiology

 

Post-trial follow-up | OS with daratumumab, bortezomib, and dexamethasone in previously treated multiple myeloma.

25 Nov, 2022 | 12:25h | UTC

Overall Survival With Daratumumab, Bortezomib, and Dexamethasone in Previously Treated Multiple Myeloma (CASTOR): A Randomized, Open-Label, Phase III Trial – Journal of Clinical Oncology

Original Study: Daratumumab, Bortezomib, and Dexamethasone for Multiple Myeloma – New England Journal of Medicine

 

RCT | Anticoagulation for 3 months reduces recurrence rates vs. treatment for 6 weeks in patients with isolated distal DVT.

24 Nov, 2022 | 13:34h | UTC

Rivaroxaban treatment for six weeks versus three months in patients with symptomatic isolated distal deep vein thrombosis: randomised controlled trial – The BMJ

News Release: Extending anti-clotting treatment after distal DVT reduces further clot risk – BMJ Newsroom

 

RCT | Low-dose morphine did not significantly reduce the intensity of chronic breathlessness in patients with COPD.

23 Nov, 2022 | 14:09h | UTC

Effect of Regular, Low-Dose, Extended-release Morphine on Chronic Breathlessness in Chronic Obstructive Pulmonary Disease: The BEAMS Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Dyspnea—When a Sensation Becomes a Symptom – JAMA (free for a limited period)

See also: Visual Abstract

Commentary: Breathlessness in Patients with COPD isn’t Reduced with Daily Morphine – HCP Live

 

RCT | Treatment of early Lyme Disease with doxycycline for 7 days is noninferior to treatment for 14 days.

23 Nov, 2022 | 14:06h | UTC

Treatment of erythema migrans with doxycycline for 7 days versus 14 days in Slovenia: a randomised open-label non-inferiority trial – The Lancet Infectious Diseases (link to abstract – $ for full-text)

Commentary: Shorter Duration of Antibiotics Noninferior for Lyme Disease – JAMA (free for a limited period)

 

Commentary on Twitter

 

RCT | Posterior cervical foraminotomy is noninferior to anterior cervical discectomy in patients with cervical radiculopathy.

23 Nov, 2022 | 13:48h | UTC

Noninferiority of Posterior Cervical Foraminotomy vs Anterior Cervical Discectomy With Fusion for Procedural Success and Reduction in Arm Pain Among Patients With Cervical Radiculopathy at 1 Year: The FACET Randomized Clinical Trial – JAMA Neurology (free for a limited period)

 

Commentary on Twitter

 

RCT | Simvastatin is ineffective as a disease-modifying treatment for patients with Parkinson’s Disease.

23 Nov, 2022 | 13:42h | UTC

Evaluation of Simvastatin as a Disease-Modifying Treatment for Patients With Parkinson Disease: A Randomized Clinical Trial – JAMA Neurology

Commentary: Simvastatin Ineffective as Disease-Modifying Therapy for Intermediate Parkinson Disease – AJMC

 

Commentary on Twitter

 

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