Randomized Trials
RCT | Efficacy and safety of Remibrutinib, a novel BTK inhibitor, for chronic spontaneous urticaria.
23 Nov, 2022 | 13:37h | UTC
RCT | Discontinuation vs. continuation of hypertonic saline or dornase alfa in modulator treated people with cystic fibrosis.
23 Nov, 2022 | 13:36h | UTC
Commentary on Twitter
NEW Article—Discontinuing daily hypertonic saline or dornase alfa in #CFTR modulator-treated individuals with #cysticfibrosis: the SIMPLIFY study
From Nicole Mayer-Hamblett & colleagues https://t.co/LwVctcOlTq#NACFC2022 @CF_Foundation pic.twitter.com/OnDe8rUoPx
— The Lancet Respiratory Medicine (@LancetRespirMed) November 4, 2022
2ry analysis of a RCT | Effect of Atogepant for preventive migraine treatment on patient-reported outcomes.
22 Nov, 2022 | 13:32h | UTCOriginal Study: Atogepant for the Preventive Treatment of Migraine – New England Journal of Medicine
SR | Pharmaceutical interventions for emotionalism after stroke.
22 Nov, 2022 | 13:24h | UTCPharmaceutical interventions for emotionalism after stroke – Cochrane Library
RCT | Subcutaneous vs. transvenous implantable cardioverter defibrillator implantations.
22 Nov, 2022 | 13:19h | UTCPerioperative Safety and Early Patient and Device Outcomes Among Subcutaneous Versus Transvenous Implantable Cardioverter Defibrillator Implantations: A Randomized, Multicenter Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries:
Subcutaneous ICD Reduces Lead-Related Complications – HealthDay
Related:
Subcutaneous or Transvenous Defibrillator Therapy – New England Journal of Medicine
Commentary on Twitter
New from @PHRIresearch @McMasterU: S-ICDs reduce lead-related complications by 92% w/out compromising effectiveness of shocks, but trend towards more inappropriate shocks: https://t.co/i7TtRr0PqP pic.twitter.com/Jhp7uprJT7
— Annals of Int Med (@AnnalsofIM) November 8, 2022
2ry analysis of a RCT | Device-related complications in subcutaneous versus transvenous ICD.
22 Nov, 2022 | 13:16h | UTCOriginal Study: Subcutaneous or Transvenous Defibrillator Therapy – New England Journal of Medicine
Related: Perioperative Safety and Early Patient and Device Outcomes Among Subcutaneous Versus Transvenous Implantable Cardioverter Defibrillator Implantations: A Randomized, Multicenter Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
RCT | Leniolisib for Activated phosphoinositide 3-kinase delta syndrome.
22 Nov, 2022 | 13:12h | UTC
RCT | Zanubrutinib vs. Ibrutinib in relapsed/refractory Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma.
22 Nov, 2022 | 13:03h | UTC
RCT | New drug can improve constipation in patients with Parkinson Disease.
22 Nov, 2022 | 13:00h | UTCOral ENT-01 Targets Enteric Neurons to Treat Constipation in Parkinson Disease: A Randomized Controlled Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries:
New Drug Could Ease Parkinson’s-Related Constipation – HealthDay
Commentary on Twitter
A #RTC of 150 persons with #ParkinsonDisease has found that ENT-01 is safe for up to 25 days of treatment and significantly improves constipation and possibly neurological symptoms: https://t.co/JdDhaHiFOA @MayoClinic pic.twitter.com/IWWCBzvrWV
— Annals of Int Med (@AnnalsofIM) November 8, 2022
RCT | Intermittently scanned continuous glucose monitoring vs. fingerstick testing for Type 1 DM.
21 Nov, 2022 | 14:45h | UTCRCT | Intermittently scanned continuous glucose monitoring vs. fingerstick testing for Type 1 DM.
Intermittently Scanned Continuous Glucose Monitoring for Type 1 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Continuous Monitoring Outperforms Fingerstick Testing in Patients With T1D, High Glycated Hemoglobin – AJMC
Commentary on Twitter
In persons with type 1 diabetes, intermittently scanned continuous glucose monitoring led to significantly lower glycated hemoglobin levels than participant monitoring with fingerstick testing. https://t.co/2JkNKDyoQJ pic.twitter.com/CXEcARsLD8
— NEJM (@NEJM) October 5, 2022
Cluster RCT | A personalized cooler dialysate provides no benefit for patients receiving maintenance hemodialysis.
21 Nov, 2022 | 14:38h | UTCPersonalised cooler dialysate for patients receiving maintenance haemodialysis (MyTEMP): a pragmatic, cluster-randomised trial – The Lancet (link to abstract – $ for full-text)
Commentary: Clinical trial examines optimal dialysis temperature – University of Western Ontario
Commentary on Twitter (thread – click for more)
Over 2 million people worldwide with #kidneyfailure rely on maintenance #dialysis treatments.
