RCT | Low-dose morphine did not significantly reduce the intensity of chronic breathlessness in patients with COPD.

Effect of Regular, Low-Dose, Extended-release Morphine on Chronic Breathlessness in Chronic Obstructive Pulmonary Disease: The BEAMS Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Dyspnea—When a Sensation Becomes a Symptom – JAMA (free for a limited period)

See also: Visual Abstract

Commentary: Breathlessness in Patients with COPD isn’t Reduced with Daily Morphine – HCP Live