Trial, MyTEMP, assesses the effects of cooler dialysate compared with standard temperature in individuals receiving outpatient maintenance dialysis.🧵 pic.twitter.com/M9JscDqM2v
— The Lancet (@TheLancet) November 17, 2022
RCT | Quality of recovery with low-pressure vs. standard-pressure pneumoperitoneum during laparoscopic colorectal surgery.
21 Nov, 2022 | 14:23h | UTCQuality of Recovery and Innate Immune Homeostasis in Patients Undergoing Low-pressure Versus Standard-pressure Pneumoperitoneum During Laparoscopic Colorectal Surgery (RECOVER): A Randomized Controlled Trial – Annals of Surgery (free for a limited period)
RCT | Comparison between different corticosteroid injection techniques in adhesive capsulitis.
21 Nov, 2022 | 14:18h | UTC
Guide to statistics and methods | Adjustment for baseline characteristics in randomized clinical trials.
21 Nov, 2022 | 14:05h | UTCAdjustment for Baseline Characteristics in Randomized Clinical Trials – JAMA (free for a limited period)
Commentary: Should you adjust for baseline characteristics within randomized controlled trials? – Healthcare Economist
RCT | Influenza vaccine to reduce adverse vascular events in patients with heart failure.
18 Nov, 2022 | 13:26h | UTCCommentary:
Flu vaccines cut pneumonia, cardiovascular issues in heart failure patients – CIDRAP
Flu Shot Could Be Lifesaver for Folks With Heart Failure – HealthDay
M-A | Pharmacological interventions on smoking cessation.
18 Nov, 2022 | 13:12h | UTC
RCT | Clopidogrel is better than Aspirin for chronic maintenance monotherapy after percutaneous coronary intervention.
17 Nov, 2022 | 12:30h | UTCRelated:
Commentary on Twitter
https://twitter.com/CircAHA/status/1589647384073703426
Phase 2b RCT | Rituximab vs. IV cyclophosphamide in patients with connective tissue disease-associated interstitial lung disease.
17 Nov, 2022 | 12:24h | UTCCommentaries:
RECITAL: Rituximab represents alternative to cyclophosphamide for CTD-ILD – medwire News
CTD-ILD: Rituximab ‘a Reasonable Alternative to Cyclophosphamide’ – Medscape (free registration required)
Commentary on Twitter
https://twitter.com/LancetRespirMed/status/1592057243075112960
Phase 2 RCT | Efficacy and safety of low-dose Interleukin 2 for primary Sjögren syndrome.
17 Nov, 2022 | 12:20h | UTCCommentary: Sjogren’s Responds to Cytokine Treatment, Early Data Show — Phase II trial signals possible breakthrough for hard-to-treat illness – MedPage Today (free registration required)
RCT | Safety of withholding perioperative hydrocortisone for patients with pituitary adenomas with an intact HPA axis.
17 Nov, 2022 | 12:23h | UTC
Commentary on Twitter
https://twitter.com/JAMANetworkOpen/status/1592940564433059840
Consistency between trials presented at conferences, their subsequent publications and press releases.
17 Nov, 2022 | 12:19h | UTC
Crossover RCT | Spectacle lenses with highly aspherical lenslets for slowing myopia.
17 Nov, 2022 | 12:16h | UTCRelated:
RCT | The comparison of two different strategies of intravitreal conbercept for polypoidal choroidal vasculopathy.
17 Nov, 2022 | 12:11h | UTCCommentary: Quarterly Dosing of Conbercept Similar to Treat-and-Extend Regimen for PCV – HCP Live
RCT | In patients with end-stage ankle osteoarthritis, total ankle replacement and arthrodesis resulted in comparable results.
16 Nov, 2022 | 13:45h | UTCTotal Ankle Replacement Versus Arthrodesis for End-Stage Ankle Osteoarthritis: A Randomized Controlled Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
News Release: Trial shows benefits of two forms of ankle surgery for osteoarthritis – University College London
Summary for Patients: Total Ankle Replacement Versus Arthrodesis for End-Stage Ankle Osteoarthritis
RCT | Comparative effects of low-dose rosuvastatin vs. dietary supplements on lipids and inflammatory biomarkers.
16 Nov, 2022 | 13:41h | UTCNews Release: 6 common “heart-health” supplements ineffective at lowering cholesterol compared to statins – American Heart Association
Commentaries:
Study – For Lowering Cholesterol, Statins Work, Supplements Don’t – Science-Based Medicine
Statins vs. supplements: New study finds one is ‘vastly superior’ to cut cholesterol – NPR